Nutrition and immunity in the elderly

Proceedings of the Nutrition Society

Volumn 58, Issue 3, 1999, Pages 685-695

  Lesourd, Bruno ^a   Mazari, Lynda ^a  

^a HÔPITAL CHARLES FOIX   (France)

Author keywords

Ageing; Immune system; Infection; Nutritional status

Indexed keywords

CD5 ANTIGEN; INTERLEUKIN 2;

ADULT; AGED; AGING; CANCER SUSCEPTIBILITY; CONFERENCE PAPER; CYTOKINE PRODUCTION; FITNESS; HELPER CELL; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; INFECTION; NUTRITIONAL STATUS; T LYMPHOCYTE;

EID: 0032732348     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665199000907     Document Type: Conference Paper

References (105)

1. Abo T (1992) Extrathymic differentiation of T lymphocytes and its biological function. Biology in Medical Research 13, 1-39.
2. Alès-Martinez JE, Alvarez-Mon M, Merino F, Bonilla F, Martinez C, Durantez A & De La Hera A (1988) Decreased TcR-CD3-T cell numbers in healthy aged humans. Evidence that T cell defects are masked by a reciprocal increase of TcR-CD3- CD2+ natural killer cells. European Journal of Immunology 18, 1827-1830.
3. Amorin-Cruz JA, Moreiras O & Brzozowska A (1996) Longitudinal changes in the intakes of vitamins and minerals of elderly Europeans. European Journal of Clinical Nutrition 50, Suppl. 2, S77-S85.
4. Arreaza EE, Gibbons JJ, Sisking GW & Weksler ME (1993) Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotype antibody in old compared with young humans. Clinical and Experimental Immunology 92, 169-176.
5. Barrat F, Lesourd BM, Louise A, Boulouis HJ, Vincent-Naulleau S, Thibault D, Neway T, Sanaa M & Pilet Ch. (1997) Surface antigens expression in spleen cells of C57 B1/6 mice during aging: influence of sex and breeding. Clinical and Experimental Immunology 107, 593-600.
6. Batory G, Janeso A, Puskas E, Redei A & Lengyei E (1984) Antibody and immunoglobulin levels in aged humans. Archives of Gerontology and Geriatrics 3, 175-188.
7. Ben-Yehuda A, Szabo P & Weksler ME (1994) Age associated changes in the B-cell: effect of age on RAG-1 gene expression in murine bone marrow. Immunology Letters 40, 287-290.
8. Bogden JD, Oleske JM, Lavenhar MA, Munves EM, Kemp FW, Bruening KS, Holding KJ, Denny TN, Guarino MA & Holland BK (1990) Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. Journal of the American College of Nutrition 9, 214-225.
9. Bogden JD, Bendich A, Kemp FW, Bruening KS, Shurrick JH, Denny T, Baker H & Louria DB (1994) Daily micronutrient supplements enhanced delayed-hypersensitivity skin test responses in older people. American Journal of Clinical Nutrition 60, 437-447.
10. Boukaïba N, Flament C, Acher S, Chappuis Ph, Pian A, Fusselier M, Dardenne M & Lemonnier D (1993) A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. American Journal of Clinical Nutrition 57, 566-572.
11. Bruley-Roseet M & Payelle B (1987) Deficient tumor specific immunity in old mice: in vivo mediation by suppressor cells, and correction of the defect interleukin 2 by supplementation in vitro but not in vivo. Journal of Immunology 17, 307-312.
12. Cakman I, Rohwer J, Schûtz RM, Kirchner H & Rink L (1996) Dysregulation betwen TH1 and TH2 cell sub-populations in the elderly. Mechanisms of Ageing and Development 87, 197-209.
13. Cannon JG, Meydani SN, Fielding RA, Meydani M, Fiatarone MA, Farhangmehr M, Orencole SF, Blumberg JB & Ewans WJ (1991) The acute phase response in exercise. II. Associations between vitamin E, cytokines and muscle proteolysis. American Journal of Physiology 260, R1235-R1240.
14. Cederholm T, Wretling B, Hellstrom K, Andersson B, Engstrom L, Brismark K, Scheynius A, Faslid J & Palmblad J (1997) Enhanced generation of interleukins 1β and 6 may contribute to the cachexia of chronic disease. American Journal of Clinical Nutrition 65, 876-882.
15. Chandra RK (1989) Nutrition, regulation of immunity and risk of infection on old age. Immunology 67, 141-147.
16. Chandra RK (1992a) Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340, 1124-1127.
17. Chandra RK (editor) (1992b) Nutrition and immunobiology: experience of an old traveller and recent observations. In Nutrition and Immunology, pp. 9-43. St John's, Nfld.: ARTS Biomedical.
