-
1
-
-
0027258466
-
Thymocyte apoptosis induced by p53-dependent and independent pathways
-
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362: 849-852, 1993.
-
(1993)
Nature
, vol.362
, pp. 849-852
-
-
Clarke, A.R.1
Purdie, C.A.2
Harrison, D.J.3
Morris, R.G.4
Bird, C.C.5
Hooper, M.L.6
Wyllie, A.H.7
-
2
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe, S., Ruley, H., Jacks, T., and Housman, D. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.1
Ruley, H.2
Jacks, T.3
Housman, D.4
-
3
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams, J. M., and Cory, S. The Bcl-2 protein family: arbiters of cell survival. Science (Washington DC), 281: 1322-1326, 1998.
-
(1998)
Science (Washington DC)
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
4
-
-
0025751550
-
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
-
Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67: 879-888, 1991.
-
(1991)
Cell
, vol.67
, pp. 879-888
-
-
Sentman, C.L.1
Shutter, J.R.2
Hockenbery, D.3
Kanagawa, O.4
Korsmeyer, S.J.5
-
5
-
-
0025786164
-
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
-
Strasser, A., Harris, A. W., and Cory, S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell, 67: 889-899, 1991.
-
(1991)
Cell
, vol.67
, pp. 889-899
-
-
Strasser, A.1
Harris, A.W.2
Cory, S.3
-
6
-
-
0027166048
-
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
-
Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
7
-
-
0029760303
-
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
-
Zhu, W., Cowie, A., Wasfy, G. W., Penn, L. Z., Leber, B., and Andrews, D. W. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J., 15: 4130-4141, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 4130-4141
-
-
Zhu, W.1
Cowie, A.2
Wasfy, G.W.3
Penn, L.Z.4
Leber, B.5
Andrews, D.W.6
-
8
-
-
0030861571
-
Bcl-2 and Bax function independently to regulate cell death
-
Knudson, C. M., and Korsmeyer, S. J. Bcl-2 and Bax function independently to regulate cell death. Nat. Genet., 16: 358-363, 1997.
-
(1997)
Nat. Genet.
, vol.16
, pp. 358-363
-
-
Knudson, C.M.1
Korsmeyer, S.J.2
-
9
-
-
0031982545
-
The p53 network
-
Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chemova, O. B., and Stark, G. R. The p53 network. J. Biol. Chem., 273: 1-4, 1998.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1-4
-
-
Agarwal, M.L.1
Taylor, W.R.2
Chernov, M.V.3
Chemova, O.B.4
Stark, G.R.5
-
10
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
-
(1993)
Nature (Lond.)
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
11
-
-
0021616838
-
UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
-
Maltzman, W., and Czyzyk, L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol., 4: 1689-1694, 1984.
-
(1984)
Mol. Cell. Biol.
, vol.4
, pp. 1689-1694
-
-
Maltzman, W.1
Czyzyk, L.2
-
12
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
13
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia
-
Kastan, M. B., Zhan, Q., el-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia. Cell, 77: 587-597, 1992.
-
(1992)
Cell
, vol.77
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
El-Deiry, W.S.3
Carrier, F.4
Jacks, T.5
Walsh, W.V.6
Plunkett, B.S.7
Vogelstein, B.8
Fornace, A.J.9
-
14
-
-
0027332996
-
Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
-
Lu, X., and Lane, D. P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell, 75: 765-778, 1993.
-
(1993)
Cell
, vol.75
, pp. 765-778
-
-
Lu, X.1
Lane, D.P.2
-
15
-
-
0029050533
-
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
-
Almasan, A., Yin, Y., Kelly, R. E., Lee, E. Y., Bradley, A., Li, W-W., Bertino, J. R., and Wahl, G. M. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA, 92: 5436-5440, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5436-5440
-
-
Almasan, A.1
Yin, Y.2
Kelly, R.E.3
Lee, E.Y.4
Bradley, A.5
Li, W.-W.6
Bertino, J.R.7
Wahl, G.M.8
-
16
-
-
0027944228
-
Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
-
Zhan, Q., Fan, S., Bae, I., Guillouf, C., Uebermann, D. A., O'Connor, P. M., and Fornace, A. J., Jr. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9: 3743-3751, 1994.
