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Volumn 19, Issue 4, 1999, Pages 265-274

Strategy of liver-directed gene therapy: Present status and future prospects

Author keywords

Cell specific gene transfer; Gene switch; Gene therapy; Tissue specific gene transfer; Transcriptional regulation; Transcriptional targeting

Indexed keywords

ANTIVIRUS AGENT;

EID: 0032767241     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.1999.tb00048.x     Document Type: Review
Times cited : (9)

References (83)
  • 1
    • 0026775132 scopus 로고
    • Concepts and strategies for human gene therapy
    • ROEMER K, FRIEDMANN T. Concepts and strategies for human gene therapy. Eur J Biochem 1992; 208: 211-25.
    • (1992) Eur J Biochem , vol.208 , pp. 211-225
    • Roemer, K.1    Friedmann, T.2
  • 2
    • 0028350767 scopus 로고
    • Gene therapy: Applications to the treatment for gastrointestinal and liver diseases
    • CHANG A Y, WU G Y. Gene therapy: applications to the treatment for gastrointestinal and liver diseases. Gastroenterology 1994; 106: 1076-84.
    • (1994) Gastroenterology , vol.106 , pp. 1076-1084
    • Chang, A.Y.1    Wu, G.Y.2
  • 3
    • 0029557063 scopus 로고
    • Liver-directed gene therapy: Molecular tools and recurrent pre-clinical and clinical studies
    • ALT M, CASELMANN W F. Liver-directed gene therapy: molecular tools and recurrent pre-clinical and clinical studies. J Hepatol 1995; 23: 746-58.
    • (1995) J Hepatol , vol.23 , pp. 746-758
    • Alt, M.1    Caselmann, W.F.2
  • 4
    • 0028426914 scopus 로고
    • Liver-directed gene therapy: Prospective and problems
    • STRAUSS M. Liver-directed gene therapy: prospective and problems. Gene Therapy 1994; 1: 156-64.
    • (1994) Gene Therapy , vol.1 , pp. 156-164
    • Strauss, M.1
  • 5
    • 0031014778 scopus 로고    scopus 로고
    • Hepatic drug delivery and gene therapy
    • ZERN M A, KRESINA T F. Hepatic drug delivery and gene therapy. Hepatology 1997; 25: 484-91.
    • (1997) Hepatology , vol.25 , pp. 484-491
    • Zern, M.A.1    Kresina, T.F.2
  • 6
    • 0028875936 scopus 로고
    • Transfer of genes to human: Early lessons and obstacles to success
    • CRYSTAL R G. Transfer of genes to human: early lessons and obstacles to success. Science 1995; 270: 404-10.
    • (1995) Science , vol.270 , pp. 404-410
    • Crystal, R.G.1
  • 7
    • 0032552417 scopus 로고    scopus 로고
    • Liver-directed gene transfer vectors
    • FERRY N, HEARD J M. Liver-directed gene transfer vectors. Hum Gene Ther 1998; 9: 1975-81.
    • (1998) Hum Gene Ther , vol.9 , pp. 1975-1981
    • Ferry, N.1    Heard, J.M.2
  • 9
    • 0028145721 scopus 로고
    • Gene therapy for cancer
    • GORE M E, COLLINS M K. Gene therapy for cancer. Eur J Cancer 1994; 30: 1047-9.
    • (1994) Eur J Cancer , vol.30 , pp. 1047-1049
    • Gore, M.E.1    Collins, M.K.2
  • 10
    • 0029918243 scopus 로고    scopus 로고
    • Genomic targeting and genetic conversion in cancer therapy
    • KMIEC E B. Genomic targeting and genetic conversion in cancer therapy. Semin Oncol 1996; 23: 188-93.
    • (1996) Semin Oncol , vol.23 , pp. 188-193
    • Kmiec, E.B.1
  • 11
    • 0030010148 scopus 로고    scopus 로고
    • Human alpha 1-antitrypsin gene transfer to in vivo mouse hepatocytes
    • ALINO S F, BOBADILLA M, CRESPO J, LEJARRETA M. Human alpha 1-antitrypsin gene transfer to in vivo mouse hepatocytes. Hum Gene Ther 1996; 7: 531-6.
