Abnormal CD40-Mediated Activation Pathway in B Lymphocytes from Patients with Hyper-IgM Syndrome and Normal CD40 Ligand Expression

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 2576-2584

  Durandy, A ^a   Hivroz, C ^a   Mazerolles, F ^a   Schiff, C ^b   Bernard, F ^a   Jouanguy, E ^a   Revy, P ^a   DiSanto, J P ^a   Gauchat, J F ^c   Bonnefoy, J Y ^c   Casanova, J L ^a   Fischer, A ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b Immunology Center   (France)

^c GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CD40 ANTIGEN; CD40 LIGAND; COMPLEMENTARY DNA; IMMUNOGLOBULIN M; LIGAND; MEMBRANE PROTEIN; TRAF3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CHILD; CODON; FEMALE; GENETICS; HUMAN; HYPERGAMMAGLOBULINEMIA; IMMUNOLOGY; INTRACELLULAR FLUID; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD; SYNDROME;

ADOLESCENT; ADULT; ANTIGENS, CD40; B-LYMPHOCYTES; CARRIER PROTEINS; CD40 LIGAND; CHILD; CHILD, PRESCHOOL; CODON; DNA, COMPLEMENTARY; FEMALE; HUMANS; HYPERGAMMAGLOBULINEMIA; IMMUNOGLOBULIN M; INTRACELLULAR FLUID; LIGANDS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; SYNDROME; TNF RECEPTOR-ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

