β-Galactosidase marker genes to tag and track human hematopoietic cells

Cancer Gene Therapy

Volumn 6, Issue 1, 1999, Pages 3-13

  Bagnis, Claude ^a   Chabannon, Christian ^a   Mannoni, Patrice ^a  

^a INSTITUT PAOLI CALMETTES   (France)

Author keywords

Gene marking; Gene therapy; Human hematopoiesis; LacZ; Retroviruses; Stem cell

Indexed keywords

BETA GALACTOSIDASE;

ADENOVIRUS; ANIMAL; CLINICAL TRIAL; DOG; GENE VECTOR; GENETIC MARKER; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOLOGY; LACTOSE OPERON; METABOLISM; MOUSE; PH; REPORTER GENE; RETROVIRUS; REVIEW;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; CLINICAL TRIALS; DOGS; GENES, REPORTER; GENETIC MARKERS; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LAC OPERON; MICE; RETROVIRIDAE;

EID: 0032609117     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700016     Document Type: Article

References (172)

1. Mulligan RC. The basic science of gene therapy. Science. 1993;260:926-932.
2. Bronner-Fraser M, Fraser SE. Cell lineage analysis reveals multipotency of some avian neural crest cells. Nature. 1988;335:161-164.
3. Kimmel CB, Warga RM. Tissue-specific cell lineages originate in the gastrula of the zebrafish. Science. 1986; 231:365-368.
4. Weisblat DA, Sawyer RT, Stent GS. Cell lineage analysis by intracellular injection of a tracer enzyme. Science. 1978;202:1295-1298.
5. Weisblat DA, Zackson SL, Blair SS, Young JD. Cell lineage analysis by intracellular injection of fluorescent tracers. Science. 1980;209:1538-1541.
6. LeDouarin NM. Particularités du noyau interphasique chez la caille japonaise (Coturnix coturnix japonica): utilisation de ses particularités comme "marquage biologique" dans des recherches. Bull Biol Fr Belg. 1969; 103:435-452.
7. Sanes JR, Rubenstein JRL, Nicolas J-F. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 1986;5:3133-3142.
8. Varmus H. Retroviruses. Science. 1988;240:1427-1435.
9. Brenner MK, Rill DR, Holladay MS, et al. Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet. 1993;342:1134-1137.
10. Dunbar CE, Cottler-Fox M, O'Shaughnessy JA, et al. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood. 1995;85: 3048-3057.
11. + cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood. 1994;83:3068-3076.
12. Hanania EG, Giles RE, Kavanagh J, et al. Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy. Proc Natl Acad Sci USA. 1996;93:15346-15351.
13. 3+ hematopoietic stem/progenitor cells from human umbilical cord blood. J Exp Med. 1993;178:2089-2096.
14. Valera A, Perales JC, Hatzoglou M, Bosch F. Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism. Hum Gene Ther. 1994;5:449-456.
15. Artelt P, Grannemann R, Stocking C, Friel J, Bartsch J, Hauser H. The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells. Gene. 1991;99:249-254.
16. Fernex C, Dubreuil P, Mannoni P, Bagnis C. Cre/loxP-mediated excision of a neomycin resistance expression unit from an integrated retroviral vector increases the LTR-driven transcription in human hematopoietic cells. J Virol. 1997;71:7533-7540.
17. Kalmins A, Otto K, Ruther U, Muller-Hill B. Sequence of the LacZ gene of E. coli. EMBO J. 1983;2:593-597.
18. Lederberg J. The β-galactosidase of Escherichia coli, strain K-12. Genetics. 1950;35:381-391.
19. Weiss DJ, Liggitt D, Clark JG. In situ histochemical detection of β-galactosidase activity in lung: assessment of X-Gal reagent in distinguishing lacZ gene expression and endogenous β-galactosidase activity. Hum Gene Ther. 1997;8:1545-1554.
20. Lojda Z. Indigogenic methods for glycosidases: an improved method for β-galactosidase and its application to localization studies of the enzymes in the intestine and in other tissues. Histochemie. 1970;23:266-288.
