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Volumn 82, Issue 8, 1997, Pages 2695-2701

Diversity and prevalence of somatic mutations in the thyrotropin receptor and G(s)α genes as a cause of toxic thyroid adenomas

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN RECEPTOR;

EID: 8544221172     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.8.2695     Document Type: Article
Times cited : (259)

References (41)
  • 1
    • 0029941917 scopus 로고    scopus 로고
    • Mutations in G proteins and G protein-coupled receptors in endocrine diseases
    • Spiegel AM. 1996 Mutations in G proteins and G protein-coupled receptors in endocrine diseases. J Clin Endocrinol Metab. 81:2434-2442.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2434-2442
    • Spiegel, A.M.1
  • 2
    • 0026661582 scopus 로고
    • Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors
    • Dumont JE, Lamy F, Roger P, Maenhaut C. 1992 Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 72:667-697.
    • (1992) Physiol Rev , vol.72 , pp. 667-697
    • Dumont, J.E.1    Lamy, F.2    Roger, P.3    Maenhaut, C.4
  • 3
    • 0027297275 scopus 로고
    • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
    • Lefkowitz RJ, Cotecchia S, Samama P, Costa T. 1994 Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins, TiPS. 14:303-307.
    • (1994) TiPS , vol.14 , pp. 303-307
    • Lefkowitz, R.J.1    Cotecchia, S.2    Samama, P.3    Costa, T.4
  • 4
    • 0027318238 scopus 로고
    • Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors
    • Conklin BR, Bourne HR. 1993 Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73:631-641.
    • (1993) Cell , vol.73 , pp. 631-641
    • Conklin, B.R.1    Bourne, H.R.2
  • 5
    • 0027369421 scopus 로고
    • Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
    • Parma J, Duprez L, Van Sande J, et al. 1993 Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature. 365:649-651.
    • (1993) Nature , vol.365 , pp. 649-651
    • Parma, J.1    Duprez, L.2    Van Sande, J.3
  • 9
    • 0029093051 scopus 로고
    • Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan
    • Takeshita A, Nagayama Y, Yokoyama N, et al. 1995 Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan. J Clin Endocrinol Metab. 80:2607-2611.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2607-2611
    • Takeshita, A.1    Nagayama, Y.2    Yokoyama, N.3
  • 10
    • 0029964174 scopus 로고    scopus 로고
    • Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas
    • Russo D, Arturi F, Suarez HG, et al. 1996 Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab. 81:1548-1551.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1548-1551
    • Russo, D.1    Arturi, F.2    Suarez, H.G.3
  • 11
    • 0027166893 scopus 로고
    • The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: Structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms
    • Matsuo K, Friedman E, Gejman PV, Fagin JA. 1993 The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms. J Clin Endocrinol Metab. 76:1446-1451.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1446-1451
    • Matsuo, K.1    Friedman, E.2    Gejman, P.V.3    Fagin, J.A.4
  • 12
    • 0029044073 scopus 로고
    • Somatic mutations causing constitutive activity of the TSH receptor are the major cause of hyperfunctional thyroid adenomas: Identification of additional mutations activating both the cAMP and inositolphosphate-Ca++ cascades
    • Parma J, Van Sande J, Swillens S, Tonacchera M, Dumont JE, Vassart G. 1995 Somatic mutations causing constitutive activity of the TSH receptor are the major cause of hyperfunctional thyroid adenomas: identification of additional mutations activating both the cAMP and inositolphosphate-Ca++ cascades. Mol Endocrinol. 9:725-733.
    • (1995) Mol Endocrinol , vol.9 , pp. 725-733
    • Parma, J.1    Van Sande, J.2    Swillens, S.3    Tonacchera, M.4    Dumont, J.E.5    Vassart, G.6
  • 15
    • 0023836898 scopus 로고
    • Pathogenesis of autonomous thyroid nodules: In vitro study of iodine and adenosine 3′,5′-monophosphate metabolism
    • Van Sande J, Lamy F, Lecocq R, et al. 1988 Pathogenesis of autonomous thyroid nodules: in vitro study of iodine and adenosine 3′,5′-monophosphate metabolism. J Clin Endocrinol Metab. 66:570-579.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 570-579
    • Van Sande, J.1    Lamy, F.2    Lecocq, R.3
  • 16
    • 0025127424 scopus 로고
    • Two G protein oncogenes in human endocrine tumors
    • Lyons J, Landis CA, Harsh G, et al. 1990 Two G protein oncogenes in human endocrine tumors. Science. 249:655-659.
