Genetics of experimental hypertension

Journal of Hypertension

Volumn 16, Issue 12 SUPPL., 1998, Pages 1859-1869

  Dominiczak, Anna F ^a,b   Clark, James S ^a   Jeffs, Baxter ^a   Anderson, Niall H ^a   Negrin, Cervantes D ^a   Lee, Wai K ^a   Brosnan, M Julia ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

Author keywords

Cardiac hypertrophy; Congenic strains; Genetics; Hypertension; Pharmacogenetics; Positional cloning; Rat models; Stroke

Indexed keywords

BLOOD PRESSURE REGULATION; CONFERENCE PAPER; ESSENTIAL HYPERTENSION; GENE LOCUS; GENETICS; HEART VENTRICLE HYPERTROPHY; HEREDITARY HYPERTENSION; HUMAN; METABOLIC DISORDER; METHODOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT; STROKE;

EID: 0032438401     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816121-00003     Document Type: Conference Paper

References (60)

1. Ward R: Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH. Brenner BM (editors). Hypertension: Pathophysiology, Diagnosis and Management. New York: Raven Press; 1990. pp. 811-1000.
2. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, et al.: Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71:169-180.
3. Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark AJ: Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994; 330:1629-1633.
4. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, et al.: A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription. J Clin Invest 1997; 99:1786-1797.
5. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, et al.: Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349:1353-1357.
6. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, et al.: Association of a human G-protein β3 subunit variant with hypertension. Nat Genet 1998; 18:45-48.
7. Kuntz R, Kreutz R, Beige J, Distler A, Sharma AM: Association between the angiotensinogen 235T-variant and essential hypertension in whites. J Hypertens 1997; 30:1331-1337.
8. Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, et al.: Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension 1998; 31:725-729.
9. Smirk FH, Hall WH: Inherited hypertension in rats. Nature 1958; 182:727-728.
10. Dahl LK, Heine M, Tassinari L: Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 1962; 194:480-482.
11. Okamoto K, Aoki K: Development of a strain of spontaneously hypertensive rats. Jpn Circ J 1963; 27:282-293.
12. Schlager G: Selection for blood pressure levels in mice. Genetics 1974; 76:537-549.
13. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994; 265:2037-2048.
14. Dominiczak AF, Lindpainter K: Genetics of hypertension: a current appraisal. News Physiol Sci 1994; 9:246-251.
15. Hilbert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, et al.: Chromosomal mapping of the genetic loci associated with blood pressure regulation in hereditary hypertensive rats. Nature 1991; 353:521-529.
16. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, et al.: Genetic mapping of a gene causing hypertension in stroke-prone spontaneously hypertensive rat. Cell 1991; 67:213-224.
17. Yagil C, Sapojnikov M, Kreutz R, Katni G, Lindpaintner K, Ganten D, Yagil Y: Salt susceptibility maps to chromosome 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension 1998; 31 (part 1):119-124.
18. Deng AY, Rapp JP: Locus for the inducible, but not constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest 1995; 95:2170-2177.
19. Gu L, Dene H, Deng AY, Hoebee, Bihoreau M-T, James M, Rapp JP: Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest 1996; 97:777-788.
20. Dubay C, Vincent M, Samani NJ, Hilbert P, Kaiser MA, Beressi J-P, et al.: Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Nat Genet 1993; 3:354-358.
21. Zhang L, Summers KM, West MJ: Cosegregation of genes on chromosome 5 with heart weight and blood pressure in genetic hypertension. Clin Exp Hypertens 1996; 18:1073-1087.
22. Pravenec M, Gauguier D, Schott J-J, Buard J, Kren V, Bila V, et al.: Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest 1995; 96:1973-1978.
23. Deng AY, Dene H, Rapp JP: Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 1994; 94:431-436.
24. Samani NJ, Gauguier D, Vincent M, Kaiser MA, Bihoreau M-T, Lodwick D, et al.: Analysis of quantitative trait loci for blood pressure on rat chromosome 2 and 13. Hypertension 1996; 28:1118-1122.
25. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau M-T, et al.: Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension 1996; 28:898-906.
