Differences in substrate specificity among glutathione conjugates (GS-X) pump family members: Comparison between multidrug resistance-associated protein and a novel transporter expressed on a cisplatin-resistant cell line (KCP-4)

Japanese Journal of Cancer Research

Volumn 90, Issue 4, 1999, Pages 439-447

  Ueda, Kaoru ^a   Suzuki, Hiroshi ^a   Akiyama, Shin Ichi ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

ABC transporter; Cisplatin resistance; GS X pump; MRP; Substrate specificity

Indexed keywords

2,4 DINITROPHENOL; CARRIER PROTEIN; CISPLATIN; GLUTATHIONE; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN; PLATINUM;

ANION TRANSPORT; ARTICLE; CANCER CELL; CELL LINE; COMPARATIVE STUDY; CONJUGATE; CONTROLLED STUDY; ENZYME SPECIFICITY; EPIDERMOID TUMOR; HUMAN; HUMAN CELL; MEMBRANE VESICLE; NORTHERN BLOTTING; PRIORITY JOURNAL; PUMP; TRANSPORT KINETICS;

EID: 0032935501     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1999.tb00767.x     Document Type: Article

References (48)

1. Gottesman, M. M., Pastan, I. and Ambudkar, S. V. P-Glycoprotein and multidrug resistance. Curr. Opin. Genet. Dev., 6, 610-617 (1996).
2. Loe, D. W., Deeley, R. G. and Cole, S. P. Biology of the multidrug resistance-associated protein, MRP. Eur. J. Cancer, 32A, 945-957 (1996).
3. Lautier, D., Canitrot, Y., Deeley, R. G. and Cole, S. P. Multidrug resistance mediated by the multidrug resistance protein (MRP) gene. Biochem. Pharmacol., 52, 967-977 (1996).
4. Zaman, G. J., Lankelma, J., van Tellingen, O., Beijnen, J., Dekker, H., Paulusma, C., Oude Elferink, R. P., Baas, F. and Borst, P. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc. Natl. Acad. Sci. USA, 92, 7690-7694 (1995).
5. Ishikawa, T. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci., 17, 463-468 (1992).
6. 1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Mol. Pharmacol., 51, 1034-1041 (1997).
7. Barnouin, K., Leier, I., Jedlitschky, G., Pourtier-Mazanedo, A., König, J., Lehmann, W. D. and Keppler, D. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br. J. Cancer, 77, 201-209 (1998).
8. Paulusma, C. C., Bosma, P. J., Zaman, G. J., Bakker, C. T., Otter, M., Scheffer, G. L., Scheper, R. J., Borst, P. and Oude Elferink, R. P. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science, 271, 1126-1128 (1996).
9. Büchler, M., König, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T. and Keppler, D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem., 271, 15091-15098 (1996).
10. Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T. and Sugiyama, Y. Molecular cloning of canalicular multi-specific organic anion transporter defective in EHBR. Am. J. Physiol., 272, G16-G22 (1997).
11. Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T. and Sugiyama, Y. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J. Biol. Chem., 273, 1684-1688 (1998).
12. Madon, J., Eckhardt, U., Gerloff, T., Stieger, B. and Meier, P. J. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett., 406, 75-78 (1997).
13. Taniguchi, K., Wada, M., Kohno, K., Nakamura, T., Kawabe, T., Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S. and Kuwano, M. A human canalicular multispecific organic anion transporter (cMOAT) gene is over-expressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res., 56, 4124-4129 (1996).
14. Paulusma, C. C., Kool, M., Bosma, P. J., Scheffer, G. L., ter Borg, F., Scheper, R. J., Tytgat, G. N., Borst, P., Baas, F. and Oude Elferink, R. P. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology, 25, 1539-1542 (1997).
15. Masuda, M., Iizuka, Y., Yamazaki, M., Nishigaki, R., Kato, Y., Niinuma, K., Suzuki, H. and Sugiyama, Y. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res., 57, 3506-3510 (1997).
16. Chu, X. Y., Kato, Y., Niinuma, K., Sudo, K. I., Hakusui, H. and Sugiyama, Y. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J. Pharmacol. Exp. Ther., 281, 304-314 (1997).
17. Chu, X. Y., Kato, Y. and Sugiyama, Y. Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res., 57, 1934-1938 (1997).
18. Chu, X. Y., Suzuki, H., Ueda, K., Kato, Y., Akiyama, S. and Sugiyama, Y. Active efflux of CPT-11 and its metabolites in human KB-derived cell lines. J. Pharmacol. Exp. Ther., 288, 735-741 (1999).
19. Inaba, M., Ohnishi, Y., Ishii, H., Tanioka, Y., Yoshida, Y., Sudoh, K., Hakusui, H., Mizuno, N., Ito, K. and Sugiyama, Y. Pharmacokinetics of CPT-11 in rhesus monkeys. Cancer Chemother. Pharmacol., 41, 103-108 (1998).
20. Koike, K., Kawabe, T., Tanaka, T., Toh, S., Uchiumi, T., Wada, M., Akiyama, S., Ono, M. and Kuwano, M. A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res., 57, 5475-5479 (1997).
21. Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F. and Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res., 57, 3537-3547 (1997).
22. Borst, P., Kool, M. and Evers, R. Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR? Semin. Cancer Biol., 8, 205-213 (1997).
23. Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T. and Sugiyama, Y. Hepatic expression of multidrug resistance-associated protein (MRP)-like proteins maintained in Eisai hyperbilirubinemic rats (EHBR). Mol. Pharmacol., 53, 1068-1075 (1998).
24. Suzuki, T., Nishio, K., Sasaki, H., Kurokawa, H., Saito-Ohara, F., Ikeuchi, T., Tanabe, S., Terada, M. and Saijo, N. cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line, Biochem. Biophys. Res. Commun., 238, 790-794 (1997).
25. Kiuchi, Y., Suzuki, H., Hirohashi, T., Tyson, C. A. and Sugiyama, Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett., 433, 149-152 (1998).
26. Lee, K., Belinsky, M. G., Bell, D. W., Testa, J. R. and Kruh, G. D. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multi-specific organic anion transporter-related transporter. Cancer Res., 58, 2741-2747 (1998).
27. 4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. J. Natl. Cancer Inst., 86, 1781-1784 (1994).
28. 4 transporter in cisplatin-resistant human KB cells. Biochem. Biophys. Res. Commun, 226, 158-165 (1996).
29. Fujii, R., Mutoh, M., Niwa, K., Yamada, K., Aikou, T., Nakagawa, M., Kuwano, M. and Akiyama, S. Active efflux system for cisplatin in cisplatin-resistant human KB cells. Jpn. J. Cancer Res., 85, 426-433 (1994).
30. Ishikawa, T. and Ali-Osman, F. Glutathione-associated cis-diamminedichloro-platinum (II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J. Biol. Chem., 268, 20116-20125 (1993).
31. Sumizawa, T., Chuman, Y., Sakamoto, H., Iemura, K., Almquist, K. C., Deeley, R. G., Cole, S. P. and Akiyama, S. Non-P-glycoprotein-mediated multidrug-resistant human KB cells selected in medium containing adriamycin, cepharanthine, and mezerein. Somat. Cell Mol. Genet., 20, 423-435 (1994).
32. Keppler, D. and König, J. Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J., 11, 509-516 (1997).
33. Kobayashi, K., Sogame, Y., Hara, H. and Hayashi, K. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem., 265, 7737-7741 (1990).
34. Akiyama, S., Fojo, A., Hanover, J. A., Pastan, I. and Gottesman, M. M. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat. Cell Mol. Genet., 11, 117-126 (1985).
35. Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D. and Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemo-sensitivity testing. Cancer Res., 47, 936-942 (1987).
36. Feinberg, A. P. and Vogelstein, B. A technique for radio-labeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132, 6-13 (1983).
37. + gradient-stimulated uptake. J. Biol. Chem., 252, 1990-1997 (1977).
38. Cornwell, M. M., Gottesman, M. M. and Pastan, I. H. Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells. J. Biol. Chem., 261, 7921-7928 (1986).
39. Schlemmer, S. R. and Sirotnak, F. M. Energy-dependent efflux of methotrexate in L1210 leukemia cells. J. Biol. Chem., 267, 14746-14752 (1992).
40. 2+-dependent cardiac transport system for glutathione S-conjugales. A study using rat heart sarcolemma vesicles. J. Biol. Chem., 264, 17343-17348 (1989).
41. Yamaoka, K., Tanigawara, Y., Nakagawa, T. and Uno, T. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiodyn., 4, 879-885 (1981).
42. Cole, S. P., Sparkes, K. E., Fraser, K., Loe, D. W., Grant, C. E., Wilson, G. M. and Deeley, R. G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res., 54, 5902-5910 (1994).
43. Marshall, J. L. and Andrews, P. A. Preclinical and clinical experience with cisplatin resistance. Hematol. Oncol. Clin. North Am., 9, 415-429 (1995).
44. Kauffman, H. M., Keppler, D., Kartenbeck, J. and Schrenk, D. Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Hepatalogy, 26, 980-985 (1997).
45. Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G. and Keppler, D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res., 56, 988-994 (1996).
46. Ishikawa, T., Wright, C. D. and Ishizuka, H. GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J. Biol. Chem., 269, 29085-29093 (1994).
47. Ishikawa, T., Bao, J. J., Yamane, Y., Akimaru, K., Frindrich, K., Wright, C. D. and Kuo, M. T. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J. Biol. Chem., 271, 14981-14988 (1996).
48. Jedlitschky, G., Leier, I., Buchholz, U., Hummel-Eisenbeiss, J., Burchell, B. and Keppler, D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J., 327, 305-310 (1997).