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Volumn 24, Issue 9, 1999, Pages 1181-1188

Advanced transgenic and gene-targeting approaches

Author keywords

Conditional gene targeting; Genetic manipulation; Inducible transgene expression

Indexed keywords

GAMMA INTERFERON; HEAVY METAL; METAL ION; STEROID RECEPTOR; TETRACYCLINE;

EID: 0032830909     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020772706279     Document Type: Review
Times cited : (34)

References (53)
  • 1
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi, M. R. 1989. Altering the genome by homologous recombination. Science 244:1288-1292.
    • (1989) Science , vol.244 , pp. 1288-1292
    • Capecchi, M.R.1
  • 2
    • 0027460182 scopus 로고
    • Animal models of human genetic diseases
    • Smithies, O. 1993. Animal models of human genetic diseases. Trends Genet. 9:112-116.
    • (1993) Trends Genet. , vol.9 , pp. 112-116
    • Smithies, O.1
  • 3
    • 0344032066 scopus 로고    scopus 로고
    • An overview of mouse models in neuroscience research
    • Popko, B. (ed.), Mouse Models in the Study of Genetic Neurological Disorders, Klumer Academic/Plenum Publishers, New York
    • Popko, B. 1999. An overview of mouse models in neuroscience research. Advances in Neurochemistry. Vol. 9, Pages 1-23, in Popko, B. (ed.), Mouse Models in the Study of Genetic Neurological Disorders, Klumer Academic/Plenum Publishers, New York.
    • (1999) Advances in Neurochemistry , vol.9 , pp. 1-23
    • Popko, B.1
  • 4
    • 0029969678 scopus 로고    scopus 로고
    • Mechanisms of selective motor neuron death in ALS: Insights from transgenic mouse models of motor neuron disease
    • Bruijn, L. I., and Cleveland, D. W. 1996. Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Neuropathol. Appl. Neurobiol. 22:373-387.
    • (1996) Neuropathol. Appl. Neurobiol. , vol.22 , pp. 373-387
    • Bruijn, L.I.1    Cleveland, D.W.2
  • 6
    • 0028916152 scopus 로고
    • Death before birth: Clues from gene knockouts and mutations
    • Copp, A. J. 1995. Death before birth: clues from gene knockouts and mutations. Trends Genet. 11:87-93.
    • (1995) Trends Genet. , vol.11 , pp. 87-93
    • Copp, A.J.1
  • 7
    • 0027382270 scopus 로고
    • Thinking about genetic redundancy
    • Thomas, J. H. 1993. Thinking about genetic redundancy. Trends Genet. 9:395-409.
    • (1993) Trends Genet. , vol.9 , pp. 395-409
    • Thomas, J.H.1
  • 8
    • 0031898727 scopus 로고    scopus 로고
    • Inducible gene expression in the nervous system of transgenic mice
    • Gingrich, J. R., and Roder, J. 1998. Inducible gene expression in the nervous system of transgenic mice. Annu. Rev. Neurosci. 21 : 377-405.
    • (1998) Annu. Rev. Neurosci. , vol.21 , pp. 377-405
    • Gingrich, J.R.1    Roder, J.2
  • 9
    • 0030681310 scopus 로고    scopus 로고
    • Inducible gene expression in mammalian cells and transgenic mice
    • Saez, E., No, D., West, A., and Evans, R. M. 1997. Inducible gene expression in mammalian cells and transgenic mice. Curr. Opin. Biotechnol. 8:608-616.
    • (1997) Curr. Opin. Biotechnol. , vol.8 , pp. 608-616
    • Saez, E.1    No, D.2    West, A.3    Evans, R.M.4
  • 11
    • 0026655171 scopus 로고
    • Synergistic induction of promoters containing metal- and glucocorticoid-responsive elements
    • Filmus, J., Remani, J., and Klein, M. H. 1992. Synergistic induction of promoters containing metal- and glucocorticoid-responsive elements. Nucleic Acids Res. 20:2755-2760.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2755-2760
    • Filmus, J.1    Remani, J.2    Klein, M.H.3
  • 12
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M., and Rajewsky. K. 1995. Inducible gene targeting in mice. Science 269:1427-1429.
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 13
    • 0025369703 scopus 로고
    • Transgenic mice with intracellular immunity to influenza virus
    • Arnheiter, H., Skuntz, S., Noteborn, M., Chang, S., and Meier, E. 1990. Transgenic mice with intracellular immunity to influenza virus. Cell 62:51-61.
    • (1990) Cell , vol.62 , pp. 51-61
    • Arnheiter, H.1    Skuntz, S.2    Noteborn, M.3    Chang, S.4    Meier, E.5
  • 15
    • 0029865151 scopus 로고    scopus 로고
    • Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    • No, D., Yao, T. P., and Evans, R. M. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93:3346-3351.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3346-3351
