Changes in brain protease activity in aging

Journal of Neurochemistry

Volumn 67, Issue 5, 1996, Pages 2019-2029

  Benuck, Myron ^a   Banay Schwartz, Miriam ^a   DeGuzman, Teresita ^a   Lajtha, Abel ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Aging; Calpain; Cathepsin D; Neurofilament; Tubulin

Indexed keywords

CALPAIN; CATHEPSIN D; NEUROFILAMENT PROTEIN; PROTEINASE; TUBULIN;

ADOLESCENT; AGED; AGING; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT;

ANIMALIA;

EID: 0029799703     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67052019.x     Document Type: Article

References (43)

1. Avola R., Condorelli D. F., Ragusa N., Renis M., Alberghina M., Giuffrida-Stella A. M., and Lajtha A. (1988) Protein synthesis rates in rat brain regions and subcellular fractions during aging. Neurochem. Res. 13, 337-342.
2. Banay-Schwartz M., Bracco F., DeGuzman T., and Lajtha A. (1983) Developmental changes in the breakdown of brain tubulin by cerebral cathepsin D. Neurochem. Res. 8, 51-61.
3. Banay-Schwartz M., Dahl D., Hui K.-S., and Lajtha A. (1987) The breakdown of the individual neurofilament proteins by cathepsin D. Neurochem. Res. 12, 361-367.
4. Banay-Schwartz M., DeGuzman T., Kenessey A., Palkovits M., and Lajtha A. (1992) The distribution of cathepsin D activity in adult and aging human brain regions. J. Neurochem. 58, 2207-2211.
5. Banay-Schwartz M., DeGuzman T., Palkovits M., and Lajtha A. (1994) Calpain activity in adult and aged human brain regions. Neurochem. Res. 19, 563-567.
6. Baudry M., Simonson L., Dubrin R., and Lynch G. (1986) A comparative study of soluble calcium-dependent proteolytic activity in brain. J. Neurobiol. 17, 15-28.
7. Benuck M., Banay-Schwartz M., DeGuzman T., Vizi E. S., Kekes-Szabo A., and Lajtha A. (1995) Effect of diet on tissue protease activity. J. Neurosci. Res. 40, 675-679.
8. Blomgren K. and Karlsson J. O. (1989) Developmental changes of calpain and calpastatin in rabbit brain. Neurochem. Res. 14, 1149-1152.
9. Blomgren K., Nilsson E., and Karlsson J. O. (1989) Calpain and calpastatin levels in different organs of the rabbit. Comp. Biochem. Physiol. [B] 93, 403-407.
10. Bongarzone E. R., Soto E. F., and Pasquini J. M. (1995) Increased susceptibility to degradation by trypsin and subtilisin of in vitro peroxidized myelin proteins. Neurochem. Res. 20, 421-426.
11. Bracco F., Banay-Schwartz M., DeGuzman T., and Lajtha A. (1982) Breakdown of brain tubulin by cerebral cathepsin D. Neurochem. Int. 4, 541-549.
12. Carney J. M., Starke-Reed P. E., Oliver C. N., Landum R. W., Cheng M. S., Wu J. F., and Floyd R. A. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenyl-nitrone. Proc. Natl. Acad. Sci. USA 88, 3633-3636.
13. Chiu F.-C., Norton W. T., and Fields K. L. (1981) The cytoskeleton of primary astrocytes in culture contains actin, glial fibrillary acidic protein, and the fibroblast-type filament protein, vimentin. J. Neurochem. 37, 147-157.
14. Chue C. H., Yukioka N., Yamada E., and Hazama F. (1993) The possible role of lysosomal enzymes in the pathogenesis of hypertensive cerebral lesions in spontaneously hypertensive rats. Acta Neuropathol. 85, 383-389.
15. David L. L., Azuma M., and Shearer T. R. (1994) Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens. Invest. Ophthalmol. Vis. Sci. 35, 785-793.
16. Dunlop D. S., Van Eiden W., and Lajtha A. (1978) Protein degradation rates in regions of the central nervous system in vivo during development. Biochem. J. 170, 637-642.
17. Gou J. P., Eyer J., and Leterrier J. F. (1995) Progressive hyperphosphorylation of neurofilament heavy subunits with aging: possible involvement in the mechanism of neurofilament accumulation. Biochem. Biophys. Res. Commun. 215, 368-376.
18. Greenwood J. A., Troncoso J. C., Costello A. C., and Johnson G. V. W. (1993) Phosphorylation modulates calpain-mediated proteolysis and calmodulin binding of the 200-kDa and 160-kDa neurofilament proteins. J. Neurochem. 61, 191-199.