-
(1994)
Oncogene
, vol.9
, pp. 3743-3751
-
-
Zhan, Q.1
Fan, S.2
Bae, I.3
Guillouf, C.4
Uebermann, D.A.5
O'Connor, P.M.6
Fornace A.J., Jr.7
-
17
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
18
-
-
0030930366
-
A model for p53-induced apoptosis
-
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., and Vogelstein, B. A model for p53-induced apoptosis. Nature (Lond.), 389: 300-305, 1997.
-
(1997)
Nature (Lond.)
, vol.389
, pp. 300-305
-
-
Polyak, K.1
Xia, Y.2
Zweier, J.L.3
Kinzler, K.W.4
Vogelstein, B.5
-
19
-
-
0027525104
-
The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme
-
Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell, 75: 641-652, 1993.
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvitz, H.R.5
-
20
-
-
0009530192
-
Human ICE/CED-3 protease nomenclature
-
Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., and Yuan, J. Human ICE/CED-3 protease nomenclature. Cell, 87: 171, 1996.
-
(1996)
Cell
, vol.87
, pp. 171
-
-
Alnemri, E.S.1
Livingston, D.J.2
Nicholson, D.W.3
Salvesen, G.4
Thornberry, N.A.5
Wong, W.W.6
Yuan, J.7
-
21
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
-
Boldin, M., Goncharov, T., Goltsev, Y., and Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell, 85: 803-815, 1996.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.1
Goncharov, T.2
Goltsev, Y.3
Wallach, D.4
-
22
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
-
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85: 817-827, 1996.
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Ni, J.6
Scaffidi, C.7
Bretz, J.D.8
Zhang, M.9
Gentz, R.10
Mann, M.11
Krammer, P.H.12
Peter, M.E.13
Dixit, V.M.14
-
23
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
24
-
-
0027973061
-
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme
-
Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme. J. Biol. Chem., 269: 30761-30764, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 30761-30764
-
-
Fernandes-Alnemri, T.1
Litwack, G.2
Alnemri, E.S.3
-
25
-
-
0029068871
-
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
-
Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T-T., Yu, V. L., and Miller, D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376: 37-43, 1995.
-
(1995)
Nature (Lond.)
, vol.376
, pp. 37-43
-
-
Nicholson, D.W.1
Ali, A.2
Thornberry, N.A.3
Vaillancourt, J.P.4
Ding, C.K.5
Gallant, M.6
Gareau, Y.7
Griffin, P.R.8
Labelle, M.9
Lazebnik, Y.A.10
Munday, N.A.11
Raju, S.M.12
Smulson, M.E.13
Yamin, T.-T.14
Yu, V.L.15
Miller, D.K.16
-
26
-
-
0028990125
-
Yama/CPP32 β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
-
Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. Yama/CPP32 β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81: 801-809, 1995.
-
(1995)
Cell
, vol.81
, pp. 801-809
-
-
Tewari, M.1
Quan, L.T.2
O'Rourke, K.3
Desnoyers, S.4
Zeng, Z.5
Beidler, D.R.6
Poirier, G.G.7
Salvesen, G.S.8
Dixit, V.M.9
-
27
-
-
0029025549
-
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family
-
Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res., 55: 2737-2742, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2737-2742
-
-
Fernandes-Alnemri, T.1
Litwack, G.2
Alnemri, E.S.3
-
28
-
-
0027255417
-
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
-
Kaufmann, S., Desnoyers, S., Ottaviano, Y., Davidson, N., and Poirier, G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res., 53: 3976-3985, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 3976-3985
-
-
Kaufmann, S.1
Desnoyers, S.2
Ottaviano, Y.3
Davidson, N.4
Poirier, G.5
-
29
-
-
0028102478
-
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
-
Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (Lond.), 371: 346-347, 1994.
