메뉴 건너뛰기




Volumn 65, Issue 4, 1999, Pages 416-427

Insights into the neurodegenerative process of Alzheimer's disease: A role for mononuclear phagocyte-associated inflammation and neurotoxicity

Author keywords

Apoptosis; Central nervous system; Complement; Immunopathology; Mononuclear phagocytes; Neurotrophins; Pro inflammatory cytokines; Signal transduction; amyloid protein

Indexed keywords

AMYLOID BETA PROTEIN; BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FAS ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NERVE GROWTH FACTOR; NEUROTOXIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLATELET DERIVED GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032925694     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.65.4.416     Document Type: Review
Times cited : (74)

References (136)
  • 1
    • 0000293742 scopus 로고
    • Allgemeine zeitschrift fur psychiatrie und psychischt
    • Alzheimer, A. (1907) About a peculiar disease of the cerebral cortex. Allgemeine Zeitschrift fur Psychiatrie und Psychischt. Gerichtliche Medizin 64, 146.
    • (1907) Gerichtliche Medizin , vol.64 , pp. 146
    • Alzheimer, A.1
  • 3
    • 0024317904 scopus 로고
    • Prevalence of Alzheimer's disease in a community population higher than previously reported
    • Evans, D., Funkenstein, H., Albert, M., et al. (1989) Prevalence of Alzheimer's disease in a community population higher than previously reported. J. Am. Med. Assoc. 262, 2551-2556.
    • (1989) J. Am. Med. Assoc. , vol.262 , pp. 2551-2556
    • Evans, D.1    Funkenstein, H.2    Albert, M.3
  • 4
    • 0001087846 scopus 로고
    • The Alzheimer diseases
    • (S. Appel, ed.) Chicago: Mosby-Year Book
    • Roses, A. (1994) The Alzheimer diseases. In Current Neurology (S. Appel, ed.) Chicago: Mosby-Year Book, 111.
    • (1994) Current Neurology , pp. 111
    • Roses, A.1
  • 8
    • 0030917601 scopus 로고    scopus 로고
    • Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals
    • Guo, Q., Sopher, B., Furukawa, K., Pham, D., Robinson, N., Martin, G., Mattson, M. (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci 17, 4212-4222.
    • (1997) J. Neurosci , vol.17 , pp. 4212-4222
    • Guo, Q.1    Sopher, B.2    Furukawa, K.3    Pham, D.4    Robinson, N.5    Martin, G.6    Mattson, M.7
  • 9
    • 0031982670 scopus 로고    scopus 로고
    • Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
    • Mattson, M., Guo, Q., Furukawa, K., Pedersen, W. (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70, 1-14.
    • (1998) J. Neurochem. , vol.70 , pp. 1-14
    • Mattson, M.1    Guo, Q.2    Furukawa, K.3    Pedersen, W.4
  • 10
    • 0344732616 scopus 로고    scopus 로고
    • Genetic factors in the etiology of Alzheimer's disease
    • Lendon, C., Goate, A. (1998) Genetic factors in the etiology of Alzheimer's disease. Mediguide Geriatric Neurol. 2, 1-8.
    • (1998) Mediguide Geriatric Neurol. , vol.2 , pp. 1-8
    • Lendon, C.1    Goate, A.2
  • 11
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders, A., Strittmatter, W., Schmechel, D., George-Hiplop, P. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.1    Strittmatter, W.2    Schmechel, D.3    George-Hiplop, P.4
  • 13
    • 0030696944 scopus 로고    scopus 로고
    • Apolipoprotein E, a gene with complex biological interactions in the aging brain
    • Roses, A. (1997) Apolipoprotein E, a gene with complex biological interactions in the aging brain. Neurobiol. Dis. 4, 170-185.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 170-185
    • Roses, A.1
  • 17
    • 0027235553 scopus 로고
    • Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives
    • Mayeux, R., Ottman, R., Tang, M., Noboa-Bauza, L., Marder, K., Gurland, B., Stern, Y. (1993) Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives. Ann. Neurol. 33, 494-501.
    • (1993) Ann. Neurol. , vol.33 , pp. 494-501
    • Mayeux, R.1    Ottman, R.2    Tang, M.3    Noboa-Bauza, L.4    Marder, K.5    Gurland, B.6    Stern, Y.7
  • 19
    • 0030250376 scopus 로고    scopus 로고
    • Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: A current appraisal
    • Breitner, J. (1996) Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: a current appraisal. Neurobiol. Aging 17, 789-794.
    • (1996) Neurobiol. Aging , vol.17 , pp. 789-794
    • Breitner, J.1
  • 20
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer, P., Schulzer, M., McGeer, E. (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47, 425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.1    Schulzer, M.2    McGeer, E.3
  • 21
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart, W., Kawas, C., Corrada, M., Metter, E. (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology 48, 626-632.
