메뉴 건너뛰기




Volumn 7, Issue 1, 1997, Pages 87-92

DCC's function takes shape in the nervous system

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR;

EID: 0031052673     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(97)80114-1     Document Type: Article
Times cited : (14)

References (27)
  • 3
    • 0030592577 scopus 로고    scopus 로고
    • Frazzied encodes a member of the DCC immunoglobulin subfamily and is required for CNS axon guidance and motor axon targeting
    • of outstanding interest. Here, the authors identify the likely Drosophila receptor for netrin-dependent chemoattraction. The netrin and Frazzled null phenotypes are near identical. Frazzled cDNA is shown to rescue the mutant frazzled phenotype when expressed in neurons but not when expressed in target cells.
    • Kolodziej PA, Timpe L, Mitchell KJ, Goodman CS, Fried SR, Jan LY, Jan YN. frazzied encodes a member of the DCC immunoglobulin subfamily and is required for CNS axon guidance and motor axon targeting. of outstanding interest Cell. 87:1996;197-204 Here, the authors identify the likely Drosophila receptor for netrin-dependent chemoattraction. The netrin and Frazzled null phenotypes are near identical. Frazzled cDNA is shown to rescue the mutant frazzled phenotype when expressed in neurons but not when expressed in target cells.
    • (1996) Cell , vol.87 , pp. 197-204
    • Kolodziej, P.A.1    Timpe, L.2    Mitchell, K.J.3    Goodman, C.S.4    Fried, S.R.5    Jan, L.Y.6    Jan, Y.N.7
  • 4
    • 0030592485 scopus 로고    scopus 로고
    • UNC-40, a transmembrane protein related to human DCC (deleted in colorectal cancer), guides cell and pioneer growth cone migrations in C. elegans
    • of outstanding interest. The authors describe a third gene - the others being UNC-5, and UNC-6 - that is involved in netrin-mediated axon guidance events. UNC-40 is likely to be the receptor mediating netrin-dependent chemoattraction in C. elegans.
    • Chan SS-Y, Zheng H, Wilk R, Su M-W, Hedgecock EM, Culotti JG. UNC-40, a transmembrane protein related to human DCC (deleted in colorectal cancer), guides cell and pioneer growth cone migrations in C. elegans. of outstanding interest Cell. 87:1996;187-196 The authors describe a third gene - the others being UNC-5, and UNC-6 - that is involved in netrin-mediated axon guidance events. UNC-40 is likely to be the receptor mediating netrin-dependent chemoattraction in C. elegans.
    • (1996) Cell , vol.87 , pp. 187-196
    • Chan, S.-Y.1    Zheng, H.2    Wilk, R.3    Su, M.-W.4    Hedgecock, E.M.5    Culotti, J.G.6
  • 5
    • 0342928204 scopus 로고    scopus 로고
    • Deleted-in-colorectal carcinomas (DCC) encodes a netrin receptor
    • of outstanding interest
    • Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS-Y, Culotti JG, Tessier-Lavigne M. Deleted-in-colorectal carcinomas (DCC) encodes a netrin receptor. of outstanding interest Cell. 1997; The authors of this paper demonstrate that DCC is the netrin receptor on commissural axons. This key observation explains the similarities of the netrin and DCCP mutant phenotypes in C. elegans and Drosophila and may imply that defective netrin signaling resulting from DCC loss contributes to tumor progression.
    • (1997) Cell
    • Keino-Masu, K.1    Masu, M.2    Hinck, L.3    Leonardo, E.D.4    Chan, S.-Y.5    Culotti, J.G.6    Tessier-Lavigne, M.7
  • 6
    • 0030051783 scopus 로고    scopus 로고
    • The (Greek) key to structures of neural cell adhesion molecules
    • Vaughn DE, Bjorkman PJ. The (Greek) key to structures of neural cell adhesion molecules. Neuron. 16:1996;261-273.
    • (1996) Neuron , vol.16 , pp. 261-273
    • Vaughn, D.E.1    Bjorkman, P.J.2
  • 7
    • 0028606322 scopus 로고
    • Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer
    • Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol. 127:1994;2009-2020.
    • (1994) J Cell Biol , vol.127 , pp. 2009-2020
    • Vielmetter, J.1    Kayyem, J.F.2    Roman, J.M.3    Dreyer, W.J.4
  • 8
    • 0023186308 scopus 로고
    • Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation and alternatives RNA splicing
    • Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation and alternatives RNA splicing. Science. 236:1987;799-806.
    • (1987) Science , vol.236 , pp. 799-806
    • Cunningham, B.A.1    Hemperly, J.J.2    Murray, B.A.3    Prediger, E.A.4    Brackenbury, R.5    Edelman, G.M.6
  • 9
    • 0028025737 scopus 로고
    • CDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial - mesenchymal interaction
    • Chuong CM, Jiang TX, Yin E, Widelitz RB. cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial - mesenchymal interaction. Dev Biol. 164:1994;383-397.
    • (1994) Dev Biol , vol.164 , pp. 383-397
    • Chuong, C.M.1    Jiang, T.X.2    Yin, E.3    Widelitz, R.B.4
  • 10
    • 0028582004 scopus 로고
    • Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos
    • Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER. Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Dev Biol. 166:1994;654-665.