-
(1994)
Nature (Lond.)
, vol.371
, pp. 346-347
-
-
Lazebnik, Y.A.1
Kaufmann, S.H.2
Desnoyers, S.3
Poirier, G.G.4
Earnshaw, W.C.5
-
30
-
-
2642689658
-
Proteases to die for
-
Cryns, V., and Yuan, J. Proteases to die for. Genes Dev., 12: 1551-1570, 1998.
-
(1998)
Genes Dev.
, vol.12
, pp. 1551-1570
-
-
Cryns, V.1
Yuan, J.2
-
31
-
-
0030997647
-
Interleukin 1 β converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis
-
Sabbatini, P., Han, J., Chiou, S. K., Nicholson, D. W., and White, E. Interleukin 1 β converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis. Cell Growth Differ., 8: 643-653, 1997.
-
(1997)
Cell Growth Differ.
, vol.8
, pp. 643-653
-
-
Sabbatini, P.1
Han, J.2
Chiou, S.K.3
Nicholson, D.W.4
White, E.5
-
32
-
-
0030871457
-
p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32β
-
Fuchs, E. J., McKenna, K. A., and Bedi, A. p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32β. Cancer Res., 57: 2550-2554, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 2550-2554
-
-
Fuchs, E.J.1
McKenna, K.A.2
Bedi, A.3
-
33
-
-
0031059469
-
Activation of CPP32 and Mch3 α in wild-type p53-induced apoptosis
-
Chandler, J. M., Alnemri, E. S., Cohen, G. M., and MacFarlane, M. Activation of CPP32 and Mch3 α in wild-type p53-induced apoptosis. Biochem. J., 322: 19-23, 1997.
-
(1997)
Biochem. J.
, vol.322
, pp. 19-23
-
-
Chandler, J.M.1
Alnemri, E.S.2
Cohen, G.M.3
MacFarlane, M.4
-
34
-
-
0030702084
-
Caspases: Intracellular signaling by proteolysis
-
Salvesen, G. S., and Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell, 91: 443-446, 1997.
-
(1997)
Cell
, vol.91
, pp. 443-446
-
-
Salvesen, G.S.1
Dixit, V.M.2
-
35
-
-
0028878468
-
A pre-existing protease is a common effector of thymocyte apoptosis me-diated by diverse stimuli
-
Fearnhead, H. O., Rivett, A. J., Dinsdale, D., and Cohen, G. M. A pre-existing protease is a common effector of thymocyte apoptosis me-diated by diverse stimuli. FEBS Lett., 357: 242-246, 1995.
-
(1995)
FEBS Lett.
, vol.357
, pp. 242-246
-
-
Fearnhead, H.O.1
Rivett, A.J.2
Dinsdale, D.3
Cohen, G.M.4
-
36
-
-
0030984171
-
Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support
-
Stefanis, L., Troy, C. M., Qi, H., and Greene, L. A. Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support. J. Neurochem., 69: 1425-1437, 1997.
-
(1997)
J. Neurochem.
, vol.69
, pp. 1425-1437
-
-
Stefanis, L.1
Troy, C.M.2
Qi, H.3
Greene, L.A.4
-
37
-
-
0029831619
-
Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei
-
McConkey, D. J. Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation in isolated thymocyte nuclei. J. Biol. Chem., 271: 22398-22406, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22398-22406
-
-
McConkey, D.J.1
-
38
-
-
0029959819
-
Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents
-
Lotem, J., and Sachs, L. Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents. Proc. Natl. Acad. Sci. USA, 93: 12507-12512, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 12507-12512
-
-
Lotem, J.1
Sachs, L.2
-
39
-
-
0027305202
-
Radiation-induced apoptosis and necrosis in Molt-4 cells: A study of dose-effect relationships and their modification
-
Akagi, Y., Ito, K., and Sawada, S. Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification. Int. J. Radiat. Biol., 64: 47-56, 1993.