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.1    Kawas, C.2    Corrada, M.3    Metter, E.4
  • 22
    • 0001927480 scopus 로고    scopus 로고
    • The neuropathology of Alzheimer's disease: Diagnostic features and standardization
    • (Z. Khachaturian and T. Radebaugh, eds.), New York: CRC Press
    • Markesbery, W., Mira, S. (1996) The neuropathology of Alzheimer's disease: Diagnostic features and standardization. In Alzheimer's Disease-Cause(s). Diagnosis, Treatment, and Care (Z. Khachaturian and T. Radebaugh, eds.), New York: CRC Press, 111-123.
    • (1996) Alzheimer's Disease-Cause(s). Diagnosis, Treatment, and Care , pp. 111-123
    • Markesbery, W.1    Mira, S.2
  • 23
    • 0030757323 scopus 로고    scopus 로고
    • Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms
    • Sheng, J., Mrak, R., Griffin, W. (1997) Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol. Berlin 94, 1-5.
    • (1997) Acta Neuropathol. Berlin , vol.94 , pp. 1-5
    • Sheng, J.1    Mrak, R.2    Griffin, W.3
  • 24
    • 0024573330 scopus 로고
    • Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain
    • Haga, S., Akai, K., Ishii, T. (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. Acta Neuropathol. 77, 569-575.
    • (1989) Acta Neuropathol. , vol.77 , pp. 569-575
    • Haga, S.1    Akai, K.2    Ishii, T.3
  • 25
    • 0028302166 scopus 로고
    • Activation of macrophages by Alzheimer beta-amyloid peptide
    • Klegeris, A., Walker, D., McGeer, P. (1994) Activation of macrophages by Alzheimer beta-amyloid peptide. Biochem. Biophys. Res. Commun. 199, 984-991.
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 984-991
    • Klegeris, A.1    Walker, D.2    McGeer, P.3
  • 27
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta protein via a scavenger receptor
    • Paresce, D., Ghoush, R., Maxfield, F. (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta protein via a scavenger receptor. Neuron 17, 553-565.
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.1    Ghoush, R.2    Maxfield, F.3
  • 28
    • 0029040685 scopus 로고
    • Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain
    • Giulian, D., Haverkamp, L., Li, J., Karshin, W. (1995) Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochem. Int. 27, 119-137.
    • (1995) Neurochem. Int. , vol.27 , pp. 119-137
    • Giulian, D.1    Haverkamp, L.2    Li, J.3    Karshin, W.4
  • 29
    • 0030250758 scopus 로고    scopus 로고
    • Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches
    • Chen, S., Frederickson, R., Brunden, K. (1996) Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: complement activation and therapeutic approaches. Neurobiol. Aging 17, 781-787.
    • (1996) Neurobiol. Aging , vol.17 , pp. 781-787
    • Chen, S.1    Frederickson, R.2    Brunden, K.3
  • 31
    • 0013566341 scopus 로고
    • The effect of anti-inflammatory drugs on senile plaque formation
    • Mackenzie, I., Kay, K., Munoz, D. (1995) The effect of anti-inflammatory drugs on senile plaque formation. J. Neuropathol. Exp. Neurol. 54, 427.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 427
    • Mackenzie, I.1    Kay, K.2    Munoz, D.3
  • 32
    • 0032452709 scopus 로고    scopus 로고
    • Mechanism of action of antiinflammatory drugs
    • Vane, J., Botting, R. (1998) Mechanism of action of antiinflammatory drugs. Int. J. Tissue React. 20, 3-15.
    • (1998) Int. J. Tissue React. , vol.20 , pp. 3-15
    • Vane, J.1    Botting, R.2
  • 33
    • 0031900411 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
    • Mackenzie, I., Munoz, D. (1998) Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 50, 986-990.
    • (1998) Neurology , vol.50 , pp. 986-990
    • Mackenzie, I.1    Munoz, D.2
  • 35
    • 0344300397 scopus 로고    scopus 로고
    • Inflammation, beta-amyloid deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease
    • Leu, L., Brachova, L., Civin, H., Rogers, J. (1996) Inflammation, beta-amyloid deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease. J. Neuropathol. Exp. Neurol. 54.
    • (1996) J. Neuropathol. Exp. Neurol. , pp. 54
    • Leu, L.1    Brachova, L.2    Civin, H.3    Rogers, J.4
  • 36
    • 0030483686 scopus 로고    scopus 로고
    • Cellular aspects of the inflammatory response in Alzheimer's disease
    • Kalaria, R., Cohen, D., Premkumar, D. (1996b) Cellular aspects of the inflammatory response in Alzheimer's disease. Neurodegen. 5, 497-503.
    • (1996) Neurodegen. , vol.5 , pp. 497-503
    • Kalaria, R.1    Cohen, D.2    Premkumar, D.3
  • 37
    • 0031031312 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies
    • Aisen, P. (1997) Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies. Gerontol. 43, 143-149.
    • (1997) Gerontol. , vol.43 , pp. 143-149
    • Aisen, P.1
  • 38
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki, S., McGeer, P., Akiyama, H., Zhu, S., Selkoe, D. (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24, 173-182.