EID: 0031569262     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Lane, P., A. Traunecker, S. Hubele, S. Inui, A. Lanzavecchia, and D. Gray. 1992. Activated human T cells express a ligand for the human B cell-associated antigen CD40, which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22:2573.
2. Banchereau, J., P. de Paoli, A. Valle, E. Garcia, and F. Rousset. 1991. Long term human B cell lines dependent on interleukin 4 and antibody to CD40. Science 291:70.
3. Hollengaugh, D., L. Grosmaire, C. D. Kullas, N. J. Chalupny, R. J. Noelle, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T-cell antigen p39, a member of the TNF family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulating activity. EMBO J. 11:4313.
4. Lederman, S., M. J. Yellin, G. Inghirani, J. L. Lee, D. M. Knowles, and L. Chess. 1992. Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles: roles of T cell-B cell activity molecule (5c 8 antigen) and CD40 in contact-dependent help. J. Immunol. 149:3815.
5. Holder, M. J., H. Wang, A. E. M. Casamayor, R. Armitage, M. K., Spriggs, W. C. Fanslow, I. C. M. MacLennan, C. D. Gregory, and J. Gordon. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocyte by CD40 ligand is independent of Bcl2 induction. Eur. J. Immunol. 23:2368.
6. Zabra, H. U., S. M. Fu, R. S. Geha, and D. Vercelli. 1990. CD40 and IgE: synergism between anti-CD40 monoclonal antibody interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172:1861.
7. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig chain isotypes in human B cells. J. Immunol. 152:438.
8. Zhang, K., E. A. Clark, and A. Saxon. 1991. CD40 stimulation provides an IFN-γ independent and IL-4-dependent differentiation signal directly to human B cells for IgE production. J. Immunol. 146:1836.
9. Rousset, F., E. Garcia, and J. Banchereau. 1991. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J. Exp. Med. 173:705.
10. Shapira, S. K., D. Vercelli, H. H Jabara, S. M. Fu, and R. S. Geha. 1992. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J. Exp. Med. 175:285.
11. Spriggs, M. K., R. J Armitage, L. Strockbine, K. N. Clifford, B. N. MacDuff, T. A. Sato, C. R. Maliszewski, and W. C. Fanslow. 1992. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 176:1543.
12. +) B cells to secrete IgG1 and IgG3. J. Exp. Med. 179:757.
13. Allen, R., R. J. Armitage, M. E. Conley, H. Rosenblatt, N. A. Jenkis, N. G. Copeland, M. A. Bedel, S. Edelhoff, C. M. Disteche, D. K. Simoneaux, W. C. Danslow, J. Belmont, and M. K. Spriggs. 1993. CD40 ligand gene defects responsible for X-linked hyper IgM syndrome. Science 259:990.
14. Aruffo, A., M. Farrington, B. Hollenbaugh, X. Li, A. Milatovich, S. Nonoyama, J. Bajorath, L. S. Grosmaire, R. Stenkamp, M. Neubauer, R. L. Roberts, E. J. Noelle, J. A. Ledbetter, U. Francke, and H. D. Ochs. 1993. The CD40 ligand, gp39, is defective in activated hyper IgM syndrome. Cell 72:291.
15. Korthäuer, U., D. Graf, H. W. Mages, F. Brière, M. Padayachee, S. Malcolm, A. G. Ugazio, L. D. Notarangelo, and R. A. Kroczek. 1993. Defective expression of T cell CD40 ligand causes X-linked immunodeficiency with hyper IgM. Nature 361:539.
16. DiSanto, J. P., J. Y. Bonnefoy, J. F. Gauchat, A. Fischer, and G. de Saint Basile. 1993. CD40 ligand mutations in theX-linked form of hyper-IgM syndrome. Nature 361:541.
17. Fuleihan, R., N. Ramesu, R. Loh, H. Jabara, F. S. Rosen, T. Chatila, S. M. Fu, I. Stamenkovic, and R. Geha. 1993. Defective expression of the CD4Q-ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl. Acad. Sci. USA 90:2170.
18. Durandy, A., C. Schiff, J. Y. Bonnefoy, M. Forveille, F. Rousset, G. Mazzei, M. Milili, and A. Fischer. 1994. Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgGl IgA and IgE production by B cells from patients with X-linked hyper-IgM syndrome. Eur. J. Immunol. 23:2294.
19. Callard, R. E., S. H. Smith, J. Herbert, G. Morgan, M. Padayachee, S. Lederman, L. Chess, R. A. Kroczek, W. C. Fanslow, and R. J. Armitage. 1994. CD40 ligand (CD40L) expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM (HIM). J. Immunol. 153:3295.
20. Conley, M. E., M. Larché, V. R. Bonagura, A. R. Lawton III, R. H. Buckley, S. M. Fu, E. Coustan-Smith, H. G. Herrod, and D. Campana. 1994. Hyper IgM syndrome associated with defective CD40-mediated B cell activation J. Clin. Invest. 94:1404.
21. Oliva, A., I. Quinti, E. Scala, E. Fanales-Belasio, L. Rainaldi, M. Pierdominici, A. Giovannetti, R. Paganelli, F. Aiuti, and F. Pandolfi. 1995. Immunodeficiency with hyperimmunoglobulinemia M in two female patients is not associated with abnormalities of CD40 or CD40 ligand expression. Allergy Clin. Immunol. 96: 403.
22. Ren, C. L., T. Mono, S. M. Fu, and R. S. Geha. 1994. Signal transduction via CD40 involves activation of lyn kinase and phosphatidyl inositol-3-kinase and phosphorylation of phosphoryiase Cγ2. J. Exp. Med. 179:673.
23. Berberich, L. G. Shu, F. Siebelt, J. R. Woodgett, J. M. Kyriakis, and E. A. Clark. 1996. Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO J. 15:92.