    • (1994) Dev Biol , vol.166 , pp. 654-665
    • Pierceall, W.E.1    Reale, M.A.2    Candia, A.F.3    Wright, C.V.4    Cho, K.R.5    Fearon, E.R.6
  • 11
    • 0027504088 scopus 로고
    • Antioncogenes and human cancer
    • Knudson AJ. Antioncogenes and human cancer. Proc Natl Acad Sci USA. 90:1993;10914-10921.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10914-10921
    • Knudson, A.J.1
  • 12
    • 15844390729 scopus 로고    scopus 로고
    • Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
    • of special interest. This paper surveys the possible contribution of several genes at 18q to colon cancer and concludes that there may be multiple tumor suppressors in this region. Inactivating mutations in two Smad genes - presumably involved in TGF-β signaling and/or loss of DCC - are LOH events identified in tumors. No single gene, however, accounts for all of the LOH; most 18q events alter more than one gene and 18q is associated with, but not shown to promote, tumorigenesis. Insensitivity of tumors to TGF-β may result from loss of Smad activities and many contribute to tumor development because TGFβ and related proteins are antiproliferative factors for may epithelial cell types.
    • Thiagalingan S, Lengauer C, Leach F, Schutte M, Hahn S, Overhauser J, Wilson JKV, Markowitz S, Hamilton S, Kern S, et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. of special interest Nat Genet. 13:1996;343-346 This paper surveys the possible contribution of several genes at 18q to colon cancer and concludes that there may be multiple tumor suppressors in this region. Inactivating mutations in two Smad genes - presumably involved in TGF-β signaling and/or loss of DCC - are LOH events identified in tumors. No single gene, however, accounts for all of the LOH; most 18q events alter more than one gene and 18q is associated with, but not shown to promote, tumorigenesis. Insensitivity of tumors to TGF-β may result from loss of Smad activities and many contribute to tumor development because TGFβ and related proteins are antiproliferative factors for may epithelial cell types.
    • (1996) Nat Genet , vol.13 , pp. 343-346
    • Thiagalingan, S.1    Lengauer, C.2    Leach, F.3    Schutte, M.4    Hahn, S.5    Overhauser, J.6    Wilson, J.K.V.7    Markowitz, S.8    Hamilton, S.9    Kern, S.10
  • 14
    • 0028959978 scopus 로고
    • DCC: Linking tumor suppresor genes and altered cell surface interactions in cancer?
    • Cho KR, Fearon ER. DCC: linking tumor suppresor genes and altered cell surface interactions in cancer? Curr Opin Genet Dev. 5:1995;72-78.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 72-78
    • Cho, K.R.1    Fearon, E.R.2
  • 15
    • 0031050237 scopus 로고    scopus 로고
    • DCC loss of expression and glioma progression
    • Demonstrating precursor - product relationships in tumor development in difficult but important for showing that loss of a gene contributes to cancer. In this study, the authors examine DCC expression in matched pairs of early and late gliomas taken from the same site in several different patients; thus, in this case, it is likely that reductions in DCC expression correlate with the progression of the disease of special interest
    • Reyes-Mugica M, Rieger-Christ K, Ohgaki H, Helie M, Kleinman G, Bogler O, Yahanda A, Cavanee W, Ekstrand B, Fearon E, et al. DCC loss of expression and glioma progression. of special interest Cander Res. 1997; Demonstrating precursor - product relationships in tumor development in difficult but important for showing that loss of a gene contributes to cancer. In this study, the authors examine DCC expression in matched pairs of early and late gliomas taken from the same site in several different patients; thus, in this case, it is likely that reductions in DCC expression correlate with the progression of the disease.
    • (1997) Cander Res
    • Reyes-Mugica, M.1    Rieger-Christ, K.2    Ohgaki, H.3    Helie, M.4    Kleinman, G.5    Bogler, O.6    Yahanda, A.7    Cavanee, W.8    Ekstrand, B.9    Fearon, E.10
  • 16
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • of special interest. of outstanding interest. These authors identify the Smad2 (alternatively MADR2 or JV18-1 [12]) gene at 18q21 as altered in 6% of 66 examined sporadic colon tumors. Missense mutations in Smad2 recovered from these tumors prevent phosphorylation by TGF-β receptors. Mutant Smad2 products fail to induce mesoderm in Xenopus animal caps, an assay to TGF-β function. This paper thus provides the clearest link between mutation at 18q and colon tumorigenesis albeit in a small subset of tumors.
