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Volumn 16, Issue 2, 1999, Pages 113-134

Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples

Author keywords

Power; Relative efficiency; Statistical genetics; Type I error rate; Unbiasedness

Indexed keywords

AGE; ANALYTICAL ERROR; ARTICLE; ENVIRONMENTAL FACTOR; GENE LOCATION; GENETIC DISORDER; GENETIC LINKAGE; GENOTYPE; HUMAN; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT; SEX DIFFERENCE; SIBLING; VARIANCE;

EID: 0032909574     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1999)16:2<113::AID-GEPI1>3.0.CO;2-6     Document Type: Article
Times cited : (55)

References (70)
  • 1
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative trait linkage analysis in general pedigrees
    • Almasy L, Blangero J. 1998. Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
    • (1998) Am J Hum Genet , vol.62 , pp. 1198-1211
    • Almasy, L.1    Blangero, J.2
  • 2
    • 0031439473 scopus 로고    scopus 로고
    • Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages
    • Almasy L, Dyer TD, Blangero J. 1997. Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet Epidemiol 14:953-958.
    • (1997) Genet Epidemiol , vol.14 , pp. 953-958
    • Almasy, L.1    Dyer, T.D.2    Blangero, J.3
  • 3
    • 0028058128 scopus 로고
    • Robust variance-components approach for assessing genetic linkage in pedigrees
    • Amos CI. 1994. Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543.
    • (1994) Am J Hum Genet , vol.54 , pp. 535-543
    • Amos, C.I.1
  • 4
    • 84889172881 scopus 로고    scopus 로고
    • Comparison of variance components and extremely discordant sib pair (EDSP) linkage methods for quantitative traits
    • Amos CI, de Andrade M. 1997. Comparison of variance components and extremely discordant sib pair (EDSP) linkage methods for quantitative traits. Genet Epidemiol 14:518.
    • (1997) Genet Epidemiol , vol.14 , pp. 518
    • Amos, C.I.1    De Andrade, M.2
  • 6
    • 0029875522 scopus 로고    scopus 로고
    • Assessing genetic linkage and association with robust components of variance approaches
    • Amos CI, Zhu DK, Boerwinkle E. 1996. Assessing genetic linkage and association with robust components of variance approaches. Ann Hum Genet 60:143-160.
    • (1996) Ann Hum Genet , vol.60 , pp. 143-160
    • Amos, C.I.1    Zhu, D.K.2    Boerwinkle, E.3
  • 10
    • 0016044116 scopus 로고
    • Comment on Dr. Robertson's communication
    • Blackwelder WC, Elston RC. 1974. Comment on Dr. Robertson's communication. Behav Genet 4:97-99.
    • (1974) Behav Genet , vol.4 , pp. 97-99
    • Blackwelder, W.C.1    Elston, R.C.2
  • 11
    • 84953499404 scopus 로고
    • Power and robustness of sib-pair linkage tests and extension to larger sibships
    • Blackwelder WC, Elston RC. 1982. Power and robustness of sib-pair linkage tests and extension to larger sibships. Commun Statist Theory Meth 11:449-484.
    • (1982) Commun Statist Theory Meth , vol.11 , pp. 449-484
    • Blackwelder, W.C.1    Elston, R.C.2
  • 12
    • 0021957675 scopus 로고
    • A comparison of sib-pair linkage tests for disease susceptibility loci
    • Blackwelder WC, Elston RC. 1985. A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 2:85-97.
    • (1985) Genet Epidemiol , vol.2 , pp. 85-97
    • Blackwelder, W.C.1    Elston, R.C.2
  • 13
    • 0027720035 scopus 로고
    • Statistical genetic approaches to human adaptability
    • Blangero J. 1993. Statistical genetic approaches to human adaptability. Hum Biol 65:941-966.
