The development of CD4+ T effector cells during the type 2 immune response

Immunologic Research

Volumn 20, Issue 1, 1999, Pages 55-65

  Gause, William C ^a   Ekkens, Melinda ^a   Nguyen, Diep ^a   Mitro, Velia ^a   Liu, Qian ^a   Finkelman, Frederick D ^b   Greenwald, Rebecca J ^a   Urban, Joseph F ^c  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

B7; CD28; CD4+ T cell; Costimulation; Cytokines; Immune response; Th2; Type 2

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; EFFECTOR CELL; HELPER CELL; IMMUNE RESPONSE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0032796512     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786507     Document Type: Review

References (66)

1. 1 Medzhitov R, Janeway CAJ: An ancient system of host defense. Curr Opinion Immunol 1998;10:12.
2. 2 Medzhitov R, Janeway CAJ: Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997;91:295.
3. 3 Grieder FB, Davis BK, Zhou XD, Chen SJ, Finkelman FD, Gause WC: Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus. Virology 1997;233:302.
4. 4 Svetic A, Jian YC, Lu P, Finkelman FD, Gause WC: Brucella abortus induces a novel cytokine gene expression characterized by elevated IL-10 and IFN-gamma in CD4+ T cells. Int Immunol 1993;5:877.
5. 5 Svetic A, Madden KB, Zhou XD, Lu P, Katona IM, Finkelman FD, et al.: A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J Immunol 1993;150:3434.
6. 6 Finkelman FD, Holmes J, Katona IM, Urban JF Jr, Beckmann MP, Park LS, et al.: Lymphokine control of in vivo immunoglobulin isotype selection. Ann Rev Immunol 1990;8:303.
7. 7 Deehan MR, Harnett MM, Harnett W: A filarial nematode secreted product differentially modulates expression and activation of protein kinase C isoforms in B lymphocytes. J Immunol 1997;159: 6105.
8. 8 Velupillai P, Harn DA: Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets [see comments]. Proc Natl Acad Sci USA 1994;91:18.
9. 9 Svetic' A, Finkelman FD, Jian YC, Dieffenbach CW, Scott DE, McCarthy KF, et al.: Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J Immunol 1991;147:2391.
10. 10 Toellner KM, Luther SA, Sze DM, Choy RK, Taylor DR, et al.: T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J Exp Med 1998;187:1193.
11. 11 Yoshimoto T, Bendelac A, Watson C, Hu-Li J, Paul WE: Role of NKL1+ T cells in a Th2 response and in immunoglobulin E production. Science 1995;270:1845.
12. 12 Yoshimoto T, Paul WE: CD4pos NKL1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994;179:1285.
13. 13 Brown DR, Fowell DJ, Borry DB, Wynn TA, Moskowitz NH, Cheever AW, et al.: beta2-microglobulin-dependent NKL1 + T cells are not essential for T helper cell 2 immune responses. J Exp Med 1996;184: 1295.
14. 14 Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB. The CD1 family of lipid antigen-presenting molecules [in process citation]. Immunol Today 1998; 19:362.
15. 15 Healy JI, Goodnow CC: Positive versus negative signaling by lymphocyte antigen receptors. Annu Rev Immunol 1998;16:645-70:645.
16. 16 Thompson CB: Distinct roles for the costimulatory lignads B7-1 and B7-2 in T helper cell differentiation. Cell 1995;81:979.
17. 17 Lenschow DJ, Walunas TL, Bluestone JA: CD28/B7 system of T cell costimulation. Ann Rev Immunol 1996;14:233.
18. 18 Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, et al.: Helper T cell differentiation is controlled by the cell cycle [In Process Citation]. Immunity 1998;9:229.
19. 19 Bancroft AJ, Else KJ, Grencis RK: Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response. Eur J Immunol 1994;24:3113.
20. 20 Bretscher PA, Wei G, Menon JN, Bielefeldt-Ohmann H: Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992;257:539.
21. 21 Brown DR, Moskowitz NH, Killeen N, Reiner SL: A role for CD4 in peripheral T cell differentiation. J Exp Med 1997;186:101.
22. 22 Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM: Impaired Th2 subset development in the absence of CD4. Immunity 1997; 6:559.
23. 23 Linsley PS, Wallace PM, Johnson J, Givson MG, Greene JL, Ledbetter JA, et al.: Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 1992;257:792.
24. 24 Corry DB, Reiner SL, Linsley PS, Locksley RM: Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental Leishmaniasis. J Immunol 1994;153:4142.
25. 25 Greenwald R, Lu P, Zhou X-D, Nguyen H, Chen SJ, Perrin PJ, et al.: Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response, J Immunol 1997;158:4088.
26. 26 Lu P, Zhou X, Chen SJ, Moorman M, Morris SC, Finkelman PD, et al.: CTLA-4 ligands are required in an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J Exp Med 1994;180:693.
27. 27 Szabo SJ, Dighe AS, Gubler U, Murphy KM: Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817.
28. 28 Guler ML, Gorham JD, Hsieh CS, Mackey AJ, Steen RG, Dietrich WF, et al.: Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development [see comments]. Science 1996;271:984.
29. 29 O'Garra A: Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998;8:275.
30. 30 Manickasingham SP, Anderton SM, Burkhart C, Wraith DC: Qualitative and quantitative effects of CD28/B7-mediated costimulation on naive T cells in vitro [in process citation]. J Immunol 1998; 161:3827.
