In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation

International Journal of Cancer

Volumn 81, Issue 5, 1999, Pages 799-807

  Fabre, Myriam ^a,b   Martin, Mercè ^a   Ulloa, Fausto ^a   Real, Francisco X ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DIPEPTIDYL PEPTIDASE IV; MESSENGER RNA; MUCIN; SUCRASE ISOMALTASE; VILLIN;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MUCUS SECRETION; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL DIVISION; CELL POLARITY; COLORECTAL NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HT29 CELLS; HUMANS; INTESTINAL MUCOSA; MUCINS; MUCUS; PHENOTYPE; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0032907348     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990531)81:5<799::AID-IJC22>3.0.CO;2-W     Document Type: Article

References (34)

1. CARRATO, C., BALAGUÉ, C., DE BOLÓS, C., GONZALÉZ, E., GAMBÚS, G., PLANAS, J., PERINI, J.M., ANDREU, D. and REAL, F.X., Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology, 107, 160-172 (1994).
2. CHAN, S.S.-Y., ZHENG, H., SU, M.-W., WILK, R., KILLEEN, M.T., HEDGECOCK, E.M. and CULOTTI, J.G., UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues. Cell, 87, 187-195 (1996).
3. CHANTRET, I., BARBAT, A., DUSSAULX, E., BRATTAIN, M.G. and ZWEIBAUM, A., Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines. Cancer Res., 48, 1936-1942 (1988).
4. CHUNG, D.C., Molecular prognostic markers and colorectal cancer: the search goes on. Gastroenterology, 114, 1330-1332 (1998).
5. CHUONG, C.M., JIANG, T.X., YIN, E. and WIDELITZ, R.B., cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelialmesenchymal interaction. Develop. Biol., 164, 383-397 (1994).
6. COOPER, H.M., ARMES, P., BRITTO, J., GAD, J. and WILKS, A.F., Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene, 11, 2243-2254 (1995).
7. FABRE, M. and GARCÍA DE HERREROS, A., Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin. J. Cell Sci., 106, 513-522 (1993).
8. FAZELI, A. and 14 OTHERS, Phenotype of mice lacking functional deleted in colorectal cancer (Dcc) gene. Nature (Lond.), 386, 796-803 (1997).
9. FEARON, E.R., CHO, K.R., NIGRO, J.M., KERN, S.E., SIMONS, J.W., RUPPERT, J.M., HAMILTON, S.R., PREISINGER, A.C., THOMAS, G., KINZLER, K.W. and VOGELSTEIN, B., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science, 247, 49-56 (1990).
10. GARCÍA DE HERREROS, A., FABRE, M., BATLLE, E., BALAGUÉ, C. and REAL, F.X., The tumor promoter 12-O-tetradecanoylphorbol-1-acetate blocks differentiation of HT-29 human colon cancer cells. J. Cell Sci., 105, 1165-1172 (1993).
11. GOI, T., YAMAGUCHI, A., NAKAGAWARA, G., URANO, T., SHIKU, H. and FURUKAWA, K., Reduced expression of delected colorectal carcinoma (DCC) protein in established colon cancers. Brit. J. Cancer, 77, 466-471 (1998).
12. GUM, J.R., BYRD, J.C., HICKS, J.W., TORIBARA, N.W., ROTHE, E.M., LAGACE, R.E. and KIM, Y.S., Molecular cloning of human intestinal mucin. J. biol. Chem., 264, 6480-6487 (1989).
13. GUM, J.R., HICKS, J.W., SWALLOW, D.M., LAGACE, R.L., BIRD, J.C., LAMPORT, D.T.A., SIDDIKI, B. and KIM, Y.S., Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. Biochem. biophys. Res. Comm., 171, 407-415 (1990).
14. HEDGECOCK, E.M., CULOTTI, J.G. and HALL, D.H., The unc-5, unc-6 and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron, 4, 61-85 (1990).
15. HEDRICK, L., CHO, K.R., FEARON, E.R., WU, T., KINZLER, K.W. and VOGELSTEIN, B., The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Develop., 8, 1174-1183 (1994).
16. KEINO-MASU, K., MASU, M., HINCK, L., LEONARDO, E.D., CHAN, S.S.Y., CULOTTI, J.G. and TESSIER-LAVIGNE, M., Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell, 87, 175-185 (1996).
