Developmental immunology of the newborn

Immunology and Allergy Clinics of North America

Volumn 19, Issue 2, 1999, Pages 253-279

  Arkachaisri, T ^a   Ballow, M ^a  

^a CHILDREN S HOSPITAL OF BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CD4 ANTIGEN; CD45 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN;

ANTIMICROBIAL THERAPY; B LYMPHOCYTE; CHILDHOOD MORTALITY; CYTOKINE PRODUCTION; DEVELOPING COUNTRY; EFFECTOR CELL; HELPER CELL; HOST RESISTANCE; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGY; MORBIDITY; NEWBORN; NEWBORN INFECTION; NEWBORN INTENSIVE CARE; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0032906481     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8561(05)70087-4     Document Type: Article

References (160)

1. A.N. Akbar L. Terry A. Timms Loss of CD45R and gain of UCHLI reactivity is a feature of primed T cells J Immunology 140 1988 2171 2178
2. U. Andersson Development of B lymphocyte function in childhood Acta Paediatr Scand 74 1985 568 573
3. J. Antin S. Emerson P. Martin LEU-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: Phenotypic and functional studies J Immunol 136 1986 505
4. Asma G.E.M. van den Bergh R.L. J.M. Vossen Use of monoclonal antibodies in a study of the development of T lymphocytes in the human fetus Clin Exp Immunol 53 1983 429 436
5. M. Ballow K.L. Cates J. Rowe Development of the immune system in very low birth weight (less than 1500 g) premature infants: Concentrations of plasma immunoglobulins and patterns of infections Pediatr Res 20 1986 899 904
6. M. Ballow K. Cates J. Rowe Peripheral blood T-cell subpopulations in the very low birth weight (less than 1500 g) infant Am J Hematol 24 1987 85 92
7. J. Banchereau F. Rousset Human B lymphocytes: Phenotype, proliferation, and differentiation Adv Immunol 52 1992 125 262
8. N. Bhat A. Kantor M. Bieber The ontogeny and functional characteristics of human B-1 (CD5+B) cells Int Immunol 4 1991 243 252
9. Z.A. Bhutta Neonatal infections Curr Opin Pediatr 9 1997 133 140
10. M. Blackman J. Kappler P. Marrack The role of the T cell receptor in positive and negative selection of developing T cells Science 248 1990 1335 1341
11. W.J. Blankenship G. Cassady J. Schaefer Serum gamma-M globulin responses in acute neonatal infections and their diagnostic significance J Pediatr 75 1969 1271
12. M. Bofill G. Janossy M. Janossa Human B-cell development, II–Subpopulations in the human fetus J Immunol 134 1985 1531
13. A. Bonati P. Zanelli S. Ferrari T-cell receptor B-chain gene rearrangement and expression during human thymic ontogenesis Blood 79 1992 1472 1483
14. J. Borst T.M. Broom J.D. Bos Tissue distribution and repertoire selection of human γδ T cells: Comparison with the murine system Curr Top Microbiol Immunol 173 1991 41 46
15. D. Brugnoni P. Airo D. Graf Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn Eur J Immunol 24 1994 1919 1924
16. M. Cairo Neonatal neutrophil host defense Am J Dis Child 143 1989 40
17. M. Cairo Y. Suen E. Knoppel Decreased G-CSF and IL-3 production and genetic expression from mononuclear cells of newborn infants Pediatr Res 31 1992 574
18. M. Cairo Y. Suen E. Knoppel Decreased stimulated GM-CSF production and GM-CSF gene expression but normal numbers of GM-CSF receptors in human term newborns compared to adults Pediatr Res 30 1991 362
19. D. Campana G. Janossy E. Coustain-Smith The expression of T cell receptor associated proteins during T cell ontogeny in man J Immunol 142 1989 57
