Caspase activation without death

Cell Death and Differentiation

Volumn 6, Issue 11, 1999, Pages 1075-1080

  Zeuner, A ^a   Eramo, A ^b   Peschle, C ^b,c   De Maria, R ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Apoptosis; CD95 (Fas Apo 1); Differentiation; Hematopoiesis; Interleukin; Survival

Indexed keywords

CASPASE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; CELL DIFFERENTIATION; ENZYME ACTIVATION; INFLAMMATION; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 0032805107     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400596     Document Type: Review

References (72)

1. Yuan J, Shaham S, Ledoux S, Ellis HM and Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75: 641-652
2. Thornberry NA and Lazebnik Y (1998) Caspases: enemies within. Science 281: 1312-1316
3. Nicholson DW and Thornberry NA (1997) Caspases: killer proteases. Trends Biochem. Sci. 22: 299-306
4. Dinarello CA (1998) Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann. NY Acad. Sci. 856: 1-11
5. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K and Black RA (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256: 97-100
6. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJF, Egger LA, Gaffney EP, Limjuco J, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA and Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356: 768-774
7. Dinarello CA (1998) Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 16: 457-499
8. Fantuzzi G and Dinarello CA (1999) Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J. Clin. Immunol. 19: 1-11
9. Black R, Kronheim S, Sleath P, Greenstreet T, Virca GD, March C and KupperT (1991) The proteolytic activation of interleukin-1 beta. Agents Aczions Suppl. 35: 85-89
10. Andrei C, Dazzi C, Lotti L, Torrisi MR, Chimini G and Rubartelli A (1999) The secretory route of the leaderless protein interleukin 1 beta involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell 10: 1463-1475
11. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamen R and Seshadri T (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80: 401-411
12. Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DDS, Mumford RA Schmidt JA and Tocci MJ (1991) IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J. Immunol. 147: 2964-2969
13. Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD, Herzog L, Hugunin M, Houy W, Mankovich JA, McGuinness L, Orlewicz E, Paskind M, Pratt CA, Reis P, Summani A, Terranova M, Weich JP, Xlong L, Moller A, Tracey DE, Kamen R and Wong WW (1994) Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Cell 78: 343-352
14. Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA and Livingston DJ (1994) Structure and mechanism of interleukin-1 beta converting enzyme [see comments]. Nature 370: 270-275
15. Wang S, Miura M, Jung Y, Zhu H, Li E and Juan J (1998) Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92: 501-509
16. Hofmann K, Bucher P and Tschopp J (1997) The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22: 155-156
17. Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN and Alnemri ES (1999) CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J. Biol. Chem. 274: 17946-17954
18. Costanzo A, Guiet C and Vito P (1999) c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. J. Biol. Chem. 274: 20127-20132
19. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D Ni J and Nunez G (1999) Nod1, an Apaf-1 -like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 274: 14560-14567
20. Koseki T, Inohara N, Chen S and Nunez G (1998) ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc. Natl. Acad. Sci. U.S.A. 95: 5156-5160
21. Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO. Nabel GJ and Nunez G (1999) CIPER, a novel NF kappaB-activating proten containing a caspase recruitment domain with homology to Herpesvirus-2 prolein E10. J. Biol. Chem. 274: 9955-9961
22. Yan M, Lee J, Schilbach S, Goddard A and Dixit V (1999) mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J. Biol. Chem. 274: 10287-10292
23. Duan H and Dixit VM (1997) RAIDD is a new 'death' adaptor molecule. Nature 385: 86-89
24. Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C and Tschopp J (1998) Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 8: 885-888
25. Friedlander RM, Brown RH, Gagliardini V, Wang J and Yuan J (1997) Inhibition of ICE slows ALS in mice [letter]. Nature 388: 31
26. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J and Moskowitz MA (1997) Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94: 2007-2012
27. Zychlinsky A, Fitting C, Cavaillon JM and Sansonetti PJ (1994) Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J. Clin. Invest. 94: 1328-1332
28. Chen Y, Smith MR, Thirumalai K and Zychlinsky A (1996) A bacterial invasion induces macrophage apoptosis by binding directly to ICE. EMBO J. 15: 3853-3860
29. Hogquist KA, Nett MA, Unanue ER and Chaplin DD (1991) Interleukin 1 is processed and released during apoptosis. Proc. Natl. Acad. Sci. U.S.A. 88: 8485-8489
30. Sarih M, Souvannavong V, Brown SC and Adam A (1993) Silica induces apoptosis in macrophages and the release of interleukin-1 alpha and interleukin-1 beta. J. Leukoc. Biol. 54: 407-413
31. Cozzolino F, Rubartelli A, Aldinucci D, Sitia R, Torcia M, Shaw A and Di Guglielmo R (1989) Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 86: 2369-2373
32. Beuscher HU, Rausch UP, Otterness IG and Rollinghoff M (1992) Transition from interleukin 1 beta (IL-1 beta) to IL-1 alpha production during maturation of inflammatory macrophages in vivo. J. Exp. Med. 175: 1793-1797
33. Watari K, Mayani H, Lee F, DragowskaW, Lansdorp PM and Schrader JW (1996) Production of interleukin 1 beta by human hematopoietic progenitor cells. J. Clin. Invest. 97: 1666-1674