    • (1996) Hum Gene Ther , vol.7 , pp. 531-536
    • Alino, S.F.1    Bobadilla, M.2    Crespo, J.3    Lejarreta, M.4
  • 12
    • 0028899573 scopus 로고
    • Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
    • KAY M A, GRAHAM F, LELAND F, WOO S L C. Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 1995; 21: 815-9.
    • (1995) Hepatology , vol.21 , pp. 815-819
    • Kay, M.A.1    Graham, F.2    Leland, F.3    Woo, S.L.C.4
  • 13
    • 0027686238 scopus 로고
    • In vivo gene therapy of hemophilia B-sustained partial correction in factor IX-deficient dogs
    • KAY M A, ROTHENBERG S, LANDEN C N, et al. In vivo gene therapy of hemophilia B-sustained partial correction in factor IX-deficient dogs. Science 1993; 262: 117-9.
    • (1993) Science , vol.262 , pp. 117-119
    • Kay, M.A.1    Rothenberg, S.2    Landen, C.N.3
  • 14
    • 0031019819 scopus 로고    scopus 로고
    • Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors
    • KOEBERL D D, ALEXANDER L E, HALBERT C L, RUSSELL D W, MILLER A D. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Proc Natl Acad Sci U S A 1997; 94: 1426-31.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 1426-1431
    • Koeberl, D.D.1    Alexander, L.E.2    Halbert, C.L.3    Russell, D.W.4    Miller, A.D.5
  • 15
    • 0030917824 scopus 로고    scopus 로고
    • Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I
    • OVERTURF K, ALDHALIMY M, OU C N, et al. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I. Hum Gene Ther 1997; 8: 513-21.
    • (1997) Hum Gene Ther , vol.8 , pp. 513-521
    • Overturf, K.1    Aldhalimy, M.2    Ou, C.N.3
  • 16
    • 0029875835 scopus 로고    scopus 로고
    • Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type I
    • OVERTURE K, ALDHALIMY M, TANGUAY R, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type I. Nat Genet 1996; 12: 266-73.
    • (1996) Nat Genet , vol.12 , pp. 266-273
    • Overture, K.1    Aldhalimy, M.2    Tanguay, R.3
  • 17
    • 0030042794 scopus 로고    scopus 로고
    • Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors
    • YE X H, ROBINSON M B, BATSHAW M L, FURTH E E, SMITH I, WILSON J M. Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors. J Biol Chem 1996; 271: 3639-46.
    • (1996) J Biol Chem , vol.271 , pp. 3639-3646
    • Ye, X.H.1    Robinson, M.B.2    Batshaw, M.L.3    Furth, E.E.4    Smith, I.5    Wilson, J.M.6
  • 18
    • 0028464358 scopus 로고
    • Gene therapy for phenylketonuria: Phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer
    • FANG B, EISENSMITH R C, LI X H, FINEGOLD M J, WOO S L. Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther 1994; 4: 247-54.
    • (1994) Gene Ther , vol.4 , pp. 247-254
    • Fang, B.1    Eisensmith, R.C.2    Li, X.H.3    Finegold, M.J.4    Woo, S.L.5
  • 19
    • 0031025272 scopus 로고    scopus 로고
    • Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: Correction of genetic deficiency and tumor formation
    • SEPPEN J, TADA K, OTTENHOFF R, SENGUPTA K, CHOWDHURY N R, CHOWDHURY J R. Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation. Hum Gene Ther 1997; 8: 27-35.
    • (1997) Hum Gene Ther , vol.8 , pp. 27-35
    • Seppen, J.1    Tada, K.2    Ottenhoff, R.3    Sengupta, K.4    Chowdhury, N.R.5    Chowdhury, J.R.6
  • 20
    • 0032032633 scopus 로고    scopus 로고
    • Gene therapy with bilirubin UDP-glucuronosyltransferase in the Gunn rat model of Crigler-Najjar syndrome type I
    • QIANHONG L, MURPFREE S S, WILLER S S, BOLLI R, FRENCH B A. Gene therapy with bilirubin UDP-glucuronosyltransferase in the Gunn rat model of Crigler-Najjar syndrome type I. Hum Gene Ther 1998; 9: 497-505.
    • (1998) Hum Gene Ther , vol.9 , pp. 497-505
    • Qianhong, L.1    Murpfree, S.S.2    Willer, S.S.3    Bolli, R.4    French, B.A.5
  • 21
    • 0028292602 scopus 로고
    • Successful ex vivo gene therapy directed to liver in a patient with familiar hypercholesterolaemia
    • GROSSMAN M, RAPER S E, KOZARSKY K, et al. Successful ex vivo gene therapy directed to liver in a patient with familiar hypercholesterolaemia. Nat Genet 1994; 6: 335-41.
