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Volumn 34, Issue 2-3, 1999, Pages 97-105

Molecular nature of mutations induced by a high dose of X-rays in spleen, liver, and brain of the lacZ-transgenic mouse

Author keywords

DNA sequence; Muta(TM)Mouse; Mutation; Tissues; X ray

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DELETION MUTANT; DNA SEQUENCE; IONIZING RADIATION; MOUSE; MUTAGEN TESTING; MUTATION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; TRANSGENE; TRANSGENIC MOUSE; WHOLE BODY RADIATION; X IRRADIATION;

EID: 0032718912     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)34:2/3<97::AID-EM7>3.0.CO;2-M     Document Type: Article
Times cited : (22)

References (57)
  • 2
    • 0023192314 scopus 로고
    • Sequence analysis of spontaneous mutations in a shuttle vector gene integrated into mammalian chromosomal DNA
    • Ashman CR, Davidson RL. 1987. Sequence analysis of spontaneous mutations in a shuttle vector gene integrated into mammalian chromosomal DNA. Proc Natl Acad Sci USA 84:3354-3358.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3354-3358
    • Ashman, C.R.1    Davidson, R.L.2
  • 3
    • 0028831596 scopus 로고
    • Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by α-and X-radiation in human lymphoblastoid cells
    • Bao CY, Ma AH, Evans HH, Horng MF, Mencl J, Hui TE, Sedwick WD. 1995. Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by α-and X-radiation in human lymphoblastoid cells. Mutat Res 326:1-15.
    • (1995) Mutat Res , vol.326 , pp. 1-15
    • Bao, C.Y.1    Ma, A.H.2    Evans, H.H.3    Horng, M.F.4    Mencl, J.5    Hui, T.E.6    Sedwick, W.D.7
  • 4
    • 0028157494 scopus 로고
    • Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
    • Cole J. Skopek TR. 1994. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat Res 304:33-105.
    • (1994) Mutat Res , vol.304 , pp. 33-105
    • Cole, J.1    Skopek, T.R.2
  • 5
    • 0031417310 scopus 로고    scopus 로고
    • Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of Cesium-137
    • da Cruz AD, Glickman BW. 1997. Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of Cesium-137. Environ Mol Mutagen 30:385-395.
    • (1997) Environ Mol Mutagen , vol.30 , pp. 385-395
    • Da Cruz, A.D.1    Glickman, B.W.2
  • 6
    • 0031953259 scopus 로고    scopus 로고
    • The lad gene as a target for mutation in transgenic rodents and Escherichia coli
    • de Boer JG, Glickman BW. 1998. The lad gene as a target for mutation in transgenic rodents and Escherichia coli. Genetics 148:1441-1451.
    • (1998) Genetics , vol.148 , pp. 1441-1451
    • De Boer, J.G.1    Glickman, B.W.2
  • 8
    • 0028017876 scopus 로고
    • Sequence spectra of spontaneous iacZ gene mutations in transgenic mouse somatic and germline tissues
    • Douglas GR, Gingerich JD, Gossen JA, Bartlett SA. 1994. Sequence spectra of spontaneous iacZ gene mutations in transgenic mouse somatic and germline tissues. Mutagenesis 9:451-458.
    • (1994) Mutagenesis , vol.9 , pp. 451-458
    • Douglas, G.R.1    Gingerich, J.D.2    Gossen, J.A.3    Bartlett, S.A.4
  • 10
    • 0031854165 scopus 로고    scopus 로고
    • Monte Carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higher-order DNA models
    • Friedland W, Jacob P, Paretzke HG, Stork T. 1998. Monte Carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higher-order DNA models. Radiat Res 150:170-182.
    • (1998) Radiat Res , vol.150 , pp. 170-182
    • Friedland, W.1    Jacob, P.2    Paretzke, H.G.3    Stork, T.4
  • 11
    • 0028787725 scopus 로고
    • A cell-free assay using cytoplasmic cell extracts to study rejoining of radiation-induced DNA double-strand breaks in human cell nuclei
    • Ganguly T, Iliakis G. 1995. A cell-free assay using cytoplasmic cell extracts to study rejoining of radiation-induced DNA double-strand breaks in human cell nuclei. Int J Radiat Biol 68:447-457.
