Targeted expression of a toxin gene to D1 dopamine receptor neurons by Cre-mediated site-specific recombination

Journal of Neuroscience

Volumn 18, Issue 23, 1998, Pages 9845-9857

  Drago, John ^a   Padungchaichot, Poolpol ^a   Wong, John Y F ^a   Lawrence, Andrew J ^b   McManus, Julie F ^a   Sumarsono, Sony H ^b   Natoli, Anthony L ^a   Lakso, Merja ^c   Wreford, Nigel ^a   Westphal, Heiner ^d   Kola, Ismail ^b   Finkelstein, David I ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Basal ganglia; Cre recombinase; D1 dopamine receptor; Gene targeting; Parkinson's disease; Striatum

Indexed keywords

DIPHTHERIA TOXIN; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; RECOMBINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL GANGLION; BRADYKINESIA; CELL DEATH; CORPUS STRIATUM; DEGENERATIVE DISEASE; DNA RECOMBINATION; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; DYSTONIA; GENE EXPRESSION; GLIOSIS; HUNTINGTON CHOREA; IN SITU HYBRIDIZATION; MOUSE; MYOCLONUS SEIZURE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 7844242559     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-23-09845.1998     Document Type: Article

References (58)

1. Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375.
2. Andrews TC, Weeks RA, Turjanski N, Brooks DJ (1998) Monitoring disease progression in presymptomatic and early Huntington's disease: D1 and D2 ligand PET and the unified Huntington's disease rating scale. Minneapolis: American Academy of Neurology.
3. Baik JH, Picetti R, Saiardi A, Thiriet G, Dierich A, Depaulis A, Le Meur M, Borrelli E (1995) Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377:424-428.
4. Bredesen DE (1995) Neural apoptosis. Ann Neurol 38:839-851.
5. Caille I, Dumartin B, Le Moine C, Begueret J, Bloch B (1995) Ontogeny of the D1 dopamine receptor in the rat striatonigral system: an immunohistochemical study. Eur J Neurosci 7:714-722.
6. Civelli O, Douglass J, Goldstein A, Herbert E (1985) Sequence and expression of the rat prodynorphin gene. Proc Natl Acad Sci USA 82:4291-4295.
7. Davie CA, Wenning GK, Barker GJ, Brennan A, Quinn N, Miller DH (1993) MRS to differentiate multiple system atrophy from idiopathic Parkinson's disease. Lancet 342:681-682.
8. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91:12564-12568.
9. Drago J, Padungchaichot P, Accili D, Fuchs S (1998) Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Dev Neurosci 20:188-203.
10. El-Ghundi M, George SR, Drago J, Fan T, Fletcher PJ, Fan T, Nguyen T, Liu C, Sibley DR, Westphal H, O'Dowd BF (1998) Disruption of dopamine D1 receptor gene expression attenuates alcohol seeking behavior. Eur J Pharmacol 353:149-158.
11. Ferrante RJ, Kowall NW, Beal MF, Richardson Jr EP, Bird ED, Martin JB (1985) Selective sparing of a class of striatal neurons in Huntington's disease. Science 230:561-563.
12. Forno LS (1982) Pathology of Parkinson's disease. In: Movement disorders (Marsden CD, Fahn S, eds), pp 25-30. London: Butterworth.
13. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
15. Gerfen CR (1992) The neostriatal mosaic: multiple levels of compartmental organization. Trends Neurosci 15:133-139.
16. 2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250:1429-1432.
17. Ginovart N, Lundin A, Farde L, Halldin C, Backman L, Swahn CG, Pauli S, Sedvall G (1997) PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease. Brain 120:503-514.
18. Graybiel AM (1990) Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 13:244-254.
19. Guennoun R, Bloch B (1992) Ontogeny of D1 and DARPP-32 gene expression in the rat striatum: an in situ hybridization study. Mol Brain Res 12:131-139.
20. Harrison GS, Maxwell F, Long CJ, Rosen CA, Glode M, Maxwell IH (1991) Activation of a diphtheria toxin A gene by expression of Human Immunodeficiency Virus-1 Tat and Rev proteins in transfected cells. Hum Gene Ther 2:53-60.
21. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) The accuracy of the clinical diagnosis of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases. J Neurol Neurosurg Psych 55:181-184.
22. Kako K, Munekata E, Hosaka M, Murakami K, Nakayama K (1993) Cloning and sequence analysis of mouse cDNAs encoding preprotachykinin A and B. Biomed Res 14:253-259.
23. Kawaguchi Y, Wilson CJ, Emson PC (1990) Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin. J Neurosci 10:3421-3438.
24. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 26:239-257.
25. Lakso M, Sauer B, Mosinger BJ, Lee EJ, Manning RW, Yu S-H, Mulder KL, Westphal H (1992) Targeted oncogene activation by site specific recombination in transgenic mice. Proc Natl Acad Sci USA 89:6232-6236.
