Blood cells with reduced mitochondrial membrane potential and cytosolic cytochrome C can survive and maintain clonogenicity given appropriate signals to suppress apoptosis

Blood

Volumn 92, Issue 12, 1998, Pages 4545-4553

  Chen, Quan ^a   Takeyama, Naoshi ^a   Brady, Ged ^a   Watson, Alastair J M ^a   Dive, Caroline ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; INTERLEUKIN 3; PROTEIN TYROSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032535730     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.12.4545     Document Type: Article

References (16)

1. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 26:239, 1972
2. Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387:773, 1997
3. Kroemer G: The proto oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 6:614, 1997
4. Liu X, Naekyung CN, Yang J, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86:147, 1997
5. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondrial blocked. Science 275:1129, 1997
6. Zou H, Henzel W, Liu X, Lutscg A, Wang X: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase 3. Cell 90:405, 1997
7. Chinnaiyan AM, Chaudhary D, O'Rourke K, Koonin EV, Dixit VM: Role of CED-4 in the activation of CED-3. Nature 388:728, 1997
8. Vaux DL: CED-4 - The third horseman of apoptosis. Cell 90:389, 1997
9. Liu X, Zou H, Slaughter C, Wang X: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175, 1997
10. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang XD: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479, 1997
11. Kluck RM, Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation. Science 275:1129, 1997
12. L as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94:6939, 1997
13. L, an inhibitor of programmed cell death. Nature 381:335, 1996
14. L forms an ion channel in synthetic lipid membranes. Nature 385:353, 1997
15. Petit PX, Lecoeur H, Zorn E, Dauguet C, Mignotte B, Gougeon ML: Alterations in mitochondrial structure and function are early events of Dexamethasone-induced thymocyte apoptosis. J Cell Biol 130:157, 1995
16. Kantrow SP, Piantadosi CA: Release of cytochrome c from liver mitochondria during permeability transition. Biochem Biophys Res Commun 232:669, 1997