    • (1989) J. Neuroimmunol. , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 39
    • 0000745758 scopus 로고
    • The prospect of developing treatments for Alzheimer disease
    • (R. Terry, R. Katzman, and K. Bick, eds.), New York: Raven Press
    • Khachaturian, Z., Phelps, C., Buckholtz, N. (1994) The prospect of developing treatments for Alzheimer disease. In Alzheimer Disease (R. Terry, R. Katzman, and K. Bick, eds.), New York: Raven Press, 445-454.
    • (1994) Alzheimer Disease , pp. 445-454
    • Khachaturian, Z.1    Phelps, C.2    Buckholtz, N.3
  • 40
    • 0017644173 scopus 로고
    • Presence of labeled monoyctes, macrophages, and microglia in a stab wound of the brain following an injection of bone marrow cells labeled with 3H-uridine into rats
    • Imamoto, K., Leblond, C. P. (1977) Presence of labeled monoyctes, macrophages, and microglia in a stab wound of the brain following an injection of bone marrow cells labeled with 3H-uridine into rats. J. Comp. Neurol. 174, 255-280.
    • (1977) J. Comp. Neurol. , vol.174 , pp. 255-280
    • Imamoto, K.1    Leblond, C.P.2
  • 41
    • 0025015655 scopus 로고
    • Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages
    • Huitinga, I., Rooijen, N. V., Groot, C. D., Uitdehaag, M., Dijkstra, D. (1990) Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J. Exp. Med. 172, 1025-1033.
    • (1990) J. Exp. Med. , vol.172 , pp. 1025-1033
    • Huitinga, I.1    Rooijen, N.V.2    Groot, C.D.3    Uitdehaag, M.4    Dijkstra, D.5
  • 42
    • 0025786684 scopus 로고
    • Glial changes following an excitotoxic lesion in the CNS-1. Microglia/macrophages
    • Marty, S., Dusart, I., Peschanski, M. (1991) Glial changes following an excitotoxic lesion in the CNS-1. Microglia/macrophages. Neurosci. 45, 529-539.
    • (1991) Neurosci. , vol.45 , pp. 529-539
    • Marty, S.1    Dusart, I.2    Peschanski, M.3
  • 44
    • 0028930457 scopus 로고
    • A regulatory role for astrocytes in HIV-1 encephalitis: An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1 infected monocytes is attenuated by primary human astrocytes
    • Nottet, H., Jett, M., Flanagan, C., Zhai, Q.-H., Persidsky, Y., Rizzino, A., Bernton, E., Genis, P., Baldwin, T., Schwartz, J., LaBenz, C., Gendelman, H. (1995) A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1 infected monocytes is attenuated by primary human astrocytes. J. Immunol. 154, 3567-3581.
    • (1995) J. Immunol. , vol.154 , pp. 3567-3581
    • Nottet, H.1    Jett, M.2    Flanagan, C.3    Zhai, Q.-H.4    Persidsky, Y.5    Rizzino, A.6    Bernton, E.7    Genis, P.8    Baldwin, T.9    Schwartz, J.10    LaBenz, C.11    Gendelman, H.12
  • 48
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • Colton, C., Gilbert, D. (1987) Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett. 223, 284-288.
    • (1987) FEBS Lett. , vol.223 , pp. 284-288
    • Colton, C.1    Gilbert, D.2
  • 50
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P., Itagaki, M., Boyes, B., McGeer, E. (1988b) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38, 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.1    Itagaki, M.2    Boyes, B.3    McGeer, E.4
  • 51
    • 0028808135 scopus 로고
    • Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlation with dementia
    • Glass, J., Fedor, H., Wesselingh, S., McArthur, J. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlation with dementia. Ann. Neurol. 38, 755-762.
    • (1995) Ann. Neurol. , vol.38 , pp. 755-762
    • Glass, J.1    Fedor, H.2    Wesselingh, S.3    McArthur, J.4
  • 52
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • Barger, S., Harmon, A. (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388, 878-881.
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, S.1    Harmon, A.2
  • 56
    • 0030687537 scopus 로고    scopus 로고
    • The role of the immune system in neurodegenerative disorders
    • McGeer, E., McGeer, P. (1997) The role of the immune system in neurodegenerative disorders. Movement Disorders 12, 855-858.
    • (1997) Movement Disorders , vol.12 , pp. 855-858
    • McGeer, E.1    McGeer, P.2
  • 57
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer, P., McGeer, E. (1995) The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21, 195-218.
    • (1995) Brain Res. Rev. , vol.21 , pp. 195-218
    • McGeer, P.1    McGeer, E.2
  • 59
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson, D., Lee, S., Mattiace, L., Yen, S.-H., Brosnan, C. (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7, 75-83.
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.1    Lee, S.2    Mattiace, L.3    Yen, S.-H.4    Brosnan, C.5
  • 60
    • 0027453380 scopus 로고
    • Cytokine indices in Alzheimer's temporal cortex: No changes in mature IL-beta or IL-IRA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein
    • Wood, J., Wood, P., Ryan, R., Graff-Radford, N., Pilapil, C., Robitaille, Y., Quirion, R. (1993) Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-beta or IL-IRA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein. Brain Res. 629, 245-252.