18. Chandra RK (1994) Nutritional regulation of immune function at the extremes of life: in infants and in the elderly. In Malnutrition Determinants and Consequences, pp. 245-251 [P White, editor]. New York: Alan R Liss.
19. 6. Annals of New York Academy of Sciences 585, 404-423.
20. Chen WF, Liu SL, Gao XM & Pang XI (1987) The capacity of lymphokine production by peripheral blood lymphocytes from aged humans. Immunology Investigation 15, 575-583.
21. Cossarizza A, Ortolani C, Paganelli R, Monti D, Barbieri D, Sansoni P, Fagiolo U, Forti E, Londei M & Franceschi C (1992) Age-related imbalance of virgin (CD45RA+) and memory (CD45RO+) cells between CD4+ and CD8+ T lymphocytes in humans: study from newborns to centenarians. Journal of Immunology Research 4, 117-126.
22. Cunningham-Rundles S, Bockam RS, Lin A, Giardana PV, Hilgartner MW, Caldwell-Brown D & Carter DM (1991) Physiological and pharmacological effects of zinc on immune response. Annals of the New York Academy of Sciences 590, 113-122.
23. Daynes RA, Areanéo BA, Ershler WB, Maloney C, Li GZ & Ryu SY (1993) Altered regulation of IL-6 production with normal aging. Journal of Immunology 150, 5219-5230.
24. Doria G. (1988) Immunoregulation in aging. International Journal of Medicine 4, 83-85.
25. Engwerda CR, Fox BS & Handwerger BS (1996) Cytokine production by T lymphocytes from young and old mice. Journal of Immunology 156, 3621-3630.
26. Ershler WB, Sun WH, Binkley N, Gravenstein S, Volk MJ, Kamoske G, Kloop RG, Roecker EB, Daynes RA & Weindruch R (1993) Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production modifiable by dietary restriction. Lymphokine and Cytokine Research 12, 225-230.
27. Fereday A, Gibson NR, Cox M, Pacy PJ & Millward DJ (1997) Protein requirements and ageing: metabolic demand and efficiency of utilization. British Journal of Nutrition 77, 685-702.
28. Fernandes G, Venkatramen JT, Turturro A, Attwood VG & Hart RW (1991) Effect of food restriction on lifespan and immune functions in long-lived Fischer-344 x Brown Norway F1 rats. Journal of Clinical Immunology 17, 85-95.
29. Fortes C, Forastiere F, Agabiti N, Fano V, Pacifia R, Virgili F, Piras G, Guidi L, Bartonoli C, Tricerri A, Ziccaro P, Ebrahim S & Perucci CA (1993) The effects of zinc and vitamin A supplementation on immune response in an older population. Journal of the American Geriatrics Society 46, 19-26.
30. Galan P, Preziosi P, Monget AL, Richard MJ, Arnaud J, Lesourd B, Girodon F, Munoz Alferez M-J, Bourgeois C, Keller H, Favier A, Hercberg S & the Geriatric Network MIN.VIT.AOX (1997) Effects of trace elements and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long-term hospitalized subjects. International Journal of Vitamin and Nutrition Research 67, 450-460.
31. Gamble DA, Schwab R, Weksler ME & Szabo P (1990) Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene. Journal of Immunology 114, 3569-3573.
32. Garry PJ, Goodwin JS, Hunt WC, Hooper ER & Leonard AG (1982) Nutritional status in a healthy elderly population: dietary and supplementation intakes American Journal of Clinical Nutrition 36, 319-331.
33. Ghosh J & Miller RA (1995) Rapid tyrosine phosphorylation of Grb2 and She in T cells exposed to anti-CD3, anti-CD4, anti-CD45 stimuli: differential effects of ageing Mechanisms of Ageing and Development 80, 171-187.
34. Goldberg TH, Baker DG & Shumacher HR (1991) Interleukin-1 and the immunology of aging and disease. Aging, Immunology and Infectious Diseases 3, 81-86.
35. 2, histamine, hydrocortosone, and X irradiation with age: studies in a healthy elderly population. Clinical and Experimental Immunology and Immunopathology 25, 243-251.
36. Goto M & Nishioka K (1989) Age- and sex-related changes of the lymphocyte subsets in healthy individuals: an analysis by two-dimensional flow cytometry. Journal of Gerontology 5, 242-253.
37. Haller J, Weggemans RM, Lammi-Keefe CJ & Ferry M (1996) Changes in the vitamin status of elderly Europeans: plasma vitamins A, E, B-6, B-12, folic acid and carotenoids. European Journal of Clinical Nutrition 50, Suppl. 2, S32-S46.
