Spectrum of spontaneous mutations in liver tissue of lacl transgenic mice

Environmental and Molecular Mutagenesis

Volumn 30, Issue 3, 1997, Pages 273-286

  De Boer, Johan G ^a   Erfle, Heather ^a   Walsh, David ^a   Holcroft, James ^a   Provost, J Scott ^b   Rogers, Brenda ^c   Tindall, Kenneth R ^d   Glickman, Barry W ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b Taconic   (United States)

^c Stratagene   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Big Blue mice; DNA sequencing; Mutational spectra; Spontaneous mutation; Tissues

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; LIVER; MALE; MOUSE; MOUSE STRAIN; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; SPONTANEOUS MUTATION; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; FRAMESHIFT MUTATION; LAC OPERON; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE DELETION;

ANIMALIA; MUS MUSCULUS;

EID: 0030781051     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)30:3<273::AID-EM5>3.0.CO;2-M     Document Type: Article

References (59)

1. Adams WT, Skopek TR (1987): Statistical test for the comparison of samples from mutational spectra. J Mol Biol 194:391-396.
2. Akasaka S, Yamamoto K (1994): Hydrogen peroxide induces G:C → T:A and G:C → C:G transversions in the supF gene of Escherichia coli. Mol Gen Genet 243:500-505.
3. Albertini RJ, Gennett IN, Lambert B, Thilly WG, Vrieling H (1989): Mutation at the hprt locus. Mutat Res 216:65-88.
4. Bottema CD, Ketterling RP, Vielhaber E, Yoon HS, Gostout B, Jacobson DP, Shapiro A, Sommers SS (1993): The pattern of spontaneous germ-line mutation: Relative rates of mutation at or near CpG dinucleotides in the factor IX gene. Human Genet 91:496-503.
5. Cooper DN, Youssoufian H (1988): The CpG dinucleotide and human genetic disease. Human Genet 78:151-155.
6. de Boer JG (1995): Software package for the management of sequencing projects using lacI transgenic animals. Environ Mol Mutagen 25:256-262.
7. de Boer JG, Glickman BW (1989): Sequence specificity of mutation induced by the anti-tumor drug cisplatin in the CHO aprt gene. Carcinogenesis 10:1363-1367.
8. de Boer JG, Ripley LS (1984): Demonstration of the production of frameshift and base-substitution mutations by quasipalindromic DNA sequences. Proc Natl Acad Sci USA 81:5528-5531.
9. Douglas GR, Gingerich JD, Gossen JA, Bartlett SA (1994): Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues. Mutagenesis 9:451-458.
10. Duncan BK, Miller JH (1980): Mutagenic deamination of cytosine residues in DNA. Nature 287:560-561.
11. El Antri S, Mauffret O, Monnot M (1993): Structural deviations of CpG provide a plausible explanation for the high frequency of mutations at this site. Phosphorus nuclear magnetic resonance and circular dichroism studies. J Mol Biol 230:373-378.
12. Endo H, Schut HA, Snyderwine EG (1994): Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF shuttle vector system. Cancer Res 54:3745-3751.
13. Erfle HL, Walsh DF, Holcroft J, Hague N, de Boer JG, Glickman BW (1996): An efficient laboratory protocol for the sequencing of large numbers of lacI mutants recovered from Big Blue® transgenic animals. Environ Mol Mutagen 28:393-396.
14. Farabaugh PJ (1978): Sequence of the lacI gene. Nature 274:765-769.
15. Foster TJ, Davis MA, Roberts DE, Takeshita K, Kleckner N (1981): Genetic organization of transposon Tn10. Cell 23:201-213.
16. Glickman BW, Ripley LS (1984): Structural intermediates of deletion mutagenesis: A role for palindromic DNA. Proc Natl Acad Sci USA 81:512-516.
17. Goodman MF, Cai H, Bloom LB, Eritja R (1994): Nucleotide insertion and primer extension at abasic template sites in different sequence contexts. Ann NY Acad Sci 726:132-142.
18. Gordon AJE, Burns PA, Glickman BW (1990): N-Methyl-N′-nitro-N-nitrosoguanidine induced DNA sequence alteration: Non-random components in alkylation mutagenesis. Mutat Res 233:95-103.
19. - mutations. Mutagenesis 8:133-139.
20. Gorelick NJ, Andrews J, Gu M, Glickman BW (1995): Mutational spectra in the lacI gene in skin from 7,12-dimethylbenzanthracene (DMBA)-treated and untreated transgenic mouse. Mol Carcinogen 14:53-62.
21. Grosovsky AJ, de Boer JG, De Jong PJ, Drobetsky EA, Glickman BW (1988): Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells. Proc Natl Acad Sci USA 85:185-188.
22. Halliday JA, Glickman BW (1991): Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli. Mutat Res 250:55-71.
23. Jiao J, Zielenska M, Anderson MW, Glickman BW (1991): Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli: IV. The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 12:221-224.
24. Kimura H, Iyehara-Ogawa H, Kato T (1994): Slippage-misalignment: To what extent does it contribute to mammalian cell mutagenesis? Mutagenesis 9:395-400.
25. Koberle B, Haupter S, Just W, Speit G (1991): Mutation screening of bleomycin-induced V79 Chinese hamster hprt mutants using multiplex polymerase chain reaction. Mutagenesis 6:527-531.
26. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock WO, Putman DL, Sorge JA, Short JM (1991a): Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ Mol Mutagen 18:316-321.
27. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock WO, Sorge JA, Putman DL, Short JM (1991b): Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci USA 88:7958-7962.
28. Kunkel TA (1990): Misalignment-mediated DNA synthesis errors. Biochemistry 29:8003-8011.
29. Lee AT, DeSimone C, Cerami A, Bucala R (1994): Comparative analysis of DNA mutations in lacI transgenic mice with age. FASEB J 8:545-550.
30. Lichtenauer-Kaligis EG, Thijssen J, den Dulk H, van de Putte P, Tasseron-de Jong JG, Giphart-Gassler M (1993): Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes. Mutagenesis 8:207-220.
31. Loeb LA (1991): Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3079.
32. Michaels ML, Cruz C, Grollman AP, Miller JH (1992): Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci USA 89:7022-7025.
33. Miller JH (1982): Carcinogens induce targeted mutations in Escherichia coli. Cell 31:5-7.
34. Miller JH, Low KB (1984): Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment. Cell 37:675-682.
35. Mirsalis JC, Provost GS, Matthews CD, Hamner RT, Schindler JE, O'Loughlin KG, MacGregor JT, Short JM (1993): Induction of hepatic mutations in lacI transgenic mice. Mutagenesis 8:265-271.
36. Monroe TJ, Mitchell MA (1993): In vivo mutagenesis induced by CC-1065 and adozelesin DNA alkylation in a transgenic mouse model. Cancer Res 53:5690-5696.
37. Nalbantoglu J, Hartley D, Pheart G, Tear G, Meuth M (1986): Spontaneous deletion formation at the aprt locus of hamster cells: The presence of short sequence homologies and dyad symmetries at deletion termini. EMBO J 5:1199-1204.
38. Nicklas JA, Hunter TC, O'Neill JP, Albertini RJ (1989): Molecular analyses of in vivo hprt mutations in human T-lymphocytes. III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins. Mutat Res 215:147-160.
39. Palmer BR, Marinus MG (1994): The dam and dcm strains of Escherichia coli - a review. Gene 143:1-12.
40. Provost GS, Kretz PL, Hamner RT, Matthews CD, Rogers BJ, Lundberg KS, Dycaico MJ, Short JM (1993): Transgenic systems for in vivo mutation analysis. Mutat Res 288:133-149.
41. Richardson KK, Crosby RM, Skopek TR (1988): Mutation spectra of N-ethyl-N′-nitro-N-nitrosoguanidine and 1-(2-hydroxyethyl)-1-nitrosourea in Escherichia coli. Mol Gen Genet 214:460-466.
42. Rideout WM, Coetzee GA, Olumi AF, Jones PA (1990): 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249:1288-1290.
43. Rogers BJ, Provost GS, Young RR, Putman DL, Short JM (1995): Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay (I). Mutat Res 327:57-66.
44. Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M (1993): Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J Biol Chem 268:23524-23530.
45. Schaaper RM, Danforth BN, Glickman BW (1986): Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene. J Mol Biol 189:273-284.
46. Schaaper RM, Dunn RL (1991): Spontaneous mutation in the Escherichia-coli lacI gene. Genetics 129:317-326.
47. Seidman MM, Bredberg A, Seetharam S, Kraemer KH (1987): Multiple point mutations in a vector propagated in human cells: Evidence for an error-prone DNA polymerase activity. Proc Natl Acad Sci USA 84:4944-4948.
48. Sisk SC, Pluta LJ, Bond JA, Recio L (1994): Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene. Carcinogenesis 15:471-477.
49. Skandalis A, Ford BN, Glickman BW (1994): Strand bias in mutation involving 5-methylcytosine deamination in the human hprt gene. Mutat Res 314:21-26.
50. Sockett H, Romac S, Hutchinson F (1991): DNA sequence changes in mutations induced by ultraviolet light in the gpt gene on the chromosome of Escherichia coli uvr+ and urvA cells. Mol Gen Genet 230:295-301.
51. Streisinger G, Okada Y, Emrich J, Newton J, Tsugita A, Terzaghi E, Inouye M (1966): Frameshift mutation and the genetic code. Cold Spring Harbor Symp Quant Biol 31th edn, pp 77-84.
52. Stuart GR, Gorelick NJ, Andrews JL, de Boer JG, Glickman BW (1996): The genetic analysis of lacI mutations in sectored plaques from Big Blue transgenic mice. Environ Mol Mutagen 28:385-392.
53. Tindall KR, Stankowski LF Jr (1989): Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. Mutat Res 220:241-253.
54. Tornatelli S, Pfeifer GP (1995): Complete and tissue-independent methylation of CpG sites in the p53 gene: Implications for mutations in human cancer. Oncogene 10:1493-1499.
55. Ushijima T, Hosoya Y, Ochiai M, Kushida H, Wakabayashi K, Suzuki T, Hayashi M, Sofuni T, Sugimura T, Nagao M (1994): Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice. Carcinogenesis 15:2805-2809.
56. Winegar RA, Lutze LH, Hamer JD, O'Loughlin KG, Mirsalis JC (1994): Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice. Mutat Res 307:479-487.
57. Young RR, Rogers BJ, Provost GS, Short JM, Putman DL (1995): Interlaboratory comparison: Liver spontaneous mutant frequency from lambda/lacI transgenic mice (BigBlue) (II). Mutat Res 327:67-73.
58. Zhang X, Mathews CW (1994): Effect of DNA cytosine methylation upon deamination-induced mutagenesis in a natural target sequence in duplex DNA. J Biol Chem 269:7066-7069.
59. Zielenska M, Ahmed A, Pienkowska M, Anderson MW, Glickman BW (1993): Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli. VI. Analysis of methylene chloride-induced mutational distribution in Uvr+ and UvrB-strains. Carcinogenesis 14:789-794.