    • (1993) Hum Biol , vol.65 , pp. 941-966
    • Blangero, J.1
  • 14
    • 0029624319 scopus 로고
    • Genetic analysis of a common oligogenic trait with quantitative correlates: Summary of GAW9 results
    • Blangero J. 1995. Genetic analysis of a common oligogenic trait with quantitative correlates: summary of GAW9 results. Genet Epidemiol 12:689-706.
    • (1995) Genet Epidemiol , vol.12 , pp. 689-706
    • Blangero, J.1
  • 15
    • 0003958977 scopus 로고    scopus 로고
    • Technical Notes No. 6, Population Genetics Laboratory, Southwest Foundation for Biomedical Research, San Antonio, TX
    • Blangero J, Almasy L. 1996. SOLAR: Sequential Oligogenic Linkage Analysis Routines. Technical Notes No. 6, Population Genetics Laboratory, Southwest Foundation for Biomedical Research, San Antonio, TX.
    • (1996) SOLAR: Sequential Oligogenic Linkage Analysis Routines
    • Blangero, J.1    Almasy, L.2
  • 16
    • 0031442937 scopus 로고    scopus 로고
    • Multipoint oligogenic linkage analysis of quantitative traits
    • Blangero J, Almasy L. 1997. Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 14:959-964.
    • (1997) Genet Epidemiol , vol.14 , pp. 959-964
    • Blangero, J.1    Almasy, L.2
  • 17
    • 0021297613 scopus 로고
    • Ascertainment and goodness of fit of variance component models for pedigree data
    • Boehnke M, Lange K. 1984. Ascertainment and goodness of fit of variance component models for pedigree data. Prog Clin Biol Res 147:173-192.
    • (1984) Prog Clin Biol Res , vol.147 , pp. 173-192
    • Boehnke, M.1    Lange, K.2
  • 18
    • 0022545964 scopus 로고
    • Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees
    • Boehnke M, Moll PP, Lange K, Weidman WH, Kottke BA. 1986. Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees. Am J Med Genet 23:775-792.
    • (1986) Am J Med Genet , vol.23 , pp. 775-792
    • Boehnke, M.1    Moll, P.P.2    Lange, K.3    Weidman, W.H.4    Kottke, B.A.5
  • 19
    • 0026047218 scopus 로고
    • Linkage analysis of quantitative traits: Increased power by using selected samples
    • Carey G, Williamson J. 1991. Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet 49:786-796.
    • (1991) Am J Hum Genet , vol.49 , pp. 786-796
    • Carey, G.1    Williamson, J.2
  • 21
    • 0031444117 scopus 로고    scopus 로고
    • Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate
    • De Andrade M, Thiel TJ, Yu LP, Amos CI. 1997. Assessing linkage on chromosome 5 using components of variance approach: univariate versus multivariate. Genet Epidemiol 14:773-778.
    • (1997) Genet Epidemiol , vol.14 , pp. 773-778
    • De Andrade, M.1    Thiel, T.J.2    Yu, L.P.3    Amos, C.I.4
  • 23
    • 0031472342 scopus 로고    scopus 로고
    • A variance component approach to dichotomous trait linkage analysis using a threshold model
    • Duggirala R, Williams JT, Williams-Blangero S, Blangero J. 1997. A variance component approach to dichotomous trait linkage analysis using a threshold model. Genet Epidemiol 14:987-992.
    • (1997) Genet Epidemiol , vol.14 , pp. 987-992
    • Duggirala, R.1    Williams, J.T.2    Williams-Blangero, S.3    Blangero, J.4
  • 24
    • 0028102233 scopus 로고
    • Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping
    • Eaves L, Meyer J. 1994. Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav Genet 24:443-455.
    • (1994) Behav Genet , vol.24 , pp. 443-455
    • Eaves, L.1    Meyer, J.2
  • 26
    • 0029911351 scopus 로고    scopus 로고
    • An improved multipoint sib-pair analysis of quantitative traits
    • Fulker DW, Cherny SS. 1996. An improved multipoint sib-pair analysis of quantitative traits. Behav Genet 26:527-532.
