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1
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0025056930
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Identification of a chromosome 18q gene that is altered in colorectal cancers
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Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, Vogelstein B. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 247:1990;49-56.
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(1990)
Science
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Fearon, E.R.1
Cho, K.R.2
Nigro, J.M.3
Kern, S.E.4
Simons, J.W.5
Ruppert, J.M.6
Hamilton, S.R.7
Preisinger, A.C.8
Thomas, G.9
Kinzler, K.W.10
Vogelstein, B.11
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2
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0028228920
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The DCC gene product in cellular differentiation and colorectal tumorigenesis
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Hendrick L, Cho KR, Fearon ER, Wu TC, Kinzler KW, Vogelstein B. The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev. 8:1994;1174-1183.
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(1994)
Genes Dev
, vol.8
, pp. 1174-1183
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Hendrick, L.1
Cho, K.R.2
Fearon, E.R.3
Wu, T.C.4
Kinzler, K.W.5
Vogelstein, B.6
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3
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0030592577
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Frazzied encodes a member of the DCC immunoglobulin subfamily and is required for CNS axon guidance and motor axon targeting
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of outstanding interest. Here, the authors identify the likely Drosophila receptor for netrin-dependent chemoattraction. The netrin and Frazzled null phenotypes are near identical. Frazzled cDNA is shown to rescue the mutant frazzled phenotype when expressed in neurons but not when expressed in target cells.
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Kolodziej PA, Timpe L, Mitchell KJ, Goodman CS, Fried SR, Jan LY, Jan YN. frazzied encodes a member of the DCC immunoglobulin subfamily and is required for CNS axon guidance and motor axon targeting. of outstanding interest Cell. 87:1996;197-204 Here, the authors identify the likely Drosophila receptor for netrin-dependent chemoattraction. The netrin and Frazzled null phenotypes are near identical. Frazzled cDNA is shown to rescue the mutant frazzled phenotype when expressed in neurons but not when expressed in target cells.
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(1996)
Cell
, vol.87
, pp. 197-204
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Kolodziej, P.A.1
Timpe, L.2
Mitchell, K.J.3
Goodman, C.S.4
Fried, S.R.5
Jan, L.Y.6
Jan, Y.N.7
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4
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0030592485
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UNC-40, a transmembrane protein related to human DCC (deleted in colorectal cancer), guides cell and pioneer growth cone migrations in C. elegans
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of outstanding interest. The authors describe a third gene - the others being UNC-5, and UNC-6 - that is involved in netrin-mediated axon guidance events. UNC-40 is likely to be the receptor mediating netrin-dependent chemoattraction in C. elegans.
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Chan SS-Y, Zheng H, Wilk R, Su M-W, Hedgecock EM, Culotti JG. UNC-40, a transmembrane protein related to human DCC (deleted in colorectal cancer), guides cell and pioneer growth cone migrations in C. elegans. of outstanding interest Cell. 87:1996;187-196 The authors describe a third gene - the others being UNC-5, and UNC-6 - that is involved in netrin-mediated axon guidance events. UNC-40 is likely to be the receptor mediating netrin-dependent chemoattraction in C. elegans.
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(1996)
Cell
, vol.87
, pp. 187-196
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Chan, S.-Y.1
Zheng, H.2
Wilk, R.3
Su, M.-W.4
Hedgecock, E.M.5
Culotti, J.G.6
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5
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0342928204
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Deleted-in-colorectal carcinomas (DCC) encodes a netrin receptor
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of outstanding interest
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Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS-Y, Culotti JG, Tessier-Lavigne M. Deleted-in-colorectal carcinomas (DCC) encodes a netrin receptor. of outstanding interest Cell. 1997; The authors of this paper demonstrate that DCC is the netrin receptor on commissural axons. This key observation explains the similarities of the netrin and DCCP mutant phenotypes in C. elegans and Drosophila and may imply that defective netrin signaling resulting from DCC loss contributes to tumor progression.
