Function and regulation of memory CD4 T cells

Immunologic Research

Volumn 19, Issue 2-3, 1999, Pages 127-141

  Metz, Daniela P ^a   Bottomly, Kim ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD28; CD4; Costimulation; CTLA 4; Memory; Naive; T cells

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMOCYTE;

EID: 0032807782     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786482     Document Type: Review

References (78)

1. Murphy KM, Heimberger AB, Loh DY: Induction by antigen of intrathymic apoptosis of CD4/CD8/TCR-lo thymocytes in vivo. Science 1990;250:1720-1723.
2. Sebzda E, Wallace VA, Mayer J, Yeung RSM, Mak TW, Ohashi PS: Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994;263:1615-1618.
3. von Boehmer H: The selection of the alpha-beta heterodimeric T cell receptor for antigen. Immunol Today 1986;7:333-336.
4. Kirberg J, Bems A, von Boehmer H: Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med 1997;186:1269-1275.
5. Takeda S, Rodewald H-R, Arakawa H, Bluethmann H, Shimizu T: MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their longterm life span. Immunity 1996;5:217-228.
6. Sebzda E, Kundig TM, Thompson CT, Aoki K, Mak SY, Mayer JP, et al.: Mature T cell reactivity altered by peptide agonist that induces positive selection. J Exp Med 1996:183:1093-1104.
7. Hogquist KA, Tomlinson AJ, Kieper WC, McGargill MA, Hart MC, Naylor S, et al.: Identification of a naturally occuring ligand for thymic positive selection. Immunity 1997:6:389-399.
8. Yagi J, Janeway CA: Ligand thresholds at different stages of T cell development. Int Immunol 1990;2:83-88.
9. Vasquez NJ, Kaye J, Hedrick SM: In vivo and in vitro clonal deletion of double-positive thymocytes. J Exp Med 1992;175:1307-1316.
10. Davey GM, Schober SL, Endrizzi BT, Dutcher AK, Jameson SC, Hogquist KA: Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J Exp Med 1998;188:1867-1874.
11. Barthlott T, Wright RJ, Stockinger B: Normal thymic selection of TCR transgenic CD4 T cells, but impaired survival in the periphery despite the presence of selecting MHC molecules. J Immunol 1998;161:3992-3999.
12. Shahinian A, Pfeffer K, Lee KP, Kundig TM, Kishihara K, Wakeham A, et al.: Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993;261:609-612.
13. Linsley P, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA: Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 1991;173:721-730.
14. Koulova L, Clark EA, Shu G, Dupont B: The CD28 Ligand B7/BB1 provides costimulalory signal for alloactivation of CD4+ T cells. J Exp Med 1991;173:759-762.
15. Linsley PS, Ledbetter JA: The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993;11:191-212.
16. Swain SL, Croft M, Dubey C, Haynes L, Rogers P, Zhang X, et al.: From naive to memory T cells. Immunol Rev 1996;150:143-167.
17. Farber DL: Cutting Edge commentary: Differential TCR signaling and the generation of memory T cells. J Immunol 1998;160:535-539.
18. Byrne JA, Butler JL, Cooper MD: Differential activation requirements for virgin and memory T cells. J Immunol 1988;141:3249-3257.
19. Byrne JA, Butler JL, Reinherz EL, Cooper MD: Virgin and memory T cells have different requirements for activation via the CD2 molecule. Int. Immunol 1989;1:29-35.
20. Pihlgren M, Dubois PM, Tomkowiak M, Sjogren T, Marvel J: Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro. J Exp Med 1996;184:2141-2151.
21. Bradley LM, Duncan DD, Yoshimoto K, Swain SL: Memory effectors: A potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J Immunol 1993;150:3119-3130.
22. Farber DL, Acuto O, Bottomly K: Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur J Immunol 1997;27:2094-2101.
23. McHeyzer-Williams M, Altman JD, Davis MM: Enumeration and characterization of memory cells in the TH compartment. Immunol Rev 1996;150:5-21.
24. Lin MY, Welsh RM: Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice. J Exp Med 1998;188:1993-2005.
