Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene

Journal of Virology

Volumn 70, Issue 3, 1996, Pages 1873-1881

  Herber, Renee ^a   Liem, Amy ^a   Pitot, Henry ^a   Lambert, Paul F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CARCINOMA; CELL GROWTH; CELL HYPERPLASIA; EPIDERMIS HYPERPLASIA; GENE EXPRESSION; HYPERKERATOSIS; MOUSE; NONHUMAN; ONCOGENE; PAPILLOMA VIRUS; PRIORITY JOURNAL; SQUAMOUS EPITHELIUM; TRANSGENIC MOUSE; VIRUS GENE;

EID: 0030064068     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.3.1873-1881.1996     Document Type: Article

References (52)

1. Arbeit, J. M., K. Munger, P. M. Howley, and D. Hanahan. 1993. Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs Am. J. Pathol. 142:1187-1197.
2. Arbeit, J. M., K. Munger, P. M. Howley, and D. Hanahan. 1994 Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol. 68:4358-4368.
3. Auewarakul, P., L. Gissmann, and A. A. Cid. 1994. Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors. Mol. Cell. Biol. 14:8250-8258.
4. Band, V., J. DeCaprio, L. Delmolino, V. Kulesa, and R. Sager. 1991 Loss of p53 protein in human papillomavirus type 16 E6 immortalized human mammary epithelial cells. J. Virol. 65:6671-6676.
5. Chellappan, S., V. B. Kraus, B. Kroger, K. Munger, P. M. Howley, W. C. Phelps, and J. R. Nevins. 1992. Adenovirus E1A. simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product Proc. Natl. Acad. Sci. USA 89:4549-4553
6. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979 Isolation of biologically active ribonucleic acid from source enriched in ribonuclease. Biochemistry 18:5294-5299.
7. Crook, T., A. Storey, N. Almond, K. Osborn, and L. Crawford. 1988. Human papillomavirus type 16 cooperates with activated ras and ncogenes in the hormone-dependent transformation of primary mouse. Proc Natl Acad Sci USA 85:8820-8824.
8. Crook, T., D. Wrede, J. Tidy, J. Scholefield, L. Crawford, and K. H. Vousden. 1991 Status of c-myc. p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus. Oncogene 6: 1251-1257.
9. DiPaolo, J. A., C. D. Woodworth, N. C. Popeseu, V. Notario, and J. Doniger. 1989. Induction of human cervical squamous cell carcinoma by sequential transaction with human papillomavirus 16 DNA and viral Harvey ras. Oncogene 4:395-399.
10. Drinkwater, N. R., and L. M. Bennett. 1991. Genetic control of carcinogenesis in experimental animals, p. 1-20. In I. N. Sugano (ed.), Modification of tumor development in rodents, vol. 33. Karger, Basel.
11. Durst, M., F. X. Bosch, D. Glitz, A. Schneider, and H. zur Hausen. 1991. Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines. J Virol. 65:796-804.
12. Durst, M., P. R. Dzarlieva, P. Boukamp, N. E. Fusenig, and L. Gissmann. 1987 Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA Oncogene 1:251-256.
13. Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
14. Eckert, R. L. 1989. Structure, function, and differentiation of the keratinocyte Physiol. Rev. 69:1316-1346.
15. Gage, J. R., C. Meyers, and F. O. Wettstein. 1990 The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J Virol. 64:723-730.
16. Greenhalgh, D. A., X. J. Wang, J. A. Rothnagel, J. N. Eckhardt, M. I. Quintanilla, J. L. Barber, D. S. Bundman, M. A. Longley, R. Schlegel, and D. R. Roop. 1994. Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas. Cell Growth Differ. 5:667-675.
17. Griep, A. E., R. Herber, S. Jeon, J. K. Lohse, R. R. Dubielzig, and P. F. Lambert. 1993. Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation. J. Virol. 67:1373-1384
18. Griep, A. E., T. Kuwabara, E. J. Lee, and H. Westphal. 1989. Perturbed development of the mouse lens by polyoma large T antigen: evidence for regulation by an endogenous growth factor. Genes Dev. 3:1075-1085.
19. Griep, A. E., and P. F. Lambert. 1994. Role of papillomavirus oncogenes in human cervical cancer transgenic animal studies. Proc. Soc. Exp Biol. Med. 206:24-34. (Review )
20. Hawley-Nelson, P., K. H. Vousden, N. L. Hubbert, D. R. Lowy, and J. T. Schiller. 1989. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes EMBO J. 8:3905-3910.
21. Hennings, H., A. B. Glick, D. T. Lowry, L. S. Krsmanovic, L. M. Sly, and S. H. Yuspa. 1993 FVB/n mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14:2353-2358