    • (1993) Brain Res. , vol.629 , pp. 245-252
    • Wood, J.1    Wood, P.2    Ryan, R.3    Graff-Radford, N.4    Pilapil, C.5    Robitaille, Y.6    Quirion, R.7
  • 61
    • 0026638409 scopus 로고
    • Inflammatory cytokines within the central nervous system: Sources, function and mechanism of action
    • Benveniste, E. (1992) Inflammatory cytokines within the central nervous system: sources, function and mechanism of action. Am. J. Physiol. 263, C1-C16.
    • (1992) Am. J. Physiol. , vol.263
    • Benveniste, E.1
  • 62
    • 0030483487 scopus 로고    scopus 로고
    • AIDS dementia and HIV-1-induced neurotoxicity: Possible pathogenic associations and mechanisms
    • Kolson, D., Pomerantz, R. (1996) AIDS dementia and HIV-1-induced neurotoxicity: possible pathogenic associations and mechanisms. J. Biomed. Sci. 3, 389-414.
    • (1996) J. Biomed. Sci. , vol.3 , pp. 389-414
    • Kolson, D.1    Pomerantz, R.2
  • 63
    • 0029823018 scopus 로고    scopus 로고
    • Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B
    • Lieb, K., Fiebich, B., Schaller, H., Berger, M., Bauer, J. (1996) Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B. J. Neurochem. 67, 2039-2044.
    • (1996) J. Neurochem. , vol.67 , pp. 2039-2044
    • Lieb, K.1    Fiebich, B.2    Schaller, H.3    Berger, M.4    Bauer, J.5
  • 64
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer B-protein into filaments
    • Ma, J., Yee, A., Brewer, B., Das, S., Potter, H. (1994) Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer B-protein into filaments. Nature 372, 92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer, B.3    Das, S.4    Potter, H.5
  • 65
    • 0024357791 scopus 로고
    • Focusing on IL-1 promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer's disease
    • Blume, A., Vitek, M. (1989) Focusing on IL-1 promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer's disease. Neurobiol. Aging 10, 406-408.
    • (1989) Neurobiol. Aging , vol.10 , pp. 406-408
    • Blume, A.1    Vitek, M.2
  • 66
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's diseases: Significance in plaque evolution
    • Griffin, W., Sheng, J., Roberts, G., Mrak, R. (1995) Interleukin-1 expression in different plaque types in Alzheimer's diseases: Significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54, 276-281.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 276-281
    • Griffin, W.1    Sheng, J.2    Roberts, G.3    Mrak, R.4
  • 67
    • 0031455983 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells
    • Blasko, I., Schmitt, T., Steiner, E., Trieb, K., Grubeck-Loebenstein, B. (1997) Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. Neurosci. Lett. 238, 17-20.
    • (1997) Neurosci. Lett. , vol.238 , pp. 17-20
    • Blasko, I.1    Schmitt, T.2    Steiner, E.3    Trieb, K.4    Grubeck-Loebenstein, B.5
  • 68
    • 0028577356 scopus 로고
    • Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures
    • Chao, C., Hu, S. (1994) Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev. Neurosci. 16, 172-179.
    • (1994) Dev. Neurosci. , vol.16 , pp. 172-179
    • Chao, C.1    Hu, S.2
  • 69
    • 0026696836 scopus 로고
    • 2+ currents in cultured sympathetic neurons
    • 2+ currents in cultured sympathetic neurons. J. Neurosci. 12, 2665-2671.
    • (1992) J. Neurosci. , vol.12 , pp. 2665-2671
    • Soliven, B.1    Albert, J.2
  • 70
    • 0029620390 scopus 로고
    • Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
    • Chao, C., Hu, S., Erlich, L., Peterson, P. (1995d) Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav. Immun. 9, 355-365.
    • (1995) Brain Behav. Immun. , vol.9 , pp. 355-365
    • Chao, C.1    Hu, S.2    Erlich, L.3    Peterson, P.4
  • 71
    • 0345162908 scopus 로고
    • Interleukin-1 inhibits synaptic strength and long-term potentiation in the CA3 region of mouse hippocampal slices
    • Bellinger, F., Madamba, S., Siggins, G. (1993) Interleukin-1 inhibits synaptic strength and long-term potentiation in the CA3 region of mouse hippocampal slices. Eur. J. Pharmacol. 181, 323-326.
    • (1993) Eur. J. Pharmacol. , vol.181 , pp. 323-326
    • Bellinger, F.1    Madamba, S.2    Siggins, G.3
  • 73
    • 0031114650 scopus 로고    scopus 로고
    • A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
    • Persidsky, Y., Stins, M., Way, D., et al. (1997) A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J. Immunol. 158, 499-510.
    • (1997) J. Immunol. , vol.158 , pp. 499-510
    • Persidsky, Y.1    Stins, M.2    Way, D.3
  • 74
    • 0030250852 scopus 로고    scopus 로고
    • The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
    • Eikelenboom, P., Veerhuis, R. (1996) The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol. Aging 17, 673-680.