21. Murnane RD, Wright RW, Hoffman KR, Prieur DJ. Expression of β-galactosidase in preimplantation bovine and porcine embryos. Proc Soc Exp Biol Med. 1990;194: 144-148.
22. Kalderon D, Roberts BL, Richardson WD, Smith AE. A short amino acid sequence able to specify nuclear location. Cell. 1984;39:499-509.
23. Huang C, Samsonoff WA, Grzelecki A. Vaccinia virus recombinants expressing an 11-kilodalton β-galactosidase fusion protein incorporate active β-galactosidase in virus particles. J Virol. 1988;62:3855-3861.
24. Turner DL, Cepko CL. A common progenitor for neurons and glia persists in rat retina late in development. Nature. 1987;328:131-136.
25. Bonnerot C, Rocancourt D, Briand P, Grimber G, Nicolas J-FA. β-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies. Proc Natl Acad Sci USA. 1987;84:6795-6799.
26. Galileo DS, Gray GE, Owens GC, Majors J, Sanes JR. Neurons and glia arise from a common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type-specific antibodies. Proc Natl Acad Sci USA. 1990;87:458-462.
27. Miller JH. Assay of β-galactosidase. In: Miller JH, ed. Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Press; 1972:p352-355.
28. MacGregor GR, Mogg AE, Burke JF, Caskey CT. Histochemical staining of clonal mammalian cell lines expressing E. coli β-galactosidase indicates heterogeneous expression of the bacterial gene. Somat Cell Mol Genet. 1987;13:253-265.
29. Couffinhal T, Kearney M, Sullivan A, Silver M, Tsurumi Y, Isner JM. Histochemical staining following lacZ gene transfer underestimates transfection efficiency. Hum Gene Ther. 1997;8:929-934.
30. Fiering SN, Roederer M, Nolan GP, Micklem DR, Parks DR, Herzenberg LA. Improved FACS-Gal flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry. 1991;12:291-301.
31. Nolan GP, Fiering S, Nicolas JF, Herzenberg LA. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transduction of E. coli LacZ. Proc Natl Acad Sci USA. 1988;85:2603-2607.
32. Strair RK, Towle M, Smith BR. Retroviral-mediated gene transfer into bone marrow progenitor cells: use of β-galactosidase as a selectable marker. Nucleic Acids Res. 1990;18:4759-4762.
33. Zhang YZ, Naleway JJ, Larison KD, Huang Z, Haugland RP. Detecting LacZ gene expression in living cells with new lipophilic, fluorogenic β-galactosidase substrates. FASEB J. 1991;5:3108-3113.
34. Brody SL, Metzger M, Danel C, Rosenfeld MA, Crystal RG. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum Gene Ther. 1994;5:821-836.
35. Simon RH, Engelhardt JF, Yang Y, et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum Gene Ther. 1993;4: 771-780.
36. Yei S, Mittereder N, Wert S, Whittsett JA, Willmott RW, Trapnell BC. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum Gene Ther. 1994;5:731-744.
37. Davidson BL, Doran SE, Shewach DS, Latta JM, Hartman JW, Roessler BJ. Expression of Escherichia coli β-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral-mediated gene transfer. Exp Neurol. 1994;125:258-267.
38. Lisosovski F, Cadusseau J, Akli S, et al. In vivo transfer of a marker gene to study motoneural development. Neuroreport. 1994;5:1069-1072.
39. Ridoux V, Robert JJ, Zhang X, Perricaudet M, Mallet J, Le Gal La Salle G. The use of adenovirus vectors for intracerebral grafting of transfected nervous cells. Neuroreport. 1994;5:801-804.
40. Roessler BJ, Davidson BL. Direct plasmid-mediated transfection of adult murine brain cells in vivo using cationic liposomes. Neurosci Lett. 1994;167:5-10.
41. Bennett J, Wilson J, Sun D, Forbes B, Maguire A. Adenovirus vector-mediated in vivo gene transfer into adult murine retina. Invest Ophthalmol Vis Sci. 1994;35: 2535-2542.
42. Jomary C, Piper TA, Dickson G, et al. Adenovirus-mediated gene transfer to murine retinal cells in vitro and in vivo. FEBS Lett. 1994;347:117-122.
43. + peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease. Blood. 1994;84:53-58.
44. Jensen UB, Jensen TG, Jensen PK, et al. Gene transfer into cultured human epidermis and its transplantation onto immunodeficient mice: an experimental model for somatic gene therapy. J Invest Dermatol. 1994;103:391-394.
45. Setoguchi Y, Jaffe HA, Danel C, Crystal RG. Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors. J Invest Dermatol. 1994;103:415-412.
46. Morris BD, Drazan KE, Csete ME, et al. Adenoviral-mediated gene transfer to bladder in vivo. J Urol. 1994; 152:506-509.
47. Maeda H, Danel C, Crystal RG. Adenovirus-mediated transfer of human lipase complementary DNA to the gallbladder. Gastroenterology. 1994;106:1638-1644.
48. Kitamura M, Taylor S, Unwin R, Burton S, Shimizu F, Fine LG. Gene transfer into the rat glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo. J Clin Invest. 1994;94:497-505.
49. Moullier P, Friedlander G, Cause D, Ronco P, Perricaudet M, Ferry N. Adenoviral-mediated gene transfer to renal tubular cells in vivo. Kidney Int. 1994;45:1220-1225.
50. Conte MS, Birinyi LK, Miyata T, et al. Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells. Circulation. 1994;89: 2161-2169.
51. French BA, Mazur W, Geske RS, Bolli R. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation. 1994;90:2414-2424.
52. Lal B, Indurti RR, Couraud PO, Goldstein GW, Laterra J. Endothelial cell implantation and survival within experimental gliomas. Proc Natl Acad Sci USA. 1994;91: 9695-9699.
53. Lemarchand P, Jones M, Danel C, Yamada I, Mastrangeli A, Crystal RG. In vivo adenovirus-mediated gene transfer to lungs via pulmonary arteries. J Appl Physiol. 1994;76:2840-2845.
54. Steg PG, Feldman LJ, Scoazec JY, et al. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation. 1994;90:1648-1656.
55. Acsadi G, Jani A, Massie B, et al. A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscles of different maturity. Hum Mol Genet. 1994;3: 579-584.
56. Alameddine HS, Quantin B, Cartaud A, Dehaupas M, Mandel JL, Fardeau M. Expression of a recombinant dystrophin in mdx mice using adenovirus vector. Neuro-muscul Disord. 1994;4:193-203.
57. French BA, Mazur W, Ali NM, et al. Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, and two models of coronary restenosis. Circulation. 1994;90:2402-2413.
58. Rando TA, Blau HM. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J Cell Biol. 1994;125:1275-1287.
59. Vitadello M, Schiaffino MV, Picard A, Scarpa M, Schiaffino S. Gene transfer in regenerating muscles. Hum Gene Ther. 1994;5:11-18.
60. Bralet MP, Branchereau S, Brechot C, Ferry N. Cell lineage study in the liver using retroviral-mediated gene transfer: evidence against the streaming of hepatocytes in normal liver. Am J Pathol 1994;144:849-854.
61. Csete ME, Drazan KE, van Bree M, et al. Adenovirus-mediated gene transfer in the transplant setting: conditions for expression of transferred genes in cold-preserved hepatocytes. Transplantation. 1994;57:1502-1507.
62. Drazan KE, Shen XD, Csete ME, et al. In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver after resection. Surgery. 1994; 116:197-203.
63. Shaked A, Csete ME, Drazan KE, Bullington D, Wu L, Busuttil RW. Adenovirus-mediated gene transfer in the transplant setting: successful expression of transferred cDNA in syngeneic liver grafts. Transplantation. 1994;57: 1508-1511.
64. Mastrangeli A, O'Connell B, Aladib W, Fox PC, Baum BJ, Crystal RG. Direct in vivo adenovirus-mediatcd gene transfer to salivary glands. Am J Physiol. 1994;266: G1146-G1155.
65. Sikes ML, O'Malley BW, Finegold MJ, Ledley FD. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection. Hum Gene Ther. 1994;5:837-844.
66. Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA. 1994;91:4407-4411.
