Exploration of β-turn scaffolding motifs as components of sialyl Le(x) mimetics and their relevance to P-selectin

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2803-2808

  Hanessian, Stephen ^a   Huynh, Hoan K ^a   Reddy, Gurijala V ^a   McNaughton Smith, Grant ^a   Ernst, Beat ^b   Kolb, Hartmuth C ^b   Magnani, John ^c   Sweeley, Charla ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Glyotech Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM DERIVATIVE; PADGEM PROTEIN; SIALIC ACID DERIVATIVE;

ARTICLE; CELL ADHESION; DRUG CONFORMATION; DRUG SYNTHESIS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PROTEIN BINDING;

BETA-LACTAMS; BINDING, COMPETITIVE; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; E-SELECTIN; INDOLIZINES; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; P-SELECTIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0032491269     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00500-9     Document Type: Article

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45. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
46. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
47. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
48. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
49. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
50. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.
51. 19. For pertinent references, see Hiramatsu, Y.; Moriyama, H.; Kiyoi, T.; Tsukida, T.; Inoue, Y.; Kondo, H. J. Med. Chem. 1998, 41, 2302; Marron, T. G.; Weltering, T. J.; Weitz-Schmidt, G.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 9037; Wy, S.-H.; Shimazaki, M., Lin, C. C.; More, W. J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. Engl. 1996, 35, 88, Himura, K.; Kajimoto, T., Weitz-Schmidt, G.; Ollmann, I.; Wong, C.-H. J. Am. Chem. Soc. 1996,118, 9265; Wang, R.; Wong, C.-H. Tetrahedron Lett. 1996, 37, 5427; Dupre, B.; Bui, H.; Scott, I. L.; Market, R. V., Keller, K. M.; Beck, B. J.; Kogan, T. P. Bioorg. Med.Chem. Lett. 1996, 6, 569; Allanson, N. M.; Davidson, A. H.; Floyd, C. D.; Martin, F. M. Tetrahedron: Asymmetry 1994, 5, 2061; see also ref 10.