-
(1993)
Int. J. Radiat. Biol.
, vol.64
, pp. 47-56
-
-
Akagi, Y.1
Ito, K.2
Sawada, S.3
-
40
-
-
0027942467
-
X-ray-induced cell death: Apoptosis and necrosis
-
Nakano, H., and Shinohara, K. X-ray-induced cell death: apoptosis and necrosis. Radiat. Res., 140: 1-9, 1994.
-
(1994)
Radiat. Res.
, vol.140
, pp. 1-9
-
-
Nakano, H.1
Shinohara, K.2
-
41
-
-
0032535730
-
Blood cells with reduced mitochondrial membrane potential and cytosolic cytochrome c can survive and maintain clonogenicity given appropriate signals to suppress apoptosis
-
Chen, Q., Takeyama, N., Brady, G., Watson, A. J. M., and Dive, C. Blood cells with reduced mitochondrial membrane potential and cytosolic cytochrome c can survive and maintain clonogenicity given appropriate signals to suppress apoptosis. Blood, 92: 4545-4553, 1998.
-
(1998)
Blood
, vol.92
, pp. 4545-4553
-
-
Chen, Q.1
Takeyama, N.2
Brady, G.3
Watson, A.J.M.4
Dive, C.5
-
42
-
-
0028800947
-
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
-
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., and Green, D. R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med., 182: 1545-1556, 1995.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1545-1556
-
-
Martin, S.J.1
Reutelingsperger, C.P.2
McGahon, A.J.3
Rader, J.A.4
Van Schie, R.C.5
LaFace, D.M.6
Green, D.R.7
-
43
-
-
0029758833
-
Cleavage of lamin A by Mch2 α but not CPP32: Multiple interleukin 1 β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
-
Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernandes-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C. Cleavage of lamin A by Mch2 α but not CPP32: multiple interleukin 1 β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc. Natl. Acad. Sci. USA, 93: 8395-8400, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8395-8400
-
-
Takahashi, A.1
Alnemri, E.S.2
Lazebnik, Y.A.3
Fernandes-Alnemri, T.4
Litwack, G.5
Moir, R.D.6
Goldman, R.D.7
Poirier, G.G.8
Kaufmann, S.H.9
Earnshaw, W.C.10
-
44
-
-
0030970351
-
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity
-
Zhou, Q., and Salvesen, G. S. Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. Biochem. J., 324: 361-364, 1997.
-
(1997)
Biochem. J.
, vol.324
, pp. 361-364
-
-
Zhou, Q.1
Salvesen, G.S.2
-
45
-
-
0031027297
-
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis
-
Datta, R., Kojima, H., Banach, D., Bump, N. J., Talanian, R. V., Alnemri, E. S., Weichselbaum, R. R., Wong, W. W., and Kufe, D. W. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J. Biol. Chem., 272: 1965-1969, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 1965-1969
-
-
Datta, R.1
Kojima, H.2
Banach, D.3
Bump, N.J.4
Talanian, R.V.5
Alnemri, E.S.6
Weichselbaum, R.R.7
Wong, W.W.8
Kufe, D.W.9
-
46
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D. A., Hoffman, B., and Reed, J. C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9: 1799-1805, 1994.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewska, M.3
Wang, H.G.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
47
-
-
0026849821
-
Definition of a consensus binding site for p53
-
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., and Vogelstein, B. Definition of a consensus binding site for p53. Nat. Genet., 1: 45-49, 1992.
-
(1992)
Nat. Genet.
