메뉴 건너뛰기




Volumn 46, Issue 2, 1997, Pages 278-283

Cloning and genomic organization of the human transforming growth factor-β type I receptor gene

Author keywords

Activin; Exon; Growth factor beta; Intron; Receptor; Transforming

Indexed keywords

PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0031453669     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.5023     Document Type: Article
Times cited : (28)

References (35)
  • 1
    • 0029832696 scopus 로고    scopus 로고
    • Chimeric granulocyte/macrophage colony-stimulating factor transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling
    • Anders, R. A., and Leof, E. B. (1996). Chimeric granulocyte/macrophage colony-stimulating factor transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling. J. Biol. Chem. 271: 21758-21766.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21758-21766
    • Anders, R.A.1    Leof, E.B.2
  • 2
    • 0029810920 scopus 로고    scopus 로고
    • Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
    • Baldwin, R. L., Friess, H., Yokoyama, M., Lopez, M. E., Kobrin, M. S., Buchler, M. W., and Korc, M. (1996). Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition. Int. J. Cancer 67: 283-288.
    • (1996) Int. J. Cancer , vol.67 , pp. 283-288
    • Baldwin, R.L.1    Friess, H.2    Yokoyama, M.3    Lopez, M.E.4    Kobrin, M.S.5    Buchler, M.W.6    Korc, M.7
  • 3
    • 0030600234 scopus 로고    scopus 로고
    • Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-β receptor: Regulation by TGFβ
    • Bloom, B. B., Humphries, D. E., Kuang, P.-P., Fine, A., and Goldstein, R. H. (1996). Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-β receptor: Regulation by TGFβ. Biochim. Biophys. Acta 1312: 243-248.
    • (1996) Biochim. Biophys. Acta , vol.1312 , pp. 243-248
    • Bloom, B.B.1    Humphries, D.E.2    Kuang, P.-P.3    Fine, A.4    Goldstein, R.H.5
  • 4
    • 0028359376 scopus 로고
    • Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
    • Carcamo, J., Weis, F. M., Ventura, F., Wieser, R., Wrana, J. L., Attisano, L., and Massague, J. (1994). Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol. Cell. Biol. 14: 3810-3821.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3810-3821
    • Carcamo, J.1    Weis, F.M.2    Ventura, F.3    Wieser, R.4    Wrana, J.L.5    Attisano, L.6    Massague, J.7
  • 5
    • 0028059199 scopus 로고
    • Homomeric interactions between type II transforming growth factor-β receptors
    • Chen, R.-H., and Derynck, R. (1994). Homomeric interactions between type II Transforming Growth Factor-β receptors. J. Biol. Chem. 269: 22868-22874.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22868-22874
    • Chen, R.-H.1    And Derynck, R.2
  • 6
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGFβ signaling
    • Chen, X., Rubock, M. J., and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGFβ signaling. Nature 383: 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 7
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y., and Wang, X. F. (1995). Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92: 5545-5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 8
    • 0030634624 scopus 로고    scopus 로고
    • Frequent inactivation of the transforming growth factor type II receptor in small cell lung carcinoma cells
    • De Jonge, R. R., Garrigue-Antar, L., Vellucci, V. F., and Reiss, M. (1997). Frequent inactivation of the transforming growth factor type II receptor in small cell lung carcinoma cells. Oncol. Res. 9: 89-98.
    • (1997) Oncol. Res. , vol.9 , pp. 89-98
    • De Jonge, R.R.1    Garrigue-Antar, L.2    Vellucci, V.F.3    Reiss, M.4
  • 9
    • 0030265714 scopus 로고    scopus 로고
    • Intracellular signalling: The mad way to do it
    • Derynck, R., and Zhang, Y. (1996). Intracellular signalling: The Mad way to do it. Curr. Biol. 6: 1226-1229.
    • (1996) Curr. Biol. , vol.6 , pp. 1226-1229
    • Derynck, R.1    Zhang, Y.2
  • 11
    • 0027332995 scopus 로고
    • Cloning of a TGFβ type I receptor that forms a heterodimeric complex with the TGFβ type II receptor
    • Franzén, P., Ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H., and Miyazono, K. (1993). Cloning of a TGFβ type I receptor that forms a heterodimeric complex with the TGFβ type II receptor. Cell 75: 681-692.
    • (1993) Cell , vol.75 , pp. 681-692
    • Franzén, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schulz, P.5    Heldin, C.-H.6    Miyazono, K.7
  • 12
    • 0027421280 scopus 로고
    • Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
    • Fynan, T. M., and Reiss, M. (1993). Resistance to inhibition of cell growth by Transforming Growth Factor-β and its role in oncogenesis. Crit. Rev. Oncogenesis 4: 493-540.
    • (1993) Crit. Rev. Oncogenesis , vol.4 , pp. 493-540
    • Fynan, T.M.1    Reiss, M.2
  • 13
    • 0029114477 scopus 로고
    • Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells
    • Garrigue-Antar, L., Munoz-Antonia, T., Antonia, S. J., Gesmonde, J., Vellucci, V. F., and Reiss, M. (1995). Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells. Cancer Res. 55: 3982-3987.
    • (1995) Cancer Res. , vol.55 , pp. 3982-3987
    • Garrigue-Antar, L.1    Munoz-Antonia, T.2    Antonia, S.J.3    Gesmonde, J.4    Vellucci, V.F.5    Reiss, M.6
  • 14
    • 0029762628 scopus 로고    scopus 로고
    • Loss of transforming growth factor-β type II receptor gene expression in human esophageal cancer
    • Garrigue-Antar, L., Souza, R. F., Vellucci, V. F., Meltzer, S. J., and Reiss, M. (1996). Loss of transforming growth factor-β type II receptor gene expression in human esophageal cancer. Lab. Invest. 75: 263-272.
