Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 11, 1996, Pages 5501-5506

  De Jong, Menno D ^a   Veenstra, Jan ^b   Stilianakis, Nikolaos I ^c   Schuurman, Rob ^a,c   Lange, Joep M A ^a   De Boer, Rob J ^c   Boucher, Charles A B ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MUNICIPAL HEALTH SERVICE   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

RNA DIRECTED DNA POLYMERASE; VIRUS RNA; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG RESISTANCE; HELPER CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS MUTATION; VIRUS RESISTANCE;

BASE SEQUENCE; CD4 LYMPHOCYTE COUNT; DNA PRIMERS; HIV SEROPOSITIVITY; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HOMOSEXUALITY, MALE; HOST-PARASITE RELATIONS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; TIME FACTORS; VARIATION (GENETICS); VIRUS REPLICATION; ZIDOVUDINE;

EID: 0029980114     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.11.5501     Document Type: Article

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