38. Harman D (1995) Role of antioxidant nutrients in aging: overview. Age 18, 51-62.
39. Hayek GM, Mura C, Wu D, Beharka AA, Han SN, Paulson E, Hwang D & Meydani SN (1997) Enhanced expression of inducible cyclooxygenase with age in murine macrophages. Journal of Immunology 159, 2445-2451.
40. Hirokawa K., Utsuyama M., Kasai M, Kurishima C, Ishijima S & Zeng YX (1994) Understanding the mechanisms of the age changes of thymic function to promote T cell differentiation. Immunology Letters 40, 269-277.
41. Hobbs MV & Ernst DN (1997) T cell differentiation and cytokine expression in late life. Developmental and Comparative Immunology 21, 464-470.
42. Huber LA, Xu QB, Jürgens G, Böck G, Buther E, Gey KF, Schronitzer D, Traill KN & Wick G (1991) Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged. European Journal of Immunology 21, 2761-2765.
43. Huppert FA, Solomou W, O'Connor S, Morgan K, Sussams P & Brayne C (1998) Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals. Experimental Immunology 33, 593-600.
44. James K, Premchand N, Skibinska A, Skibinski G, Nicol M & Mason JI (1997) IL-6, DHEA and the ageing process. Mechanisms of Ageing and Development 93, 15-24.
45. Keen CL & Gershwin ME (1990) Zinc deficiency and immune function. Annual Review of Nutrition 10, 415-431.
46. Klasing KC (1988) Nutritional aspects of leukocyte cytokines: critical review. Journal of Nutrition 11, 1436-1446.
47. Krishnaraj R (1997) Senescence and cytokines modulate the NK expression. Mechanisms of Ageing and Development 96, 89-116.
48. Kubo M & Cinader B (1990) Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulation, synthesizing IL-2, IL-3, and IL-4. European Journal of Immunology 24, 133-136.
49. Lang GA, Naryshkin S, Schneider DL, Mills BJ & Lindeman RD (1992) Low blood glutathionine levels in healthy aging adults. Journal of Laboratory and Clinical Medicine 120, 720-725.
50. Lesourd B (1990a) Le vieillissement immunologique: influence de Ia dénutrition (Immune ageing: influence of nutrition). Annales de Biologie Clinique 48, 309-318.
51. Lesourd B (1990b) La dénutrition protéique: principale cause de déficit immunitaire chez le sujet âgé (Protein malnutrition: the main cause of immunodeficiency in the elderly). Age and Nutrition 3, 132-138.
52. Lesourd B, (1992) Conséquences nutritionnelles des cytokines: facteur de gravité des hypercatabolismes chez le sujet âgé (Nutritional consequences of cytokine secretion: a prognosis factor of hypercatabolism in elderly). Age and Nutrition 3, 100-109.
53. Lesourd BM (1995) Protein undernutrition as the major cause of decreased immune function in the elderly: clinical and functional implications. Nutrition Reviews 53, S86-S94.
54. Lesourd B (1999) Immune response during disease and recovery in the elderly. Proceedings of the Nutrition Society 58, 85-98.
55. Lesourd B, Laisney C, Salvatore R, Meaume S & Moulias R (1994) Decreased maturation of T cell-population factors on the appearance of double negative CD4-, CD8-, CD2+ cells. Archives of Gerontology and Geriatrics 4 Suppl., 139-154.
56. Lesourd BM & Mazari L (1997) Immune responses during recovery from protein-energy malnutrition. Clinical Nutrition 16, Suppl. 1, 37-46.
57. Lesourd B, Mazari L & Ferry M (1998) The role of nutrition in immunity in the aged. Nutrition Reviews 56, S113-S125.
58. Lesourd B & Meaume S (1994) Cell-mediated immunity changes in aging: relative importance of cell subpopulation switches and of nutritional factors. Immunology Letters 40, 235-242.
59. Lesourd BM, Moulias R, Favre-Berrone M & Rapin CH (1992) Nutritional influences on immune responses in elderly. In Nutrition and Immunology, pp. 211-223 [RK Chandra, editor]. St John's, NPld: ARTS Biomedical.
60. Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Muller-Hermelink HK & Steinmann GG (1984) Admission criteria for immunogerontological studies in man: the Senieur protocol. Mechanisms of Ageing and Development 28, 47-55.