    • (1995) Int J Radiat Biol , vol.68 , pp. 447-457
    • Ganguly, T.1    Iliakis, G.2
  • 13
    • 0029947527 scopus 로고    scopus 로고
    • A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice
    • Gondo Y, Shioyama Y, Nakao K, Katsuki M. 1996. A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice. Mutat Res 360:1-14.
    • (1996) Mutat Res , vol.360 , pp. 1-14
    • Gondo, Y.1    Shioyama, Y.2    Nakao, K.3    Katsuki, M.4
  • 15
    • 0027535053 scopus 로고
    • Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads
    • Gossen JA, de Leeuw WJF, Molijin AC, Vijg J. 1993. Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads. BioTechniques 14:624-629.
    • (1993) BioTechniques , vol.14 , pp. 624-629
    • Gossen, J.A.1    De Leeuw, W.J.F.2    Molijin, A.C.3    Vijg, J.4
  • 16
    • 0023672576 scopus 로고
    • Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells
    • Grosovsky AJ, de Boer JG, de Jong PJ, Drobetsky EA. 1988. Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells. Proc Natl Acad Sci USA 85:185-188.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 185-188
    • Grosovsky, A.J.1    De Boer, J.G.2    De Jong, P.J.3    Drobetsky, E.A.4
  • 17
    • 0032937876 scopus 로고    scopus 로고
    • Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of big blue transgenic mice
    • Harbach PR, Zimmer DM, Filipunas AL, Mattes WB, Aaron CS. 1999. Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of Big Blue transgenic mice. Environ Mol Mutagen 33:132-143.
    • (1999) Environ Mol Mutagen , vol.33 , pp. 132-143
    • Harbach, P.R.1    Zimmer, D.M.2    Filipunas, A.L.3    Mattes, W.B.4    Aaron, C.S.5
  • 18
    • 0031662888 scopus 로고    scopus 로고
    • The use of transgenic animals in research
    • Heddle JA. 1998. The use of transgenic animals in research. Environ Mol Mutagen 32:110-114.
    • (1998) Environ Mol Mutagen , vol.32 , pp. 110-114
    • Heddle, J.A.1
  • 19
    • 0029664689 scopus 로고    scopus 로고
    • Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. I. Theoretical modeling
    • Holley WR, Chatterjee A. 1996. Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling. Radiat Res 145:188-199.
    • (1996) Radiat Res , vol.145 , pp. 188-199
    • Holley, W.R.1    Chatterjee, A.2
  • 20
    • 0031784732 scopus 로고    scopus 로고
    • Mutation studies in lad transgenic mice after exposure to radiation or cyclophosphamide
    • Hoyes KP, Wadeson PJ, Sharma HL, Hendry JH, Morris ID. 1998. Mutation studies in lad transgenic mice after exposure to radiation or cyclophosphamide. Mutagenesis 13:607-612.
    • (1998) Mutagenesis , vol.13 , pp. 607-612
    • Hoyes, Kp.1    Wadeson, P.J.2    Sharma, H.L.3    Hendry, J.H.4    Morris, I.D.5
  • 21
    • 0024408999 scopus 로고
    • Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA
    • Ikehata H, Akagi T, Kimura H, Akasaka S, Kato T. 1989. Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA. Mol Gen Genet 219:349-358.
    • (1989) Mol Gen Genet , vol.219 , pp. 349-358
    • Ikehata, H.1    Akagi, T.2    Kimura, H.3    Akasaka, S.4    Kato, T.5
  • 22
    • 0027532034 scopus 로고
    • Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers
    • Jego N, Thomas G, Hamelin R. 1993. Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers. Oncogene 8:209-213.
    • (1993) Oncogene , vol.8 , pp. 209-213
    • Jego, N.1    Thomas, G.2    Hamelin, R.3
  • 23
    • 0031423412 scopus 로고    scopus 로고
    • Frameshifts, base substitutions and minute deletions constitute X-ray-induced mutations in the endogenous tonB gene of Escherichia coli K12
    • Kanbashi K, Wang X, Komura J, Ono T, Yamamoto K. 1997. Frameshifts, base substitutions and minute deletions constitute X-ray-induced mutations in the endogenous tonB gene of Escherichia coli K12. Mutat Res 385:259-267.