26. Lakso M, Pichel JG, Gorman J, Sauer B, Okamoto Y, Lee E, Alt F, Westphal H (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 93:5860-5865.
27. Lawrence AJ, Krstew E, Jarrott B (1995) Functional dopamine D2 receptors on rat vagal afferent neurones. Br J Pharmacol 114:1329-1334.
28. Lees AJ (1987) The Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). In: Movement disorders 2 (Marsden CD, Fahn S, eds), pp 272-287. Cornwell: Butterworth.
29. Marsden CD (1982) Basal ganglia disease. Lancet 2:1141-1147.
30. Marsden CD, Hallett M, Fahn S (1982) The nosology and pathophysiology of myoclonus. In: Movement disorders (Marsden CD, Fahn S, eds), pp 196-248. London: Butterworth.
31. Maxwell F, Maxwell IH, Glode LM (1987) Cloning, sequence determination, and expression in transfected cells of the coding sequence for the tox-176 attenuated diphtheria toxin A chain. Mol Cell Biol 7:1576-1579.
32. Mochizuki H, Goto K, Mori H, Mizuno Y (1996) Histochemical detection of apoptosis in Parkinson's disease. J Neurol Sci 137:120-123.
33. Montmayeur JP, Bausero P, Amlaiky N, Maroteaux L, Hen R, Borrelli E (1991) Differential expression of the mouse D2 dopamine receptor isoforms. FEBS Lett 278:239-243.
34. Mueller RA, Lundberg DB, Breese GR, Hedner J, Hedner T, Jonason J (1982) The neuropharmacology of respiratory control. Pharmacol Rev 34:255-285.
35. Palacios JM, Landwehrmeyer B, Mengold G (1993) Brain dopamine receptors: characterization, distribution, and alteration in disease. In: Parkinson's disease and movement disorders (Jankovic J, Tolosa E, eds) pp 35-54. Baltimore: Williams and Wilkins.
36. Penney JB, Young AB (1993) Huntington's disease. In: Parkinson's disease and movement disorders (Jankovic J, Tolosa E, eds), pp 205-216. Baltimore: Williams and Wilkins.
37. Quinn N (1994) Multiple system atrophy. In: Movement disorders 3, (Marsden CD, Fahn S, eds), pp 262-281. Oxford: Butterworth-Heinemann.
38. Quinn N (1997) Parkinson's disease: clinical features. Bailliere's Clin Neurol 6:1-13.
39. Rajput AH, Rozdilsky B, Rajput A (1991) Accuracy of clinical diagnosis in parkinsonism: a prospective study. Can J Neurol Sci 18:275-278.
40. Rothwell JC, Obeso JA (1987) The anatomical and physiological basis of torsion dystonia. In: Movement disorders 2 (Marsden CD, Fahn S, eds), pp 313-331. Cornwell: Butterworth.
41. Sauer B (1993) Manipulation of transgenes by site-specific recombination; use of Cre recombinase. In: Guide to techniques in mouse development. Methods in enzymology (Wassarman PM, DePamphilis ML, eds), pp 890-900. San Diego: Academic.
42. Sauer B, Henderson N (1988a) Site specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85:5166-5170.
43. Sauer B, Henderson N (1988b) The cyclization of linear DNA in Escherichia coli by site-specific recombination. Gene 70:331-341.
44. Schambra UB, Ducan GE, Breese GR, Fornaretto MG, Caron MG, Fremeau RTJ (1994) Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding. Neuroscience 62:65-85.
45. Sibley DR, Monsma Jr FJ (1992) Molecular biology of dopamine receptors. Trends Pharmacol Sci 13:61-69.
46. Smith DR, Striplin CD, Geller AM, Mailman RB, Drago J, Lawler CP, Gallager M (1998) Behavioral assessment of mice lacking D1A dopamine receptors. Neuroscience, in press.
47. Steele JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy. Arch Neurol 10:333-359.
48. 11C] SCH-23390. Minneapolis: American Academy of Neurology.
49. Surmeier DJ, Kitai ST (1994) Dopaminergic regulation of striatal efferent pathways. Curr Opin Neurobiol 4:915-919.
50. Surmeier DJ, Eberwine J, Wilson CJ, Cao Y, Stefani A, Kitai ST (1992) Dopamine receptor subtypes colocalize in rat striatonigral neurons. Proc Natl Acad Sci USA 89:10178-10182.
51. Surmeier DJ, Reiner A, Levine MS, Ariano MA (1993) Are neostnatal dopamine receptors co-localized? Trends Neurosci 16:299-305.
52. Surmeier DJ, Song W-J, Yan Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci 16:6579-6591.
53. Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153-1163.
54. Waters CH, Faust PL, Powers J. Vinters H, Moskowitz C, Nygaard T, Hunt AL, Fahn S (1993) Neuropathology of lubag (X-linked dystonia Parkinsonism). Mov Disord 8:387-390.
55. Watts RL, Mirra SS, Richardson EP (1994) Corticobasal ganglionic degeneration. In: Movement disorders 3 (Marsden CD, Fahr S, eds), pp 282-299 Oxford: Butterworth-Heinemann.
56. Wong JYF, Liberatore GT, Donnan GA, Howells DW (1997) Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse. Exp Neurol 148:83-91.
57. Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79:729-742.
58. Zurawski G, Benedik M, Kamb BJ, Abrams JS, Zurawski SM, Lee FD (1986) Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science 232:772-775.