25. Janeway CA: The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol 1992;10:645-674.
26. Thomas ML: The leukocyte common antigen family. Annu Rev Immunol 1989;7:339-369.
27. Dianzani U, Luqman M, Rojo J, Yagi J, Baron JL, Woods A, et al.: Molecular associations on the T cell surface correlate with immunological memory. Eur J Immunol 1990;20:2249-2257.
28. Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, et al.: Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2 and LFA-1) and three other molecules (UCHL-1, CDw29 and Pgp-1) and have enhanced INF-γ production. J Immunol 1988;140:1401-1407.
29. Beverley PCL: Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin Immunol 1992;4:35-41.
30. Janeway CAJ: The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol 1992;10:645-674.
31. Mustelin T, Altman A: Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45). Oncogene 1990;5:809-813.
32. Biffen M, McMichael-Phillips D, Larson T, Venkitaraman A, Alexander D: The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59 fyn and CD4-associated p56 lck tyrosine kinases in human T-cells. EMBO J 1994;13:1920-1929.
33. Okumura M, Thomas ML: Regulation of immune function by protein tyrosine phosphatase. Curr Opinion Immunol 1995;7:312-319.
34. Leitenberg D, Novak TJ, Farber D, Smith BR, Bottomly K: The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. J Exp Med 1996;183:249-259.
35. Novak T, Farber D, Cheol Hong S, Johnson P, Bottomly K: Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity 1994:1:109-119.
36. Zhou Q, Wu Y, Nielsen PJ, Liu Y: Homotypic interaction of the heat- stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur J Immunol 1997;27:2525-2528.
37. Gray D: Immunological memory. Annu Rev Immunol 1993;11:49-77.
38. MacKay CR, Marston WL, Dudler L: Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med 1990;171:801-811.
39. Lee WT, Vitetta ES: Memory T cells are anergic to the super-antigen staphylococcal enterotoxin B J Exp Med 1992;176:575-579.
40. Miller RA, Flurkey K, Molloy M, Luby T, Stadecker MJ: Differential sensitivity of virgin and memory T lymphocytes to calcium ionophores suggests a buoyant density separation method and a model for memory cell hyporesponsiveness to Con A J Immunol 1991;147:3080-3086.
41. Farber DL, Luqman M, Acuto O, Bottomly K: Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity 1995;2:249-259.
42. Bottomly K, Luqman M, Greenbaum L, Carding S, West J, Pasqualini T, et al.: A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur J Immunol 1989:19:617-623.
43. Newell MK, Haughn LJ, Maroun CR, Julius MH: Death of mature T cells by separate ligation of CD4 and the T cell receptor for antigen. Nature 1990:347:286-288.
44. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN: The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med 1997:185:219-229.
45. Doyle C, Strominger JL: Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 1987:330:256-259.
46. Mazerolles F, Hauss P, Barbat C, Figdor CG, Fischer A: Regulation of LFA-1-mediated T cell adhesion by CD4. Eur J Immunol 1991;21:887-894.
47. Mazerolles F, Auffray C, Fischer A: Down regulation of T-cell adhesion by CD4. Hum Immunol 1991; 31:40-46.
48. Wolff CHJ, Hong S-C, Von Grafenstein H, Janeway CA, Jr.: TCR-CD4 and TCR-TCR interactions as distinctive mechanisms for the induction of increased intracellular calcium in T-cell signalling. J Immunol 1993; 151:1337-1345.
49. Julius M, Maroun CR, Haughn L: Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling. Immunol Today 1993;14:177-183.
50. Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM: Impaired Th2 subset development in the absence of CD4. Immunity 1997;6:559-569.
51. Brown DR, Moskowitz NH, Killeen N, Reiner SL: A role for CD4 in peripheral T cell differentiation. J Exp Med 1997;186:101-107.