    • (1997) Mutat Res , vol.385 , pp. 259-267
    • Kanbashi, K.1    Wang, X.2    Komura, J.3    Ono, T.4    Yamamoto, K.5
  • 24
    • 0344498876 scopus 로고
    • Late somatic effects
    • Berlin: Springer-Verlag
    • Kiefer J. 1990. Late somatic effects. In: Biological radiation effects. Berlin: Springer-Verlag. p 319-356.
    • (1990) Biological Radiation Effects , pp. 319-356
    • Kiefer, J.1
  • 25
    • 0027256069 scopus 로고    scopus 로고
    • Sequence analysis of X-ray-induced mutations occurring in a cDNA of the human hprt gene integrated into mammalian chromosomal DNA
    • Kimura H, Higuchi H, Iyehara-Ogawa H, Kato T. Sequence analysis of X-ray-induced mutations occurring in a cDNA of the human hprt gene integrated into mammalian chromosomal DNA. Radiat Res 134:202-208.
    • Radiat Res , vol.134 , pp. 202-208
    • Kimura, H.1    Higuchi, H.2    Iyehara-Ogawa, H.3    Kato, T.4
  • 26
    • 0028150623 scopus 로고
    • Spontaneous mutations in lacI-containing X lysogens derived from transgenic mice: The observed patterns differ in liver and spleen
    • Knöll A, Jacobson DP, Kretz PL, Lundberg KS, Short JM, Sommer SS. 1994. Spontaneous mutations in lacI-containing X lysogens derived from transgenic mice: the observed patterns differ in liver and spleen. Mutat Res 311:57-67.
    • (1994) Mutat Res , vol.311 , pp. 57-67
    • Knöll, A.1    Jacobson, D.P.2    Kretz, P.L.3    Lundberg, K.S.4    Short, J.M.5    Sommer, S.S.6
  • 28
    • 0025762012 scopus 로고
    • Gene deletions causing human genetic disease: Mechanisms of mutagenesis and the role of the local DNA sequence environment
    • Krawczak M, Cooper DN. 1991. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment. Hum Genet 86:425-441.
    • (1991) Hum Genet , vol.86 , pp. 425-441
    • Krawczak, M.1    Cooper, D.N.2
  • 29
    • 0032574750 scopus 로고    scopus 로고
    • Homology-directed repair is a major double-strand break repair pathway in mammalian cells
    • Liang F, Han M, Romanienko PJ, Jasin M. 1998. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc Natl Acad Sci USA 95:5172-5177.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5172-5177
    • Liang, F.1    Han, M.2    Romanienko, P.J.3    Jasin, M.4
  • 30
    • 0029612225 scopus 로고
    • Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: Joining of correct and incorrect ends
    • Löbrich M, Rydberg B, Cooper PK. 1995. Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc Natl Acad Sci USA 92:12050-12054.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12050-12054
    • Löbrich, M.1    Rydberg, B.2    Cooper, P.K.3
  • 31
    • 0029860006 scopus 로고    scopus 로고
    • Non-random distribution of DNA double-strand breaks induced by particle irradiation
    • Löbrich M, Cooper PK, Rydberg B. 1996. Non-random distribution of DNA double-strand breaks induced by particle irradiation. Int J Radiat Biol 70:493-503.
    • (1996) Int J Radiat Biol , vol.70 , pp. 493-503
    • Löbrich, M.1    Cooper, P.K.2    Rydberg, B.3
  • 32
    • 0031661806 scopus 로고    scopus 로고
    • Transgenic animal models for mutagenesis studies: Role in mutagenesis research and regulatory testing
    • MacGregor JT. 1998. Transgenic animal models for mutagenesis studies: role in mutagenesis research and regulatory testing. Environ Mol Mutagen 32:106-109.
    • (1998) Environ Mol Mutagen , vol.32 , pp. 106-109
    • MacGregor, J.T.1
  • 34
    • 0024458459 scopus 로고
    • DNA sequence determination of γ-radiation-induced mutations of the hamster aprt locus
    • Miles C, Meuth M. 1989. DNA sequence determination of γ-radiation-induced mutations of the hamster aprt locus. Mutat Res 227:97-102.
