T cell differentiation and cytokine expression in late life

Developmental and Comparative Immunology

Volumn 21, Issue 6, 1997, Pages 461-470

  Hobbs, Monte V ^a   Ernst, David N ^b  

^a UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^b BD Technologies   (United States)

Author keywords

Aging; Cell differentiation; Cytokine; Disease; Human; Immune deficiency; Mouse; T cell

Indexed keywords

BETA1 INTEGRIN; CD3 ANTIGEN; CD45 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERMES ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; PADGEM PROTEIN;

AGING; CANCER; HELPER CELL; HUMAN; IMMUNE DEFICIENCY; INFECTION; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE; THYMUS;

EID: 0031460323     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-305X(97)00026-8     Document Type: Article

References (32)

1. Mittelmark, M. B. The epidemiology of aging. In Principles of Geriatric Medicine and Gerontology, eds W. R. Hazzard, E. L. Bierman, J. P. Blass, W. H. Ettinger, Jr. and J. B. Halter. McGraw-Hill, Inc., New York, 1994, 135-151.
2. Adler, W. H. and Nagel, J. E. Clinical immunology and aging. In Principles of Geriatric Medicine and Gerontology, eds W. R. Hazzard, E. L. Bierman, J. P. Blass, W. H. Ettinger and J. B. Halter. McGraw-Hill, Inc., New York, 1994, 61-75.
3. Miller, R. A. Immune system. In Handbook of Physiology: Aging, ed. E. Masoro. Oxford University Press, New York, 1995, 555-590.
4. Sprent, J. T lymphocytes and the thymus. In Fundamental Immunology, ed. W. E. Paul. Raven Press, New York, 1993, 75-109.
5. Mosmann, T. R.; Sad, S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today 17:138-146; 1996.
6. Scollay, R. G.; Butcher, E. C.; Weissman, I. L. Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. European Journal of Immunology 10:210-218; 1980.
7. Hobbs, M. V. and Emst, D. N. The role of cytokines in aging. In Human Cytokines: Their Role in Disease and Therapy, eds B. B. Aggarwal and R. K. Puri. Blackwell Science, Cambridge, MA, 1995, 353-367.
8. Swain, S. L.; Croft, M.; Dubey, C.; Haynes, L.; Rogers, P.; Zhang, X.; Bradley, L. M. From naive to memory T cells. Immunological Reviews 150:143-167; 1996.
9. Sprent, J. T and B memory cells. Cell 76:315-322; 1994.
10. Janeway, C. A. Jr; Bottomly, K. Signals and signs for lymphocyte responses. Cell 76:275-285; 1994.
11. Abehsira-Amar, O.; Gibert, M.; Joliy, M.; Theze, J.; Jankovic, D. L. IL-4 plays a dominant role in the differential development of Th0 into Thl and Th2 cells. Journal of Immunology 148:3820-3829; 1992.
12. + T cells. Annual Review of Immunology 12:635-673; 1994.
13. hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. European Journal of Immunology 19:977-982; 1989.
14. + T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. Journal of Immunology 151:575-587; 1993.
15. + T cells. European Journal of Immunology 21:273-281; 1991.
16. Ligthart, G. J.; Corberand, J. X.; Fournier, C.; Galanaud, P.; Hijmans, W.; Kennes, B.; Muller-Hermelink, H. K.; Steinmann, G. G. Admission criteria for immunogerontological studies in man: The SENIEUR protocol. Mechanisms of Ageing and Development 28:47-55; 1984.
17. Flurkey, K.; Stadecker, M.; Miller, R. A. Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency. European Journal of Immunology 22:931-935; 1992.
18. + cells from old mice. Journal of Cellular Biochemistry 46:312-320; 1991.
19. Farber, D. L.; Luqman, M.; Acuto, O.; Bottomly, K. Control of memory CD4 T cell activation: MMC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity 2:249-259; 1995.
20. + T cells from young and old mice. Journal of Immunology 150:3602-3614; 1993.
21. + cells and cell subsets from young and old mice. Cellular Immunology 154:264-272; 1994.
22. Engwerda, C. R.; Fox, B. S.; Handwerger, B. S. Cytokine production by T lymphocytes from young and aged mice. Journal of Immunology 156:3621-3630; 1996.
23. + T cells from aged mice display functional and phenotypic characteristics of memory cells. International Immunology 6:1227-1234; 1994.
24. Linton, P.-J.; Haynes, L.; Klinman, N. R.; Swain, S. L. Antigen-independent changes in naive CD4 T cells with aging. Journal of Experimental Medicine 184:1891-1900; 1996.
25. Beckman, I.; Dimopoulos, K.; Xu, X.; Ahern, M.; Bradley, J. Age-related changes in the activation requirements of human CD4 + T-cell subsets. Cellular Immunology 132:17-25; 1991.
26. Beckman, I.; Shepherd, K.; Firgaira, F.; Ahern, M. Age-related defects in CD2 receptor-induced activation in human T-cell subsets. Immunology 86:533-536; 1995.
27. Engwerda, C. R.; Handwerger, B. S.; Fox, B. S. Aged T cells are hyporesponsive to costimulation mediated by CD28. Journal of Immunology 152:3740-3747; 1994.
28. Tough, D. F.; Sprent, J. Turnover of naive-and memory-phenotype T cells. Journal of Experimental Medicine 179:1127-1135; 1994.
29. Unutmaz, D.; Pileri, P.; Abrignani, S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. Journal of Experimental Medicine 180:1159-1164; 1994.
30. Li, S. P.; Miller, R. A. Age-associated decline in IL-4 production by murine T lymphocytes in extended culture. Cellular Immunology 151:187-195; 1993.
31. Carding, S. R.; Allan, W.; McMickle, A.; Doherty, P. C. Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. Journal of Experimental Medicine 177:475-482; 1993.
32. Tough, D. F.; Borrow, P.; Sprent, J. Induction of bystander T cell proliferation by viruses and type 1 interferon in vivo. Science 272:1947-1950; 1996.