    • (1994) Nat Genet , vol.6 , pp. 335-341
    • Grossman, M.1    Raper, S.E.2    Kozarsky, K.3
  • 22
    • 0028793489 scopus 로고
    • A pilot study of ex vivo gene therapy for homozygous familiar hypercholesterolemia
    • GROSSMAN M, RADER D J, MULLER D, et al. A pilot study of ex vivo gene therapy for homozygous familiar hypercholesterolemia. Nat Med 1995; 1: 1148-54.
    • (1995) Nat Med , vol.1 , pp. 1148-1154
    • Grossman, M.1    Rader, D.J.2    Muller, D.3
  • 23
    • 0030852745 scopus 로고    scopus 로고
    • Gene therapy for chronic viral hepatitis: Ribozymes, antisense oligonucleotides, and dominant negative mutants
    • VON WEIZSACKER F, WIELAND S, KOCK J, et al. Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants. Hepatology 1997; 26: 251-5.
    • (1997) Hepatology , vol.26 , pp. 251-255
    • Von Weizsacker, F.1    Wieland, S.2    Kock, J.3
  • 24
    • 0032079483 scopus 로고    scopus 로고
    • Gene therapy for hepatic micrometastasis of murine colon carcinoma
    • SHIRATORI Y, KANAI F, HAMADA H, et al. Gene therapy for hepatic micrometastasis of murine colon carcinoma. J Hepatol 1998; 28: 886-95.
    • (1998) J Hepatol , vol.28 , pp. 886-895
    • Shiratori, Y.1    Kanai, F.2    Hamada, H.3
  • 25
    • 0029859405 scopus 로고    scopus 로고
    • Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
    • CARSO M, PHAM-NGUYEN K, KWONG Y L, et al. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc Natl Acad Sci USA 1996; 93: 11302-6.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11302-11336
    • Carso, M.1    Pham-Nguyen, K.2    Kwong Y, L.3
  • 27
    • 15844416306 scopus 로고    scopus 로고
    • Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex thymidine kinase gene
    • KANAI F, SHIRATORI Y, YOSHIDA Y, et al. Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex thymidine kinase gene. Hepatology 1996; 23: 1359-68.
    • (1996) Hepatology , vol.23 , pp. 1359-1368
    • Kanai, F.1    Shiratori, Y.2    Yoshida, Y.3
  • 28
    • 0028808656 scopus 로고
    • Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression
    • KANEKO S, HALLENBECK P, NAKABAYASHI H, et al. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res 1995; 55: 5283-7.
    • (1995) Cancer Res , vol.55 , pp. 5283-5287
    • Kaneko, S.1    Hallenbeck, P.2    Nakabayashi, H.3
  • 29
    • 0023811723 scopus 로고
    • Receptor-mediated gene delivery and expression in vivo
    • WU G Y, WU C H. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988; 263: 14621-4.
    • (1988) J Biol Chem , vol.263 , pp. 14621-14624
    • Wu, G.Y.1    Wu, C.H.2
  • 30
    • 0028618172 scopus 로고
    • Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers
    • CHIOU H C, TANGCO M V, LEVINE S M, et al. Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers. Nucleic Acids Res 1994; 22: 5439-46.
    • (1994) Nucleic Acids Res , vol.22 , pp. 5439-5446
    • Chiou, H.C.1    Tangco, M.V.2    Levine, S.M.3
  • 31
    • 0029979929 scopus 로고    scopus 로고
    • Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA lactosylated polylysine complex
    • ERBACHER P, ROCHE A C, MONSIGNY M, MIDOUX P. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA lactosylated polylysine complex. Exp Cell Res 1996; 225: 186-94.
    • (1996) Exp Cell Res , vol.225 , pp. 186-194
    • Erbacher, P.1    Roche, A.C.2    Monsigny, M.3    Midoux, P.4
  • 32
    • 0028223310 scopus 로고
    • Gene transfer in vivo-sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake
    • PERALES J C, FERKOL T, BEEGEN H. RATNOFF O D, HANSON R W. Gene transfer in vivo-sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc Natl Acad Sci USA 1994; 92: 4086-90.