    • (1996) Lab. Invest. , vol.75 , pp. 263-272
    • Garrigue-Antar, L.1    Souza, R.F.2    Vellucci, V.F.3    Meltzer, S.J.4    Reiss, M.5
  • 16
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371: 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 18
    • 0030048263 scopus 로고    scopus 로고
    • Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells
    • Kim, I. Y., Ahn, H. J., Zelner, D. J., Shaw, J. W., Sensibar, J. A., Kim, J. H., Kato, M., and Lee, C. (1996). Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells. Cancer Res. 56: 44-48.
    • (1996) Cancer Res. , vol.56 , pp. 44-48
    • Kim, I.Y.1    Ahn, H.J.2    Zelner, D.J.3    Shaw, J.W.4    Sensibar, J.A.5    Kim, J.H.6    Kato, M.7    Lee, C.8
  • 19
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massague, J. (1996). Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383: 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 20
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Liu, F., Hata, A., Baker, J. C., Doody, J., Carcamo, J., Harland, R. M., and Massague, J. (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381: 620-622.
    • (1996) Nature , vol.381 , pp. 620-622
    • Liu, F.1    Hata, A.2    Baker, J.C.3    Doody, J.4    Carcamo, J.5    Harland, R.M.6    Massague, J.7
  • 21
    • 0029792338 scopus 로고    scopus 로고
    • Signaling by chimeric erythropoietin-TGF-beta receptors: Homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction
    • Luo, K., and Lodish, H. F. (1996). Signaling by chimeric erythropoietin-TGF-beta receptors: Homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. EMBO J. 15: 4485-4496.
    • (1996) EMBO J. , vol.15 , pp. 4485-4496
    • Luo, K.1    Lodish, H.F.2
  • 22
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L., and Wrana, J. L. (1996). MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 24
    • 0030604542 scopus 로고    scopus 로고
    • TGF-β signaling: Receptors, transducers, and MAD proteins
    • Massague, J. (1996). TGF-β Signaling: Receptors, transducers, and MAD proteins. Cell 85: 947-950.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massague, J.1
  • 25
    • 0028179120 scopus 로고
    • The TGFβ family and its composite receptors
    • Massagué, J., Attisano, L., and Wrana, J. L. (1994). The TGFβ family and its composite receptors. Trends Cell Biol. 4: 172-178.
    • (1994) Trends Cell Biol. , vol.4 , pp. 172-178
    • Massagué, J.1    Attisano, L.2    Wrana, J.L.3
  • 26
    • 0028786163 scopus 로고
    • Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function
    • McAllister, K. A., Baldwin, M. A., Thukkani, A. K., Gallione, C. J., Berg, J. N., Porteous, M. E., Guttmacher, A. E., and Marchuk, D. A. (1995). Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function. Hum. Mol. Genet. 4: 1983-1985.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1983-1985
    • McAllister, K.A.1    Baldwin, M.A.2    Thukkani, A.K.3    Gallione, C.J.4    Berg, J.N.5    Porteous, M.E.6    Guttmacher, A.E.7    Marchuk, D.A.8
  • 27
    • 0028556486 scopus 로고
    • Genetic changes in the transforming growth factor β (TGFβ) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to TGFβ
    • Park, K., Kim, S.-J., Bang, Y.-J., Park, J.-G., Kim, N. K., Roberts, A. B., and Sporn, M. B. (1994). Genetic changes in the transforming growth factor β (TGFβ) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to TGFβ. Proc. Natl. Acad. Sci. USA 91: 8772-8776.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8772-8776
    • Park, K.1    Kim, S.-J.2    Bang, Y.-J.3    Park, J.-G.4    Kim, N.K.5    Roberts, A.B.6    Sporn, B.M.7
  • 28
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta)
    • Roberts, A. B., and Sporn, M. B. (1993). Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8: 1-9.
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 29
    • 0026703169 scopus 로고
    • Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector
    • Shizuya, H., Birren, B., Kim, U.-J., Mancino, V., Slepak, T., Tachiiri, Y., and Simon, M. (1992). Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl. Acad. Sci. USA 89: 8794-8797.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8794-8797
    • Shizuya, H.1    Birren, B.2    Kim, U.-J.3    Mancino, V.4    Slepak, T.5    Tachiiri, Y.6    Simon, M.7
  • 30
    • 0027367937 scopus 로고
    • Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region
    • Wieser, R., Attisano, L., Wrana, J. L., and Massagué, J. (1993). Signaling activity of Transforming Growth Factor β type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol. 13: 7239-7247.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7239-7247
    • Wieser, R.1    Attisano, L.2    Wrana, J.L.3    Massagué, J.4
  • 31
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex
    • Wieser, R., Wrana, J. L., and Massague, J. (1995). GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J. 14: 2199-2208.
    • (1995) EMBO J. , vol.14 , pp. 2199-2208
    • Wieser, R.1    Wrana, J.L.2    Massague, J.3
  • 34
    • 0027992209 scopus 로고
    • Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition
    • Xu, J., Matsuzaki, K., McKeehan, K., Wang, F., Kan, M., and McKeehan, W. L. (1994). Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. Proc. Natl. Acad. Sci. USA 91: 7957-7961.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7957-7961
    • Xu, J.1    Matsuzaki, K.2    McKeehan, K.3    Wang, F.4    Kan, M.5    McKeehan, W.L.6
  • 35
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y., Feng, X.-H., Wu, R.-Y., and Derynck, R. (1996). Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383: 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.