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Volumn 10, Issue 3, 1998, Pages 311-316

DNA mismatch repair and cancer

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTOTOXIC AGENT;

EID: 0031804961     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80005-7     Document Type: Article
Times cited : (50)

References (59)
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    • Yamada M, O'Regan E, Brown R, Karran P. Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins. of special interest Nucleic Acids Res. 25:1997;491-496 Binding assays were used to demonstrate that human cell lines contain proteins that recognize 1,2-diguanyl cisplatin intrastrand cross-links. Binding activity is sequence-context-specific, and is absent in colorectal carcinoma cell lines deficient for hMSH2 (LoVo) or hMSH6 (GTBP) DNA mismatch repair activity.
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    • Yamada, M.1    O'Regan, E.2    Brown, R.3    Karran, P.4
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    • 15444348851 scopus 로고    scopus 로고
    • Role of DNA mismatch repair in the cytotoxicity of ionizing radiation
    • -/- cell lines were found to exhibit higher levels of clonogenic survival following radiation treatment. The authors propose that introduction of modified bases, such as 8-oxo-G, in replicating DNA of wild-type cells may lead to MMR-mediated cell death. Presumably, the presence of modified bases in the parental DNA strands leads to futile repair attempts that eventually lead to DNA strand breaks and cell death.
    • -/- cell lines were found to exhibit higher levels of clonogenic survival following radiation treatment. The authors propose that introduction of modified bases, such as 8-oxo-G, in replicating DNA of wild-type cells may lead to MMR-mediated cell death. Presumably, the presence of modified bases in the parental DNA strands leads to futile repair attempts that eventually lead to DNA strand breaks and cell death.
    • (1997) Cancer Res , vol.57 , pp. 5143-5147
    • Fritzell, J.A.1    Narayanan, L.2    Baker, S.M.3    Bronner, C.E.4    Andrew, S.E.5    Prolla, T.A.6    Bradley, A.7    Jirik, F.R.8    Liskay, R.M.9    Glazer, P.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.