    • (1990) Science , vol.249 , pp. 655-659
    • Lyons, J.1    Landis, C.A.2    Harsh, G.3
  • 17
    • 0024806929 scopus 로고
    • Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: Evidence for binding of autoantibodies
    • Libert F, Lefort A, Gerard C, et al. 1989 Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Commun. 165:1250-1255.
    • (1989) Biochem Biophys Res Commun , vol.165 , pp. 1250-1255
    • Libert, F.1    Lefort, A.2    Gerard, C.3
  • 18
    • 9044240477 scopus 로고    scopus 로고
    • Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia
    • Tonacchera M, Van Sande J, Cetani F, et al. 1996 Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia. J Clin Endocrinol Metab. 81:547-554.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 547-554
    • Tonacchera, M.1    Van Sande, J.2    Cetani, F.3
  • 20
    • 0029888302 scopus 로고    scopus 로고
    • Specific activation of the thyrotropin receptor by trypsin
    • Van Sande J, Massart C, Costagliola S, et al. 1996 Specific activation of the thyrotropin receptor by trypsin. Mol Cell Endocrinol. 119:161-168.
    • (1996) Mol Cell Endocrinol , vol.119 , pp. 161-168
    • Van Sande, J.1    Massart, C.2    Costagliola, S.3
  • 21
    • 0028588698 scopus 로고
    • Identification and functional characterization of two new somatic mutations causing constitutive activation of the TSH receptor in hyperfunctioning autonomous adenomas of the thyroid
    • Paschke R, Tonacchera M, Van Sande J, Parma J, Vassart G. 1994 Identification and functional characterization of two new somatic mutations causing constitutive activation of the TSH receptor in hyperfunctioning autonomous adenomas of the thyroid. J Clin Endocrinol Metab. 79:1785-1789.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1785-1789
    • Paschke, R.1    Tonacchera, M.2    Van Sande, J.3    Parma, J.4    Vassart, G.5
  • 22
    • 0028927822 scopus 로고
    • Genetic alterations in thyroid hyperfunctioning adenomas
    • Russo D, Arturi F, Wicker R, et al. 1995 Genetic alterations in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab. 80:1347-1351.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1347-1351
    • Russo, D.1    Arturi, F.2    Wicker, R.3
  • 23
    • 0031014717 scopus 로고    scopus 로고
    • Two autonomous nodules of a patient with multinodular goiter harbor different activating mutations of the thyrotropin receptor gene
    • Duprez L, Hermans J, Van Sande J, Dumont JE, Vassart G, Parma J. 1997 Two autonomous nodules of a patient with multinodular goiter harbor different activating mutations of the thyrotropin receptor gene. J Clin Endocrinol Metab. 82:306-308.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 306-308
    • Duprez, L.1    Hermans, J.2    Van Sande, J.3    Dumont, J.E.4    Vassart, G.5    Parma, J.6
  • 24
    • 0028891649 scopus 로고
    • Congenital non-autoimmune hyperthyroidism caused by a neomutation in the thyrotropin receptor gene
    • Kopp P, Van Sande J, Parma J, et al. 1995 Congenital non-autoimmune hyperthyroidism caused by a neomutation in the thyrotropin receptor gene. N Engl J Med. 332:150-154.
    • (1995) N Engl J Med , vol.332 , pp. 150-154
    • Kopp, P.1    Van Sande, J.2    Parma, J.3
  • 25
    • 0029973239 scopus 로고    scopus 로고
    • A neomutation of the TSH receptor in a severe neonatal hyperthyroidism
    • de Roux N, Polak M, Couet J, et al. 1996 A neomutation of the TSH receptor in a severe neonatal hyperthyroidism. J Clin Endocrinol Metab. 81:2023-2026.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2023-2026
    • De Roux, N.1    Polak, M.2    Couet, J.3
  • 26
    • 0343553834 scopus 로고    scopus 로고
    • Diversity and prevalence of somatic mutations in the TSH receptor gene as a cause of toxic adenoma
    • Duprez L, Parma J, Dumont JE, Hermans J, Vassart G. 1996 Diversity and prevalence of somatic mutations in the TSH receptor gene as a cause of toxic adenoma. J Endocrinol Invest. 19:69.