24. Sakata, N., H. R. Patel, N. Terada, A. Aruffo, G L. Johnson, and E. W. Gelfand. 1995. Selective activation of c-jun kinase mitogen-activated protein kinase by CD40 on human B cells. J. Biol. Chem. 270:30823.
25. Berberich, I., G. L. Shu, and E. A Clark. 1994. Cross-linking CD40 on B cells rapidly activates nuclear factor-κB. J. Immunol. 153:4357.
26. Choi, S. K., R. D. Brines, M. J. Holman, and G. G. B. Klaus. 1994. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1:179.
27. Stamenkovic, I., E. A. Clark, and B. Seed. 1989. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8:1403.
28. Hu, H. M., K. O'Rourke, M. S. Boguski, and V. M. Dixit. 1994. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269:30069.
29. Sato, T., S. Irie, and J. C. Reed. 1995. A novel member of the TRAF family of putative signal-transducting proteins binds to the cytosolic domain of CD40. FEBS Lett. 358:113.
30. Cheng, G., A. M. Cleary, Z. S. Ye, D. I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494.
31. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424.
32. Morio, T., S. Hanissian, and R. S. Geha. 1995. Characterization of a 23-kDa protein associated with CD40. Proc. Natl. Acad. Sci. USA 92:11633.
33. Callard, R. E., R. J. Armitage, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559.
34. Gauchat, J. F., J. P. Aubry, G. Mazzei, P. Life, T. Jomone, G. Elson, and J. Y. Bonnefoy. 1993. Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production. FEBS Lett. 315:255.
35. Rottapel, R., M. Reedijk, D. E. Williams, S. D. Lyman, D. M. Anderson, T. Pawson, and A. Bernstein. 1991. The steel/w transduction pathway: kit auto-phosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the steel factor. Mol. Cell. Biol. 11:3043.
36. Pages, F., M. Ragueneau, R. Rottapel, A. Truneh, J. Nunes, J. Imbert, and D. Olive. 1994. Binding of phosphotidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling. Nature 369:327.
37. Hivroz-Burgaud, C., N. A. Clipstone, and D. A. Cantrell. 1991. Signaling requirements for the expression of the transactivating factor NF-AT in human T lymphocytes. Eur. J. Immunol 21:2811.
38. Casanova, J. L., C. Pannetier, C. Jaulin, and P. Kourilsky. 1990. Optimal conditions for direct sequencing of double-stranded PCK products with sequenase. Nucleic Acids Res. 18:4028.
39. Durandy, A., G. de Saint Basile, J. Gauchat, B. Lisowska-Grospierre, M. Forveille, R. Kroczeck, J. Bonnefoy, and A. Fischer. 1995. Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns. J. Immunol. 154:1560.
40. Yellin, M. J., J. Sinning, L. R. Covey, W. Sherman, J. S. Lee, E. Glickman-Nir, K. C. Slippel, J. Rogers, A. M. Cleary, M. Parker, L. Chess, and S. Lederman. 1994. T lymphocyte T cell-B cell-activating molecule/CD40L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7-BB-1) and enhance their costimulatory activity. J. Immunol. 153:666.
41. Fujieda, S., K. Zhang, and A. Saxon. 1995. IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: switching to γ1, γ3, and γ4, but not γ2. J. Immunol. 155:2318.
42. Gauchat, J. F., D. A. Lebman, R. L. Coffman, H. Gascan, and J. E. de Vries. 1990. Structure and expression of germline ∈ transcripts in human B cells induced by interleukin 4 to switch IgE production. J. Exp. Med. 172:463.
43. Castigli, E., F. W. Alt, L. Davidson, A. Bottaro, E. Mizoguchi, A. K. Bhan, and R. S. Geha. 1994. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. USA 91:12135.
44. Renshaw, B. R., W. C. Fanslow, R. J. Armitage, K. A. Campbell, D. Liggitt, B, Wright, B. L. Davison, and C. R. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
45. Obiri, N. I., W. Debinsky, W. J. Leonard, and R. K. Puri. 1995. Receptor for interleukin-13: interaction with interleukin-4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9 and 15. J. Biol. Chem. 270:8797.
46. Sumimoto, S. I., T. Heike, S. I. Kanazashi, N. Shintaku, E. Y. Jung. D. Hata, K. Katamura, and M. Mayumi. 1994. Involvement of LFA-1/intracellular adhesion molecule-1-dependent cell adhesion in CD40-mediated inhibition of human B lymphoma cell death induced by surface IgM cross-linking. J. Immunol. 153: 2488.
47. Schattner, E. J., K. B. Elkon, Y. Dae-Hyun, J. Tumang, P. H. Krammer, M. K. Crow, and S. M. Friedman. 1995. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J. Exp. Med. 182:1557.
48. Life, P., J. F. Gauchat, V. Schnuriger, S. Estoppey, G. Mazzei, A. Durandy, A. Fischer, and J. Y. Bonnefoy. 1994. T cell clones from an X-Iinked hyperimmunoglobulin (IgM) patient induce IgE synthesis in vitro despite expression of nonfunctional CD40 ligand. J. Exp. Med. 180:1775.
49. Lane, P., C. Burdet, F. McConnel, A. Lanzavecchia, and E. Padovan. 1995. CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation. Eur. J. Immunol. 25:1788.
50. Mosialos, G., M. Birkenbach, R. Yalamanchill, T. Van Arsdale, C. Ware, and E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389.
51. Kieff, E. 1995. Epstein-Barr virus-increasing evidence of a link to carcinoma. N. Engl. J. Med. 333:724.