67. Savatier P, Morgenstern J, Beddington RSP. Permissiveness to murine leukemia virus expression during preimplantation and early postimplantation mouse development. Development. 1990;109:655-665.
68. Volckaert FA, Hellemans BA, Galbusera P, Ollevier F, Sekkali B, Belayew A. Replication, expression, and fate of foreign DNA during embryonic and larval development of the African catfish (Clarias gariepinus). Mol Mar Biol Biotechnol. 1994;3:57-69.
69. Goodman S, Xiao X, Donahue RE, et al. Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood. 1994;84:1492-1500.
70. Zhou SZ, Cooper S, Kang LY, et al. Adeno-associated virus 2-mediated high efficiency gene transfer into immature and mature subsets of hematopoietic progenitor cells in human umbilical cord blood. J Exp Med. 1994;179: 1867-1875.
71. + cell populations and into TF-1 cells: future prospects in gene therapy. Hum Gene Ther. 1994;5:1325-1333.
72. Riddell SR, Elliott M, Lewinsohn DA, et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med. 1996;2:216-223.
73. Bonini C, Ferrari G, Verzeletti S, et al. HSV-TK gene transfer into donor lymphocytes for control of allogencic graft versus leukemia. Science. 1997;276:1719-1724.
74. Abina MA, Lee MG, Descamps V, et al. LacZ gene transfer into tumor cells abrogates tumorigenicity and protects mice against the development of further tumors. Gene Ther. 1996;3:212-216.
75. Stockschlader MAR, Schuenning FG, Graham TC, Storb R. Transplantation of retrovirus-transduced canine keratinocytes expressing the β-galactosidase. Gene Ther. 1994; 1:317-322.
76. Kessler PD, Podsakoff GM, Chen X, et al. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc Natl Acad Sci USA. 1996;93:14082-14087.
77. Schreiber JH, Schisa JA, Wilson JM. Recombinant retroviruses containing novel reporter genes. Biotechniques. 1993;14:818-822.
78. Zolotukhin S, Potter M, Hauswirth WW, Guy J, Muzyczka NA. "Humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol. 1996;70:4646-4654.
79. Anderson MT, Tjioe IM, Lorincz MC, et al. Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins. Proc Natl Acad Sci USA. 1996;93:8508-8511.
80. Crameri A, Whitehorn EA, Täte E, Stemmer WPC. Improved green fluorescent protein by molecular evolution using DNA shuffling. Nat Biotechnol. 1996;14:315-319.
81. Persons DA, Allay JA, Allay ER, et al. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood. 1997; 90:1777-1786.
82. Cheng L, Du C, Murray D, et al. A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells. Gene Ther. 1997;4:1013-1022.
83. Jolly D. Viral vector systems for gene therapy. Cancer Gene Ther. 1994;1:51-64.
84. Neering SJ, Hardy SF, Minamoto D, Spratt SK, Jordan CJ. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors. Blood. 1996;88: 1147-1155.
85. Miller DG, Edwards RH, Miller AD. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci USA. 1994;91:78-82.
86. Van Zeijl M, Johann SV, Cloos E, et al. A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family. Proc Natl Acad Sci USA. 1994;91:1168-1172.
87. Mikawa T, Fischman DA, Dougherty JP, Brown AMC. In vivo analysis of a new LacZ retrovirus vector suitable for cell lineage marking in avian and other species. Exp Cell Res. 1991;195:516-523.
88. Price J, Turner D, Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA. 1987;84:156-160.
89. Faustinella F, Kwon H, Serrano F, Belmont JW, Caskey CT, Aguilar-Cordova E. A new family of murine retroviral vectors with extended multiple cloning sites for gene insertion. Hum Gene Ther. 1994;5:307-312.
90. Hawley RG, Lieu FHL, Fong AZC, Hawley TS. Versatile vectors for potential use in gene therapy. Gene Ther. 1994;1:136-138.
91. Saleh M. A retroviral vector that allows efficient coexpression of two genes and the versatility of alternate selection markers. Hum Gene Ther. 1997;8:879-893.