, vol.1
, pp. 45-49
-
-
El-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
48
-
-
0030764172
-
Regulation of p53 by metal ions and by antioxidants: Dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper
-
Verhaegh, G. W., Richard, M. J., and Hainaut, P. Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol. Cell. Biol., 17: 5699-5706, 1997.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 5699-5706
-
-
Verhaegh, G.W.1
Richard, M.J.2
Hainaut, P.3
-
49
-
-
0032190057
-
p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines
-
Yu, Y., and Little, J. B. p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines. Cancer Res., 58: 4277-4281, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 4277-4281
-
-
Yu, Y.1
Little, J.B.2
-
50
-
-
0030973417
-
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
-
Faleiro, L., Kobayashi, R., Fearnhead, H., and Lazebnik, Y. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J., 16: 2271-2281, 1997.
-
(1997)
EMBO J.
, vol.16
, pp. 2271-2281
-
-
Faleiro, L.1
Kobayashi, R.2
Fearnhead, H.3
Lazebnik, Y.4
-
51
-
-
9844226204
-
Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: Differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis
-
Kitanaka, C., Namiki, T., Noguchi, K., Mochizuki, T., Kagaya, S., Chi, S., Hayashi, A., Asai, A., Tsujimoto, Y., and Kuchino, Y. Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis. Oncogene, 15: 1763-1772, 1997.
-
(1997)
Oncogene
, vol.15
, pp. 1763-1772
-
-
Kitanaka, C.1
Namiki, T.2
Noguchi, K.3
Mochizuki, T.4
Kagaya, S.5
Chi, S.6
Hayashi, A.7
Asai, A.8
Tsujimoto, Y.9
Kuchino, Y.10
-
52
-
-
0029906828
-
BAX-induced cell death may not require interteukin 1 β-converting enzyme-like proteases
-
Xiang, J., Chao, D. T., and Korsmeyer, S. J. BAX-induced cell death may not require interteukin 1 β-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA, 93: 14559-14563, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14559-14563
-
-
Xiang, J.1
Chao, D.T.2
Korsmeyer, S.J.3
-
53
-
-
0032576692
-
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
-
Rosse, T., Olivier, R., Monney, L., Rager, M., Conus, S., Fellay, I., Jansen, B., and Borner, C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature (Lond.), 391: 496-499, 1998.
-
(1998)
Nature (Lond.)
, vol.391
, pp. 496-499
-
-
Rosse, T.1
Olivier, R.2
Monney, L.3
Rager, M.4
Conus, S.5
Fellay, I.6
Jansen, B.7
Borner, C.8
-
54
-
-
0029959632
-
Specific cleavage of α-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1 β-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease
-
Cryns, V. L., Bergeron, L., Zhu, H., Li, H., and Yuan, J. Specific cleavage of α-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1 β-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J. Biol. Chem., 271: 31277-31282, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31277-31282
-
-
Cryns, V.L.1
Bergeron, L.2
Zhu, H.3
Li, H.4
Yuan, J.5
-
55
-
-
0031038137
-
Bax suppresses tumorigenesis and stimulates apoptosis in vivo
-
Yin, C., Knudson, C. M., Korsmeyer, S. J., and Van Dyke, T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (Lond.), 385: 637-640, 1997.
-
(1997)
Nature (Lond.)
, vol.385
, pp. 637-640
-
-
Yin, C.1
Knudson, C.M.2
Korsmeyer, S.J.3
Van Dyke, T.4
-
56
-
-
0030812173
-
Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells
-
Strobel, T., Swanson, L., Korsmeyer, S., and Cannistra, S. A. Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells. Oncogene, 14: 2753-2758, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 2753-2758
-
-
Strobel, T.1
Swanson, L.2
Korsmeyer, S.3
Cannistra, S.A.4
-
57
-
-
0029671112
-
Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo
-
Kitada, S., Krajewski, S., Miyashita, T., Krajewska, M., and Reed, J. C. Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo. Oncogene, 12: 187-192, 1996.
