Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia

European Journal of Pharmacology

Volumn 216, Issue 2, 1992, Pages 335-336

  Chiamulera, Christian ^a   Albertini, Paola ^a   Valerio, Enzo ^a   Reggiani, Angelo ^a  

^a GSK   (Italy)

Author keywords

Cerebral ischaemia; Excitatory amino acids; Metabotropic receptors

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CEREBRAL ARTERIES; CYCLOLEUCINE; DISEASE MODELS, ANIMAL; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; RECEPTORS, GLUTAMATE;

EID: 0026647040     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(92)90382-E     Document Type: Article

References (7)

1. Trans-ACPD depresses synaptic transmission in the hippocampus
2. Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures
3. Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action
4. Spatial learning potentiates the stimulation of phosphonoinositide hydrolysis by excitatory amino acids in rat hippocampal slices
5. Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors
6. Stimulation of inositol phospholipid hydrolysis by excitatory amino acids is enhanced in brain slices from vulnerable regions after transient global ischemia
7. Evidence for metabotropic excitatory amino acid receptor heterogeneity: developmental and brain regional studies