    • (1996) Behav Genet , vol.26 , pp. 527-532
    • Fulker, D.W.1    Cherny, S.S.2
  • 27
    • 0028947057 scopus 로고
    • Multipoint interval mapping of quantitative trait loci, using sib pairs
    • Fulker DW, Cherny SS, Cardon LR. 1995. Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233.
    • (1995) Am J Hum Genet , vol.56 , pp. 1224-1233
    • Fulker, D.W.1    Cherny, S.S.2    Cardon, L.R.3
  • 28
    • 0014578695 scopus 로고
    • On the probability that a twin pair is monozygotic
    • Gaines RE, Elston RC. 1969. On the probability that a twin pair is monozygotic. Am J Hum Genet 21:457-465.
    • (1969) Am J Hum Genet , vol.21 , pp. 457-465
    • Gaines, R.E.1    Elston, R.C.2
  • 29
    • 0025245437 scopus 로고
    • Multipoint analysis of human quantitative genetic variation
    • Goldgar DE. 1990. Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967.
    • (1990) Am J Hum Genet , vol.47 , pp. 957-967
    • Goldgar, D.E.1
  • 33
    • 0030843362 scopus 로고    scopus 로고
    • A linkage strategy for detection of human quantitative-trait loci. I. Generalized relative risk ratios and power of sib pairs with extreme trait values
    • Gu C, Rao DC. 1997a. A linkage strategy for detection of human quantitative-trait loci. I. Generalized relative risk ratios and power of sib pairs with extreme trait values. Am J Hum Genet 61:200-210.
    • (1997) Am J Hum Genet , vol.61 , pp. 200-210
    • Gu, C.1    Rao, D.C.2
  • 34
    • 0030873885 scopus 로고    scopus 로고
    • A linkage strategy for detection of human quantitative-trait loci. II. Optimization of study designs based on extreme sib pairs and generalized relative risk ratios
    • Gu C, Rao DC. 1997b. A linkage strategy for detection of human quantitative-trait loci. II. Optimization of study designs based on extreme sib pairs and generalized relative risk ratios. Am J Hum Genet 61:211-222.
    • (1997) Am J Hum Genet , vol.61 , pp. 211-222
    • Gu, C.1    Rao, D.C.2
  • 35
    • 0030471517 scopus 로고    scopus 로고
    • Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci
    • Gu C, Todorov A, Rao DC. 1996. Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci. Genet Epidemiol 13:513-533.
    • (1996) Genet Epidemiol , vol.13 , pp. 513-533
    • Gu, C.1    Todorov, A.2    Rao, D.C.3
  • 36
    • 0014730823 scopus 로고
    • The estimation of genetic variance from twin data
    • Haseman JK, Elston RC. 1970. The estimation of genetic variance from twin data. Behav Genet 1:11-20.
    • (1970) Behav Genet , vol.1 , pp. 11-20
    • Haseman, J.K.1    Elston, R.C.2
  • 37
    • 0015309467 scopus 로고
    • The investigation of linkage between a quantitative trait and a marker locus
    • Haseman JK, Elston RC. 1972. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
    • (1972) Behav Genet , vol.2 , pp. 3-19
    • Haseman, J.K.1    Elston, R.C.2
  • 38
    • 0021669736 scopus 로고
    • The information contained in multiple sibling pairs
    • Hodge SE. 1984. The information contained in multiple sibling pairs. Genet Epidemiol 1:109-122.
    • (1984) Genet Epidemiol , vol.1 , pp. 109-122
    • Hodge, S.E.1
  • 39
    • 0027529253 scopus 로고
    • Asymptotic properties of affected-sib-pair linkage analyses
    • Holmans P. 1993. Asymptotic properties of affected-sib-pair linkage analyses. Am J Hum Genet 52:362-374.
    • (1993) Am J Hum Genet , vol.52 , pp. 362-374
    • Holmans, P.1
  • 40
    • 0019920786 scopus 로고
    • Extensions to multivariate normal models for pedigree analysis
    • Hopper JL, Mathews JD. 1982. Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet 46:373-383.