20. R. Carr N. Modi Haemopoietic colony stimulating factors for preterm neonates Arch Dis Child 76 1997 F128 F133
21. P. Casali S. Burastero M. Nakamura Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset Science 236 1987 77 80
22. P. Casali A.L. Notkins CD5+ B lymphocytes, polyreactive antibodies and the human B cell repertoire Immunol Today 10 1989 362 368
23. K. Cates J. Rowe M. Ballow The premature infant as a compromised host Curr Probl Pediatr 13 1983 1 63
24. K.L. Cates C. Goetz N. Rosenberg Longitudinal development of specific and functional antibody in very low birth weight premature infants Pediatr Res 23 1988 14 23
25. M. Chang Y. Suen S.M. Lee Transforming growth factor-β1 macrophage inflammatory protein-1α and interleukin-8 gene expression is lower in stimulated human neonatal compared with adult mononuclear cells Blood 84 1994 118 124
26. S. Chawareewong A. Jirapongsa K. Lokaphadhana Immune response to hepatitis B vaccine in premature neonates Southeast Asian J Trop Med Public Health 22 1991 39 40
27. S. Chheda K. Palkowetz R. Garogalo Decreased interleukin-10 production by neonatal monocytes and T cells: Relationship to decreased production and expression of tumor necrosis factor-α and its receptors Pediatr Res 40 1996 475 483
28. T. Chin B. Ank D. Murakami Cytotoxic studies in human newborns: Lessened allogeneic cell-induced (augmented) cytotoxicity but strong lymphokine-activated cytotoxicity of cord mononuclear cells Cell Immunol 103 1986 241 251
29. Y. Choi M.H. Rickert M. Ballow Human IgH-V gene repertoire in neonatal cord blood, adult peripheral blood, and EBV-transformed cells Ann NY Acad Sci 764 1995 261 264
30. E.A. Clark J.A. Ledbetter How B and T cells talk to each other Nature 367 1994 425 428
31. S. Clark R. Kamen The human hematopoietic colony-stimulating factors Science 236 1987 1229 1237
32. L.T. Clement Isoforms of the CD45 common leukocyte antigen family: Markers for human T-cell differentiation J Clin Immunol 12 1992 1
33. M. Clerici L. DePalma E. Roilides Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages J Clin Invest 91 1993 2829 2836
34. M.E. Conley M. Larche V.R. Bonagura Hyper IgM syndrome associated with defective CD40-mediated B cell activation J Clin Invest 94 1994 1404 1409
35. M. Cooper R. Buckley Developmental immunology and the immunodeficiency diseases JAMA 248 1982 2658 2670
36. J. Dancis J.J. Osborn H.W. Kunz Studies of immunology of the newborn infant, IV: Antibody formation in the premature infant Pediatrics 12 1953 151 157
37. deBont E. A. Martens vanRaan J. Tumor necrosis factor-α, interleukin-1β, and interlukin-6 plasma levels in neonatal sepsis Pediatr Res 33 1993 380 383
38. A. Durandy C. Hivroz F. Mazerolles Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression J Immunol 158 1997 2576 2584
39. A. Durandy L. Thuillier M. Forveille Phenotypic and functional characteristics of human newborns' B lymphocytes J Immunol 144 1990 60 65
40. E. Eichenwald Perinatally transmitted neonatal bacterial infections Infec Dis Clin North Am 11 1997 223
41. M.S. Einhorn D.M. Granoff M.H. Nahm Concentrations of antibodies in paired maternal and infant sera: Relationships to IgG subclass J Pediatr 111 1987 783 788
42. U. Elsasser-Beile B. Dursunoglu H. Gallati Comparison of cytokine production in blood cell cultures of health children and adults Pediatr Allergy Immunol 6 1995 170 174
43. B.K. English S.K. Burchett J.D. English Production of lymphotoxin and tumor necrosis factor by human neonatal mononuclear cells Pediatr Res 24 1988 717