    • (1996) Neurobiol. Aging , vol.17 , pp. 673-680
    • Eikelenboom, P.1    Veerhuis, R.2
  • 75
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao, C., Hu, S., Molitor, W., Shaskin, E., Peterson, P. (1992a) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149, 2736-2741.
    • (1992) J. Immunol. , vol.149 , pp. 2736-2741
    • Chao, C.1    Hu, S.2    Molitor, W.3    Shaskin, E.4    Peterson, P.5
  • 76
    • 0030795049 scopus 로고    scopus 로고
    • β-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
    • Klegeris, A., McGeer, P. (1997) β-amyloid protein enhances macrophage production of oxygen free radicals and glutamate. J. Neurosci. Res. 49, 229-235.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 229-235
    • Klegeris, A.1    McGeer, P.2
  • 78
    • 0028065290 scopus 로고
    • Brain macrophages: Neurotoxic or neurotrophic effector cells?
    • Mallat, M., Chamak, B. (1994) Brain macrophages: neurotoxic or neurotrophic effector cells? J. Leukoc. Biol. 56, 416-422.
    • (1994) J. Leukoc. Biol. , vol.56 , pp. 416-422
    • Mallat, M.1    Chamak, B.2
  • 79
    • 0027463358 scopus 로고
    • Brain glia release factors with opposing actions upon neuronal survival
    • Giulian, D., Vaca, K., Corpuz, M. (1993) Brain glia release factors with opposing actions upon neuronal survival. J. Neurosci. 13, 29-37.
    • (1993) J. Neurosci. , vol.13 , pp. 29-37
    • Giulian, D.1    Vaca, K.2    Corpuz, M.3
  • 80
    • 0031418664 scopus 로고    scopus 로고
    • The role of the phosphoinositide signalling system in the pathogenesis of sporadic Alzheimer's disease: A hypothesis
    • Fowler, C. (1997) The role of the phosphoinositide signalling system in the pathogenesis of sporadic Alzheimer's disease: a hypothesis. Brain Res. Rev. 25, 373-380.
    • (1997) Brain Res. Rev. , vol.25 , pp. 373-380
    • Fowler, C.1
  • 81
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman, J., Beckman, T., Chen, J., Marshall, P., Freeman, B. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1620-1624
    • Beckman, J.1    Beckman, T.2    Chen, J.3    Marshall, P.4    Freeman, B.5
  • 82
    • 0025773785 scopus 로고
    • Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
    • Dawson, V., Dawson, T., London, E., Bredt, D., Snyder, S. (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88, 6368-6371.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6368-6371
    • Dawson, V.1    Dawson, T.2    London, E.3    Bredt, D.4    Snyder, S.5
  • 83
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • Bonfoco, E., Kraine, D., Ankarerona, M., Nicotera, P., Lipton, S. (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92, 7162-7166.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Kraine, D.2    Ankarerona, M.3    Nicotera, P.4    Lipton, S.5
  • 84
    • 0025637595 scopus 로고
    • Excitotoxin-mediated neuron death in youth and old age
    • Olney, J. (1990) Excitotoxin-mediated neuron death in youth and old age. Prog. Brain Res. 86, 37-51.
    • (1990) Prog. Brain Res. , vol.86 , pp. 37-51
    • Olney, J.1
  • 85
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle, J., Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.1    Puttfarcken, P.2
  • 87
    • 0021848540 scopus 로고
    • Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons by Glu and aspartate
    • DeBoni, U., McLachlan, D. (1985) Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons by Glu and aspartate, J. Neurol. Sci. 68, 105-118.
    • (1985) J. Neurol. Sci. , vol.68 , pp. 105-118
    • DeBoni, U.1    McLachlan, D.2
  • 89
    • 0027247422 scopus 로고
    • Altered calcium signaling and neuronal injury: Stroke and Alzheimer's disease as examples
    • Mattson, M., Rydel, R., Lieberburg, I., Smith-Swintosky, V. (1993) Altered calcium signaling and neuronal injury: stroke and Alzheimer's disease as examples. Ann. NY. Acad. Sci. 679, 1-21.
    • (1993) Ann. NY. Acad. Sci. , vol.679 , pp. 1-21
    • Mattson, M.1    Rydel, R.2    Lieberburg, I.3    Smith-Swintosky, V.4
  • 90
    • 0029972857 scopus 로고    scopus 로고
    • Brain microglia/ macrophages express neurotrophins that selectively regulate microglial proliferation and function
    • Elkabes, S., DiCicco-Bloom, E., Black, I. (1996) Brain microglia/ macrophages express neurotrophins that selectively regulate microglial proliferation and function. J. Neurosci. 16, 2508-2521.
    • (1996) J. Neurosci. , vol.16 , pp. 2508-2521
    • Elkabes, S.1    Dicicco-Bloom, E.2    Black, I.3
  • 91
    • 0026530256 scopus 로고
    • Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lymphokines and trophic factors
    • Araujo, D., Cotman, C. (1992) Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors. J. Neurosci. 112, 1668-1678.
