Comparison of model-free linkage mapping strategies for the study of a complex trait

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 743-748

  Amos, C I ^a   Krushkal, J ^a   Thiel, T J ^a   Young, A ^a   Zhu, D K ^a   Boerwinkle, E ^a   De Andrade, M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Components of variance; Estimation; Linkage; Lod scores

Indexed keywords

CHROMOSOME 5; CONFERENCE PAPER; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; MARKER GENE;

ANALYSIS OF VARIANCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 5; FEMALE; GENETIC MARKERS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LOD SCORE; MALE; MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE;

EID: 0031444622     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<743::AID-GEPI30>3.0.CO;2-O     Document Type: Conference Paper

References (7)

1. Amos CI (1988): Robust methods for the detection of genetic linkage for data from extended families and pedigrees. Ph.D. dissertation, Dept. of Biometry and Genetics, Louisiana State University, New Orleans.
2. Amos CI, Zhu DK, Boerwinkle E (1996): Assessing genetic linkage and association with robust components of variance approaches. Ann Hum Genet 60:143-160.
3. Fulker DW, Cardon LR (1994): A sib-pair approach to interval mapping of quantitative trait loci. Am J Hum Genet 54:1092-1103.
4. Gessler DDG, Xu S (1996). Using the expectation or the distribution of identity by descent for mapping quantitative trait loci under the random model. Am J Hum Genet 59:1382-1390.
5. Haseman, JK, Elston RC (1972): The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
6. Kruglyak L, Lander ES (1995): Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57: 439-454.
7. Wright FA (1997): The phenotypic difference may discard sibpair QTL linkage information. Am J Hum Genet (in press).