    • (1994) Proc Natl Acad Sci USA , vol.92 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 33
    • 0031446338 scopus 로고    scopus 로고
    • In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel non viral vector
    • HARA T, TAN Y, HUANG L. In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel non viral vector. Proc Natl Acad Sci USA 1997; 94: 14547-52.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14547-14552
    • Hara, T.1    Tan, Y.2    Huang, L.3
  • 34
    • 0028939896 scopus 로고
    • Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligand: A stage toward artificial viruses
    • REMY J S, KICHLER A, MORDVINOV V, SCHUBER F, BEHR J P. Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligand: a stage toward artificial viruses. Proc Natl Acad Sci USA 1995; 92: 1744-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1744-1748
    • Remy, J.S.1    Kichler, A.2    Mordvinov, V.3    Schuber, F.4    Behr, J.P.5
  • 35
    • 0028567517 scopus 로고
    • Tissue-specific targeting of retro viral vectors through ligand-receptor interaction
    • KASAHARA N, DOZY A M, KAN Y W. Tissue-specific targeting of retro viral vectors through ligand-receptor interaction. Science 1994; 266: 1373-5.
    • (1994) Science , vol.266 , pp. 1373-1375
    • Kasahara, N.1    Dozy, A.M.2    Kan, Y.W.3
  • 36
    • 0027447460 scopus 로고
    • Hepatic gene therapy -adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes
    • CRISTIANO R J, SMITH L C, WOO S L C. Hepatic gene therapy -adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. Proc Natl Acad Sci USA 1993; 90: 2122-6.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2122-2126
    • Cristiano, R.J.1    Smith, L.C.2    Woo, D.L.C.3
  • 38
    • 0028533695 scopus 로고
    • The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer
    • KASS-EISLER A, FALCK-PEDERSEN E, ELFENBEIN D H, ALVIRA M, BUTTRICK P M, LEINWAND L A. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther 1994; 1: 395-402.
    • (1994) Gene Ther , vol.1 , pp. 395-402
    • Kass-Eisler, A.1    Falck-Pedersen, E.2    Elfenbein, D.H.3    Alvira, M.4    Buttrick, P.M.5    Leinwand, L.A.6
  • 39
    • 0030951645 scopus 로고    scopus 로고
    • Transient immuno-suppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviral vectors
    • ILAN Y, JONA V K, SENGUPTA K, et al. Transient immuno-suppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviral vectors. J Clin Invest 1997; 99: 1098-106.
    • (1997) J Clin Invest , vol.99 , pp. 1098-1106
    • Ilan, Y.1    Jona, V.K.2    Sengupta, K.3
  • 40
    • 0031034030 scopus 로고    scopus 로고
    • Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
    • WORGALL S, WOLFF G, FALCK-PEDERSEN E, CRYSTAL R G. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997; 8: 37-44.
    • (1997) Hum Gene Ther , vol.8 , pp. 37-44
    • Worgall, S.1    Wolff, G.2    Falck-Pedersen, E.3    Crystal, R.G.4
  • 41
    • 0029743163 scopus 로고    scopus 로고
    • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
    • JOOSS K, YANG Y, WILSON J M. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum Gene Ther 1996; 7: 1555-66.
    • (1996) Hum Gene Ther , vol.7 , pp. 1555-1566
    • Jooss, K.1    Yang, Y.2    Wilson, J.M.3
  • 42
    • 0031916435 scopus 로고    scopus 로고
    • Genomic DNA transfer with a high capacity adenovirus vector results in improved in vivo expression and decreased toxicity
    • SCHIEDNER G, MORRAL N, PARKS R J, WU Y, KOOPMANS S C, LANGSTON C. Genomic DNA transfer with a high capacity adenovirus vector results in improved in vivo expression and decreased toxicity. Nature Genet 1998; 18: 180-3.
    • (1998) Nature Genet , vol.18 , pp. 180-183
    • Schiedner, G.1    Morral, N.2    Parks, R.J.3    Wu, Y.4    Koopmans, S.C.5    Langston, C.6
  • 43
    • 0030997346 scopus 로고    scopus 로고
    • Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
    • SNYDER R O, MIAO C H, PATUN G A, SPRATT S K, DANOS O, NAGY D. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet 1997; 16: 270-6.