    • (1996) J Endocrinol Invest , vol.19 , pp. 69
    • Duprez, L.1    Parma, J.2    Dumont, J.E.3    Hermans, J.4    Vassart, G.5
  • 28
    • 0002817709 scopus 로고
    • The thyrotropin receptor and the regulation of thyrocyte function and growth: Update 1994
    • Vassart G, Parma J, Van Sande J, Dumont J. 1994 The thyrotropin receptor and the regulation of thyrocyte function and growth: update 1994. Endocr Rev. 3:77-80.
    • (1994) Endocr Rev , vol.3 , pp. 77-80
    • Vassart, G.1    Parma, J.2    Van Sande, J.3    Dumont, J.4
  • 29
    • 0026499881 scopus 로고
    • Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism
    • Ledent C, Dumont JE, Vassart G, Parmentier M. 1992 Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism. EMBO J. 11:537-542.
    • (1992) EMBO J , vol.11 , pp. 537-542
    • Ledent, C.1    Dumont, J.E.2    Vassart, G.3    Parmentier, M.4
  • 30
    • 0027988614 scopus 로고
    • Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice
    • Michiels FM, Caillou B, Talbot M, et al. 1994 Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice. Proc Natl Acad Sci USA. 91:10488-10492.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10488-10492
    • Michiels, F.M.1    Caillou, B.2    Talbot, M.3
  • 31
    • 0027498052 scopus 로고
    • Molecular basis of epithelial tumorigenesis: The thyroid model
    • Wynford TD. 1993 Molecular basis of epithelial tumorigenesis: the thyroid model. Crit Rev Oncog. 4:1-23.
    • (1993) Crit Rev Oncog , vol.4 , pp. 1-23
    • Wynford, T.D.1
  • 32
    • 0029187438 scopus 로고
    • Multiple facets of the modulation of growth by cAMP
    • Roger P, Reuse S, Maenhaut C, Dumont JE. 1995 Multiple facets of the modulation of growth by cAMP. Vitam Horm. 51:59-191.
    • (1995) Vitam Horm , vol.51 , pp. 59-191
    • Roger, P.1    Reuse, S.2    Maenhaut, C.3    Dumont, J.E.4
  • 33
    • 0030013462 scopus 로고    scopus 로고
    • Both the 5′ and 3′ noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells
    • Kakinuma A, Chazenbalk G, Filetti S, McLachlan SM, Rapoport B. 1996 Both the 5′ and 3′ noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells. Endocrinology. 137:2664-2669.
    • (1996) Endocrinology , vol.137 , pp. 2664-2669
    • Kakinuma, A.1    Chazenbalk, G.2    Filetti, S.3    McLachlan, S.M.4    Rapoport, B.5
  • 34
    • 0028240982 scopus 로고
    • Germline mutations in the thyrotropin receptor gene cause nonautoimmune autosomal dominant hyperthyroidism
    • Duprez L, Parma J, Van Sande J, et al. 1994 Germline mutations in the thyrotropin receptor gene cause nonautoimmune autosomal dominant hyperthyroidism. Nat Genet. 7:396-401.
    • (1994) Nat Genet , vol.7 , pp. 396-401
    • Duprez, L.1    Parma, J.2    Van Sande, J.3
  • 35
    • 0026592357 scopus 로고
    • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation
    • Kjelsberg MA, Cotecchia S, Ostrowski J, Caron MG, Lefkowitz RJ. 1992 Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem. 267:1430-1433.
    • (1992) J Biol Chem , vol.267 , pp. 1430-1433
    • Kjelsberg, M.A.1    Cotecchia, S.2    Ostrowski, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 36
    • 0025212680 scopus 로고
    • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function
    • Cotecchia S, Exum S, Caron MG, Lefkowitz RJ. 1990 Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proc Natl Acad Sci USA. 87:2896-2900.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2896-2900
    • Cotecchia, S.1    Exum, S.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 37
    • 0026568620 scopus 로고
    • The thyrotropin receptor 25 years after its discovery: New insight after its molecular cloning
    • Nagayama Y, Rapoport B. 1992 The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Mol Endocrinol. 6:145-156.
    • (1992) Mol Endocrinol , vol.6 , pp. 145-156
    • Nagayama, Y.1    Rapoport, B.2
  • 38
    • 0028863032 scopus 로고
    • TSH receptor and LH receptor, 1995
    • Kosugi S, Mori T. 1995 TSH receptor and LH receptor, 1995. Endocrine J 42:587-606.
    • (1995) Endocrine J , vol.42 , pp. 587-606
    • Kosugi, S.1    Mori, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.