    • No, D.1    Yao, T.P.2    Evans, R.M.3
  • 16
    • 0026646635 scopus 로고
    • Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    • Yao, T. P., Segraves, W. A., Oro, A. E., McKeown, M., and Evans, R. M. 1992. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell 71:63-72.
    • (1992) Cell , vol.71 , pp. 63-72
    • Yao, T.P.1    Segraves, W.A.2    Oro, A.E.3    McKeown, M.4    Evans, R.M.5
  • 17
    • 0032493446 scopus 로고    scopus 로고
    • High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor
    • Suhr, S. T., Gil, E. B., Senut, M. C., and Gage, F. H. 1998. High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc. Natl. Acad. Sci. USA 95:7999-8004.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7999-8004
    • Suhr, S.T.1    Gil, E.B.2    Senut, M.C.3    Gage, F.H.4
  • 18
    • 0002103670 scopus 로고    scopus 로고
    • A regulatory system for target gene expression
    • Burcin, M. M., O'Malley, B. W., and Tsai, S. Y. 1998. A regulatory system for target gene expression. Front Biosci. 3:1-7.
    • (1998) Front Biosci. , vol.3 , pp. 1-7
    • Burcin, M.M.1    O'Malley, B.W.2    Tsai, S.Y.3
  • 19
    • 0030965628 scopus 로고    scopus 로고
    • Ligand-inducible and liver-specific target gene expression in transgenic mice
    • Wang, Y., DeMayo, F. J., Tsai, S. Y., and O'Malley, B. W. 1997. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnol. 15:239-243.
    • (1997) Nature Biotechnol. , vol.15 , pp. 239-243
    • Wang, Y.1    DeMayo, F.J.2    Tsai, S.Y.3    O'Malley, B.W.4
  • 20
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M., and Bujard, H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 23
  • 24
    • 0029816480 scopus 로고    scopus 로고
    • Conditional transgene expression in the heart
    • Yu, Z., Redfern, C. S., and Fishman, G. I. 1996. Conditional transgene expression in the heart. Circ. Res. 79:691-697.
    • (1996) Circ. Res. , vol.79 , pp. 691-697
    • Yu, Z.1    Redfern, C.S.2    Fishman, G.I.3
  • 25
    • 0030781142 scopus 로고    scopus 로고
    • Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes
    • Ray, P., Tang, W., Wang, P., Homer, R., Kuhn, C. 3rd., Flavell, R. A., and Elias, J. A. 1997. Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J. Clin. Invest. 100:2501-2511.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2501-2511
    • Ray, P.1    Tang, W.2    Wang, P.3    Homer, R.4    Kuhn C. III5    Flavell, R.A.6    Elias, J.A.7
  • 27
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • Yrjanheikki, J., Keinanen, R., Pellikka, M., Hokfelt, T., and Koistinaho, J. 1998. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc. Natl. Acad. Sci. USA 95:15769-15774.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15769-15774
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3    Hokfelt, T.4    Koistinaho, J.5
  • 28
    • 0030797223 scopus 로고    scopus 로고
    • Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
    • Baron, U., Gossen, M., and Bujard, H. 1997. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25:2723-2729.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2723-2729
    • Baron, U.1    Gossen, M.2    Bujard, H.3
  • 29
    • 0029807527 scopus 로고    scopus 로고
    • Control of memory formation through regulated expression of a CaMKII transgene
    • Mayford, M., Bach, M. E., Huang, Y. Y., Wang, L., Hawkins, R. D., and Kandel, E. R. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-1683.
    • (1996) Science , vol.274 , pp. 1678-1683
    • Mayford, M.1    Bach, M.E.2    Huang, Y.Y.3    Wang, L.4    Hawkins, R.D.5    Kandel, E.R.6
  • 30
    • 0032498227 scopus 로고    scopus 로고
    • Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
    • Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R., and Bach, M. E. 1998. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92:39-49.
    • (1998) Cell , vol.92 , pp. 39-49
    • Mansuy, I.M.1    Mayford, M.2    Jacob, B.3    Kandel, E.R.4    Bach, M.E.5
  • 31
  • 32
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas, K. R., and Capecchi, M. R. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 34
    • 0026764280 scopus 로고
    • Tissue- and site-specific DNA recombination in transgenic mice
    • Orban, P. C., Chui, D., and Marth, J. D. 1992. Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89:6861-6865.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 35