44. F.M. Erkeller-Yuksel V. Deneys B. Yuksel Age-related changes in human blood lymphocyte subpopulations J Pediatr 1120 1992 216 222
45. European Collaborative Study Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women Pediatr Infect Dis 11 1992 1018 1026
46. H.E. Evans S.O. Akpata L. Glass Serum immunoglobulin levels in premature and full-term infants Am J Pathol 56 1971 416 418
47. A.A. Ferreira M. Bunn-Moreno Sant Anna C. BCG vaccination in low birth weight newborns: Analysis of lymphocyte proliferation, IL-2 generation of intradermal reaction to PPD Tubercle and Lung Disease 77 1996 476 481
48. P. Ferrieri Neonatal susceptibility and immunity to major bacterial pathogens Reviews of Infectious Diseases 12 1990 S392
49. B.J. Fowlkes D.M. Pardoll Molecular and cellular events of T cell development Adv Immunol 44 1989 207 264
50. J. Gaddy G. Risdon H.E. Broxmeyer Cord blood natural killer cells are functionally and phenotypically immature but readily respond to interleukin-2 and interleukin-12 J Interferon Cytokine Res 15 1995 527
51. A. Gandhi L. Brodsky M. Ballow Benefits of antibiotic prophylaxis in children with chronic sinusitis: Assessment of outcome predictors Allergy Proc 14 1993 37 43
52. L. Garderet N. Dulphy C. Douay The umbilical cord blood αβ T-cell repertoire: Characteristics of a polyclonal and naive but completely formed repertoire Blood 91 1998 340 346
53. W.E. Gathings A.R. Lawton M.D. Cooper Immunoflourescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans Eur J Immunol 7 1977 804
54. J.F.J. George H.W.J. Schroeder Developmental regulation of Dβ reading frame and junctional diversity in T cell receptor-β transcripts from human thymus J Immunol 148 1992 1230 1239
55. R. Gerli E. Agea C. Muscat Activation of cord T lymphocytes Cell Immunol 148 1993 32 47
56. Gold M.R. de Franco A.L. Biochemistry of B lymphocyte activation Adv Immunol 55 1994 221 295
57. C.C. Goodnow Transgenic mice and analysis of B cell tolerance Annu Rev Immunol 10 1992 489 518
58. D.M. Granoff P.G. Shackelford J.P. Pandey Antibody responses to Haemophilus influenzae type b polysaccharide vaccine in relation to Km (1) and G2m (23) immunoglobulin allotypes J Infect Dis 154 1986 257 264
59. J. Hassan D. Reen Neonatal CD4, CD45RA, T cells: Precursors of adult CD4, CD45RA T cells Res Immunol 144 1993 87 92
60. B.F. Haynes C.S. Heinly Early human T cell development: Analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment J Exp Med 181 1995 1445
61. B.F. Haynes M.E. Martin H.H. Kay Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell percursors in early human fetal tissues J Exp Med 168 1988 1061 1080
62. A. Hayward M. Cosyns Proliferative and cytokine responses by human newborn T cells stimulated with staphylococcal enterotoxin B Pediatr Res 35 1994 293 298
63. A. Hayward J. Groothuis Development of T cells with memory phenotype in infancy Mestecky J. Immunology of Milk and the Neonate 1991 Plenum Press New York 71
64. S. Hickey G. McCracken Postnatal bacterial infections Fanaroff A.A. Martin R.J. Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant ed 6 1997 Mosby-Year Book St. Louis 717 720
65. H. Hill Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate Pediatr Res 22 1987 375
66. J.R. Hobbs J.A. Davis Serum G-globulin levels and gestational age in premature babies Lancet 1 1967 77
67. P. Hohlfeld F. Forestier S. Marion Toxoplasma gondii infection during pregnancy T lymphocyte subpopulation in mothers and fetuses Pediatr Infect Dis J 9 1990 878 881