    • (1992) J. Neurosci. , vol.112 , pp. 1668-1678
    • Araujo, D.1    Cotman, C.2
  • 92
    • 0027397794 scopus 로고
    • Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos
    • Taylor, L., Marshak, D., Landreth, G. (1993) Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos. Proc. Natl. Acad. Sci. USA 90, 368-372.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 368-372
    • Taylor, L.1    Marshak, D.2    Landreth, G.3
  • 93
    • 0026676398 scopus 로고
    • Neurotransmitter, receptor and signal transduction disturbances in Alzheimer's disease
    • Fowler, C., O'Neill, C., Winblad, B., Cowburn, R. (1992) Neurotransmitter, receptor and signal transduction disturbances in Alzheimer's disease. Acta Neurol. Scand. Suppl. 139, 59-62.
    • (1992) Acta Neurol. Scand. Suppl. , vol.139 , pp. 59-62
    • Fowler, C.1    O'Neill, C.2    Winblad, B.3    Cowburn, R.4
  • 95
    • 0030725599 scopus 로고    scopus 로고
    • Support of homeostatic glial cell signaling: A novel therapeutic approach by propentofylline
    • Schubert, P., Ogata, T., Rudolphi, K., Marchini, C., McRae, A., Ferroni, S. (1997) Support of homeostatic glial cell signaling: a novel therapeutic approach by propentofylline. Ann. NY Acad. Sci. 826, 337-347.
    • (1997) Ann. NY Acad. Sci. , vol.826 , pp. 337-347
    • Schubert, P.1    Ogata, T.2    Rudolphi, K.3    Marchini, C.4    McRae, A.5    Ferroni, S.6
  • 96
    • 0032478715 scopus 로고    scopus 로고
    • The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor
    • Yao, H., York, R., Mirsa-Press, A., Carr, D., Stork, P. (1998) The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor. J. Biol. Chem. 273, 8240-8247.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8240-8247
    • Yao, H.1    York, R.2    Mirsa-Press, A.3    Carr, D.4    Stork, P.5
  • 98
    • 0030924310 scopus 로고    scopus 로고
    • Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation
    • Lee, R., Araki, W., Wurtman, R. (1997) Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proc. Natl. Acad. Sci. USA 94, 5422-5426.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5422-5426
    • Lee, R.1    Araki, W.2    Wurtman, R.3
  • 99
    • 0030035594 scopus 로고    scopus 로고
    • Intracellular cyclic AMP inhibits constitutive and phorbol-ester-stimulated secretory cleavage of amyloid precursor protein
    • Efthimiopoulos, S., Punj, S., Manolopoulus, V., Pangalos, M., Wang, G., Refolo, L., Robakis, N. (1996) Intracellular cyclic AMP inhibits constitutive and phorbol-ester-stimulated secretory cleavage of amyloid precursor protein. J. Neurochem. 67, 872-875.
    • (1996) J. Neurochem. , vol.67 , pp. 872-875
    • Efthimiopoulos, S.1    Punj, S.2    Manolopoulus, V.3    Pangalos, M.4    Wang, G.5    Refolo, L.6    Robakis, N.7
  • 100
    • 0029900084 scopus 로고    scopus 로고
    • Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons
    • Kelly, J., Furukawa, K., Barger, S., Rengen, M., Mark, R., Blanc, E., Roth, G., Mattson, M. (1996) Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons. Proc. Natl. Acad. Sci. USA 93, 6753-6758.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6753-6758
    • Kelly, J.1    Furukawa, K.2    Barger, S.3    Rengen, M.4    Mark, R.5    Blanc, E.6    Roth, G.7    Mattson, M.8
  • 101
    • 0026011516 scopus 로고
    • A role for protein kinase C in associative learning
    • Olds, J., Alkon, D. (1991) A role for protein kinase C in associative learning. New Biol. 3, 27-35.
    • (1991) New Biol. , vol.3 , pp. 27-35
    • Olds, J.1    Alkon, D.2
  • 102
    • 0027453490 scopus 로고
    • Activation of protein kinase C inhibits cellular production of the amyloid-protein
    • Hung, A., Haas, C., Nitsch, R., et al. (1993) Activation of protein kinase C inhibits cellular production of the amyloid-protein. J. Biol. Chem. 268, 22959-22962.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22959-22962
    • Hung, A.1    Haas, C.2    Nitsch, R.3
  • 103
    • 0029789253 scopus 로고    scopus 로고
    • Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: Relationship to phosphoinositide hydrolysis
    • Li, X., Song, L., Jope, R. (1996) Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis. J. Neurosci. 16, 5914-5922.
    • (1996) J. Neurosci. , vol.16 , pp. 5914-5922
    • Li, X.1    Song, L.2    Jope, R.3
  • 104
    • 0031051353 scopus 로고    scopus 로고
    • Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain
    • Jope, R., Song, L., Powers, R. (1997) Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol. Aging 18, 111-120.