61. Ligthart GJ, Van Vlokhoven PC, Schuit HRE & Hijmans W (1986) The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cells subset in human blood. Immunology 59, 353-357.
62. Lipschitz DA & Udupa KB (1986) Influence of ageing and protein deficiency on neutrophil function. Journal of Gerontology 41, 281-288.
63. Makinodan T & Kay MMB (1980) Age influence on the immune system. Advances in Immunology 29, 287-330.
64. Mazari L & Lesourd B (1998) Nutritional influences on immune response in healthy aged persons. Mechanisms of Ageing and Development 104, 25-40.
65. Mbawuike IN, Acuna CL, Walz KC, Atmar RL, Greenberg SB & Couch RB (1997) Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12. Mechanisms of Ageing and Development 94, 25-39.
66. Meydani SN, Barklund MP, Lui S, Meydani M & Miller RA (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly. American Journal of Clinical Nutrition 52, 557-563.
67. Meydani SN, Meydani M, Blumberg JB, Lekal S, Siber G, Loszewski R, Thompson C, Pedrosa C, Diamond RD & Stollar BD (1997) Vitamin E supplementation and in vivo immune responses in healthy elderly subject. Journal of the American Medical Association 277, 1380-1386.
68. Meydani SN, Ribaya-Mercado JD, Russell RB, Sahyoun N, Morrow FD & Gershoff SN (1991) Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults American Journal of Clinical Nutrition 53, 1275-1280.
69. Meydani SN, Wu D, Santos MS & Hayek MG (1995) Antioxidants and immune response in aged persons: overview of the present evidence. American Journal of Clinical Nutrition 62, Suppl., 1462S-1476S.
70. Miller RA (1992) Aging and immune function. International Review of Immunology 124, 890-904.
71. Miller RA (1996) The aging immune system: primer and prospectus. Science 273, 70-74.
72. Moulias R, Devillechabrolle A, Lesourd B, Proust J, Marescot MR, Doumerc S, Favre-Berrone M, Congy F & Wang A (1985) Respective roles of immune and nutritional factors in the priming of the immune responses in the elderly. Mechanisms of Ageing and Development 31, 123-137.
73. Moulias R, Proust J, Wang A, Congy F, Marescot M, Devillechabrolle A, Paris-Hamelin A & Lesourd B (1984) Age related increase in auto-antibodies. Lancet i, 1128-1129.
74. Muller S, Chang HC, Ward MM, Huang JH & Kölner H (1986) Idiotype shifts. In Aging and the Immune Responses: Cellular and Humoral Aspects, pp. 309-327 [E Goidl, editor]. New York: Marcel Dekker.
75. Murasko DM, Weiner P & Kaynes D (1987) Decline in mitogen induced proliferation of lymphocytes with increasing age. Clinical and Experimental Immunology 70, 440-448.
76. Mysliwska J, Bryl E, Foerster J & Mysliwski A (1998) Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status. Mechanisms of Ageing and Development 100, 313-328.
77. Nafziger J, Bessege JP, Guillosson JJ, Damais C & Lesourd B (1993) Decreased capacity of IL-1 production by monocytes of infected elderly patients. Aging, Immunology and Infectious Diseases 4, 25-34.
78. Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ & Adler WH (1988) Decreased proliferation, interleukin 2 synthesis and interleukin 2 receptor expression are accompanied by decreased mRNA expression, in phytohemagglutinin-stimulated cells from elderly donors. Journal of Clinical Investigation 81, 1096-1102.
79. Nagelkerken L, Hertogh-Huijbregts A, Dobber R & Dräger A (1991) Age-related changes in lymphokine production related to a decreased number of CD45Rbohi CD4+ T cells. European Journal of Immunology 21, 273-281.
80. Nakayama KI, Nakayama K, Negishi I, Kuida K, Louie MC, Kanagawa O, Nakauchi H & Loh DY (1994) Requirement for CDS beta chain in positive selection of CD8 lineage T cells. Science 263, 1131-1133.
81. Penn ND, Purkins L, Kelleher J, Heartley RV, Masie-Taylor BH & Belfield PW (1991) The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized, controlled trial. Age and Aging 20, 169-174.
82. Perillo NL, Neaim F, Walford RL & Effros RB (1993) In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Experimental Cell Research 207, 131-135.
83. Prasad AS, Fitzgerald JT, Hess JW, Kaplan J, Pelen F & Dardenne M (1993) Zinc deficiency in elderly patients. Nutrition 9, 218-224.