34. Fries G, Perneczky A and Kempski O (1994) Enhanced interleukin-1 beta release and longevity of glioma-associated peripheral blood monocytes in vitro. Neurosurgery 35: 264-270
35. William R, Watson G, Rotstein OD, Parodo J, Bitar R and Marshall JC (1998) The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. J. Immunol. 161: 957-962
36. Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L. Sekut L, Talanian R, Paskind M, Wong W, Kamen R, Tracey D and Allen H (1997) Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386: 619-623
37. Dinarello CA (1999) IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol. 103: 11-24
38. Ku G, Faust T, Lauffer LL, Livingston DJ and Harding MW (1996) Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine 8: 377-386
39. Dinarello CA and Wolff SM (1993) The role of interleukin-1 in disease. N. Engl. J. Med. 328: 106-113
40. De Maria R and Testi R (1998) Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol. Today 19: 121-125
41. Jaattela M, Wissing D, Kokholm K, Kallunki T and Egeblad M (1998) Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 17: 6124-6134
42. Miossec C, Dutilleul V, Fassy F and Diu-Hercend A (1997) Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J. Biol. Chem. 272: 13459-13462
43. Wilhelm S, Wagner H and Hacker G (1998) Activation of caspase-3-like enzymes in non-apoptoticTcells. Eur. J. Immunol. 28: 891-900
44. Zapata JM, Takahashi R, Salvesen GS and Reed JC (1998) Granzyme release and caspase activation in activated human T-lymphocytes. J. Biol. Chem. 273: 6916-6920
45. Postmantur R, Wang KK and Gilbertsen RB (1998) Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells. Exp. Cell. Res. 244: 302-309
46. Center DM, Kornfeld H and Cruikshank WW (1996) Interleukin 16 and its function as a CD4 ligand. Immunol. Today 17: 476-481
47. Zhang Y, Center DM, Wu DM, Cruikshank WW, Juan Y, Andrews DW and Kornfeld H (1998) Processing and activation of pro-interleukin-16 by caspase-3. J. Biol. Chem. 273: 1144-1149
48. Wu DM, Zhang Y, Parada NA, Kornfeld H, Nicoll J, Center DM and Cruikshank WW (1999) Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent. J. Immunol. 162: 1287-1293
49. Akita K, Ohtsuki T, Nukada Y, Tanimoto T, Namba M, Okura T, Takakura-Yamamoto R, Torigoe K, Gu Y, Su MSS, Fujii M, Satoh-Itoh M, Yamamoto K, Kohno K, Ikeda M and Kurimoto M (1997) Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocyticTHP.1 cells. J. Biol. Chem. 272: 26595-26603
50. Janicke RU, Walker PA, Lin XY and Porter AG (1996) Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15: 6969-6978
51. Rudel T and Bokoch GM (1997) Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571-1574
52. Rheaume E, Cohen LY, Uhlmann F, LazureC, Alam A, Hurwitz J, Sekaly RP and Denis F (1997) The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3 like protease during Fas-mediated apoptosis. EMBO J. 16: 6346-6354
53. Beyaert R, Kidd VJ, Cornells S, Van de Craen M, Denecker G, Lahti JM, Gururajan R, Vandenabeele P and Fiers W (1997) Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J. Biol. Chem. 272: 11694-11697
54. Stack JH and Newport JW (1997) Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle. Development 124: 3185-3195
55. Widmann C, Gibson S and Johnson GL (1998) Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J. Biol. Chem. 273: 7141-7147
56. Zenner G, Dirk zur Hausen J, Burn P and Mustelin T (1995) Towards unraveling the complexity of T cell signal transduction. Bioessays 17: 967-975
57. Ellis HM and Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817-829
58. Honda R, Tanaka H and Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420: 25-27
59. Pochampally R, Fodera B, Chen L, Lu W and Chen J (1999) Activation of an MDM2-specific caspase by p53 in the absence of apoptosis. J. Biol. Chem. 274: 15271-15277
60. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P and Flavell RA (1996) Decreased apoptosis in the brain and premature lethality in CP32-deficient mice. Nature 384: 368-372
61. KuidaK, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P and Flavell RA (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337
62. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM and Mak TW (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352
63. Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P and Wallach D (1998) Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9: 267-276
64. Ishizaki Y, Jacobson MD and Raff MC (1998) A role for caspases in lens fiber differentiation. J. Cell. Biol. 140: 153-158
65. Lang RA (1997) Apoptosis in mammalian eye development: lens morphogenesis, vascular regression and immune privilege. Cell Death Differ. 4: 12-20
66. Weiss MJ and Orkin SH (1995) Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92: 9623-9627
67. DeMaria R, Zeuner A, Eramo A, Domenichelli C, Bond D, Grignani F, Srinivasula SM, Alnemri ES, Testa U and Peschle C (1999) Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 401: 489-493
68. De Maria R, Testa U, Luchetti L, Zeuner A, Stassi G, Pelosi E, Riccioni R, Felli N, Samoggia P and Peschle C (1999) Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood 93: 796-803
69. Krantz SB (1991) Erythropoietin. Blood 77: 419-434
70. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ and Orkin SH (1995) Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81: 695-704
71. Vyas P, Ault K, Jackson CW, Orkin SH and Shivdasani R A (1999) Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood 93: 2867-2875
72. Nervi C, Ferrara FF, Fanelli M, Rippo MR, Tomassini B, Ferrucci PF, Ruthard M, Gelmetti V, Gambacorti-Passerini C, Diverio D, Grignani F, Pelicci PG and Testi R (1998) Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein. Blood 92: 2244-2251