Allelic variation in transcription modulates MHC class II expression and function

Microbes and Infection

Volumn 1, Issue 11, 1999, Pages 919-927

  Beaty, Jon S ^a,b   Sukiennicki, Teresa L ^a,b   Nepom, Gerald T ^a,b  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLELISM; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0032742405     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(99)00225-7     Document Type: Article

References (44)

1. Andersen L.C., Beaty J.S., Nettles J.W., Seyfried C.E., Nepom G.T., Nepom B.S. Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes. J. Exp. M. 173:1991;181-192.
2. Baumgart M., Moos V., Schuhbauer D., Müller B. Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc. Natl. Acad. Sci. USA. 95:1998;6936-6940.
3. Beaty J.S., Nepom G.T. Allele-specific transcriptional control of HLA-DQB1 is cell-type dependent. Charron D. Genetic Diversity of HLA: Functional and Medical Implications. 1996;307-309 K, Sevres, France.
4. Beaty J.S., West K.A., Nepom G.T. Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol. Cell. Biol. 15:1995;4771-4782.
5. Boss J.M. Regulation of transcription of MHC class II genes. Curr. Opin. Immunol. 9:1997;107-113.
6. Clausen B.E., Waldburger J.M., Schwenk F., Barras E., Mach B., Rajewsky K., Forster I., Reith W. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity. 8:1998;143-155.
7. Cogswell J.P., Zeleznik-Le N., Ting J.P.Y. Transcriptional regulation of the HLA-DRA gene. Crit. Rev. Immunol. 11:1991;87-112.
8. Crowe P.D., Boehme S.A., Wong T., Gaur A., Sidney J., Sette A., Conlon P.J. Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells. Hum. Immunol. 59:1998;679-689.
9. De Waal Malefyt R., Haanen J., Spits H., Roncarolo M.G., Te Velde A., Figdor C., Johnson K., Kastelein R., Yssel H., DeVries J.E. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. M. 174:1991;915-924.
10. Dimolfetto L., Neal H.A., Wu A., Reilly C., Lo D. The density of the class II MHC T cell receptor ligand influences IFN-γ/IL-4 ratios in immune responses in vivo. Cell. Immunol. 183:1998;70-79.
11. Douhan III J., Lieberson R., Knoll J.H.M., Zhou H., Glimcher L.H. An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator. J. Exp. M. 185:1997;1885-1895.
12. Dyer R.B., Herzog N.K. Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. BioTechniques. 19:1995;192-195.
13. + thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity. 6:1997;401-410.
14. Hanson M.S., Cetkovic-Cvrlje M., Ramiya V.K., Atkinson M.A., Maclaren N.K., Singh B., Elliott J.F., Serreze D.V., Leiter E.H. Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J. Immunol. 157:1996;1279-1287.
15. Hasegawa S.L., Boss J.M. Two B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters. Nucl. Acids Res. 19:1991;6269-6276.
16. Hesse M., Bayrak S., Mitchison A. Protective major histocompatibility complex genes and the role of interleukin-4 in collagen-induced arthritis. Eur. J. Immunol. 26:1996;3234-3237.
17. Hsu B.L., Evavold B.D., Allen P.M. Modulation of T cell development by an endogenous altered peptide ligand. J. Exp. M. 181:1995;805-810.
18. Janitz M., Mitchison A., Reiners-Schramm L., Lauster R. Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines. Tissue Antigens. 49:1997;99-106.
19. Kobr M., Reith W., Herrero-Sanchez C., Mach B. Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family. Mol. Cell. Biol. 10:1990;965-971.
20. Leech N., Sorrentino R., McCulloch D.K., Nepom G.T. Ultrastructural allelic variation in HLA-DQB1 promoter elements. Human Immunol. 43:1995;251-258.
21. Louis-Plence P., Moreno C.S., Boss J.M. Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory regions of HLA class II genes. J. Immunol. 159:1997;3899-3909.