68. W. Holtmeier T. Witthoft A. Hennemann The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development J Immunol 158 1997 5632 5461
69. E. Horst C.J.L.M. Meijer A.M. Duijvestijn The ontogeny of human lymphocyte recirculation: High endothelial cell antigen (HECA-452) and CD44 homing receptor expression in the development of the immune system Eur J Immunol 20 1990 1483 1489
70. T. Hoshino A. Yamada J. Honda Tissue-specific distribution and age-dependent increase of human CD11b T cells J Immunol 151 1993 2237 2246
71. M. Hyvarinen P. Zelter W. Oh Influence of gestational age on serum levels of alpha-1 fetoprotein, IgG globulin, and albumin in newborn infants J Pediatr 82 1973 430 437
72. S. Itohara P. Mombaerts J. Lafaille T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes Cell 72 1993 337 348
73. S.C. Jameson K.A. Hogquist M.J. Bevan Positive selection of thymocytes Annu Rev Immunol 13 1996 93 126
74. D. Kagi B. Ledermann K. Burki Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo Annu Rev Immunol 14 1996 207 232
75. Kantor The development and repertoire of B-1 cells (CD5 cells) Immunol Today 12 1991 389 391
76. J.W. Kappler M. Roehm P.T. Marack T cell tolerance by clonal selection in the thymus Cell 49 1987 273 280
77. Y. Kawano T. Noma Role of interleukin-2 and interferon-γ in inducing production of IgG subclasses in lymphocytes of human newborns Immunology 88 1996 40 48
78. R. Kibler M.J. Hicks A.L. Wright A comparative analysis of cord blood and adult lymphocytes: Interleukin-2 and interferon production, natural killer cell activity, and lymphocyte populations Diagnostic Immunology 4 1986 201 208
79. C. Kim L. Pelus J. White Differential chemotactic behavior of developing T cells in response to thymic chemokines Blood 91 1998 4434 4443
80. J. Klein S. Marcy Bacterial sepsis and meningitis Remington J. Klein J. Infectious diseases of the fetus and newborn infant ed 4 1995 WB Saunders Philadelphia 836 878
81. P.F. Kohler R.S. Farr Elevation of cord over maternal IgG immunoglobulin: Evidence for an active placental IgG transport Nature 210 1966 1070 1071
82. A. Kotiranta-Ainamo J. Rautonen N. Rautonen Interleukin-10 production by cord blood mononuclear cells Pediatr Res 41 1997 110 113
83. T.G. Krediet F.J.M. Beurskens van Duk H. Antibody responses and opsonic activity in sera of preterm neonates with coagulase-negative staphylococcal septicemia and the effect of the administration of fresh frozen plasma Pediatr Res 43 1998 645 651
84. Y.L. Lau A.Y.C. Tam K.W. Ng Response of preterm infants to hepatitis B vaccine J Pediatr 121 1992 962 965
85. S. Lee E. Knoppel van de Ven C. Transcriptional rates of granulocyte-macrophage colony-stimulating factor, granulocyte colony stimulating factor, interleukin-3 and macrophage colony-stimulating factor genes in activated cord versus adult mononuclear cells: Alteration in cytokine expression may be secondary to post-transcriptional instability Pediatr Res 34 1993 560
86. J.M. Leider Transcriptional regulation of T cell receptor genes Annu Rev Immunol 11 1993 539 570
87. A. Leino O. Ruuskanen P. Kero Depressed phytohemagglutinin and concanavalin A responses in premature infants Clin Immunol Immunopathol 19 1981 260 267
88. D.B. Lewis Cellular immunity of the human fetus and neonate Immunology and Allergy Clinics of North America 18 1998 291
89. D.B. Lewis C.C. Yu J. Meyer Cellular and molecular mechanisms for reduced interleukin 4 and interferon-γ production by neonatal T cells J Clin Invest 87 1991 194 202