52. Leitenberg D, Boutin Y, Constant S, Bottomly K: CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR J Immunol 1998;161:1194-1203.
53. Metz DP, Farber DL, Konig R, Bottomly K: Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction. J Immunol 1997:159:2567-2571
54. Lecomte O, Fischer A: Antigen-independent adhesion of CD45RA (naive) and CD45RO (memory) CD4 T cells to B cells. Int Immunol 1991;4:191-196.
55. Marsh EW, Dalke DP, Pierce SK: Biochemical evidence for the rapid assembly and disassembly of processed antigen-major histocompatibility complex class II complexes in acidic vesicles of B cells. J Exp Med 1992;175:425-436.
56. Lub M, Van Kooyk Y, Figdor CG: Ins and outs of LFA-1. Immunol Today 1995;16:459-503.
57. Geppert TD, Lipsky PE: Association of various T cell-surface molecules with the cytoskeleton. J Immunol 1991;146:3298-3305.
58. Lee JK, Black JD, Repasky EA, Kubo RT, Bankert RB: Activation induces a rapid reorganization of spectrin in lymphocytes. Cell 1988:55:807-816.
59. Valitutti S, Dessing M, Aktories K, Gallati H, Lanzavecchia A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med 1995;181;577-584.
60. Sloan-Lancaster J, Allen PM: Altered peptide ligand-induced partial T cell activation: molecular mechansims and role in T cell biology. Annu Rev Immunol 1996;14:1-27.
61. Bluestone JA: New perspectives of CD28-B7-mediated T cell costimulation. Immunity 1995;2:555-559.
62. Chamber CA, Allison JP: Costimulation in T cell responses. Curr Opinion Immunol 1997:9:396-404.
63. Lenschow DJ, Walunas TL, Bluestone JA: CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996;14:233-258.
64. Croft M, Bradley LM, Swain SL: Naive versus memory CD4 T cell response to antigen. J Immunol 1994;152:2675-2684.
65. Luqman M, Bottomly K: Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol 1992:149:2300-2306.
66. Cause WC, Lu P, Zhou X, Chen S, Madden KB, Morris SC, et al.: H polygyrus: B7-independence of the secondary type 2 response. Exp Parasitol 1996;84:264-273.
67. Lu P, Zhou X, Chen S, Moorman M, Schoneveld A, Morris S, et al.: Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevation during a primary systemic in vivo immune response. J Immunol 1995;154:1078-1087.
68. Keane-Myers A, Gause WC, Linsley PS, Chen S-J, Wills-Karp M: B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigen. J Immunol 1997;158:2042-2049.
69. Chambers CA, Krummel MF, Boitel B, Hurwitz A, Sullivan TJ, Fournier S, et al.: The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol Rev 1996;153:27-46.
70. Metz DP, Farber DL, Taylor T, Bottomly K: Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J Immunol 1998;161:5855-5861.
71. Waterhouse P, Marengere LEM, Mittruecker H-W, Mak TW: CTLA-4, a negative regulator of T-lymphocyte activation. Immunol Rev 1996;153:183-207.
72. Thompson CB, Allison JP: The emerging role of CTLA-4 as an immune attenuator. Immunity 1997;7:445-450.
73. Van der Merwe PA, Bodian DL, Daenke S, Linsley P, Davis SJ: CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med 1997;185:393-403.
74. Bradshaw JD, Lu P, Leytze G, Rodgers J, Schieven GL, Bennett KL, et al.: Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phophorylation. Biochem 1997;36:15975-15982.
75. Marengere LEM, Waterhouse P, Duncan GS, Mittruecker H-W, Feng G-S, Mak TW: Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 1996;272:1170-1173.
76. Lalvani A, Brookes R, Hambleton S, Britton WJ, Hill AVS, McMichael AJ: Rapid effector function in CD8 memory T cells. J Exp Med 1997;186:859-865.
77. Chamber CA, Sullivan TJ, Allison JP: Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 1997;7:885-895.
78. Konig R, Shen X, Germain RN: Involvement of both MHC class II α and β chains in CD4 function indicate a role for ordered oligomerization in T cell activation. J Exp Med 1995;182:779-787.