22. Mach B., Steimle V., Martinez-Soria E., Reith W. Regulation of MHC class II genes: Lessons from a disease. Annu. Rev. Immunol. 14:1996;301-331.
23. Mahanta S.K., Scholl T., Yang F.C., Strominger J.L. Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA. 94:1997;6324-6329.
24. Morzycka-Wroblewska E., Harwood J.I., Smith J.R., Kagnoff M.F. Structure and evolution of the promoter regions of the DQA genes. Immunogenetics. 37:1993;364-372.
25. Morzycka-Wroblewska E., Munshi A., Ostermayer M., Harwood J.I., Kagnoff M.F. Differential expression of HLA-DQA1 alleles associated with promoter polymorphism. Immunogenetics. 45:1997;163-170.
26. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:1989;145-173.
27. Muhlethaler-Mottet A., Otten L.A., Steimle V., Mach B. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:1997;2851-2860.
28. Nepom G.T., Chung J.S., West K.A. Differential expression of HLA-DQB1 alleles in a heterozygous cell line. Immunogenetics. 42:1995;143-148.
29. Nepom G.T., Kwok W.W. Molecular basis for HLA-DQ associations with IDDM. Diabetes. 47:1998;1177-1184.
30. Nickoloff B.J., Turka L.A. Immunological functions of nonprofessional antigen-presenting cells: new insight from studies of T-cell interactions with keratinocytes. Immunol. Today. 15:1994;464-469.
31. Ono S.J., Song Z. Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box. J. Biol. Chem. 270:1995;6396-6402.
32. Otten L.A., Steimle V., Bontron S., Mach B. Quantitative control of MHC class II expression by the transactivator CIITA. Eur. J. Immunol. 28:1998;473-478.
33. Ploski R., Ek J., Thorsby E., Sollid L.M. On the HLA-DQ α1*0501, β1*0201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB1*0201. Tissue Antigens. 41:1993;173-177.
34. Reichstetter S., Krellner P.H., Meenzen C.M., Kalden J.R., Wassmuth R. Comparative analysis of sequence variability in the upstream regulatory region of the HLA-DQB1 gene. Immunogenetics. 39:1994;207-212.
35. Riley J.L., Westerheide S.D., Price J.A., Brown J.A., Boss J.M. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity. 2:1995;533-543.
36. Schmidt D., Verdaguer J., Averill N., Santamaria P. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. M. 186:1997;1059-1075.
37. Scholl T., Stevens M.B., Mahanta S., Strominger J.L. A zinc finger protein that represses transcription of the human MHC class II gene, DPA. J. Immunol. 156:1996;1448-1457.
38. Singal D.P., Qiu X., D'Souza M., Sood S.K. Polymorphism in the upstream regulatory regions of HLA-DRB genes. Immunogenetics. 37:1993;143-147.
39. Steimle V., Otten L.A., Zufferey M., Mach B. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell. 75:1993;135-146.
40. Valitutti S., Muller S., Dessing M., Lanzavecchia A. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. M. 183:1996;1917-1921.
41. Vilen B.J., Penta J.F., Ting J.P.Y. Structural constraints within a trimeric transcriptional regulatory region: Constitutive and interferon-γ inducible expression of the HLA-DRA gene. J. Biol. Chem. 267:1992;23728-23734.
42. Vincent R., Louis P., Gongora C., Papa I., Clot J., Eliaou J.F. Quantitative analysis of the expression of the HLA-DRB genes at the transcriptional level by competitive polymerase chain reaction. J. Immunol. 156:1996;603-610.
43. Walowitz J.L., Bradley M.E., Chen S., Lee T. Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression. J. Biol. Chem. 273:1998;6656-6661.
44. Woolfrey A.E., Andersen L.C., Shewey L., Chung J.S., Nepom G.T. Analysis of differential HLA-DQB expression in autologous B cell lines. J. Leuk. Biol. 53:1993;697-706.