-
(1996)
Oncogene
, vol.12
, pp. 187-192
-
-
Kitada, S.1
Krajewski, S.2
Miyashita, T.3
Krajewska, M.4
Reed, J.C.5
-
58
-
-
0025152051
-
p53 mutations in colorectal cancer
-
Rodrigues, N., Rowan, A., Smith, M., Kerr, I., Bodmer, W., Gannon, J., and Lane, D. p53 mutations in colorectal cancer. Proc. Natl. Acad. Sci. USA, 87: 7555-7559, 1990.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7555-7559
-
-
Rodrigues, N.1
Rowan, A.2
Smith, M.3
Kerr, I.4
Bodmer, W.5
Gannon, J.6
Lane, D.7
-
59
-
-
0030865104
-
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
-
O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., Friend, S., Fornace, A. J., Jr., and Kohn, K. W. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res., 57: 4285-4300, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 4285-4300
-
-
O'Connor, P.M.1
Jackman, J.2
Bae, I.3
Myers, T.G.4
Fan, S.5
Mutoh, M.6
Scudiero, D.A.7
Monks, A.8
Sausville, E.A.9
Weinstein, J.N.10
Friend, S.11
Fornace A.J., Jr.12
Kohn, K.W.13
-
60
-
-
0345336383
-
Bcl-2 activation by ionizing radiation in a glioblastoma cell line
-
Goss, V., Gong, B., Jiang, X., and Almasan, A. Bcl-2 activation by ionizing radiation in a glioblastoma cell line. Int. J. Rad. Oncol. Biol. Phys., 39: 178, 1998.
-
(1998)
Int. J. Rad. Oncol. Biol. Phys.
, vol.39
, pp. 178
-
-
Goss, V.1
Gong, B.2
Jiang, X.3
Almasan, A.4
-
61
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
-
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
62
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck, R., Bossy-Wetzel, E., Green, D., and Newmeyer, D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.
-
(1997)
Science (Washington DC)
, vol.275
, pp. 1132-1136
-
-
Kluck, R.1
Bossy-Wetzel, E.2
Green, D.3
Newmeyer, D.4
-
63
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang, J., Liu, X., Bhalla, K., Kim, C., Ibrado, A., Cai, J., Peng, T., Jones, D., and Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
-
(1997)
Science (Washington DC)
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.4
Ibrado, A.5
Cai, J.6
Peng, T.7
Jones, D.8
Wang, X.9
-
64
-
-
15144349717
-
Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells
-
Chauhan, D., Pandey, P., Ogata, A., Teoh, G., Krett, N., Halgren, R., Rosen, S., Kufe, D., Kharbanda, S., and Anderson, K. Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells. J. Biol. Chem., 272: 29995-29997, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29995-29997
-
-
Chauhan, D.1
Pandey, P.2
Ogata, A.3
Teoh, G.4
Krett, N.5
Halgren, R.6
Rosen, S.7
Kufe, D.8
Kharbanda, S.9
Anderson, K.10
-
65
-
-
0031771414
-
Ionizing radiation stimulates mitochondrial gene expression and activity
-
Gong, B., Chen, Q., and Almasan, A. Ionizing radiation stimulates mitochondrial gene expression and activity. Radiat. Res., 150: 505-512, 1998.
-
(1998)
Radiat. Res.
, vol.150
, pp. 505-512
-
-
Gong, B.1
Chen, Q.2
Almasan, A.3
-
66
-
-
0030988817
-
The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate
-
Chernov, M. V., and Stark, G. R. The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate. Oncogene, 14: 2503-2510, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 2503-2510
-
-
Chernov, M.V.1
Stark, G.R.2
-
67
-
-
0030916417
-
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
-
Liu, X., Zou, H., Slaughter, C., and Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell, 89: 175-184, 1997.
-
(1997)
Cell
, vol.89
, pp. 175-184
-
-
Liu, X.1
Zou, H.2
Slaughter, C.3
Wang, X.4
|