92. Wiznerowicz M, Fong AZC, Mackiewicz A, Hawley RG. Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: application to melanoma vaccine development. Gene Ther. 1997;4:1061-1068.
93. Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol. 1986;6:2895-2902.
94. Danos O, Mulligan RC. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci USA. 1988;85:6460-6464.
95. Baum C, Hegewisch-Becker S, Eckert HG, Stocking C, Ostertag W. Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells. J Virol. 1995;69:7541-7547.
96. Miller DG, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol. 1990; 10:4239-4245.
97. Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272:263-267.
98. Markowitz D, Goff S, Bank A. Construction and use of a safe and efficient packaging cell line. Virology. 1988;167: 400-406.
99. Miller AD, Garcia JV, von Suhr N, Lynch CM, Wilson C, Eiden MV. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol. 1991;65:2220-2224.
100. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-liter helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA. 1993;90:8392-8396.
101. Cosset FL, Takeuchi Y, Battini JL, Weiss RA, Collins MKL. High-titer packaging cells producing recombinant retroviruses resistant to human serum. J Virol. 1995;69: 7430-7436.
102. Van Beusechem VW, Bakx TA, Kaptein LCM, et al. Retrovirus-mediated gene transfer into rhesus monkey hematopoietic stem cells: the effect of viral titers on transduction efficiency. Hum Gene Ther. 1993;4:239-247.
103. - bone marrow progenitor cells capable of repopulating lymphoid and myeloid lineages. Hum Gene Ther. 1994;5:295-305.
104. Paul RW, Morris D, Hess BW, Dunn J, Overell RW. Increased viral titer through concentration of viral harvests from retroviral packaging lines. Hum Gene Ther. 1993;4:609-615.
105. Xu LC, Young HA, Blanco M, Kessler S, Roberts AB, Karlsson S. Poor transduction efficiency of human hematopoictic progenitor cells by a high titer amphotropic retrovirus producer cell clone. J Virol. 1994;68:7634-7636.
106. Forestell SP, Bohnlein E, Rigg RJ. Retroviral end-point titer is not predictive of gene transfer efficiency: implications for vector production. Gene Ther. 1995;2:723-730.
107. Bagnis C, Chischportich C, Imbert AM, Van Den Broeke A, Cornet V, Mannoni P. Efficiency of retroviral transduction into hematopoietic cells by cocultivation does not correlate with viral titer. Cancer Gene Ther. 1997;4:5-8.
108. Cosset FL, Russel SJ. Targeting retrovirus entry. Gene Ther. 1996;3:946-956.
109. Kotin RM. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum Gene Ther. 1994;5:793-801.
110. Malik P, McQuiston SA, Yu X-J, et al. Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line. J Virol. 1997;71:1776-1783.
111. Shelling AN, Smith MG. Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene. Gene Ther. 1994;1: 165-169.
112. Podsakoff G, Wong KK, Chatterjee S. Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J Virol. 1994;68:5656-5666.
113. Feng M, Jackson WH, Goldman CK, et al. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nat Biotechnol. 1997;15:866-870.
114. Bagnis C, Mannoni P. Stem cell-based gene therapy. Oncologist. 1997;2:196-202.
115. Kitamura T, Tange T, Terasawa T, et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol. 1989;140:323-334.
116. Hatzfeld A, Batard P, Panterne B, Taieb F, Hatzfeld J. Increased stable retroviral gene transfer in early hematopoietic progenitors released from quiescence. Hum Gene Ther. 1996;7:207-213.
117. Humeau L, Chabannon C, Firpo MT, Bagnis C, Roncarolo M-G, Namikawa R. Successful reconstitution of human hematopoiesis in the SCID-hu mouse by genetically modified, highly enriched progenitors isolated from fetal liver. Blood. 1997;90:3496-3506.
118. + peripheral blood progenitors and increases the number of transduced progenitors. Exp Hematol. 1998;26:374-381.
119. Maciejewski JP, Bruening EE, Donahue RE, Mocarski ES, Young NS, St Jeor SC. Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood. 1992; 80:170-178.
