Age-related changes in ultrastructural features of cathepsin B- and D-containing neurons in rat cerebral cortex

Brain Research

Volumn 844, Issue 1-2, 1999, Pages 43-54

  Jung, Ho ^a   Lee, Eun Young ^b   Lee, Sang Ik ^b  

^a Eulji University School of Medicine   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

Author keywords

Aging; Cathepsin B; Cathepsin D; Cerebral cortex; Degenerating cell; Ultrastructural location

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN D;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYSOSOME; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

AGING; ANIMALS; CATHEPSIN B; CATHEPSIN D; CEREBRAL CORTEX; MICROSCOPY, IMMUNOELECTRON; NERVE DEGENERATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032852272     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01888-0     Document Type: Article

References (51)

1. Amano T., Nakanishi H., Kondo T., Tanaka T., Oka M., Yamamoto K. Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neurons. Mech. Ageing Dev. 83:1995;133-141.
2. F. Authier, B.I. Posner, J.J.M. Bergeron, Hepatic endosomes are a major physiological locus of insulin and glucagon degradation in vivo. In A.J. Ciechanover, A.L. Schwartz (Eds.), Cellular Proteolytic Systems, Wiley-Liss, 1994, pp. 89-113.
3. Azaryan A.V., Galoyan A.A. Brain cathepsin B acts as a dipeptidyl carboxypeptidase, converting provasopressor, proopioid and model peptides. Vop. Med. Khim. 33:1987;78-81.
4. Banay-Schwartz M., Baracco F., DeGuzman T., Lajtha A. Developmental changes in the breakdown of tubulin by cerebral cathepsin D. Neurochem. Res. 8:1983;51-61.
5. Banay-Schwartz M., Dahl D., Hui K.S., Lajtha A. The breakdown of the individual neurofilament proteins by cathepsin D. Neurochem. Res. 12:1987;361-367.
6. Barrett A.J. Cellular proteolysis. Ann. New York Acad. Sci. 674:1992;1-15.
7. Bednarski E., Lynch G. Cytosolic proteolysis of τ by cathepsin D in hippocampus following suppression of cathepsin B and L. J. Neurochem. 67:1996;1846-1855.
8. Bednarski E., Ribak C.E., Lynch G. Suppression of cathepsin B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. J. Neurosci. 17:1997;4006-4021.
9. Benuck M., Banay-Schwartz M., DeGuzman T., Lajtha A. Changes in brain protease activity in aging. J. Neurochem. 67:1996;2019-2029.
10. Bohley P., Seglen P.O. Proteases and proteolysis in the lysosome. Experientia. 48:1992;151-157.
11. Brown A.M., Tummolo D.M., Spruyt M.A., Jacobsen J.S., Sonnenberg-Reines J. Evaluation of cathepsin D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates. J. Neurochem. 66:1996;2436-2445.
12. Brunk U.T., Zhang H., Roberg K., Ollinger K. Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage. Redox Rep. 1:1995;267-277.
13. Buxbaum J.D., Gandy S.E., Cicchetti P., Ehrlich M.E., Czernik A.J., Fracasso R.P., Ramabhadran T.V., Unterbeck A.J., Greengard P. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. 87:1990;6003-6006.
14. Cataldo A.M., Nixon R.A. Enzymatically active lysosomal proteinases are associated with amyloid deposits in Alzheimer brain. Proc. Natl. Acad. Sci. 87:1990;3861-3865.
15. Cataldo A.M., Paskevich P.A., Kominami E., Nixon R.A. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer's disease. Proc. Natl. Acad. Sci. 88:1992;10998-11002.
16. Cataldo A.M., Thayer C.Y., Bird E.D., Wheelock T.R., Nixon R.A. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Res. 513:1990;181-192.
17. Chevallier N., Vizzavona J., Marambaud P., Baur C.P., Spillantini M., Fulcrand P., Martinez J., Goedert M., Vincent J.P., Checler F. Cathepsin D displays in vitro beta-secretase-like specificity. Brain Res. 750:1997;11-19.
18. Chopra V.S., Moozar K.L., Mehindate K., Schipper H.M. A cellular stress model for the differential expression of glial lysosomal cathepsins in the aging nervous system. Exp. Neurol. 147:1997;221-228.
19. Deiss L.P., Galinka H., Berissi H., Cohen O., Kimchi A. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 1:1996;3861-3870.
20. Dreyer R.N., Bausch K.M., Fracasso P., Hammond L.J., Wunderlich D., Wirak D.O., Davis G., Brini C.M., Buckholz T.M., Koenig G., Kamarck M.E., Tamburini P.P. Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation. Eur. J. Biochem. 224:1994;265-271.
21. Golde T.E., Estus S.S., Younkin L.H., Selkoe D.J., Younkin S.G. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science. 255:1992;728-730.
22. Haas U., Sparks D.L. Cortical cathepsin D activity and immunolocalization in Alzheimer's disease, critical coronary artery disease, and aging. Mol. Chem. Neuropathol. 29:1996;1-14.
23. Haass C., Lemere C., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., Selkoe D. The Swedish mutation causes early-onset AD by beta-secretase cleavage within the secretory pathway. Nature Med. 1:1995;1291-1295.
24. Hetman M., Filipkowski R.K., Domagala W., Kaczmarek L. Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration. Exp. Neurol. 136:1995;53-63.