    • (1997) Nat Genet , vol.16 , pp. 270-276
    • Snyder, R.O.1    Miao, C.H.2    Patun, G.A.3    Spratt, S.K.4    Danos, O.5    Nagy, D.6
  • 44
    • 0029781318 scopus 로고    scopus 로고
    • Naked DNA delivered intraportally expresses efficiently in hepatocytes
    • BUDKER V, ZHANG G, KNECHTLE S, WOLFF J. Naked DNA delivered intraportally expresses efficiently in hepatocytes. Gene Ther 1996; 3: 593-8.
    • (1996) Gene Ther , vol.3 , pp. 593-598
    • Budker, V.1    Zhang, G.2    Knechtle, S.3    Wolff, J.4
  • 45
    • 0030709447 scopus 로고    scopus 로고
    • Expression of naked plasmid DNA injected into afferent and efferent vessels of rodents and dog liver
    • ZHANG G, VARGO D, BUDKER V, ARMSTRONG N, KNECHTLE S, WOLFF J. Expression of naked plasmid DNA injected into afferent and efferent vessels of rodents and dog liver. Hum Gene Ther 1997; 8: 1763-72.
    • (1997) Hum Gene Ther , vol.8 , pp. 1763-1772
    • Zhang, G.1    Vargo, D.2    Budker, V.3    Armstrong, N.4    Knechtle, S.5    Wolff, J.6
  • 46
    • 0025160084 scopus 로고
    • Expression of human factor IX in rabbit hepatocytes by retrovirus mediated gene transfer: Potential for gene therapy to hemophilia B
    • ARMENTANO D, TGHOMPSON A R, DARLINGTON G, WOO S L. Expression of human factor IX in rabbit hepatocytes by retrovirus mediated gene transfer: potential for gene therapy to hemophilia B. Proc Natl Acad Sci USA 1990; 87: 6141-5.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6141-6145
    • Armentano, D.1    Tghompson, A.R.2    Darlington, G.3    Woo, S.L.4
  • 47
    • 0031055741 scopus 로고    scopus 로고
    • Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy
    • LE M, OKUYAMA T, CAI S R, KENNEDY S C, BOWLING W M, FLYE M W, PONDER K P. Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy. Blood 1997; 89: 1254-9.
    • (1997) Blood , vol.89 , pp. 1254-1259
    • Le, M.1    Okuyama, T.2    Cai, S.R.3    Kennedy, S.C.4    Bowling, W.M.5    Flye, M.W.6    Ponder, K.P.7
  • 48
    • 0027133660 scopus 로고
    • Hepatic gene therapy: Efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex
    • CRISTIANO R J, DSMITH L C, KAY M A, BRINKLEY B R, WOO S L C. Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proc Natl Acad Sci USA 1993; 90: 11548-52.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11548-11552
    • Cristiano, R.J.1    Dsmith, L.C.2    Kay, M.A.3    Brinkley, B.R.4    Woo, S.L.C.5
  • 49
    • 0030996011 scopus 로고    scopus 로고
    • Progress in transcriptionally targeted and regulatable vectors for genetic therapy
    • MILLER N, WHELAN J. Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum Gene Ther 1997; 8: 803-15.
    • (1997) Hum Gene Ther , vol.8 , pp. 803-815
    • Miller, N.1    Whelan, J.2
  • 50
    • 0028890311 scopus 로고
    • Codelivery to mammalian cells of a transcriptional factor with cis-acting element using cationic liposomes
    • FARHOOD H, GAO X, BARSOUM J, HUANG L. Codelivery to mammalian cells of a transcriptional factor with cis-acting element using cationic liposomes. Anal Biochem 1995; 225: 89-93.
    • (1995) Anal Biochem , vol.225 , pp. 89-93
    • Farhood, H.1    Gao, X.2    Barsoum, J.3    Huang, L.4
  • 51
    • 0028961480 scopus 로고
    • Transcriptional regulation of the carcinoembryonic antigen gene
    • HAUCK W, STANNERS C P. Transcriptional regulation of the carcinoembryonic antigen gene. J Biol Chem 1995; 270: 3602-10.
    • (1995) J Biol Chem , vol.270 , pp. 3602-3610
    • Hauck, W.1    Stanners, C.P.2
  • 52
    • 0029809551 scopus 로고    scopus 로고
    • Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adenovirus vectors
    • LAN K H, KANAI F, SHIARTORI Y, OKABE S, YOSHIDA Y, WAKIMOTO H. Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adenovirus vectors. Gastroenterology 1996; 111: 1241-51.
