Binding of CD4 ligands induces tyrosine phosphorylation of phosphatidylinositol-3 kinase p110 subunit

International Immunology

Volumn 10, Issue 12, 1998, Pages 1897-1905

  Mazerolles, Fabienne ^a   Fischer, Alain ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

CD4; p110; p56(lck); Phosphatidylinositol 3 kinase; Tyrosine phosphorylation

Indexed keywords

CD4 ANTIGEN; HLA ANTIGEN CLASS 2; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; B LYMPHOCYTE; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0031649538     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.12.1897     Document Type: Article

References (33)

1. + T cell activation. Int. Immunol. 8:267.
2. Nag, B., Wada, H. G., Passmore, D., Clartk, B. R., Sharma, S. D. and McConnell, H. 1993. Purified β-chain of MHC class II binds to CD4 molecules on transfected HeLa cells. J. Immunol. 150:1358.
3. Mazerolles, F., Amblard, F, Lumbroso, C., Lecomte, P, Van De Moortele, O., Barbat, C., Piatier-Tonneau, D., Auffray, C. and Fischer, A. 1990. Regulation of T helper-B lymphocyte adhesion through CD4-HLA class II interaction. Eur J. Immunol. 20:637.
4. lck tyrosine kinase. J. Immunol. 152:5670.
5. lck/CD4 dependent down-regulation of LFA-1 mediated T cell adhesion. J. Immunol. 157:4844.
6. Luo, K. and Sefton, B. M. 1990. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the Lck tyrosine protein kinase at the autophosphorylation cell. Mol. Cell. Biol. 10:5305.
7. lck) that phosphorylates the CD3 complex. Proc. Natl Acad. Sci. USA 86:3277
8. Sleckman, B. P., Peterson, A., Foran, J. A . Gorga, J. C., Karec, C. J., Strominger, J. L., Burakoff, S. J. and Greestein, J. L. 1988. Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule. J. Immunol. 141:49.
9. lck. Nature 338:257.
10. Veillette, A., Bolen, J. B. and Bookman, M A. 1989b. Alterations in tyrosine phosphorylation induced by antibody-mediated crosslinking of the CD4 receptor of T lymphocytes. Mol. Cell. Biol. 9:4441.
11. lck. J. Biol. Chem. 269:19435.
12. lck tyrosine kinase. Eur. J. Immunol. 24:234.
13. lck SH3 domain binds to PI3-kinase but not PI4-kinase. Mol. Cell. biol. 13:7708.
14. Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayatou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, S, A., Courtneidge, S., Parker, P. J. and Waterfield, M. J. 1992. Phosphatidylinositol 3-kinase: structure and expression of the p110 kd catalytic subunit. Cell 70:419.
15. Escobedo, J. A., Navankasattusas, S., Kavanaugh, W. M., Milfay, D., Fried, A. V. and Williams, L. T. 1991. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGFβ receptor. Cell 65:75.
16. Whitman, M., Downes, C. P., Keeler, M., Keller, T. and Cantley, L. 1988. Type I phosphatidyl kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644.
17. Coughlin, S. R., Escobedo, J. A. and Williams, L. 1989. Role of Phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243:1119.
18. Pages, F., Ragueneau, M., Rottapel, R., Truneh, A., Nunes, J., Imbert, J. and Olive, D. 1994. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T cell signalling. Nature 369:327.
19. Merida, I., Diez, E. and Gaulton, G. N. 1991. IL-2 binding activates a tyrosine phosphorylated Phosphatidylinositol 3-kinase. J. Immunol. 147:2202.
20. Hayashi, H., Nishioka, Y, Kamahora, S., Kanai, F., Ishii, K., Fukui, Y., Shibasaki, F., Takenawa,T, Kido, H., Katsunuma, N. and Ebina, Y 1993. The alpha-type 85-kDa subunit of phosphatidylinositol-3-kinase is phosphorylated at tyrosine 368, tyrosine 580 and tyrosine 607 by the insulin receptor. J. Biol. Chem. 268:7107.
21. Kavanaugh, W. M., Turck, C., W. Klippel, A. and Williams, L. T. 1994. Tyrosine-508 of the 85 kDa subunit of phosphatidylinositol-3 kinase is phosphorylated by the platelet-derived growth-factor receptor. Biochemistry 33:11046.
22. lck mediates both intermolecular and intramolecular interactions. Proc. Natl Acad. Sci. USA 90:10285.
23. Liu, X., Marengere, L. E. M., Koch, C A. and Pawson, T. 1993. The v-src SH3 domain binds phosphatidylinositol-3 kinase. Mol. Cell. Biol. 13:5225.
24. lck is involved in binding to phosphatidylinositol-3′ kinase. Mol. Cell. Biol. 13:7408.
25. Backer, J. M., Myers, M. G., Shoelson, S. E., Chin, D. J., Sun, X. J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., Schlessinger, J. and White, M. 1992. Phosphatidylinositol-3′-kinase is activated by association with IRS1 during insulin stimulation. EMBO J. 11:3469.
26. Shimizu, Y, Mobley, J. L., Finkelstein, L. D. and Chan, A. 1995. A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen. J. Cell. Biol. 131:1867.
27. Cammarota, G., Scheirle, A., Takacs, B., Doran, D. M., Knorr, R., Bannwarth, W., Guardiola, J. and Sinigaglia. F. 1992 Identification of a CD4 binding site on the β2 domain of HLA-DR molecules. Nature 356:799.
28. Thompson, P. A., Gutkind, J. S., Robbins, K. C., Ledbetter, J. A. and Bolen, J. B, 1992. Identification of distinct populations of PI3-kinase activity following T-cell activation. Oncogene 7:719.
29. Ruiz-Larrea, F. vicendo, P., Yaish, P., End, P., Pannayotou, G., Fry, H. J., Morgan, S. J., Thompson, A., Parker, P. J. and Waterfield, M. D. 1993. Characterization of the bovine brain cytosolic phosphatidylinositol-3 kinase complex. Biochem. J 290:609.
30. Cohen, B., Yoachim, M., Piwnica-Worms, H., Roberts, T. M. and Schaffhausen, B. S. 1990. Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85 KDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. Proc. Natl Acad. Sci. USA 87:4458.
31. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H. and Seed, B. 1996. αLβ2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86:233.
32. Franke, T., Yang, S., Chan, T., Datta, K., Kazlauskas, A., Morrison, D., Kaplan, D. and Tsichlis, P. 1995. The protein kinase encoded the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol-3 kinase. Cell 81:1.
33. Nagel, W., Zeitlmann, L., Schilcher, P, Geiger, C., Kolanus, J. and Kolanus, W. 1998. Phosphoinositide 3-OH kinase activates the b2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1 J. Biol. Chem. 273:14853.