    • (1989) Mutat Res , vol.227 , pp. 97-102
    • Miles, C.1    Meuth, M.2
  • 35
    • 0027404612 scopus 로고
    • Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts
    • Morris T, Thacker J. 1993. Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts. Proc Natl Acad Sci USA 90:1392-1396.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1392-1396
    • Morris, T.1    Thacker, J.2
  • 36
    • 0022730368 scopus 로고
    • Spontaneous deletion formation at the aprt locus of hamster cells: The presence of short sequence homologies and dyad symmetries at deletion termini
    • Nalbantoglu J, Hartley D, Phear G, Tear G, Meuth M. 1986. Spontaneous deletion formation at the aprt locus of hamster cells: the presence of short sequence homologies and dyad symmetries at deletion termini. EMBO J 5:1199-1204.
    • (1986) EMBO J , vol.5 , pp. 1199-1204
    • Nalbantoglu, J.1    Hartley, D.2    Phear, G.3    Tear, G.4    Meuth, M.5
  • 37
    • 0028323180 scopus 로고
    • Spectrum of X-ray-induced mutations in the human hprt gene
    • Nelson SL, Giver CR, Grosovsky AJ. 1994. Spectrum of X-ray-induced mutations in the human hprt gene. Carcinogenesis 15:495-502.
    • (1994) Carcinogenesis , vol.15 , pp. 495-502
    • Nelson, S.L.1    Giver, C.R.2    Grosovsky, A.J.3
  • 38
    • 0028916130 scopus 로고
    • Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines
    • Nelson SL, Jones IM, Fuscoe JC, Burkhart-Schultz K, Grosovsky AJ. 1995. Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines. Radiat Res 141:2-10.
    • (1995) Radiat Res , vol.141 , pp. 2-10
    • Nelson, S.L.1    Jones, I.M.2    Fuscoe, J.C.3    Burkhart-Schultz, K.4    Grosovsky, A.J.5
  • 40
    • 0027488523 scopus 로고
    • Analysis of large X-ray-induced mutant populations by denaturing gradient gel electrophoresis
    • Okinaka RT, Anzick SL, Oller A, Thilly WG. 1993. Analysis of large X-ray-induced mutant populations by denaturing gradient gel electrophoresis. Radiat Res 135:212-221.
    • (1993) Radiat Res , vol.135 , pp. 212-221
    • Okinaka, R.T.1    Anzick, S.L.2    Oller, A.3    Thilly, W.G.4
  • 41
    • 0022413953 scopus 로고
    • Absence of gross change in primary DNA sequence during aging process of mice
    • Ono T, Okada S, Kawakami T, Honjo T, Getz MJ. 1985. Absence of gross change in primary DNA sequence during aging process of mice. Mech Ageing Dev 32:227-234.
    • (1985) Mech Ageing Dev , vol.32 , pp. 227-234
    • Ono, T.1    Okada, S.2    Kawakami, T.3    Honjo, T.4    Getz, M.J.5
  • 44
    • 0027941291 scopus 로고
    • The repair fidelity of restriction enzyme-induced double strand breaks in plasmid DNA correlates with radioresistance in human tumor cell lines
    • Powell SN, McMillan TJ. 1994. The repair fidelity of restriction enzyme-induced double strand breaks in plasmid DNA correlates with radioresistance in human tumor cell lines. Int J Radiat Oncol Biol Phys 29:1035-1040.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 1035-1040
    • Powell, S.N.1    McMillan, T.J.2
  • 45
    • 0027153293 scopus 로고
    • Tandem double CC→TT mutations are produced by reactive oxygen species
    • Reid TM, Loeb LA. 1993. Tandem double CC→TT mutations are produced by reactive oxygen species. Proc Natl Acad Sci USA 90: 3904-3907.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3904-3907
    • Reid, T.M.1    Loeb, L.A.2
  • 46
    • 0030023098 scopus 로고    scopus 로고
    • Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. II. Experimental detection
    • Rydberg B. 1996. Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. Experimental detection. Radiat Res 145:200-209.
    • (1996) Radiat Res , vol.145 , pp. 200-209
    • Rydberg, B.1
  • 47
    • 0002059397 scopus 로고    scopus 로고
    • Repair of ionizing radiation induced DNA double-strand breaks (dsb) at the c-myc locus in comparison to the overall genome
    • Sak A, Stuschke M. 1998. Repair of ionizing radiation induced DNA double-strand breaks (dsb) at the c-myc locus in comparison to the overall genome. Int J Radiat Biol 73:35-43.
