Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate β-secretase proteases using peptide and amyloid precursor protein substrates

Journal of Neurochemistry

Volumn 66, Issue 6, 1996, Pages 2436-2445

  Brown, Abraham M ^a,b   Tummolo, Donna M ^a   Spruyt, Michael A ^a,c   Jacobsen, J Steven ^a   Sonnenberg Reines, June ^a  

^a PFIZER INC   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^c Cadus Pharmaceuticals   (United States)

Author keywords

Amyloid precursor protein; Cathepsin D; Cathepsin G; EC 3.4.24.15; Proteolytic processing; Swedish type familial Alzheimer's disease; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARAGINE; CATHEPSIN D; CATHEPSIN G; LEUCINE; LYSINE; METHIONINE; PROTEINASE; SYNTHETIC PEPTIDE; THIMET OLIGOPEPTIDASE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME SUBSTRATE; EPITOPE MAPPING; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RABBIT; SWEDEN;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; BRAIN CHEMISTRY; CATHEPSIN D; CATHEPSINS; ENDOPEPTIDASES; EVALUATION STUDIES; HYDROLYSIS; METALLOENDOPEPTIDASES; METHIONINE; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; RABBITS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0029975425     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66062436.x     Document Type: Review

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