31. 31 Leitenberg D, Boutin Y, Constant S, Bottomly K: CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR. J Immunol 1998; 161:1194.
32. 32 Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K: Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med 1995;182:1591.
33. 33 Tao X, Grant C, Constant S, Bottomly K: Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding. J Immunol 1997;158:4237.
34. 34 Constant SL, Bottomly K: Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15:297-322:297.
35. 35 Gause WC, Urban JF, Linsley P, Lu P: Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4 producing T helper cells. Immunol Res 1995;14:176.
36. 36 Subramanian G, Kazura JW, Pearlman E, Jia X, Malhotra I, King CL: B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. J Immunol 1997;158: 5914.
37. 37 Brown JA, Titus RG, Nabavi N, Glimcher LH: Blockade of CD86 ameliorates Leishmania major infection by downregulating the Th2 response. J Infect Dis 1997; 174:1303.
38. 38 Gause WC, Halvorson MJ, Lu P, Greenwald R, Linsley P, Urban JF, et al.: The function of costimulatory molecules and the development of IL-4-producing T cells. Immunol Today 1997;18:115.
39. 39 Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Linsley PS, et al.: CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181:1869.
40. 40 Schweitzer AN, Sharpe AH: Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production [in process citation]. J Immunol 1998;161:2762.
41. 41 Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ: Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 1994;180 (2):631.
42. 42 Inaba K, Witmer-Pack M, Inaba M, Hathcock KS, Sakuta H, Azuma M, et al.: The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 1994; 180:1849.
43. 43 Linsley PS, Greenwald JL, Brady W, Bajorath J, Ledbetter JA, Peach R: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994;1:793.
44. 44 Van der Merwe P, Bodian DL, Daenke S, Linsley P, Davis SJ: CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med 1997;185:393.
45. 45 Ellis JH, Burden MN, Vinogradov DV, Linge C, Crowe JS: Interactions of CD80 and CD86 with CD28 and CTLA4. J Immunol 1996.
46. 46 Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK: Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997;6:411.
47. 47 Fournier S, Rathmell JC, Goodnow CC, Allison JP: T cell-mediated elimination of B7.2 transgenic B cells. Immunity 1997;6:327.
48. 48 June CH, Bluestone JA, Nadler LM, Thompson CB: The B7 and CD28 receptor families. Immunol Today 1993;15:321.
49. 49 Finkelman FD, Urban JF Jr, Beckmann MP, Schooley KA, Holmes JM, Katona IM: Regulation of murine in vivo IgG and IgE responses by a monoclonal anti-IL-4 receptor antibody. Int Immunol 1991;3:599.
50. 50 Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, et al.: Absence of B7-dependent response in CD28-deficient mice. Immunity 1994;1:501.
51. 51 Gause WC, Greenwald R, Halvorson MJ, Lu P, Zhou X-D, Chen S-J, et al.: CD28-dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J Immunol 1997;158:4082.
52. 52 Brown DR, Green JM, Moskowitz NH, Davis M, Thompson CB, Reiner SL: Limited role of CD28-mediated signals in T helper subset differentiation. J Exp Med 1996;184:803.
53. 53 Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al.: Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995;270:932.
54. 54 Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH: Loss of CTLA-4 leads to massive lymphoproliferations and fetal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541.
55. 55 Krummel MF, Allison JP: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation [see comments]. J Exp Med 1995;182:459.
56. 56 Alegre ML, Shiels H, Thompson CB, Gajewski TF: Expression and function of CTLA-4 in Th1 and Th2 cells [in process citation]. J Immunol 1998;161:3347.
57. 57 Wu Y, Guo Y, Huang A, Zheng P, Liu Y: CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J Exp Med 1997; 185:1327.
58. 58 Wu Y, Zhou Q, Zheng P, Liu Y: CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen. J Exp Med 1998;187:1151.
59. 59 Lu P, Zhou X-D, Chen S-J, Moorman M, Schoneveld A, Morris S, Finkelman FD, et al.: Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a systemic in vivo immune response. J Immunol 1995;154:1078.
60. 60 Liu Y, Wenger RH, Zhao M, Nielsen PJ: Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med 1997; 185:251.
61. 61 Steinman RM: Some misconceptions about understanding autoimmunity through experiments with knockouts. J Exp Med 1997; 185:2039.
62. 62 Grewal IS, Flavell RA: CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998;16:111-35:111.
63. 63 Lu P, Urban JF, Zhou X-D, Chen S-J, Morris SC, Finkelman FD, et al.: CD40-mediated costimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production. J Immunol 1996;156:3327.
64. 64 Roos A, Schilder-Tol EJ, Weening JJ, Aten J: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment [in process citation]. J Leukoc Biol 1998;64:503.
65. 65 Flynn S, Toellner KM, Raykundalia C, Goodall M, Lane P: CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med 1998; 188:297.
66. 66 Greenwald RJ, Urban JF, Ekkens MJ, Chen S, Nguyen D, Fang H, Finkelman FD, Sharpe AH, Gause WC: B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite. J Immunol 1999;162:4133-4139.