90. K. Liechty J. Koenig M. Mitchell Production of interleukin-6 by fetal and maternal cells in vivo during intraamniotic infection and in vitro after stimulation with interleukin-1 Pediatr Res 29 1991 1
91. D. Lilic A. Cant M. Abinun Cytokine production differs in children and adults Pediatr Res 42 1997 237 240
92. C.C. Liu L.H.Y. Young J.D.E. Young Lymphocyte-mediated cytolysis and disease New Engl J Med 335 1996 1651 1659
93. Y.J. Liu F. Malisan deBouteiller O. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation Immunity 4 1996 241 250
94. R. Lubens S. Gard M. Soderberg-Watner Lectin-dependent T lymphocyte and natural killer cytotoxic deficiencies in human newborns Cell Immunol 74 1982 40 53
95. G. Lucivero A. Dell'Osso A. Iannone Phenotypic immaturity of T and B lymphocytes in cord blood of full-term normal neonates Biol Neonate 44 1983 303 308
96. L.S. Marshall A. Aruffo J.A. Ledbetter The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39 J Clin Immunol 13 1993 165 174
97. F. Matsuda T. Honjo Organization of the human heavy chain locus Adv Immunol 62 1996 1 29
98. T. McNabb T.Y. Koh K.J. Dorrington Structure and function of immunoglobulin domains, V. Binding of immunoglobulin G and fragments to placental membrane preparations J Immunol 117 1976 882 888
99. J.D. Merrill M. Sigaroudinia S. Kohl Characterization of natural killer and antibody-dependent cellular cytotoxicity of preterm infants against human immunodeficiency virus-infected cells Pediatr Res 40 1996 498
100. C.A. Michie A. McLean C. Alcock Lifespan of human lymphocyte subsets defined by CD45 isoforms Nature 360 1992 264 265
101. T. Miyawake H. Seki K. Taga Disassociated production of interleukin-2 and immune (γ) interferon by phytohaemagglutinin-stimulated lymphocytes in healthy infants Clin Exp Immunol 59 1985 505 511
102. D. Montagna A. Moretta M. Marconi In vivo activated cord blood lymphocytes express high affinity interleukin-2 receptor: Evaluation of their responsiveness to in vitro stimulation with recombinant interleukin-2 Biol Neonate 62 1992 385 394
103. C.T. Morita C. Parker M.B. Brenner TCR usage and functional capabilities of human γδ T cells at birth J Immunology 153 1994 3979
104. K. Muller M. Zak S. Nielsen In vitro cytokine production and phenotype expression by blood mononuclear cells from umbilical cords, children and adults Pediatr Allergy Immunol 7 1996 117 124
105. S. Nonoyama L.A. Penix C.P. Edwards Diminished expression of CD40 ligand by activated neonatal T cells J Clin Invest 96 1995 66
106. H.D. Ochs R.J. Wedgewood IgG subclass deficiencies Annu Rev Med 38 1987 325 340
107. A. Ozdemir N. Oygur M. Gultikin Neonatal tumor necrosis factor, interluekin-1, interleukin-1B and interleukin-6 response to infection Am J Perinatol 11 1994 282 285
108. H.F. Pabst J.C. Godel D.W. Spady Transfer of maternal specific cell-mediated immunity to the fetus Clin Exp Immunol 68 1987 209 214
109. A. Panaro A. Amati diLoreto M. Lymphocyte subpopulations in pediatric age. Definition of reference values by flow cytometry Allergol Immunopathol (Madr) 19 1991 112 109
110. M. Peakman A.G. Buggins K.H. Nicolaides Analysis of lymphocyte phenotypes in cord blood from early gestation fetuses Clin Exp Immunol 90 1992 345
111. R.M. Perlmutter J.F. Kearney S.P. Chang Developmentally controlled expression of immunoglobulin VH genes Science 227 1985 1597 1601