    • (1997) Neurobiol. Aging , vol.18 , pp. 111-120
    • Jope, R.1    Song, L.2    Powers, R.3
  • 105
    • 0030793593 scopus 로고    scopus 로고
    • Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospo-epitopes
    • Boyce, J., Shea, T. (1997) Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospo-epitopes. Int. J. Dev. Neurosci. 15, 295-307.
    • (1997) Int. J. Dev. Neurosci. , vol.15 , pp. 295-307
    • Boyce, J.1    Shea, T.2
  • 106
    • 0023823738 scopus 로고
    • 3H]inositol 1, 4, 5-trisphosphate binding in Alzheimer's disease
    • 3H]inositol 1, 4, 5-trisphosphate binding in Alzheimer's disease. Neurosci. Lett. 94, 198-202.
    • (1988) Neurosci. Lett. , vol.94 , pp. 198-202
    • Young, L.1    Kish, S.2    Li, P.3    Warsh, J.4
  • 107
    • 0027474051 scopus 로고
    • Widespread activation of calcium-activated neutral protease (calpain) in the brain in AD: A potential molecular basis of neuronal degeneration
    • Saito, K., Elce, J., Hamos, J., Nixon, R. (1993) Widespread activation of calcium-activated neutral protease (calpain) in the brain in AD: a potential molecular basis of neuronal degeneration. Proc. Natl. Acad. Sci. USA 90, 2628-2632.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2628-2632
    • Saito, K.1    Elce, J.2    Hamos, J.3    Nixon, R.4
  • 108
    • 0027262189 scopus 로고
    • Calcium-induced degradation of the IP3 receptor/calcium channel
    • Magnusson, A., Haug, L., Walaas, S., Ostvold, A. (1993) Calcium-induced degradation of the IP3 receptor/calcium channel. FEBS Lett. 323, 229-232.
    • (1993) FEBS Lett. , vol.323 , pp. 229-232
    • Magnusson, A.1    Haug, L.2    Walaas, S.3    Ostvold, A.4
  • 109
    • 0027985193 scopus 로고
    • Disturbances of the neuronal calcium homeostasis in the aging nervous system
    • Hartmann, H., Eckert, A., Muller, W. (1994) Disturbances of the neuronal calcium homeostasis in the aging nervous system. Life Sci. 55, 2011-2018.
    • (1994) Life Sci. , vol.55 , pp. 2011-2018
    • Hartmann, H.1    Eckert, A.2    Muller, W.3
  • 110
    • 0026495712 scopus 로고
    • Mechanisms of neuronal death in brain aging and Alzheimer's disease: Role of endocrine-mediated calcium dyshomeostasis
    • Landfield, P., Thibault, O., Mazzanti, M., Porter, N., Kerr, D. (1992) Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. J. Neurobiol. 23, 1247-1260.
    • (1992) J. Neurobiol. , vol.23 , pp. 1247-1260
    • Landfield, P.1    Thibault, O.2    Mazzanti, M.3    Porter, N.4    Kerr, D.5
  • 111
    • 0026636023 scopus 로고
    • Calcium as sculptor and destroyer of neural circuitry
    • Mattson, M. (1992) Calcium as sculptor and destroyer of neural circuitry. Exp. Gerontol. 27, 29-49.
    • (1992) Exp. Gerontol. , vol.27 , pp. 29-49
    • Mattson, M.1
  • 112
    • 0030567761 scopus 로고    scopus 로고
    • Lymphocytes and neutrophils as peripheral models to study the effect of beta-amyloid on cellular calcium signalling in Alzheimer's disease
    • Eckert, A., Forstl, H., Zerfass, R., Hartmann, H., Muller, W. (1996) Lymphocytes and neutrophils as peripheral models to study the effect of beta-amyloid on cellular calcium signalling in Alzheimer's disease. Life Sci. 59, 499-510.
    • (1996) Life Sci. , vol.59 , pp. 499-510
    • Eckert, A.1    Forstl, H.2    Zerfass, R.3    Hartmann, H.4    Muller, W.5
  • 114
    • 0002204915 scopus 로고
    • Apoptosis: The molecular basis of cell death
    • Cold Spring Harbor, NY: Cold Spring Harbor Press
    • Kerr, J., Harmon, B. (1991) Apoptosis: The molecular basis of cell death. In Current Communications on Cell and Molecular Biology, Volume 3, Cold Spring Harbor, NY: Cold Spring Harbor Press, 5-29.
    • (1991) Current Communications on Cell and Molecular Biology , vol.3 , pp. 5-29
    • Kerr, J.1    Harmon, B.2
  • 115
    • 0031776912 scopus 로고    scopus 로고
    • Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores
    • Wei, H., Wei, W., Bredesen, D., Perry, D. (1998) Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores. J. Neurochem. 70, 2305-2314.
    • (1998) J. Neurochem. , vol.70 , pp. 2305-2314
    • Wei, H.1    Wei, W.2    Bredesen, D.3    Perry, D.4
  • 116
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed, J. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.1
  • 117
    • 0031958152 scopus 로고    scopus 로고
    • Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
    • Cotman, C. (1998) Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol. Aging 19, S29-S32.