    • (1982) Ann Hum Genet , vol.46 , pp. 373-383
    • Hopper, J.L.1    Mathews, J.D.2
  • 41
    • 0029046177 scopus 로고
    • Complete multipoint sib-pair analysis of qualitative and quantitative traits
    • Kruglyak L, Lander ES. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454.
    • (1995) Am J Hum Genet , vol.57 , pp. 439-454
    • Kruglyak, L.1    Lander, E.S.2
  • 42
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander ES, Schork NJ. 1994. Genetic dissection of complex traits. Science 265:2037-2048.
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.S.1    Schork, N.J.2
  • 43
    • 0018179274 scopus 로고
    • Central limit theorems for pedigrees
    • Lange K. 1978. Central limit theorems for pedigrees. J Math Biol 6:59-66.
    • (1978) J Math Biol , vol.6 , pp. 59-66
    • Lange, K.1
  • 44
    • 0020608018 scopus 로고
    • Extensions to pedigree analysis. IV. Covariance components models for multivariate traits
    • Lange K, Boehnke M. 1983. Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet 14:513-524.
    • (1983) Am J Med Genet , vol.14 , pp. 513-524
    • Lange, K.1    Boehnke, M.2
  • 45
    • 0024190141 scopus 로고
    • Programs for pedigree analysis: MENDEL, FISHER, and dGENE
    • Lange K, Weeks D, Boehnke M. 1988. Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 5:471-472.
    • (1988) Genet Epidemiol , vol.5 , pp. 471-472
    • Lange, K.1    Weeks, D.2    Boehnke, M.3
  • 47
    • 0021850103 scopus 로고
    • Multilocus linkage analysis in humans: Detection of linkage and estimation of recombination
    • Lathrop GM, Lalouel JM, Julier C, Ott J. 1985. Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet 37:482-498.
    • (1985) Am J Hum Genet , vol.37 , pp. 482-498
    • Lathrop, G.M.1    Lalouel, J.M.2    Julier, C.3    Ott, J.4
  • 48
    • 0031454584 scopus 로고    scopus 로고
    • GAW10: Simulated family data for a common oligogenic disease with quantitative risk factors
    • MacCluer JW, Blangero J, Dyer TD, Speer MC. 1997. GAW10: simulated family data for a common oligogenic disease with quantitative risk factors. Genet Epidemiol 14:737-742.
    • (1997) Genet Epidemiol , vol.14 , pp. 737-742
    • MacCluer, J.W.1    Blangero, J.2    Dyer, T.D.3    Speer, M.C.4
  • 52
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 53
    • 0029001682 scopus 로고
    • Extreme discordant sib pairs for mapping quantitative trait loci in humans
    • Risch N, Zhang H. 1995. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
    • (1995) Science , vol.268 , pp. 1584-1589
    • Risch, N.1    Zhang, H.2
  • 54
    • 0029979336 scopus 로고    scopus 로고
    • Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations
    • Risch NJ, Zhang H. 1996. Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am J Hum Genet 58:836-843.
    • (1996) Am J Hum Genet , vol.58 , pp. 836-843
    • Risch, N.J.1    Zhang, H.2
  • 56
    • 0027362259 scopus 로고
    • Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modeling considerations
    • Schork NJ. 1993. Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet 53:1306-1319.
    • (1993) Am J Hum Genet , vol.53 , pp. 1306-1319
    • Schork, N.J.1
  • 58
    • 0031047461 scopus 로고    scopus 로고
    • Optimal weighting scheme for affected sib-pair analysis of sibship data
    • Sham PC, Zhao JH, Curtis D. 1997. Optimal weighting scheme for affected sib-pair analysis of sibship data. Ann Hum Genet 61:61-69.
    • (1997) Ann Hum Genet , vol.61 , pp. 61-69
    • Sham, P.C.1    Zhao, J.H.2    Curtis, D.3
  • 59
    • 0031442619 scopus 로고    scopus 로고
    • The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs
    • Shugart YY, Goldgar DE. 1997. The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs. Genet Epidemiol 14:897-902.
