The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 897-902

  Shugart, Yin Y ^a   Goldgar, David E ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

False postive rate; MAPMAKER SIBS; Multipoint identity by descent method (MIM); Peak length; Power

Indexed keywords

CONFERENCE PAPER; GENE LOCUS; GENE MAPPING; GENETIC DISORDER; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; HUMAN; QUANTITATIVE TRAIT; SCORING SYSTEM; SIBLING;

CHROMOSOME MAPPING; FEMALE; GENETIC SCREENING; GENOME, HUMAN; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LOD SCORE; MALE; MATCHED-PAIR ANALYSIS; NUCLEAR FAMILY; PREDICTIVE VALUE OF TESTS; QUANTITATIVE TRAIT, HERITABLE; SOFTWARE;

EID: 0031442619     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H     Document Type: Conference Paper

References (7)

1. Goldgar DE (1990): Multipoint analysis for human quantitative genetic variation. Am J Hum Genet 47:957-967.
2. Haseman JK, Elston RC (1972): The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
3. Lander E, Kruglyak L (1995): Genetic dissection of complex traits: guideline for interpreting and reporting linkage results. Nature Genet 11:241-247.
4. Kruglyak L, Lander ES (1995): Complete multipoint sib-pairs analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454.
5. Shannon WD, Goldin WD, Chase GA, Weeks D (1995): Distinguish true and false positive peaks in allele-sharing statistics. Am J Hum Genet 57:A35.
6. Shugart Y, Ott J (1996): Using lod score peak length to distinguish true and false positives. In Clementi M, Forabosso P (eds): "Mathematical Genetics" Padova: CLEUP Padova Publisher, pp 127-133.
7. Terwilliger JD, Shannon WD, Lathrop GM, Nolan JP, Goldin LR, Chase GA, Weeks DE (in press): True and false positive peaks in genome-wide scans: application of length-biased sampling to linkage mapping. Am J Hum Genet.