Transgenic animal models for mutagenesis studies: Role in mutagenesis research and regulatory testing

Environmental and Molecular Mutagenesis

Volumn 32, Issue 2, 1998, Pages 106-109

  MacGregor, James T ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENESIS; CHROMOSOME INSERTION; ENVIRONMENTAL EXPOSURE; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; HERITABILITY; MAMMAL; MUTAGENESIS; REPORTER GENE; REVIEW; RODENT; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARCINOGENS, ENVIRONMENTAL; MAMMALS; MUTAGENESIS; MUTAGENICITY TESTS; MUTAGENS; RESEARCH DESIGN; TOXICOLOGY; TRANSGENES;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0031661806     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1998)32:2<106::AID-EM4>3.0.CO;2-E     Document Type: Review

References (26)

1. Ames BN, Gold LS, Willett WC (1995): The causes and prevention of cancer, Proc Natl Acad Sci USA 92:5258-5265.
2. Arcy PFD, Harron DWG, eds. (1997): Proceedings of the Fourth International Conference on Harmonization. Queen's University of Belfast, Ireland, pp. 233-260.
3. Auerbach C, Robson JM (1946): Chemical production of mutations. Nature 157:302.
4. Auletta AE, Dearfield KL, Cimino MC (1993): Mutagenicity test schemes and guidelines: U.S. EPA Office of Pollution Prevention and Toxics and Office of Pesticide Programs. Environ Mol Mutagen 21:38-45.
5. Environmental Contaminants Advisory Committee (1988): Guidelines on the use of mutagenicity tests in toxicological evaluation of chemicals: A report of the DNH&W/DOE Environmental Contaminants Advisory Committee, Canada. Environ Mol Mutagen 11:261-304.
6. Gossen JA, de Leeuw WJF, Tan CHT, Zwartoff EC, Berends F, Lohman PHM, Knook DL, Vijg J (1989): Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying gene mutations in vivo. Proc Natl Acad Sci USA 86:7971-7975.
7. Health Protection Branch (1993): The assessment of mutagenicity: Health Protection Branch mutagenicity guidelines, Department of National Health and Welfare, Ottawa, Canada (reprint). Environ Mol Mutagen 21:15-37.
8. Hollaender A (1971): Forward to "Chemical Mutagens: Principles and Methods for their Detection." Hollaender A (ed). New York: Plenum Press, pp vii-viii.
9. Kirkland DJ (1993): Genetic toxicology testing requirements: Official and unofficial views from Europe. Environ Mol Mutagen 21:8-14.
10. Kohler S, Provost S, Kretz P, Dycaico M, Sorge J, Short JM (1990): Development of a short term, in vivo mutagenesis assay: The effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice, Nucleic Acids Res 18:3007-3013.
11. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock B, Sorge JA, Putman D, Short JM (1991): Spectra of spontaneous and induced mutations using a lambda ZAP® lacI shuttle vector in transgenic mice. Proc Natl Acad Sci USA 88:7958-7962.
12. MacGregor JT, Claxton LD, Lewtas J, Jensen R, Lower W, Pesch G (1994): Monitoring environmental genotoxicants: A report of the ICPEMC Working Group on Environmental Monitoring. In Brusick DJ (ed): "Methods for Genotoxic Risk Assessment." Boca Raton. FL: Lewis Publishers, CRC Press, pp 171-243.
13. Meselson M (1971): Forward to "Chemical Mutagens: Principles and Methods for their Detection." Hollaender A (ed). New York: Plenum Press, pp ix-xii.
14. Miller EC, Miller JA (1966): Mechanisms of chemical carcinogenesis: Nature of the proximate carcinogens and interactions with macromolecules. Pharmacol Rev 18:805-838.
15. Ministry of Health and Welfare (1990): "Guidelines for Toxicity Studies of Drugs Manual." New Drugs Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, Japan. Tokyo: Yakuji Nippon, Ltd.
16. Ministry of Health and Welfare (1992): "Guidelines for Toxicity Test- ing of Chemicals: Testing Methods for New Chemical Substances." Office of Environmental Chemicals Safety, Environmental Health Bureau, Ministry of Health and Welfare, Japan. Tokyo: Chemical Daily.
17. Mittelstaedt RA, Manjanatha MG, Shelton SD, Lyn-Cook LE, Chen JB, Aidoo A, Casciano DA, Heflich RH (1998): Comparison of the types of mutations induced by 7,12 dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue® rats. Environ Mol Mutagen 31:149-156.
18. Nohmi T, Suzuki H, Katoh M, Masumura K, Yamada M, Suzuki M, Ueda O, Matsui K, Matsui M, Watanabe M, Horiya N, Shibuya T, Ikeda H, Sofuni T (1998): New transgenic mouse gpt-delta: An efficient method to detect point mutations and deletions in vivo. Environ Mol Mutagen 31(Suppl 29):6.
19. Parsons BL, Heflich RH (1997): Genotypic selection methods for the direct analysis of point mutations. Mutat Res 387:97-121.
20. Riccardi, VM (1977): "The Genetic Approach to Human Disease." New York: Oxford University Press.
21. Skopek T (1998): Transgenic mutation models: Research, testing, and reality checks. Environ Mol Mutagen 32:104-105.
22. Sofuni T (1993): Japanese guidelines for mutagenicity testing. Environ Mol Mutagen 21:2-7.
23. Tao, KS, Urlando C, Heddle JA (1993): Comparison of somatic mutations in a transgenic versus host locus. Proc Natl Acad Sci USA 90:10681-10685.
24. UK Environmental Mutagen Society (1983): "Report of the UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Part 1: Basic Test Battery, Minimal Criteria. Professional Standards, Interpretation, Selection of Supplementary Assays," Swansea, Wales: UK Environmental Mutagen Society.
25. US Food and Drug Administration (1993): "Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food, Draft Redbook II." Washington, DC: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration.
26. Wassom JS (1989): Origins of genetic toxicology and the Environmental Mutagen Society. Environ Mol Mutagen 14(Suppl 16):1-6.