112. J. Phillips T. Hori A. Nagler Ontogeny of human natural killer (NK) cells: Fetal NK cells mediate cytolytic function and express cytoplasmic CD3 ε, δ proteins J Exp Med 175 1992 1055 1066
113. M.P. Piccinni L. Beloni L. Giannarini Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T cells from newborns with atopic parents Eur J Immunol 26 1996 2293 2298
114. H. Pirenne Y. Aujard A. Eljaafari Comparison of T cell functional changes during childhood with the ontogeny of CDw29 and CD45RA expression on CD4+ T cells Pediatr Res 32 1992 81 86
115. H. Pirenne-Ansart F. Paillard De Groote D. Defective cytokine expression but adult-type T-cell receptors, CD8, and p56 modulation in CD3 or CD2 activated T cells from neonates Pediatr Res 37 1995 64 69
116. J.X. Qian S.M. Lee Y. Suen Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood Blood 90 1997 3106 3117
117. F.M. Raaphorst E. Timmers M.J. Kenter Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements Eur J Immunol 22 1992 247
118. M. Rainaut M. Pagniez T. Hercent Characterization of mononuclear cell subpopulations in normal fetal peripheral blood Human Immunology 18 1987 331 337
119. E.S. Raveche Possible immunoregulatory role for CD5+B cells Clin Immunol Immunopathol 56 1990 135 150
120. M. Reth Antigen receptors on B lymphocytes Annu Rev Immunol 10 1992 97 121
121. J. Ridings I.C. Nicholson W. Goldsworthy Somatic hypermutation of immunoglobulin genes in human neonates Clin Exp Immunol 108 1997 366 374
122. G. Risdon J. Gaddy F. Stehman Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogenic stimulation Cell Immunol 154 1994 14 24
123. E. Rothenberg D. Triglia Clonal proliferation unlinked to terminal deoxynudeotidyl transferase synthesis in thymocytes of young mice J Immunol 130 1983 1627
124. M.E. Sanders M.W. Makgoba S. Shaw Human naive and memory T cells: Reinterpretation of helper-inducer and suppressor-inducer subsets Immunol Today 9 1988 195 199
125. B. Sautois G. Fillet Y. Beguin Comparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood Experimental Hematology 25 1997 103 108
126. D.G. Schatz M.A. Oettinger M.S. Schlissel V(D)J recombination: Molecular biology and regulation Annu Rev Immunol 10 1992 359 383
127. R. Schelonka F. Raphorst D. Infante T cell receptor repertoire diversity and clonal expansion in human neonates Pediatr Res 43 1998 396
128. K. Schibler K. Liechty W. White Defective production of interleukin-6 by monocytes: A possible mechanism underlying several host defense deficiencies of neonates Pediatr Res 31 1992 18 21
129. H.W. Schroeder J.L. Hillson R.M. Perlmutter Early restriction of the human antibody repertoire Science 238 1987 791 793
130. H.W. Schroeder R.M. Perlmutter Development of the human antibody repertoire Griscelli C. Gupta S. New Concepts in Immunodeficiency Diseases 1993 John Wiley and Sons London 1 20
131. H.W.J. Schroeder F. Mortari S. Shiokawa Development regulation of the human antibody repertoire Ann NY Acad Sci 764 1995 242 260
132. M. Seghaye W. Heyl R. Grabitz Production of pro and anti inflammatory cytokines in neonates assessed by stimulated whole cord blood cultures and by plasma levels at birth Biol Neonates 73 1998 220 227
133. I. Series J. Pichette C. Carrier Quantitative analysis of T/B cell subsets in healthy and sick premature infants Early Hum Dev 26 1991 143 154
134. C. Sieff Hematopoietic growth factors J Clin Invest 79 1987 1549 1557
135. J. Sloan-Lancaster P.M. Allen Altered peptide ligand-induced partial T-cell activation: Molecular mechanisms and role in T cell biology Annu Rev Immunol 14 1996 1 27