25. Hill I.E., Preston E., Monette R., MacManus J.P. A comparison of cathepsin B processing and distribution during neuronal death in rats following global ischemia or decapitation necrosis. Brain Res. 751:1997;206-216.
26. Ivy G.O. Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain. Ann. New York Acad. Sci. 674:1992;89-102.
27. Ivy G.O., Schottler F., Wenzel J., Baudry M., Lynch G. Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain. Science. 226:1984;985-987.
28. Johnson G.V.W., Litersky J.M., Whitaker J.N. Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D. J. Neurochem. 57:1991;1577-1583.
29. Kenessey A., Banay-Schwartz M., DeGuzman T., Lajtha A. Increase in cathepsin D activity in rat brain in aging. J. Neurosci. Res. 23:1989;454-456.
30. H. Kirschke, A. Barrett, Chemistry of lysosomal proteases, in: H. Glaumann, F.J. Ballard (Eds.), Lysosomes: Their Role in Protein Breakdown, Academic Press, London, 1987, pp. 193-238.
31. Kloss P., Bernstein H.G., Kirschke H., Wiederanders B. Ultrastructural study of cathepsin B immunoreactivity in rat brain neurons: lysosomal and extralysosomal localizations of the antigen. Acta Anat. 142:1991;138-140.
32. Ladror U., Snyder S., Wang G.T., Holzman T.F., Grant K.A. Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D. J. Biol. Chem. 269:1994;18422-18428.
33. Mackay E.A., Ehrhard A., Miniatte M., Guenet C., Tardif C., Tarnus C., Sorokine O., Heintzelmann B., Nay C., Remy J.M., Higaki J., Van Dorsselaer A., Wagner J., Danzin C., Mamont P. A possible role for cathepsin D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease. Eur. J. Biochem. 244:1997;414-425.
34. Marks N., Berg M.J., Benuck M. Preferential action of rat brain cathepsin B as a peptidyl dipeptidase converting proopioid oligopeptides. Arch. Biochem. Biophys. 249:1986;489-499.
35. Matus A., Green G.D.J. Age-related increase in cathepsin D like protease that degrades brain microtubule-associated proteins. Biochemistry. 26:1987;8083-8086.
36. Nakanishi H., Amano T., Sastradipura D.F., Yoshimine Y., Tsukuba T., Tanabe K., Hirotsu I., Ohono T., Yamamoto K. Increased expression of cathepsin E and D in neurons of the aged rat brain and their localization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J. Neurochem. 68:1997;739-749.
37. Nakanishi H., Tominaga K., Amano T., Hirotsu I., Inoue T., Yamamoto K. Age-related changes in activities and localization of cathepsin D, E, B, and L in the rat brain tissues. Exp. Neurol. 126:1994;119-128.
38. Nakanishi H., Tsukuba T., Kondou T., Tanaka T., Yamamoto K. Transient forebrain ischemia induces increased expression and specific localization of cathepsin E and D in rat hippocampus and neostriatum. Exp. Neurol. 121:1993;215-223.
39. Nitatori T., Sato N., Kominami E., Uchiyama Y. Participation of cathepsins B, H, and L in perikaryal condensation of CA1 pyramidal neurons undergoing apoptosis after brief ischemia. Adv. Exp. Med. Biol. 389:1996;177-185.
40. Nixon R.A., Cataldo A.M. The endosomal-lysosomal system of neurons: new roles. Trends Neurosci. 18:1995;489-496.
41. Nixon R.A., Marotta C.A. Degeneration of neurofilament proteins by purified human brain cathepsin D. J. Neurochem. 43:1984;507-516.
42. Porta E., Llesuy S., Monserrat A.J., Benavides S., Travacio M. Changes in cathepsin B and lipofuscin during development and aging in rat brain and heart. Gerontology. 41:1995;81-93.
43. Roberg K., Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am. J. Physiol. 152:1998;1151-1156.
44. Roberts L.R., Kurosawa H., Bronk S.F., Fesmier P.J., Agellon L.B., Leung W.Y., Mao F., Gores G.J. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocyte. Gastroenterology. 113:1997;1714-1726.
45. Ryan R.E., Sloane B.F., Sameni M., Wood P.L. Microglial cathepsin B: an immunological examination of cellular and secreted species. J. Neurochem. 65:1995;1035-1045.
46. Siman R., Mistretta S., Durkin J.T., Savage M.J., Loh T., Trusko S., Scott R.W. Processing of the beta-amyloid precursor; multiple proteases generate and degrade potentially amyloidogenic fragments. J. Biol. Chem. 268:1993;16602-16609.
47. Snyder D.S., Simonis S., Uzman B.G., Whitaker J.N. Rat neural tissue cathepsin D: ultrastructural immunocytochemistry. J. Neurocytol. 14:1985;579-596.
48. Thompson A., Grueninger-Leitch F., Huber G., Malherbe P. Expression and characterization of human beta-secretase candidates metalloendopeptidase MP78 and cathepsin D in APP-overexpressing cells. Mol. Brain Res. 48:1997;206-214.
49. Tominaga K., Nakanishi H., Yasuda Y., Yamamoto K. Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E. J. Neurochem. 71:1998;2574-2584.
50. Tummers S., Zuhlsdorf M., Robenek H., Hasilik A., von Figura K. Molecular forms of cathepsin D in coated vesicle preparations. Hoppe-Seyler's Z. Physiol. Chem. 364:1983;1287-1295.
51. Yokota S., Atsumi S. Immunocytochemical localization of cathepsin B: Immunoelectron microscopic localization of cathespin D in lysosomes of rat nerve cell. Histochemistry. 79:1983;345-352.