84. Proust J, Moulias R, Mumeron F, Beckkhoucha F, Bussone M, Schmid M & Hors J (1982) HLA and longevity. Tissue Antigens 19, 168-173.
85. Rabinowich H, Goses Y, Reshef T & Klajman A (1985) Interleukin 2 production and activity in aged humans. Mechanisms of Ageing and Development 32, 213-226.
86. Rail LC & Meydani SN (1993) Vitamin B6 and immune competence. Nutrition Reviews 51, 217-225.
87. Reibnegger G, Hubber LA, Jurgens G, Schrönitzer D, Werner, ER, Watcher H, Wick G & Traill KN (1988) Approach to define 'normal aging' in man: immune function, serum lipids, lipoproteins and neopterin. Mechanisms of Ageing and Development 46, 67-82.
88. Rudd AG & Banerjeee DK (1989) Interleukin-1 production by human monocytes in ageing and disease. Age and Ageing 18, 43-46.
89. Sanders ME, Maggoba MW, Sharrow SE, Stephany D, Springer A, Young HA & Shaw S (1988) Human memory T lymphocytes express increased level of three cell adhesion molecules (LFA3, CD2, and LFA1) and three other molecules (UCHL-1, CDw29, and Pgp-1) and have enhanced IFN-γ production. Journal of Immunology 140, 1401-1407.
90. Shearer GM (1997) Th1/Th2 changes in aging. Mechanisms of Ageing and Development 94, 1-5.
91. Sindermann J, Kruse A, Frercks HJ, Schutz RM & Kirchner H (1993) Investigations of the lymphokine system in elderly individuals. Mechanisms of Ageing and Development 70, 149-159.
92. Steinmann GG, Klaus B & Muller-Hermelink HK (1985) The involution of the ageing human thymic epithelium is independent of puberty. Scandinavian Journal of Immunology 22, 563-575.
93. Stulning TM, Bühler E, Böck G, Kirchebner C, Schönitzer D & Wick G (1995) Altered switch in lipid composition during T cell blast transformation in the healthy elderly. Journal of Gerontology 50A, 383-390.
94. Talbott MC, Miller LT & Kerkvliet NI (1987) Pyridoxine supplementation: effect on lymphocyte responses in elderly persons. American Journal of Clinical Nutrition 46, 659-664.
95. Thoman ML (1997) Effects of the aged microenvironment on CD4+ T cell maturation. Mechanisms of Ageing and Development 96, 75-88.
96. Traill KN, Schönitzer D, Jürgens G, Böck G, Pfeilschifter R, Hilchenbach M, Holasek A, Förster O & Wick G (1985) Age related changes in lymphocyte subset proportions, surface differentiation antigen density and plasma membrane fluidity: application of the Eurage Senieur Protocol admission criteria. Mechanisms of Ageing and Development 33, 39-66.
97. Tyan ML (1981) Marrow stem cells during development and aging. In Handbook of Immunology and Aging, pp. 87-102 [MMB Kay and T Makinodan, editors]. New York: CRC Press.
98. Utsuyama M, Kasai M, Kurashima C & Hirokawa K (1997) Age influence on the thymic capacity to promote differentiation of T cells: induction of different composition of T cells subsets by aging thymus. Mechanisms of Ageing and Development 58, 167-177.
99. Venkatraman JT, Attwood VG, Turturro A, Hart RW & Fernandes G (1994) Maintenance of virgin T-cells and immune functions by food restriction during aging in long-lived B6D2F1 female mice. Aging, Immunology and Infectious Diseases 5, 13-26.
100. Weksler ME (1995) Immune senescence: deficiency or dysregulation. Nutrition Reviews 53, S3-S7.
101. Welle S, Thornton C & Jozefowicz R (1993) Myofibrillar protein synthesis in young and old men. American Journal of Physiology 264, E693-E698.
102. Wick G & Grubeck-Lowenstein B (1997) Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunological Reviews 160, 171-184.
103. Wick G, Huber LA, Xu Q, Jarosch E, Schönitzer D & Jürgens G (1991) The decline of the immune response during aging: the role of an altered lipid metabolism. Annals of the New York Academy of Sciences 621, 277-290.
104. Yarasheski KE, Zachwieja JJ & Bier DM (1993) Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. American Journal of Physiology 265, E210-E214.
105. Yong-Xing M, Yue Z, Zan-Shun W, Chuan-Fu W, Su-Ying C, Mao-Tong Z, Gong-Liang Z, Su-Qin Z, Jian-Gang Z, Qi G & Lin H (1997) HLA and longevity or aging among Shanghai Chinese. Mechanisms of Ageing and Development 94, 191-198.