    • (1998) Neurobiol. Aging , vol.19
    • Cotman, C.1
  • 118
    • 0029983170 scopus 로고    scopus 로고
    • Upregulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease
    • Su, J., Satou, T., ANderson, A., Cotman, C. (1996) Upregulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. NeuroReport 7, 437-440.
    • (1996) NeuroReport , vol.7 , pp. 437-440
    • Su, J.1    Satou, T.2    Anderson, A.3    Cotman, C.4
  • 119
    • 0027717968 scopus 로고
    • Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
    • Kane, D., Sarafian, T., Anton, R., et al. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274-1277.
    • (1993) Science , vol.262 , pp. 1274-1277
    • Kane, D.1    Sarafian, T.2    Anton, R.3
  • 120
    • 0028036895 scopus 로고
    • Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
    • Krajewski, S., Krajewski, M., Shabaik, A., Miyashita, T., Wang, H., Reed, J. (1994) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Pathol. 145, 1323-1336.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1323-1336
    • Krajewski, S.1    Krajewski, M.2    Shabaik, A.3    Miyashita, T.4    Wang, H.5    Reed, J.6
  • 121
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
    • Oltvai, Z., Milliman, C., Korsmeyer, S. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.1    Milliman, C.2    Korsmeyer, S.3
  • 122
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, bcl-2 expression and brain pathology
    • Su, J., Deng, G., Cotman, C. (1997) Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, bcl-2 expression and brain pathology. J. Neuropathol. Exp. Neurol. 56, 86-93.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 86-93
    • Su, J.1    Deng, G.2    Cotman, C.3
  • 124
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53 and fas (CD95)-mediated apoptosis in Alzheimer's disease
    • De La Monte, S., Sohn, Y., Wands, J. (1997) Correlates of p53 and fas (CD95)-mediated apoptosis in Alzheimer's disease. J. Neurol. Sci. 152, 73-83.
    • (1997) J. Neurol. Sci. , vol.152 , pp. 73-83
    • De La Monte, S.1    Sohn, Y.2    Wands, J.3
  • 126
    • 0030071720 scopus 로고    scopus 로고
    • Activation of c-Fos contributes to amyloid beta-peptide-induced neurotoxicity
    • Gillardon, F., Skutella, T., Uhlmann, E., Holsboer, F., Zimmerman, M., Behl, C. (1996) Activation of c-Fos contributes to amyloid beta-peptide-induced neurotoxicity. Brain Res. 706, 169-172.
    • (1996) Brain Res. , vol.706 , pp. 169-172
    • Gillardon, F.1    Skutella, T.2    Uhlmann, E.3    Holsboer, F.4    Zimmerman, M.5    Behl, C.6
  • 127
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
    • Mattson, M., Goodman, Y., Luo, H., Fu, W., Furukawa, K. (1997) Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49, 681-697.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 681-697
    • Mattson, M.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 128
    • 0031172065 scopus 로고    scopus 로고
    • NF-κB: A crucial transcription factor for glial and neuronal cell function
    • O'Neill, L., Kaltschmidt, C. (1997) NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurol. Sci. 20, 252-258.
    • (1997) Trends Neurol. Sci. , vol.20 , pp. 252-258
    • O'Neill, L.1    Kaltschmidt, C.2
  • 129
    • 0029858387 scopus 로고    scopus 로고
    • TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappa B
    • Wang, C., Mayo, M., Baldwin, A. (1996) TNF and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B. Science 274, 784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.1    Mayo, M.2    Baldwin, A.3
  • 130
    • 0030983079 scopus 로고    scopus 로고
    • Transcription factor NK-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer's disease
    • Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P., Kaltschmidt, C. (1997) Transcription factor NK-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA 94, 2642-2647.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2642-2647
    • Kaltschmidt, B.1    Uherek, M.2    Volk, B.3    Baeuerle, P.4    Kaltschmidt, C.5
  • 131
    • 0032510692 scopus 로고    scopus 로고
    • Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism
    • Akama, K., Albanese, C., Pestell, R., VanEldik, L. (1998) Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism. Proc. Natl. Acad. Sci. USA 95, 5795-5800.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5795-5800
    • Akama, K.1    Albanese, C.2    Pestell, R.3    Vaneldik, L.4
  • 132
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    • Stadelmann, C., Bruck, W., Bancher, C., Jellinger, K., Lassmann, H. (1998) Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J. Neuropathol. Exp. Neurol. 57, 456-464.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 456-464
    • Stadelmann, C.1    Bruck, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 134
    • 0029912056 scopus 로고    scopus 로고
    • Mechanisms of neuronal death in Alzheimer's disease
    • Cotman, C., Su, J. (1996) Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6, 493-506.
    • (1996) Brain Pathol. , vol.6 , pp. 493-506
    • Cotman, C.1    Su, J.2
  • 136
    • 0025508543 scopus 로고
    • Ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly
    • Abate, C., Luk, D., Curran, T. (1990) Ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly. Cell Growth Diff. 1, 455-462.
    • (1990) Cell Growth Diff. , vol.1 , pp. 455-462
    • Abate, C.1    Luk, D.2    Curran, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.