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(1997)
Cell
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Keino-Masu, K.1
Masu, M.2
Hinck, L.3
Leonardo, E.D.4
Chan, S.-Y.5
Culotti, J.G.6
Tessier-Lavigne, M.7
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6
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0030051783
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The (Greek) key to structures of neural cell adhesion molecules
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Vaughn DE, Bjorkman PJ. The (Greek) key to structures of neural cell adhesion molecules. Neuron. 16:1996;261-273.
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(1996)
Neuron
, vol.16
, pp. 261-273
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Vaughn, D.E.1
Bjorkman, P.J.2
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7
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0028606322
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Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer
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Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol. 127:1994;2009-2020.
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(1994)
J Cell Biol
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, pp. 2009-2020
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Vielmetter, J.1
Kayyem, J.F.2
Roman, J.M.3
Dreyer, W.J.4
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8
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0023186308
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Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation and alternatives RNA splicing
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Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation and alternatives RNA splicing. Science. 236:1987;799-806.
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(1987)
Science
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Cunningham, B.A.1
Hemperly, J.J.2
Murray, B.A.3
Prediger, E.A.4
Brackenbury, R.5
Edelman, G.M.6
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9
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0028025737
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CDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial - mesenchymal interaction
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Chuong CM, Jiang TX, Yin E, Widelitz RB. cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial - mesenchymal interaction. Dev Biol. 164:1994;383-397.
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(1994)
Dev Biol
, vol.164
, pp. 383-397
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Chuong, C.M.1
Jiang, T.X.2
Yin, E.3
Widelitz, R.B.4
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10
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0028582004
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Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos
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Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER. Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Dev Biol. 166:1994;654-665.
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(1994)
Dev Biol
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Pierceall, W.E.1
Reale, M.A.2
Candia, A.F.3
Wright, C.V.4
Cho, K.R.5
Fearon, E.R.6
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11
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0027504088
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Antioncogenes and human cancer
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Knudson AJ. Antioncogenes and human cancer. Proc Natl Acad Sci USA. 90:1993;10914-10921.
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(1993)
Proc Natl Acad Sci USA
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Knudson, A.J.1
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12
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15844390729
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Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
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of special interest. This paper surveys the possible contribution of several genes at 18q to colon cancer and concludes that there may be multiple tumor suppressors in this region. Inactivating mutations in two Smad genes - presumably involved in TGF-β signaling and/or loss of DCC - are LOH events identified in tumors. No single gene, however, accounts for all of the LOH; most 18q events alter more than one gene and 18q is associated with, but not shown to promote, tumorigenesis. Insensitivity of tumors to TGF-β may result from loss of Smad activities and many contribute to tumor development because TGFβ and related proteins are antiproliferative factors for may epithelial cell types.
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Thiagalingan S, Lengauer C, Leach F, Schutte M, Hahn S, Overhauser J, Wilson JKV, Markowitz S, Hamilton S, Kern S, et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. of special interest Nat Genet. 13:1996;343-346 This paper surveys the possible contribution of several genes at 18q to colon cancer and concludes that there may be multiple tumor suppressors in this region. Inactivating mutations in two Smad genes - presumably involved in TGF-β signaling and/or loss of DCC - are LOH events identified in tumors. No single gene, however, accounts for all of the LOH; most 18q events alter more than one gene and 18q is associated with, but not shown to promote, tumorigenesis. Insensitivity of tumors to TGF-β may result from loss of Smad activities and many contribute to tumor development because TGFβ and related proteins are antiproliferative factors for may epithelial cell types.