    • (1998) Int J Radiat Biol , vol.73 , pp. 35-43
    • Sak, A.1    Stuschke, M.2
  • 48
    • 0025893854 scopus 로고
    • Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation
    • Sankaranarayanan K. 1991. Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation. Mutat Res 258:75-97.
    • (1991) Mutat Res , vol.258 , pp. 75-97
    • Sankaranarayanan, K.1
  • 49
    • 0025120978 scopus 로고
    • Endogenous gene systems for the study of mutational specificity in mammalian cells
    • Skandalis A, Glickman BW. 1990. Endogenous gene systems for the study of mutational specificity in mammalian cells. Cancer Cells 2:79-83.
    • (1990) Cancer Cells , vol.2 , pp. 79-83
    • Skandalis, A.1    Glickman, B.W.2
  • 51
    • 0027421332 scopus 로고    scopus 로고
    • Comparison of somatic mutation in a transgenic versus host locus
    • Tao KS, Urlando C, Heddle JA. Comparison of somatic mutation in a transgenic versus host locus. Proc Natl Acad Sci USA 90:10681-10685.
    • Proc Natl Acad Sci USA , vol.90 , pp. 10681-10685
    • Tao, K.S.1    Urlando, C.2    Heddle, J.A.3
  • 52
    • 0024565192 scopus 로고
    • The use of integrating DNA vectors to analyse the molecular defects in ionising radiation-sensitive mutants of mammalian cells including ataxia telangiectasia
    • Thacker J. 1989. The use of integrating DNA vectors to analyse the molecular defects in ionising radiation-sensitive mutants of mammalian cells including ataxia telangiectasia. Mutat Res 220:187-204.
    • (1989) Mutat Res , vol.220 , pp. 187-204
    • Thacker, J.1
  • 53
    • 0033007157 scopus 로고    scopus 로고
    • Asymmetric crossover for spontaneous formation of large deletions at the tonB-trp region of Escherichia coli K-12 cells
    • Uematsu N, Matsuoka C, Agemizu Y, Nagoshi E, Yamamoto K. 1999. Asymmetric crossover for spontaneous formation of large deletions at the tonB-trp region of Escherichia coli K-12 cells. Mol Gen Genet 261:523-529.
    • (1999) Mol Gen Genet , vol.261 , pp. 523-529
    • Uematsu, N.1    Matsuoka, C.2    Agemizu, Y.3    Nagoshi, E.4    Yamamoto, K.5
  • 54
    • 0019413225 scopus 로고
    • Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals
    • Ward JF. 1981. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiat Res 86:185-195.
    • (1981) Radiat Res , vol.86 , pp. 185-195
    • Ward, J.F.1
  • 55
    • 0028336644 scopus 로고
    • Radiation-induced point mutations, deletions and micronuclei in lad transgenic mice
    • Winegar RA, Lutze LH, Hamer JD, O'Loughlin KG, Mirsalis JC. 1994. Radiation-induced point mutations, deletions and micronuclei in lad transgenic mice. Mutat Res 307:479-487.
    • (1994) Mutat Res , vol.307 , pp. 479-487
    • Winegar, R.A.1    Lutze, L.H.2    Hamer, J.D.3    O'Loughlin, K.G.4    Mirsalis, J.C.5
  • 56
    • 0029887714 scopus 로고    scopus 로고
    • Molecular analysis and comparison of radiation-induced large deletions of HPRT locus in primary human skin fibroblasts
    • Yamada Y, Park MS, Okinaka RT, Chen DJ. 1996. Molecular analysis and comparison of radiation-induced large deletions of HPRT locus in primary human skin fibroblasts. Radiat Res 145:481-490.
    • (1996) Radiat Res , vol.145 , pp. 481-490
    • Yamada, Y.1    Park, M.S.2    Okinaka, R.T.3    Chen, D.J.4
  • 57
    • 0029879235 scopus 로고    scopus 로고
    • Cellular and molecular analysis of mutagenesis induced by charged particles of defined linear energy transfer
    • Zhu LX, Waldren CA, Vannais D, Hei TK. 1996. Cellular and molecular analysis of mutagenesis induced by charged particles of defined linear energy transfer. Radiat Res 145:251-259.
    • (1996) Radiat Res , vol.145 , pp. 251-259
    • Zhu, L.X.1    Waldren, C.A.2    Vannais, D.3    Hei, T.K.4


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