    • (1996) Gastroenterology , vol.111 , pp. 1241-1251
    • Lan, K.H.1    Kanai, F.2    Shiartori, Y.3    Okabe, S.4    Yoshida, Y.5    Wakimoto, H.6
  • 53
    • 0031584726 scopus 로고    scopus 로고
    • Adenovirus mediated gene therapy of gastric carcinoma using cancer specific gene expression in vivo
    • TANAKA T, KANAI F, LAN K H, OHASHI M, SHIRATORI Y, YOSHIDA Y. Adenovirus mediated gene therapy of gastric carcinoma using cancer specific gene expression in vivo. Biochem Biophys Res Commun 1997; 231: 775-9.
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 775-779
    • Tanaka, T.1    Kanai, F.2    Lan, K.H.3    Ohashi, M.4    Shiratori, Y.5    Yoshida, Y.6
  • 54
    • 0030767678 scopus 로고    scopus 로고
    • In vivo selective gene expression and therapy mediated by adenoviral vector for human carcinoembryonic antigen-producing gastric carcinoma
    • LAN K H, KANAI F, SHIRATORI Y, et al. In vivo selective gene expression and therapy mediated by adenoviral vector for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res 1997; 57: 4279-84.
    • (1997) Cancer Res , vol.57 , pp. 4279-4284
    • Lan, K.H.1    Kanai, F.2    Shiratori, Y.3
  • 55
    • 15144346189 scopus 로고    scopus 로고
    • In-vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer
    • OHASHI M, KANAI F, TANAKA T, LAN KH, SHIRATORI Y, KOMATSU Y. In-vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer. Jpn J Cancer Res 1998; 89: 457-62.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 457-462
    • Ohashi, M.1    Kanai, F.2    Tanaka, T.3    Lan, K.H.4    Shiratori, Y.5    Komatsu, Y.6
  • 56
    • 0032080867 scopus 로고    scopus 로고
    • Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil
    • KANAI F, KAWAKAMI T, HAMADA H, et al. Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil. Cancer Res 1998; 58: 1946-51.
    • (1998) Cancer Res , vol.58 , pp. 1946-1951
    • Kanai, F.1    Kawakami, T.2    Hamada, H.3
  • 57
    • 0028990234 scopus 로고
    • Human von willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice
    • AIRD W C, JAHROUDI N, WEILER-GUETTLER H, RAY-BURN H B, ROSENBERG R D. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci U S A 1995; 92: 4567-71.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4567-4571
    • Aird, W.C.1    Jahroudi, N.2    Weiler-Guettler, H.3    Ray-Burn, H.B.4    Rosenberg, R.D.5
  • 58
    • 0029743162 scopus 로고    scopus 로고
    • Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC
    • OZAKI K, YOSHIDA T, IDE H, et al. Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC. Hum Gene Ther 1996; 7: 1483-90.
    • (1996) Hum Gene Ther , vol.7 , pp. 1483-1490
    • Ozaki, K.1    Yoshida, T.2    Ide, H.3
  • 59
    • 0028918281 scopus 로고
    • Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin promoter
    • HARATS D, KURIHARA H, BELLONI P, et al. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin promoter. J Clin Invest 1995; 95: 1335-44.
    • (1995) J Clin Invest , vol.95 , pp. 1335-1344
    • Harats, D.1    Kurihara, H.2    Belloni, P.3
  • 60
    • 0028880451 scopus 로고
    • A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-speciflc gene expression
    • MORISHITA K, JOHNSON D E, WILLIAMS L T. A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-speciflc gene expression. J Biol Chem 1995; 270: 27948-53.
    • (1995) J Biol Chem , vol.270 , pp. 27948-27953
    • Morishita, K.1    Johnson, D.E.2    Williams, L.T.3
  • 61
    • 0032505742 scopus 로고    scopus 로고
    • Genetically engineered antibodies in gene transfer and gene therapy
    • PELEGRIN M, MARIN M, NOEL D, PIECHACZYK M. Genetically engineered antibodies in gene transfer and gene therapy. Hum Gene Ther 1998; 9: 2165-75.
