Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate character

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 3, 1996, Pages 239-244

  Bamford, Mark J ^a   Bird, Michael ^a   Gore, Paul M ^a   Holmes, Duncan S ^a   Priest, Richard ^a   Prodger, Jeremy C ^a   Saez, Victoria ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; OLIGOSACCHARIDE; SIALYL LEWIS X DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0030021762     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00008-X     Document Type: Article

References (13)

1. Springer, T. A. Nature 1990, 346, 425.
2. Walz, G.; Aruffo, A.; Kolanus, W.; Bevilacqua, M.; Seed, B. Science 1990, 250, 132.
3. Buerke, M.; Weyrich, A. S.; Zheng, Z.; Gaeta, F. C. A.; Forrest, M. J.; Lefer A. M. J. Clin. Invest. 1994, 1140.
4. Mulligan, M. S.; Paulson, J. C.; De Frees, S.; Zheng, Z. -L.; Lowe, J. B.; Ward, P. A. Nature 1993, 364, 149.
5. (a) Ragan, J. A.; Cooper, K. Bioorg. Med. Chem. Lett. 1994, 4, 2563;
6. (b) Allanson, N. M.; Davidson, A. H.; Martin, F. M. Tetrahedron Lett. 1993, 34, 3945;
7. (c) Huang, H.; Wong, C. -H. J. Org. Chem. 1995, 60, 3100.
8. Hasegawa, A.; Yoshida, M.; Uchimura, A.; Kiso, M. Glycoconjugate J. 1993, 10, 3;
9. Tiermeyer, M.; Swiedler, S. J.; Ishihara, M.; Moreland, M.; Schweingruber, H.; Hirtzer, P.; Brandley, B. K. Proc. Natl. Acad. Sci. (USA) 1991, 88, 1138.
10. Yuen, C. -T.; Lawson, A. M.; Chai, W.; Larkin, M.; Stoll, M. S.; Stuart, A. C.; Sullivan, F. X.; Ahern, T. J.; Feizi, T. Biochemistry 1992, 31, 9126.
11. Musser, J. Trends in Drug Research; Claassen, V, Ed.; Elsevier, Amsterdam, 1993.
12. Hasegawa, A.; Fushimi, K.; Ishida, H.; Kiso, M. J. Carbohydr. Chem. 1993, 12, 1203.
13. Prodger, J. C.; Bamford, M. J.; Gore, P. M.; Holmes, D. S.; Saez, V.; Ward, P. Tetrahedron Lett. 1995, 36, 2339.