17. KOLODZIEJ, P.A., DCC's function takes shape in the nervous system. Curr. Opin. Genet. Develop. 7, 87-92 (1997).
18. KOLODZIEJ, P.A., TIMPE, L.C., MITCHELL, K.J., FRIED, S.R., GOODMAN, C.S., JAN, L.Y. and JAN, Y.N., Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell, 87, 197-204 (1996).
19. LEONARDO, E.D., HINCK, L., MASU, M., KEINO-MASU, K., ACKERMAN, S.L. and TESSIER-LAVIGNE, M., Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature (Lond.), 386, 833-838 (1997).
20. LESUFFLEUR, T., BARBAT, A., LUCCIONI, C., BEAUMATIN, J., CLAIR, M., KORNOWSKI, A., DUSSAULX, E., DUTRILLAUX, B. and ZWEIBAUM, A., Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells. J. Cell Biol., 115, 1409-1418 (1991).
21. LESUFFLEUR, T., PORCHET, N., AUBERT, J.P., SWALLOW, D., GUM, J.R., KIM, Y.S., REAL, F.X. and ZWEIBAUM, A., Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J. Cell Sci., 106, 771-783 (1993).
22. LESUFFLEUR, T., ROCHE, F., HILL, A., LACASA, M., SWALLOW, D.M., ZWEIBAUM, A. and REAL, F.X., Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells: a 3′ end of MUC5AC? J. biol. Chem., 270, 13665-13673 (1995).
23. LESUFFLEUR, T., ZWEIBAUM, A. and REAL, F.X., Mucins in normal and neoplastic human gastrointestinal tissues. Crit. Rev. Oncol. Hematol., 17, 153-180 (1994).
24. LLOSAS, M.M., BATLLE, E., COLL, O., SKOUDY, A., FABRE, M. and GARCÍA DE HERREROS, A., Evidence for a role of conventional protein kinase-C alpha in the control of homotypic contacts and cell scattering of HT-29 human intestinal cells. Biochem. J., 315, 1049-1054 (1996).
25. OOKAWA, K., SAKAMOTO, M., HIROHASHI, S., YOSHIDA, Y., SUGIMURA, T., TERADA, M. and YOKOTA, J., Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int. J. Cancer, 53, 382-387 (1993).
26. PIERCEALL, W.E., REALE, M.A., CANDIA, A.F., WRIGHT, C.V.E., CHO, K.R. and FEARON, E.R., Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Develop. Biol., 166, 654-665 (1994).
27. POTTEN, C.S. and LOEFFLER, M., Stem cells: attributes, cycles, spirals, pitfalls, and uncertainties: lessons for and from the crypt. Development, 110, 1001-1020 (1990).
28. REALE, M.A., HU, G., ZAFAR, A.I., GETZENBERG, R.H., LEVINE, S.M. and FEARON, E.R., Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res., 54, 4493-4501 (1994).
29. SCHMITT, C.A., THALER, K.R., WITTIG, B.M., KAULEN, H., MEYER ZUM BÜSCHENFELDE, K.-H. and DIPPOLD, W.G., Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation. Brit. J. Cancer, 77, 588-594 (1998).
30. SERAFINI, T., COLAMARINO, A., LEONARDO, E.D., WANG, H., BEDDINGTON, R., SKARNES, W.C. and TESSIER-LAVIGNE, M., Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell, 87, 1001-1014 (1996).
31. SHIBATA, D., REALE, M.A., LAVIN, P., SILVERMAN, M., FEARON, E.R., STEELE, G., JESSUP, J.M., LODA, M. and SUMMERHAYES, I.C., The DCC protein and prognosis in colorectal cancer. N. Engl. J. Med., 335, 1727-1732 (1996).
32. THIAGALINGAM, S., LENGAUER, C., LEACH, F.S., SCHUTTE, M., HAHN, S.A., OVERHAUSER, J., WILLSON, J.K.V., MARKOWITZ, S., HAMILTON, S.R., KERN, S.E., KINZLER, K.W. and VOGELSTEIN, B., Evaluation of candidate suppressor genes on chromosome 18 in colorectal cancers. Nature (Genet.), 13, 343-346 (1996).
33. TORIBARA, N.W., ROBERTON, A.M., HO, S.B., KUO, W.-L., GUM, E., HICKS, J.W., GUM, J.R., BYRD, J.C., SIDDIKI, B. and KIM, Y.S., Human gastric mucin identification of a unique species by expression cloning. J. biol. Chem., 268, 5879-5885 (1993).
34. ZWEIBAUM, A., LABURTHE, M., GRASSET, E. and LOUVARD, D., Use of cultured cell lines in studies of intestinal cell differentiation and function. In: M. Field and R.A. Frizzel (eds.), Handbook of physiology. The gastrointestinal system. Vol. IV: intestinal absorption and secretion, pp. 223-255, American Physiological Society, Washington, DC (1991).