    • (1997) Genet Epidemiol , vol.14 , pp. 897-902
    • Shugart, Y.Y.1    Goldgar, D.E.2
  • 61
    • 0021340890 scopus 로고
    • A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes
    • Suarez BK, Van Eerdewegh P. 1984. A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes. Am J Med Genet 18:135-146.
    • (1984) Am J Med Genet , vol.18 , pp. 135-146
    • Suarez, B.K.1    Van Eerdewegh, P.2
  • 62
    • 0031023617 scopus 로고    scopus 로고
    • Trade-off between sibship size and sampling scheme for detecting quantitative trait loci
    • Todorov AA, Province MA, Borecki IB, Rao DC. 1997. Trade-off between sibship size and sampling scheme for detecting quantitative trait loci. Hum Hered 47:1-5.
    • (1997) Hum Hered , vol.47 , pp. 1-5
    • Todorov, A.A.1    Province, M.A.2    Borecki, I.B.3    Rao, D.C.4
  • 63
    • 0031442493 scopus 로고    scopus 로고
    • Effects of genotype-by-sex interaction on quantitative trait linkage analysis
    • Towne B, Siervogel RM, Blangero J. 1997. Effects of genotype-by-sex interaction on quantitative trait linkage analysis. Genet Epidemiol 14:1053-1058.
    • (1997) Genet Epidemiol , vol.14 , pp. 1053-1058
    • Towne, B.1    Siervogel, R.M.2    Blangero, J.3
  • 65
    • 0031469587 scopus 로고    scopus 로고
    • Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions
    • Wijsman EM, Amos CI. 1997. Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genet Epidemiol 14:719-735.
    • (1997) Genet Epidemiol , vol.14 , pp. 719-735
    • Wijsman, E.M.1    Amos, C.I.2
  • 66
    • 0005617673 scopus 로고    scopus 로고
    • Comparison of variance-components and sibpair methods for quantitative trait linkage analysis in sibships and nuclear families
    • Williams JT, Blangero J. 1997. Comparison of variance-components and sibpair methods for quantitative trait linkage analysis in sibships and nuclear families. Genet Epidemiol 14:543.
    • (1997) Genet Epidemiol , vol.14 , pp. 543
    • Williams, J.T.1    Blangero, J.2
  • 67
    • 0031472926 scopus 로고    scopus 로고
    • Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees
    • Williams JT, Duggirala R, Blangero J. 1997. Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. Genet Epidemiol 14:1065-1070.
    • (1997) Genet Epidemiol , vol.14 , pp. 1065-1070
    • Williams, J.T.1    Duggirala, R.2    Blangero, J.3
  • 68
    • 0027756035 scopus 로고
    • Statistical validity of the Haseman-Elston sib-pair test in small samples
    • Wilson AF, Elston RC. 1993. Statistical validity of the Haseman-Elston sib-pair test in small samples. Genet Epidemiol 10:593-598.
    • (1993) Genet Epidemiol , vol.10 , pp. 593-598
    • Wilson, A.F.1    Elston, R.C.2
  • 69
    • 0031018305 scopus 로고    scopus 로고
    • The phenotypic difference discards sib-pair QTL linkage information
    • Wright FA. 1997. The phenotypic difference discards sib-pair QTL linkage information. Am J Hum Genet 60:740-742.
    • (1997) Am J Hum Genet , vol.60 , pp. 740-742
    • Wright, F.A.1
  • 70
    • 0029794185 scopus 로고    scopus 로고
    • Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: Selected sampling by parental phenotypes
    • Erratum 60:748-749
    • Zhang H, Risch N. 1996. Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. Am J Hum Genet 59:951-957 [Erratum 60:748-749].
    • (1996) Am J Hum Genet , vol.59 , pp. 951-957
    • Zhang, H.1    Risch, N.2


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