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(1996)
Nat Genet
, vol.13
, pp. 343-346
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Thiagalingan, S.1
Lengauer, C.2
Leach, F.3
Schutte, M.4
Hahn, S.5
Overhauser, J.6
Wilson, J.K.V.7
Markowitz, S.8
Hamilton, S.9
Kern, S.10
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13
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0028314271
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The DCC gene - structural analysis and mutations in colorectal carcinomas
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Cho KR, Oliner JD, Simons JW, Hedrick L, Fearon ER, Preisinger AC, Hedge P, Silverman GA, Vogelstein B. The DCC gene - structural analysis and mutations in colorectal carcinomas. Genomics. 19:1994;525-531.
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(1994)
Genomics
, vol.19
, pp. 525-531
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Cho, K.R.1
Oliner, J.D.2
Simons, J.W.3
Hedrick, L.4
Fearon, E.R.5
Preisinger, A.C.6
Hedge, P.7
Silverman, G.A.8
Vogelstein, B.9
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14
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0028959978
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DCC: Linking tumor suppresor genes and altered cell surface interactions in cancer?
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Cho KR, Fearon ER. DCC: linking tumor suppresor genes and altered cell surface interactions in cancer? Curr Opin Genet Dev. 5:1995;72-78.
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(1995)
Curr Opin Genet Dev
, vol.5
, pp. 72-78
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Cho, K.R.1
Fearon, E.R.2
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15
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0031050237
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DCC loss of expression and glioma progression
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Demonstrating precursor - product relationships in tumor development in difficult but important for showing that loss of a gene contributes to cancer. In this study, the authors examine DCC expression in matched pairs of early and late gliomas taken from the same site in several different patients; thus, in this case, it is likely that reductions in DCC expression correlate with the progression of the disease of special interest
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Reyes-Mugica M, Rieger-Christ K, Ohgaki H, Helie M, Kleinman G, Bogler O, Yahanda A, Cavanee W, Ekstrand B, Fearon E, et al. DCC loss of expression and glioma progression. of special interest Cander Res. 1997; Demonstrating precursor - product relationships in tumor development in difficult but important for showing that loss of a gene contributes to cancer. In this study, the authors examine DCC expression in matched pairs of early and late gliomas taken from the same site in several different patients; thus, in this case, it is likely that reductions in DCC expression correlate with the progression of the disease.
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(1997)
Cander Res
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Reyes-Mugica, M.1
Rieger-Christ, K.2
Ohgaki, H.3
Helie, M.4
Kleinman, G.5
Bogler, O.6
Yahanda, A.7
Cavanee, W.8
Ekstrand, B.9
Fearon, E.10
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16
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16044369574
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MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma
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of special interest. of outstanding interest. These authors identify the Smad2 (alternatively MADR2 or JV18-1 [12]) gene at 18q21 as altered in 6% of 66 examined sporadic colon tumors. Missense mutations in Smad2 recovered from these tumors prevent phosphorylation by TGF-β receptors. Mutant Smad2 products fail to induce mesoderm in Xenopus animal caps, an assay to TGF-β function. This paper thus provides the clearest link between mutation at 18q and colon tumorigenesis albeit in a small subset of tumors.
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of special interest Eppert K, Scherer S, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui L-C, Bapat B, Gallinger S, Andrulis IL, et al. MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma. of outstanding interest Cell. 86:1996;543-552 These authors identify the Smad2 (alternatively MADR2 or JV18-1 [12]) gene at 18q21 as altered in 6% of 66 examined sporadic colon tumors. Missense mutations in Smad2 recovered from these tumors prevent phosphorylation by TGF-β receptors. Mutant Smad2 products fail to induce mesoderm in Xenopus animal caps, an assay to TGF-β function. This paper thus provides the clearest link between mutation at 18q and colon tumorigenesis albeit in a small subset of tumors.
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(1996)
Cell
, vol.86
, pp. 543-552
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Eppert, K.1
Scherer, S.2
Ozcelik, H.3
Pirone, R.4
Hoodless, P.5
Kim, H.6
Tsui, L.-C.7
Bapat, B.8
Gallinger, S.9
Andrulis, I.L.10
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17
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0030593038
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DPC4 a candidate tumor suppressor gene at human chromosome 18q21.1
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of special interest. Another gene that appears to contribute to cancer is identified at 18q and encodes a human homolog of MAD, a target of TGF-β signaling. TGF-β family members modulate cell proliferation; defects in TGF-β1 signaling may contribute to tumorigenesis.