    • (1998) Hum Gene Ther , vol.9 , pp. 2165-2175
    • Pelegrin, M.1    Marin, M.2    Noel, D.3    Piechaczyk, M.4
  • 63
    • 0029794681 scopus 로고    scopus 로고
    • Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies
    • WICHAM T J, SEGAL D M, ROELVINK P W, et al. Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies. J Virol 1996; 70: 6831-8.
    • (1996) J Virol , vol.70 , pp. 6831-6838
    • Wicham, T.J.1    Segal, D.M.2    Roelvink, P.W.3
  • 65
    • 0029021083 scopus 로고
    • A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
    • SHOKETT P, DIFILIPPANTONIO M, HELLMAN N, SCHATZ D G. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA 1995; 92: 6522-6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6522-6526
    • Shokett, P.1    Difilippantonio, M.2    Hellman, N.3    Schatz, D.G.4
  • 66
    • 0028071115 scopus 로고
    • Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
    • FURTH P A, ONGE L, BOGER H, et al. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA 1994; 91: 9302-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9302-9306
    • Furth, P.A.1    Onge, L.2    Boger, H.3
  • 67
    • 0029075822 scopus 로고
    • Co-regulation of two gene activities by tetracycline via a bidirectional promoter
    • BARON U, FREUDLIEB S, GOSSEN M, BUJARD H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res 1995; 23: 3605-6.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3605-3606
    • Baron, U.1    Freudlieb, S.2    Gossen, M.3    Bujard, H.4
  • 68
    • 0032078192 scopus 로고    scopus 로고
    • Tet-on: A gene switch for exogenous regulation of transgene expression
    • Commentary
    • PAILLARD F. "Tet-on": A gene switch for exogenous regulation of transgene expression. Commentary. Hum Gene Ther 1998; 9: 983-5.
    • (1998) Hum Gene Ther , vol.9 , pp. 983-985
    • Paillard, F.1
  • 69
    • 0344648683 scopus 로고
    • The role of hepatic sinusoidal cells in liver disease
    • BIOULAC-SAGE P, BALABAUD C, eds. The role of hepatic sinusoidal cells in liver disease. Seminars in Liver Disease 1993; 13: 1-100.
    • (1993) Seminars in Liver Disease , vol.13 , pp. 1-100
    • Bioulac-Sage, P.1    Balabaud, C.2
  • 70
    • 0031930768 scopus 로고    scopus 로고
    • Signal transduction in hepatic stellate cells
    • PINZANI M, MARRA F, CARLONI V. Signal transduction in hepatic stellate cells. Liver 1998; 18: 2-13.
    • (1998) Liver , vol.18 , pp. 2-13
    • Pinzani, M.1    Marra, F.2    Carloni, V.3
  • 71
    • 0026762471 scopus 로고
    • Inhibition of hepatic metastasis of colon carcinoma by asialo GM1-positive cells in the liver
    • SHIRATORI Y, NAKATA R, OKANO K, et al. Inhibition of hepatic metastasis of colon carcinoma by asialo GM1-positive cells in the liver. Hepatology 1992; 16: 469-78.
    • (1992) Hepatology , vol.16 , pp. 469-478
    • Shiratori, Y.1    Nakata, R.2    Okano, K.3
  • 72
    • 0345079361 scopus 로고    scopus 로고
    • Gene therapy for hepatic micrometastasis of colon carcinoma
    • Wisse E, Knook D L, Balabaud C, eds. Kupffer cell foundation, Leiden
    • SHIRATORI Y, KANAI F, HAMADA H, MORIYAMA H, HIKIBA Y, OTSUKA T. Gene therapy for hepatic micrometastasis of colon carcinoma. In: Wisse E, Knook D L, Balabaud C, eds. Cells of the hepatic sinusoid. vol. 6, Kupffer cell foundation, Leiden, 1997: 418-21.
    • (1997) Cells of the Hepatic Sinusoid , vol.6 , pp. 418-421
    • Shiratori, Y.1    Kanai, F.2    Hamada, H.3    Moriyama, H.4    Hikiba, Y.5    Otsuka, T.6
  • 73
    • 0025000864 scopus 로고
    • Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • GANSBACHER B, ZIER K, DANIELS B, CRONIN K, BANNERJI R, GILBOA E. Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 1990; 72: 1217-24.