    • of special interest Eppert K, Scherer S, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui L-C, Bapat B, Gallinger S, Andrulis IL, et al. MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma. of outstanding interest Cell. 86:1996;543-552 These authors identify the Smad2 (alternatively MADR2 or JV18-1 [12]) gene at 18q21 as altered in 6% of 66 examined sporadic colon tumors. Missense mutations in Smad2 recovered from these tumors prevent phosphorylation by TGF-β receptors. Mutant Smad2 products fail to induce mesoderm in Xenopus animal caps, an assay to TGF-β function. This paper thus provides the clearest link between mutation at 18q and colon tumorigenesis albeit in a small subset of tumors.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.2    Ozcelik, H.3    Pirone, R.4    Hoodless, P.5    Kim, H.6    Tsui, L.-C.7    Bapat, B.8    Gallinger, S.9    Andrulis, I.L.10
  • 17
    • 0030593038 scopus 로고    scopus 로고
    • DPC4 a candidate tumor suppressor gene at human chromosome 18q21.1
    • of special interest. Another gene that appears to contribute to cancer is identified at 18q and encodes a human homolog of MAD, a target of TGF-β signaling. TGF-β family members modulate cell proliferation; defects in TGF-β1 signaling may contribute to tumorigenesis.
    • Hahn S, Schutte M, Hoque A, Moskaluk C, D Costa L, Rozemblum E, Weinstein C, Fischer A, Yeo CJ, Hruban R, Kern SE. DPC4 a candidate tumor suppressor gene at human chromosome 18q21.1. of special interest Science. 271:1996;350-353 Another gene that appears to contribute to cancer is identified at 18q and encodes a human homolog of MAD, a target of TGF-β signaling. TGF-β family members modulate cell proliferation; defects in TGF-β1 signaling may contribute to tumorigenesis.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.1    Schutte, M.2    Hoque, A.3    Moskaluk, C.4    D. Costa, L.5    Rozemblum, E.6    Weinstein, C.7    Fischer, A.8    Yeo, C.J.9    Hruban, R.10    Kern, S.E.11
  • 18
    • 0025332245 scopus 로고
    • The UNC-5, UNC-6, and UNC-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    • Hedgecock EM, Culotti JG, Hall DH. The UNC-5, UNC-6, and UNC-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron. 4:1990;61-85.
    • (1990) Neuron , vol.4 , pp. 61-85
    • Hedgecock, E.M.1    Culotti, J.G.2    Hall, D.H.3
  • 19
    • 0026521660 scopus 로고
    • Genes necessary for directed axonal elongation or fasciculation in C. elegans
    • McIntire SL, Garriga G, White J, Jacobson D, Horvitz HR. Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron. 8:1992;307-322.
    • (1992) Neuron , vol.8 , pp. 307-322
    • McIntire, S.L.1    Garriga, G.2    White, J.3    Jacobson, D.4    Horvitz, H.R.5
  • 20
    • 0026481173 scopus 로고
    • UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C.elegans
    • Ishii N, Wadsworth WG, Stern BD, Culotti JG, Hedgecock EM. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C.elegans. Neuron. 9:1992;873-881.
    • (1992) Neuron , vol.9 , pp. 873-881
    • Ishii, N.1    Wadsworth, W.G.2    Stern, B.D.3    Culotti, J.G.4    Hedgecock, E.M.5
  • 21
    • 0030220353 scopus 로고    scopus 로고
    • Guidance cues at the Drosophila CNS midline: Identification and characterization of two Drosophila netrin/UNC-6 homologs
    • Harris R, Sabatelli LM, Seeger MA. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila netrin/UNC-6 homologs. Neuron. 17:1996;217-228.
    • (1996) Neuron , vol.17 , pp. 217-228
    • Harris, R.1    Sabatelli, L.M.2    Seeger, M.A.3
  • 23
    • 0028061313 scopus 로고
    • Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
    • Kennedy TE, Serafini T, De la Torre JR, Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell. 78:1994;425-435.
    • (1994) Cell , vol.78 , pp. 425-435
    • Kennedy, T.E.1    Serafini, T.2    De La Torre, J.R.3    Tessier-Lavigne, M.4
  • 24
    • 0028138219 scopus 로고
    • The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    • Serafini T, Kennedy TE, Gaiko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 78:1994;409-424.
    • (1994) Cell , vol.78 , pp. 409-424
    • Serafini, T.1    Kennedy, T.E.2    Gaiko, M.J.3    Mirzayan, C.4    Jessell, T.M.5    Tessier-Lavigne, M.6
  • 25
    • 0030062518 scopus 로고    scopus 로고
    • Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
    • Wadswoth W, Bhatt H, Hedgecock E. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron. 16:1996;35-46.
    • (1996) Neuron , vol.16 , pp. 35-46
    • Wadswoth, W.1    Bhatt, H.2    Hedgecock, E.3
  • 26
    • 0029065329 scopus 로고
    • The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
    • Colamarino SA, Tessier-Lavigne M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell. 81:1995;621-629.
    • (1995) Cell , vol.81 , pp. 621-629
    • Colamarino, S.A.1    Tessier-Lavigne, M.2
  • 27
    • 0027163671 scopus 로고
    • Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
    • Hamelin M, Zhou Y, Su MW, Scott IM, Culotti JG. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature. 364:1993;327-330.
    • (1993) Nature , vol.364 , pp. 327-330
    • Hamelin, M.1    Zhou, Y.2    Su, M.W.3    Scott, I.M.4    Culotti, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.