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Hahn S, Schutte M, Hoque A, Moskaluk C, D Costa L, Rozemblum E, Weinstein C, Fischer A, Yeo CJ, Hruban R, Kern SE. DPC4 a candidate tumor suppressor gene at human chromosome 18q21.1. of special interest Science. 271:1996;350-353 Another gene that appears to contribute to cancer is identified at 18q and encodes a human homolog of MAD, a target of TGF-β signaling. TGF-β family members modulate cell proliferation; defects in TGF-β1 signaling may contribute to tumorigenesis.
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(1996)
Science
, vol.271
, pp. 350-353
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Hahn, S.1
Schutte, M.2
Hoque, A.3
Moskaluk, C.4
D. Costa, L.5
Rozemblum, E.6
Weinstein, C.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.10
Kern, S.E.11
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18
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0025332245
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The UNC-5, UNC-6, and UNC-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
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Hedgecock EM, Culotti JG, Hall DH. The UNC-5, UNC-6, and UNC-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron. 4:1990;61-85.
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(1990)
Neuron
, vol.4
, pp. 61-85
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Hedgecock, E.M.1
Culotti, J.G.2
Hall, D.H.3
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19
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0026521660
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Genes necessary for directed axonal elongation or fasciculation in C. elegans
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McIntire SL, Garriga G, White J, Jacobson D, Horvitz HR. Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron. 8:1992;307-322.
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Neuron
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McIntire, S.L.1
Garriga, G.2
White, J.3
Jacobson, D.4
Horvitz, H.R.5
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20
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0026481173
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UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C.elegans
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Ishii N, Wadsworth WG, Stern BD, Culotti JG, Hedgecock EM. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C.elegans. Neuron. 9:1992;873-881.
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Neuron
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Ishii, N.1
Wadsworth, W.G.2
Stern, B.D.3
Culotti, J.G.4
Hedgecock, E.M.5
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21
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0030220353
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Guidance cues at the Drosophila CNS midline: Identification and characterization of two Drosophila netrin/UNC-6 homologs
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Harris R, Sabatelli LM, Seeger MA. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila netrin/UNC-6 homologs. Neuron. 17:1996;217-228.
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Neuron
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Harris, R.1
Sabatelli, L.M.2
Seeger, M.A.3
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22
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0030220346
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Genetic analysis of netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
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Mitchell KJ, Doyle JL, Serafini T, Kennedy TE, Tessier-Lavigne M, Goodman CS, Dickson BJ. Genetic analysis of netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. Neuron. 17:1996;203-215.
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Neuron
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Mitchell, K.J.1
Doyle, J.L.2
Serafini, T.3
Kennedy, T.E.4
Tessier-Lavigne, M.5
Goodman, C.S.6
Dickson, B.J.7
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23
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0028061313
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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
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Kennedy TE, Serafini T, De la Torre JR, Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell. 78:1994;425-435.
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Cell
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Kennedy, T.E.1
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Tessier-Lavigne, M.4
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24
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0028138219
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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
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Serafini T, Kennedy TE, Gaiko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 78:1994;409-424.
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Cell
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Serafini, T.1
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Tessier-Lavigne, M.6
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25
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0030062518
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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
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Wadswoth W, Bhatt H, Hedgecock E. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron. 16:1996;35-46.
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Wadswoth, W.1
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The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
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Colamarino SA, Tessier-Lavigne M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell. 81:1995;621-629.
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Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
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Hamelin M, Zhou Y, Su MW, Scott IM, Culotti JG. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature. 364:1993;327-330.
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Hamelin, M.1
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Culotti, J.G.5
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