    • (1990) J Exp Med , vol.72 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3    Cronin, K.4    Bannerji, R.5    Gilboa, E.6
  • 74
    • 0027239503 scopus 로고
    • Antitumor and antimetastatic activity of interleukin 12 against murine tumors
    • BRUNDA M J, LUISTRO L, WARRIER R R, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993; 178: 1223-30.
    • (1993) J Exp Med , vol.178 , pp. 1223-1230
    • Brunda, M.J.1    Luistro, L.2    Warrier, R.R.3
  • 75
    • 0028153727 scopus 로고
    • Augmentation of antitumor immunity by tumor cells transducted with a retroviral vector carrying the interleukin-2 and interferon-gamma cDNA
    • ROSENTHAL F M, CRONIN K, BANNERIJI R, GOLDE D W, GANSBACHER B. Augmentation of antitumor immunity by tumor cells transducted with a retroviral vector carrying the interleukin-2 and interferon-gamma cDNA. Blood 1994; 38: 1289-98.
    • (1994) Blood , vol.38 , pp. 1289-1298
    • Rosenthal, F.M.1    Cronin, K.2    Banneriji, R.3    Golde, D.W.4    Gansbacher, B.5
  • 76
    • 0030066799 scopus 로고    scopus 로고
    • Interleukin 12 promotes the curative effect of a vaccine based on interleukin 2-transducted tumor cells
    • VAGLIANI M, RODOFO M, CAVALLO F, PARENZA M, MELANI C, PARMIANI G. Interleukin 12 promotes the curative effect of a vaccine based on interleukin 2-transducted tumor cells. Cancer Res 1996; 56: 467-70.
    • (1996) Cancer Res , vol.56 , pp. 467-470
    • Vagliani, M.1    Rodofo, M.2    Cavallo, F.3    Parenza, M.4    Melani, C.5    Parmiani, G.6
  • 77
    • 0030057511 scopus 로고    scopus 로고
    • Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12
    • BRAMSON J, HITT M, GALLICHAN W S, ROSENTHAL K L, GAULDIE J, GRAHAM F L. Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: in vitro and in vivo production of biologically active interleukin-12. Hum Gene Therapy 1996; 7: 333-42.
    • (1996) Hum Gene Therapy , vol.7 , pp. 333-342
    • Bramson, J.1    Hitt, M.2    Gallichan, W.S.3    Rosenthal, K.L.4    Gauldie, J.5    Graham, F.L.6
  • 78
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • MILLAUER B, SHAWVER L K, PLATE K H, RISAU W, ULLRICH A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 1994; 367: 576-9.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 79
    • 0028912119 scopus 로고
    • Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy
    • FAN T P, JAGGAR R, BICKNELL R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci 1995; 16: 57-66.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 57-66
    • Fan, T.P.1    Jaggar, R.2    Bicknell, R.3
  • 80
    • 0030029271 scopus 로고    scopus 로고
    • Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence
    • SALEH M, STACHER S A, WILKS A F. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res 1996; 56: 393-401.
    • (1996) Cancer Res , vol.56 , pp. 393-401
    • Saleh, M.1    Stacher, S.A.2    Wilks, A.F.3
  • 81
    • 16844387567 scopus 로고    scopus 로고
    • Preclinical studies for cell transplantation: Isolation of primate fetal hepatocytes, their cryopreservation, and efficient retroviral transducticn
    • ANDREOLETTI M, PAGES J C, MAHIEU D, LOUX N, FARGE D, SACQUIN P. Preclinical studies for cell transplantation: isolation of primate fetal hepatocytes, their cryopreservation, and efficient retroviral transducticn. Hum Gene Ther 1997; 8: 267-74.
    • (1997) Hum Gene Ther , vol.8 , pp. 267-274
    • Andreoletti, M.1    Pages, J.C.2    Mahieu, D.3    Loux, N.4    Farge, D.5    Sacquin, P.6
  • 83
    • 0028354154 scopus 로고
    • Characterization and enrichment of fetal rat hepatoblasts by immunoadsorbtion and fluorescence-activated cell sorting
    • SIGNAL S H, BRILL S, REID L M, Characterization and enrichment of fetal rat hepatoblasts by immunoadsorbtion and fluorescence-activated cell sorting. Hepatology 1994; 19: 999-1006.
    • (1994) Hepatology , vol.19 , pp. 999-1006
    • Signal, S.H.1    Brill, S.2    Reid, L.M.3


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