Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na+-H+ exchange

Cardiovascular Research

Volumn 35, Issue 1, 1997, Pages 80-89

  Garcia Dorado, David ^a   González, Miguel A ^a   Barrabés, José A ^a   Ruiz Meana, Marisol ^a   Solares, Julia ^c   Lidon, Rosa Maria ^a   Blanco, José ^a   Puigfel, Yolanda ^a   Piper, H Michael ^b   Soler Soler, J ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c HOSPITAL SAN PEDRO DE ALCÁNTARA   (Spain)

Author keywords

Functional studies; Hypercontracture; Infarct size; Ischemia; Myocardial infarction; Reperfusion arrhythmias; Reperfusion injury

Indexed keywords

CARIPORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART ARRHYTHMIA; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CONTRACTURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REPERFUSION INJURY; SWINE;

ANIMALS; ARRHYTHMIA; GUANIDINES; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES; SWINE;

EID: 0343488502     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00106-5     Document Type: Article

References (36)

1. Steenbergen C, Murphy E, Watts JA, London RE. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ Res 1990;66:135-146.
2. 2+ in single rat heart cells during anoxia and reoxygenation. Biochem J 1987;244:381-385.
3. Steenbergen C, Murphy E, Levy L, London RE. Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ Res 1987;60:700-707.
4. 2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 1990;22:57-72.
5. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res 1993;27:915-924.
6. Bond JM, Herman B, Lemasters JJ. Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes. Biochem Biophys Res Commun 1991;179:798-803.
7. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787-2798.
8. Meng HP, Maddaford TG, Pierce GN. Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function. Am J Physiol 1993;264:H1831-H1835.
9. + exchanger and reperfusion-induced ventricular arrhythmias in isolated perfused heart: possible role of amiloride. Mol Cell Biochem 1993;119:151-157.
10. Moffat MP, Karmazyn M. Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 1993;25:959-971.
11. Nishida M, Borzak S, Kraemer B, et al. Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion. Am J Physiol 1993;264:H1896-H1906.
12. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72-78.
13. + exchange. Circ Res 1990;66:1156-1159.
14. + exchange inhibitors in cardiac ischemia. J Mol Cell Cardiol 1992;24:731-740.
15. Myers ML, Mathur S, Li GH, Karmazyn M. Sodium-hydrogen exchange inhibitors improve postischemic recovery of function in the perfused rabbit heart. Cardiovasc Res 1995;29:209-214.
16. Bugge E, Ytrehus K. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart - a protective additive to ischemic preconditioning. Cardiovasc Res 1995;29:269-274.
17. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995;92:912-917.
18. Scholz W, Albus U, Counillon L, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995;29:260-268.
19. + exchange. Am J Physiol 1995;268:H1531-H1539.
20. + exchange during metabolic inhibition prevents reoxygenation-induced hypercontracture in isolated cardiomyocytes. Eur Heart J 1996;17:108A(Abstract).
21. Garcia-Dorado D, Théroux P, Duran JM, et al. Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion. Circulation 1992;85:1160-1174.
22. Garcia-Dorado D, Théroux P, Elizaga J, et al. Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res 1987;21:537-544.
23. Barrabés JA, Garcia-Dorado D, Oliveras J, et al. Intimal injury in a transiently occluded coronary artery increases myocardial necrosis. Effect of aspirin. Pflügers Arch (Eur J Physiol) 1996;432:663-670.
24. Kowallik P, Schulz R, Brian D, et al. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 1991;83:974-982.
25. Miyazaki S, Fujiwara H, Onodera T, et al. Quantitative analysis of contraction band and coagulation necrosis after ischemia and reperfusion in the porcine heart. Circulation 1987;75:1074-1082.
26. +-exchanger reduces infarct size in pigs. Eur Heart J 1995;16:337A(Abstract).
27. + exchange in ischemia-reperfusion. Basic Res Cardiol 1996;91:191-202.
28. Murphy E, Perlman M, London RE, Steenbergen C. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ Res 1991;68:1250-1258.
29. Meng HP, Pierce GN. Protective effects of 5-(N, N-dimethyl)amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 1990;258:H1615-H1619.
30. + exchange. Am J Physiol 1993;265:H2017-H2026.
31. + exchange on intracellular sodium and pH in working and ischemic hearts. Magn Reson Med 1994;32:556-564.
32. Fujiwara H, Ashrat H, Sato S, Millard RW. Transmural cellular damage and blood flow distribution in early ischemia in pig hearts. Circ Res 1982;51:683-693.
33. Maxwell MP, Hearse DJ, Yellon DM. Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 1987;10:737-746.
34. Barrabés JA, Garcia-Dorado D, Ruiz-Meana M, et al. Myocardial segment shrinkage during coronary reperfusion in situ. Relation to hypercontracture and myocardial necrosis. Pflügers Arch 1996;431:519-526.
35. Garcia-Dorado D, Théroux P, Esteban E, et al. Role of oxygen restoration in reperfusion-induced arrhythmias: differential effects on ventricular ectopic activity and ventricular fibrillation in the pig. J Appl Cardiol 1991;6:411-420.
36. o-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium. Phase 2 reentry. Circulation 1994;89:1839-1850.