22. Herber, R., and P. F. Lambert. Unpublished results.
23. Hogan, B., F. Costantini, and E. Lacy. 1986. Manipulating the mouse embryo a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
24. Howes, K. A., N. Ransom, D. S. Papermaster, J. G. Lasudry, D. M. Albert, and J. J. Windle. 1994. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev. 8:1300-1310.
25. Hudson, J. B., M. A. Bedell, D. J. McCance, and L. A. Laimmis. 1990. Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18. J. Virol. 64:519-526.
26. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1991. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10:4129-4135
27. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1993. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13:775-784.
28. Jeon, S., and P. F. Lambert. 1995. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl. Acad. Sci. USA 92:1654-1658.
29. Kaur, P., and J. K. McDougall. 1989. HPV-18 immortalization of human keratinocytes. Virology 173:302-310.
30. Kondoh, G., Y. Murata, K. Aozasa, M. Yutsudo, and A. Hakura. 1991. Very high incidence of germ cell tumorigenesis (seminomagenesis) in human papillomavirus type 16 transgenic mice. J. Virol. 65:3335-3339.
31. Lambert, P. F., H. Pan, H. C. Pitot, A. Liem, M. Jackson, and A. E. Griep. 1993 Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice Proc. Natl Acad. Sci USA 90:5583-5587.
32. Liem, A., and P. F. Lambert. Unpublished results
33. Matlashewski, G., J. Schneider, L. Banks, N. Jones, A. Murray, and L. Crawford. 1987. Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells. EMBO J. 6:1741-1746.
34. Morris, G. F., and M. B. Mathews. 1989 Regulation of proliferating cell nuclear antigen during the cell cycle. J. Biol. Chem. 264:13856-13864.
35. Monger, K., W. C. Phelps, V. Bubb, P. M. Howley, and R. Schlegel. 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417-4421.
36. Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley. 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product EMBO J. 8:4099-4105.
37. Pan, H., and A. E. Griep. Unpublished results.
38. Pan, H., and A. E. Griep. 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285-1299.
39. Pan, H., and A. E. Griep. 1995. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development Genes Dev. 9:2157-2169
40. Phelps, W. C., S. Bagchi, J. A. Barnes, P. Raychaudhuri, V. Kraus, K. Munger, P. M. Howley, and J. R. Nevins. 1991. Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J. Virol 65:6922-6930.
41. Phelps, W. C., C. L. Yee, K. Munger, and P. M. Howley. 1988. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A Cell 53:539-547.
42. Pirisi, L., S. Yasumoto, M. Feller, J. Doniger, and J. A. DiPaolo. 1987. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol. 61:1061-1066.
43. Scheffner, M., K. Munger, J. C. Byrne, and P. M. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88:5523-5527.
44. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
45. Schwarz, E., U. K. Freese, L. Gissmann, W. Mayer, B. Roggenbuck, A. Stremlau, and H. zur Hausen. 1985. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells Nature (London) 314: 111-114.
46. Searle, P. F., D. P. Thomas, K. B. Faulkner, and J. M. Tinsley. 1994. Stomach cancer in transgenic mice expressing human papillomavirus type 16 early region genes from a keratin promoter. J. Gen. Virol. 75:1125-1137.
47. Stoler, M. H., S. M. Wolinsky, A. Whitbeck, T. R. Broker, and L. T. Chow. 1989. Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology 172:331-340.
48. Thompson, C. B. 1995 Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
49. Vassar, R., M. Rosenberg, S. Ross, A. Tyner, and E. Fuchs. 1989. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc. Natl. Acad. Sci. USA 86:1563-1567
50. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53 Science 248:76-79.
51. Yee, C., H. I. Krishnan, C. C. Baker, R. Schlegel, and P. M. Howley. 1985. Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am. J. Pathol. 119:361-366.
52. zur Hausen, H., and E. de Villier. 1994. Human papillomaviruses. Annu. Rev. Microbiol. 48:427-147. (Review.)