    • 0028059099 scopus 로고
    • Deletion of a DNa polymerase β gene segment in T cells using cell type-specific gene targeting
    • Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K. 1994. Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265:103-106.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 36
    • 0031055834 scopus 로고    scopus 로고
    • Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain
    • Chen, C., and Tonegawa, S. 1997. Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain. Annu. Rev. Neurosci. 20:157-184.
    • (1997) Annu. Rev. Neurosci. , vol.20 , pp. 157-184
    • Chen, C.1    Tonegawa, S.2
  • 37
    • 0028173680 scopus 로고
    • Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
    • Li, Y., Erzurumlu, R., Chen, C., Jhaveri, S., and Tonegawa, S. 1994. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76:427-437.
    • (1994) Cell , vol.76 , pp. 427-437
    • Li, Y.1    Erzurumlu, R.2    Chen, C.3    Jhaveri, S.4    Tonegawa, S.5
  • 39
    • 0030446363 scopus 로고    scopus 로고
    • The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    • Tsien, J. Z., Huerta, P. T., and Tonegawa, S. 1996. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-1338.
    • (1996) Cell , vol.87 , pp. 1327-1338
    • Tsien, J.Z.1    Huerta, P.T.2    Tonegawa, S.3
  • 41
    • 0029788269 scopus 로고    scopus 로고
    • Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter
    • St.-Onge, L., Furth, P. A., and Gruss, P. 1996. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res. 24:3875-3877.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 3875-3877
    • St.-Onge, L.1    Furth, P.A.2    Gruss, P.3
  • 42
    • 0031717379 scopus 로고    scopus 로고
    • Inducible gene targeting in mice using the Cre/lox system
    • Sauer, B. 1998. Inducible gene targeting in mice using the Cre/lox system. Methods 14:381-392.
    • (1998) Methods , vol.14 , pp. 381-392
    • Sauer, B.1
  • 43
    • 0029164598 scopus 로고
    • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
    • Metzger, D., Clifford, J., Chiba, H., and Chambon, P. 1995. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl. Acad. Sci. USA 92:6991-6995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6991-6995
    • Metzger, D.1    Clifford, J.2    Chiba, H.3    Chambon, P.4
  • 47
    • 0032167985 scopus 로고    scopus 로고
    • A chimeric Cre recombinase inducible by synthetic, but not by natural ligands of the glucocorticoid receptor
    • Brocard, J., Feil, R., Chambon, P., and Metzger, D. 1998. A chimeric Cre recombinase inducible by synthetic, but not by natural ligands of the glucocorticoid receptor. Nucleic Acids Res. 26: 4086-4090.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 4086-4090
    • Brocard, J.1    Feil, R.2    Chambon, P.3    Metzger, D.4
  • 48
    • 0032481124 scopus 로고    scopus 로고
    • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    • Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K., and McMahon, A. P. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8:1323-1326.
    • (1998) Curr. Biol. , vol.8 , pp. 1323-1326
    • Danielian, P.S.1    Muccino, D.2    Rowitch, D.H.3    Michael, S.K.4    McMahon, A.P.5
  • 50
    • 0029562967 scopus 로고
    • Chromosome engineering in mice
    • Ramirez-Soils, R., Liu, P., and Bradley, A. 1995. Chromosome engineering in mice. Nature 378:720-724.
    • (1995) Nature , vol.378 , pp. 720-724
    • Ramirez-Soils, R.1    Liu, P.2    Bradley, A.3
  • 51
    • 0031252296 scopus 로고    scopus 로고
    • Cre-mediated chromosome loss in mice
    • Lewandoski, M., and Martin, G. R. 1997. Cre-mediated chromosome loss in mice. Nature Genet. 17:223-225.
    • (1997) Nature Genet. , vol.17 , pp. 223-225
    • Lewandoski, M.1    Martin, G.R.2
  • 52
    • 0029954239 scopus 로고    scopus 로고
    • Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells
    • Li, Z. W., Stark, G., Gotz, J., Rulicke, T., Gschwind, M., Huber, G., Muller, U., and Weissmann, C. 1996. Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proc. Natl. Acad. Sci. USA 93:6158-6162.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6158-6162
    • Li, Z.W.1    Stark, G.2    Gotz, J.3    Rulicke, T.4    Gschwind, M.5    Huber, G.6    Muller, U.7    Weissmann, C.8


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