Mutant Frequencies in lacZ Transgenic Mice following the Internal Irradiation from 89Sr or the External γ-Ray Irradiation

Journal of Radiation Research

Volumn 39, Issue 1, 1998, Pages 53-60

  Takahashi, Sentaro ^a   Kubota, Yoshihisa ^a   Sato, Hiroshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Mutant frequency; Mutation; Radiation; Radiostrontium; Transgenic mouse

Indexed keywords

ASSAYS; BONE; GAMMA RAYS; IRRADIATION; MAMMALS;

BONE MARROW; GENOMIC DNA; INTERNAL IRRADIATION; INTRAPERITONEAL INJECTIONS; INTRAVENOUS INJECTIONS; MOUSE STRAIN; MUTANT FREQUENCY; MUTATION; RADIOSTRONTIUM; TRANSGENIC MICE;

MUTAGENESIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS MUSCULUS;

STRONTIUM;

ANIMAL; ARTICLE; BETA RADIATION; BONE MARROW; FEMALE; GAMMA RADIATION; LACTOSE OPERON; LIVER; MOUSE; MUTAGEN TESTING; MUTATION; RADIATION EXPOSURE; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; BETA RAYS; BONE MARROW; FEMALE; GAMMA RAYS; LAC OPERON; LIVER; MICE; MICE, TRANSGENIC; MUTAGENICITY TESTS; MUTATION; SPLEEN; STRONTIUM RADIOISOTOPES;

EID: 0032013741     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.39.53     Document Type: Article

References (19)

1. Cole, J. and Skopek, T. R. (1994) Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutation Res. 304: 33-105.
2. Horn, P. L., Turker, M. S., Ogburn, C. E., Disteche, C. M. and Martin G. M. (1984) A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging. J. Cell. Physiol. 121: 309-315.
3. 89Sr in mice after a single intravenous injection of high and low doses. J. Radiat. Res. 30: 176-184.
4. 239Pu citrate injection. J. Radiat. Res. 38: 77-86.
5. Kohler, S. W., Provost, G. S., Kretz, P. L., Fieck, A., Sorge, J. A. and Short, J. M. (1990) The use of transgenic mice for short-term, in vivo mutagenicity testing. Genet. Anal. Tech. Appl. 7: 212-218.
6. Gossen, J. A., DeLeeuw, W. J. F., Tan, C. H. T., Zwaauthoff, E. C., Berends, F., Lhoman, P. H. M., Knock, D. L. and Vijg, J. (1989) Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo. Proc. Natl. Acad. Sci. 86: 7971-7975.
7. Gondo, Y., Shioyama, Y., Nakao, K. and Katsuki, M. (1996) A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice. Mutat Res. 360: 1-14.
8. Myhr, B. C. (1991) Validation studies with MutaMouse: A transgenic mouse model for detecting mutations in vivo. Environ. Mol. Mutagenesis. 18: 308-315.
9. Suzuki, T. (1991) Transgenic mouse models for mutagenicity tests. Jpn. J. Mutagenicity Tests on Chemicals. 1: 3-18.
10. ™ Mouse/PS. Positive selection system. Mutation assay manual.
11. Kasternbaum, M. A. and Bowman, K. O. (1970) Tables for determining the statistical significance of mutation frequencies. Mutation Res. 9: 527-549.
12. Suzuki, T. Hayashi, M. and Sofuni, T. (1994) Initial experiences and future directions for transgenic mouse mutation assays. Mutation Res. 307: 489-494.
13. Ono, T., Muyamura, Y., Ikehata, H., Yamanaka, H., Kurishita, A., Yamamoto, K., Suzuki, T., Nohmi, T., Hayashi, M. and Sofuni, T. (1995) Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age. Mutation Res. 338: 183-188.
14. ™ mouse. Radiat. Res. 148: 123-128.
15. Tao, K. S., Urlando, C. and Heddle, J. A. (1993) Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl. Acad. Sci. USA. 90: 10681-10685.
16. Shephard, S. E., Sengstag, C., Lutz, W. K. and Schlatter, C. (1993) Mutations in liver DNA of lacI transgenic mice (Big Blue) following subchronic exposure to 2-acetylaminofluorene. Mutataion Res. 302: 91-96.
17. Winegar, R. A., Louise, H. L., Hamer, J. D., O'Loughlin, K. G. and Mirsalis, J. C. (1994) Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice. Mutation Res. 307: 479-487.
18. Schmezer, P., Eckert, C. and Liegibel U. M. (1994) Tissue-specific induction of mutations by streptozotocin in vivo. Mutation Res. 307: 495-499.
19. 89Sr-induced monocytopenia on tissue resident macrophage populations in a normal steady state. J. Radiat. Res. 29: 189-202.