120. Hege KM, Roberts MR. T-cell gene therapy. Cuir Opin Biotech. 1996;7:629-634.
121. + cells in the human thymus are defined by expression of CD34: delineation of early events in human thymic development. J Exp Med. 1993;178: 391-401.
122. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-produced cells for treatment of experimental brain tumors. Science. 1992;256:1550-1552.
123. Tiberghien P, Reynolds CW, Keller J, et al. Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation. Blood. 1994;84:1333-1341.
124. Mavilio F, Ferrari G, Rossini S, et al. Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer. Blood. 1994;83:1988-1997.
125. Finer MH, Dull DJ, Qin L, Farson D, Roberts MR. Kat: a high-efficiency retroviral transduction system for human T lymphocytes. Blood. 1994;83:43-50.
126. Imbert AM, Costello R, Imbert J, Mannoni P, Bagnis C. Highly efficient retroviral gene transfer into human primary T lymphocytes derived from the peripheral blood. Cancer Gene Ther. 1994;1:259-265.
127. Rosenberg SA, Aebersold P, Cornetta K, et al. Gene transfer into humans: immunotherapy of patients with advanced melanoma using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med. 1990;323:570-578.
128. Culver K, Cornelia K, Morgan R, et al. Lymphocytes as cellular vehicles for gene therapy in mouse and man. Proc Natl Acad Sci USA. 1991;88:3155-3159.
129. Di Ianni M, Casciari C, Ciurnelli R, et al. β-galactosidase-transduced T lymphocytes: a comparison between stimulation by either PHA and IL-2 or a mixed lymphocyte reaction. Haematologica. 1996;81:410-417.
130. + T lymphocytes. Blood. 1995;85:3213-3222.
131. Gu J, Kuo ML, Rivera A, Sutkowski N, Ron Y, Dougherty JP. A murine model for genetic manipulation of the T cell compartment. Exp Hematol. 1996;24:1432-1440.
132. + human T cells subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells. Cancer Immunol Immunother. 1991;32:342-348.
133. Staal FJ, Res PC, Weijer K, Spits H. Development of retrovirally marked human T progenitor cells into mature thymocytes. Int Immunol. 1995;7:1301-1309.
134. Aicher A, Westermann J, Cayeux S, et al. Successful retroviral-mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with genemodified antigen-presenting cells. Exp Hematol. 1997;25: 39-44.
135. Henderson RA, Nimgaonkar MT, Watkins SC, Robbins PD, Ball ED, Finn OJ. Human dendritic cells engineered to express high levels of the human epithelial tumor antigen (MUC-1). Cancer Res. 1996;56:3763-3770.
136. Reeves ME, Royal RE, Lam JS, Rosenberg SA, Hwu P. Retroviral transduction of human dendritic cells with a tumor-associated antigen gene. Cancer Res. 1996;56: 5672-5677.
137. Weir JP, Meltzer MS. Transfection of human immunodeficiency virus lype 1 proviral DNA into primary human monocytes. Cell Immnnol. 1993;148:157-165.
138. Snodgrass R, Keller G. Clonal fluctuation within the hematopoietic system of mice reconstituted with retrovirus-infected stem cells. EMBO J. 1987;6:3955-3960.
139. Jordan CT, Lemischka IR. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev. 1990;4:220-232.
140. Van Zant G, Chen JJ, Scott-Micus K. Developmental potential of hematopoietic stem cells determined using retrovirally marked allophenic marrow. Blood. 1991;77: 756-763.
141. Dick JE, Mgli MC, Huszar D, Phillips RA, Bernstein A. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mive. Cell. 1985;42:71-79.
142. Lemischka IR, Raulet DH, Mulligan RC. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell. 1986;45:917-927.
143. Larochelle A, Vormoor J, Hanenberg H, et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med. 1996;2:1329-1337.
144. Kiem HP, Darovsky B, von Kalle C, et al. Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells. Blood. 1994;83:1467-1473.
145. Kwok WW, Schuening F, Stead RB, Miller AD. Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy. Proc Natl Acad Sci USA. 1986;83:4552-4555.
146. Carter RF, Abrams-Ogg ACG, Dick JE, et al. Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors. Blood. 1992;79:356-364.