19. Ingvar M. C., Maeder P., Sokoloff L., and Smith C. B. (1985) Effects of aging on local rates of cerebral protein synthesis in Sprague-Dawley rats. Brain 108, 155-170.
20. Kenessey A., Banay-Schwartz M., DeGuzman T., and Lajtha A. (1989a) Increase in cathepsin D activity in rat brain in aging. J. Neurosci. Res. 23, 454-456.
21. Kenessey A., Banay-Schwartz M., DeGuzman T., and Lajtha A. (1989b) Regional distribution of brain calpastatin and of calpain. II. Activity with casein and with endogenous brain protein substrates. Neurochem. Int. 15, 307-314.
22. Kenessey A., Banay-Schwartz M., DeGuzman T., and Lajtha A. (1990) Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats. Neurochem. Res. 15, 243-249.
23. Lajtha A., Banay-Schwartz M., and Dunlop D. (1992) Protein metabolism in the brain. Ann. NY Acad. Sci. 674, 16-26.
24. Leterrier J. F. and Eyer J. (1992) Age-dependent changes in the ultrastructure and in the molecular composition of rat brain microtubules. J. Neurochem. 59, 1126-1137.
25. Mantle D. and Perry E. K. (1991) Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases. J. Neurol. Sci. 102, 220-224.
26. Matus A. and Green G. D. L. (1987) Age-related increase in a cathepsin D like protease that degrades brain microtubule-associated protein. Biochemistry 26, 8083-8086.
27. Nakanishi H., Tominaga K., Amano T., Hirotsu I., Inoue T., and Yamamoto K. (1994) Age-related changes in activities and localizations of cathepsin D, E, B, and L in the rat brain tissues. Exp. Neurol. 126, 119-128.
28. Nixon R. A. and Marotta C. A. (1984) Degradation of neurofilament proteins by purified human brain cathepsin D. J. Neurochem. 43, 507-516.
29. Nixon R. A., Clarke J. F., Logvinenko K. B., Tan M. K. H., Hoult M., and Grynspan F. (1990) Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. J. Neurochem. 55, 1950-1959.
30. Nixon R. A., Saito K.-I., Grynspan F., Griffin W. R., Katayama S., Honda T., Mohan P. S., Shea T. B., and Beermann M. (1994) Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann. NY Acad. Sci. 747, 77-91.
31. Pant H. C. (1988) Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain. Biochem. J. 256, 665-668.
32. Peterson C., Vanderklish P., Seubert P., Cotman C., and Lynch G. (1991) Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors. Neurosci. Lett. 121, 239-243.
33. Peterson G. L. (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83, 346-356.
34. Ragusa N., Villa R. F., Magri G., Ingrao F., Gorini A., Turpeenoja L., and Giuffrida-Stella A. M. (1992) Modifications of synaptosomal plasma membrane protein composition in various brain regions during aging. Int. J. Dev. Neurosci. 10, 265-272.
35. Saito K., Elce J. S., Hamos J. E., and Nixon R. A. (1993) Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc. Natl. Acad. Sci. USA 90, 2628-2632.
36. Schwarz-Benmeir N., Glaser T., and Kosower N. S. (1991) Band 3 protein degradation by calpain is enhanced in erythrocytes of old people. Biochem. J. 275, 47-52.
37. Schwarz-Benmeir N., Glaser T., Barnoy S., and Kosower N. S. (1994) Calpastatin in erythrocytes of young and old individuals. Biochem. J. 304, 365-370.
38. Smith M. A., Rudnicka-Nawrot M., Richey P. L., Praprotnik D., Mulvihill P., Miller C. A., Sayre L. M., and Perry G. (1995) Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J. Neurochem. 64, 2660-2666.
39. Smith M. E., Perret V., and Eng L. F. (1984) Metabolic studies in vitro of the CNS cytoskeletal proteins: synthesis and degradation. Neurochem. Res. 9, 1493-1507.
40. Takeuchi K. H., Saito K.-I., and Nixon R. A. (1992) Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. J. Neurochem. 58, 1526-1532.
41. Vitto A. and Nixon R. A. (1986) Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms. J. Neurochem. 47, 1039-1051.
42. Wiederanders B. and Oelke B. (1984) Accumulation of inactive cathepsin D in old rats. Mech. Ageing Dev. 24, 265-271.
43. Zimmerman U. J. P. and Schlaepfer W. W. (1982) Characterization of a brain calcium-activated protease that degrades neurofilament proteins. Biochemistry 21, 3977-3983.