136. R.T. Smith D.V. Eitzman M.E. Catlin The development of the immune response: Characterization of the response of the human infant and adult to immunization with Salmonella vaccines Pediatrics 33 1964 163 183
137. H. Spits L. Lanier J. Phillips Development of human T and natural killer cells Blood 85 1995 2654 2670
138. J. Splawski P. Lipsky Cytokine regulation of immunoglobulin secretion by neonatal lymphocytes J Clin Invest 88 1991 967 977
139. J.B. Splawski D.F. Jelinek P.E. Lipsky Delineation of the functional capacity of human neonatal lymphocytes J Clin Invest 87 1991 545
140. D. Stites C. Pavia Ontogeny of human T cells Pediatrics 64 1979 795 802
141. B. Stoll The global impact of neonatal infection Clin Perinatol 24 1997 1
142. J. Strominger Developmental biology of T cell receptors Science 24 1989 943
143. O. Stutman Ontogeny of T Cells Clinics Immunol Allergy 5 1985 191 234
144. Y. Suen S. Lee M. Cairo Decreased M-CSF mRNA expression from activated cord versus adult mononuclear cells: Altered post transcriptional stability Blood 84 1994 4269
145. N. Takahaski K. Imanishi H. Nishida Evidence for immunologic immaturity of cord blood T cells J Immunol 155 1995 5213 5219
146. M. Tang A. Kemp Ontogeny of IL-4 production Pediatric Allergy and Immunology 6 1995 11 19
147. R. Thomas D. Linch Identification of lymphocyte subsets in the newborn using a variety of monoclonal antibodies Arch Dis Child 58 1983 34 38
148. P. Toivanen J. Uksila A. Leino Development of mitogen responding T cells and natural killer cells in the human fetus Immunol Rev 57 1981 89 105
149. A.G. Ugazio A.F. Marcioni A. Astaldi Peripheral blood B lymphocytes in infancy and childhood Acta Paediatr Scand 63 1974 205 208
150. B. Vahlquist F. Nordbring Studies on diphtheria, IV: The effects of diphtheria immunization on newborn prematures Acta Paediatr 41 1952 53 56
151. A. Vitiello R. Maccario D. Montagna Lymphocyte subpopulations in the Neonate: A subset of HNK-1, OKT3, OKT8, lymphocytes displays natural killer activity Cell Immunol 85 1984 252 257
152. L.B. Vogler A.R. Lawton Ontogeny of B cells and humoral immune functions Immunology and Allergy Clinics of North America 5 1985 235 252
153. C. Wilson J. Westall L. Johnston Decreased production of interferon-gamma by human neonatal cells J Clin Invest 77 1986 860 867
154. M. Wilson Immunology of the fetus and newborn: Lymphocyte phenotype and function Immunology and Allergy Clinics of North America 5 1985 271 286
155. M. Wilson F.S. Rosen S.F. Schlossman Ontogeny of human T and B lymphocytes during stressed and normal gestation: Phenotypic analysis of umbilical cord lymphocytes from term and preterm infants Clin Immunol Immunopathol 37 1985 1
156. B. Wolach Neonatal sepsis: Pathogenesis and supportive therapy Semin Perinatol 21 1997 28 38
157. A. Yachie N. Takano T. Yokoi The capability of neonatal leukocytes to produce IL-6 on stimulation assessed by whole blood culture Pediatr Res 27 1990 227 233
158. L. Yang C. Demeure D. Byun Maturation of neonatal human CD4 T cells, III: Role of B7 co-stimulation at priming Int Immunol 7 1995 1987 1993
159. C.Y. Yeung J.R. Hobbs Serum-gamma G-globulin levels in normal, premature, post-nature, and “small-for-dates” newborn babies Lancet 1 1968 1167 1170
160. H. Zola M. Fusco H. Weedon Reduced expression of the interleukin-2 receptor-γ chain on cord blood lymphocytes: Relationship to functional immaturity of the neonatal immune response Immunology 87 1996 86 91