147. Culver KW, Morgan RA, Osborne WRA, et al. In vivo expression and survival of gene-modified T lymphocytes in rhesus monkeys. Hum Gene Ther. 1990;1:399-410.
148. Kantoff PW, Gillio AP, MacLachlin JR, et al. Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. J Exp Med. 1987; 166:219-234.
149. + cord blood cells is expressed by their T-cell progeny in the SCID-hu thymus. Blood. 1996;88:107-113.
150. Bagnis C, Cosset FL, Samarut J, Moscovici G, Moscovici C. Leukemogenicity of v-myb transformed monoblast cells can be modulated by normal bone marrow environment. Oncogene. 1993;8:737-743.
151. Solari F, Flamant F, Cherel Y, Wyers M, Jurdic P. The osteoclast generation: an in vitro and in vivo study with a genetically labelled avian monocytic cell line. J Cell Sci. 1996;109:1203-1213.
152. Brenner MK, Rill RD, Moen RC, et al. Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet. 1993;341:85-86.
153. Nolta JA, Crooks GM, Overell RW, Williams DE, Kohn DB. Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines. Exp Hematol. 1992;20:1065-1071.
154. Bodine DM, Karlsson S, Nienhuis AW. Combinations of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci USA. 1989;86:8897-8900.
155. Moore KA, Desseiroth AB, Reading CL, Williams DE, Belmont JW. Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells. Blood. 1992;79:1393-1399.
156. Dube ID, Kruth S, Abrams-Ogg A, et al. Preclinical assessment of human hematopoietic progenitor cell transduction in long-term marrow cultures. Hum Gene Ther. 1996;7:2089-2100.
157. Moritz T, Patel VP, Williams DA. Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. J Clin Invest. 1994;93:1451-1457.
158. Moritz T, Dutt P, Xiao X, et al. Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments. Blood. 1996; 88:855-862.
159. Couture LA, Mullen CA, Morgan RA. Retroviral vectors containing chimeric promoter/enhancer elements exhibit cell-type-specific gene expression. Hum Gene Ther. 1994; 5:667-677.
160. Bauer TR, Osborne WRA, Kwok WW, Hickstein DD. Expression from leukocyte integrin promoters in retroviral vectors. Hum Gene Ther. 1994;5:709-716.
161. Vile R, Miller N, Chernajovsky Y, Ian H. A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes. Gene Ther. 1994;1:307-316.
162. Johnson MI, Forth DF. Present status and future prospects for HIV therapies. Science. 1993;260:1286-1293.
163. Yu M, Poeschla E, Wong Staal F. Progress towards gene therapy for HIV infection. Gene Ther. 1994;1:13-26.
164. Hoeben RC, Migchielsen AA, van der Jagt RC, van Ormondt H, van der Eb AJ. Inactivation of Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position. J Virol. 1991;65: 904-912.
165. Duch M, Paludan K, Jorgensen P, Pedersen FS. Lack of correlation between basal expression levels and susceptibility to transcriptional shutdown among single-gene murine leukemia virus vector proviruses. J Virol. 1994;68: 5569-5601.
166. MacLachlin JR, Mittereder N, Daucher MB, Kadan M, Eglitis MA. Factors affecting retroviral vector function and structural integrity. Virology. 1993;195:1-5.
167. Nilsson E, Lendhal U. Transient expression of a human β-actin promoter/LacZ gene introduced into mouse embryos correlates with a low degree of methylation. Mol Reprod Dev. 1993;34:149-157.
168. Challita PM, Kohn DB. Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc Natl Acad Sci USA. 1994;91:2567-2571.
169. Emerman M, Temin HM. Comparison of promoter suppression in avian and murine retrovirus vectors. Nucleic Acids Res. 1986;14:9381-9396.
170. Ghattas IR, Sanes JR, Majors JE. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and embryo. Mol Cell Biol. 1991;11:5848-5859.
171. Friedrich G, Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Gene Dev. 1991;5:1513-1523.
172. Baron M, Reynes JP, Stassi D, Tiraby G. A selectable bifunctional β-galactosidase: phleomycin resistance fusion protein as a potential marker for eukaryotic cells. Gene. 1992;114:239-243.