26. Schork RJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Krieger EM, et al.: A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Res 1995; 5:164-172.
27. Nara Y, Ikeda K, Mashimo T, Tamada T, Matsumoto T, Koh M, et al.: A new candidate locus for basal high blood pressure in male and female stroke-prone SHR (SHRSP/tzm). J Hypertens 1996; 14 (suppl 1): 511.
28. Harris EL, Phelan EL, Thompson CM, Millar JA, Grigor MR: Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rats. J Hypertens 1995; 134:397-404.
29. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ: Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genef 1996; 12:44-51.
30. Nara Y, Nabika T, Ikeda K, Sawamura M, Mano M, Endo J, Yamori Y: Basal high blood pressure cosegregates with the loci on chromosome 1 in the F2 generation from crosses between normotensive Wistar Kyoto rats and stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun 1993; 194:1344-1351.
31. Matsumoto C, Nara Y, Ikeda K, Tamada T, Mashimo T, Nabika T, et al.: Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol 1996; 23:1028-1034.
32. Innes BA, McLaughlin MC, Kapuscinski MK, Jacob HJ, Harrap SB: Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. Hypertension 1998; 31:741-746.
33. Julier C, Delephine M, Keavney B, Terwilliger J, Davis S, Weeks DE, et al.: Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage in the rat chromosome 10. Hum Mol Genet 1997; 6:2077-2085.
34. Rubattu S, Volpe M, Kreutz R, Ganten V, Ganten D, Lindpaintner K: Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nat Genet 1996; 13:429-434.
35. Jeffs B, Clark JS, Anderson NH, Gratton J, Brosnan MJ, Gauguier D, et al.: Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nat Genet 1997; 16:364-367.
36. Aitman TJ, Gotoda T, Evans AL, Imrie H, Heath K, Trembling PM, et al.: Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet 1997; 16:197-201.
37. Churchill PC, Churchill MC, Bidani AK, Griffin KA, Picken M, Pravanec M, et al.: Genetic susceptibility to hypertension-induced renal damage in the rat. J Clin Invest 1997; 100:1373-1382.
38. Rapp JP, Deng AY: Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Hypertension 1995; 25:1121-1128.
39. Deng AY, Dene H, Rapp JP: Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Hypertension 1997; 30 (part 1):199-202.
40. Kreutz R, Hubner N, James MR, Bihoreau M-T, Gauguier D, Lathrop GM, et al.: Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci USA 1995; 92:8778-8782.
41. Kren V, Pravenec M, Lu S, Krenova D, Wang J-M, Wang N, et al.: Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J Clin Invest 1997; 99:577-581.
42. St. Lezin E, Liu W, Wang M-J-M, Wang N, Kren V, Krenova D, et al.: Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. Hypertension 1997; 30:854-859.
43. Dukhanina OI, Dene H, Deng AY, Choi CR, Hoebee B, Rapp JP: Linkage map and congenic strains to localise blood pressure QTL on rat chromosome 10. Mamm Genome 1997; 8:229-235.
44. Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR, Dene H, Rapp JP: Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Mamm Genome 1997; 8:896-902.
45. Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP: Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome 1997; 8:636-641.
46. St. Lezin EM, Pravanec M, Wong AL, Liu W, Wang N, Lus S, et al.: Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest 1996; 97:522-527.
47. Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ: Transfer of a salt-resistant renine allele raises blood pressure in Dahl salt-sensitive rats. Hypertension 1997; 19:325-332.
48. Turner ME, Johnson ML, Ely DL: Separate sex-influenced and genetic components in spontaneously hypertensive rat hypertension. Hypertension 1991; 17:1097-1103.
49. Rapp JP, Garrett MR, Deng AY: Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin invest 1998; 101:1591-1595.
50. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ: Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 1997; 17:280-284.
51. Paterson AH, De Verna JW, Lanini B, Tanksley SD: Fine genetic mapping of quantitative trait loci using selected overlapping recombinant chromosomes in an interspecies cross of tomato. Genetics 1990; 124:735-742.
52. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, et al.: A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet 1995; 9:63-69.
53. Bihoreau M-T, Gauguier D, Kato N, Hyne G, Lindpainter K, Rapp JP, et al.: A linkage map of the rat genome derived from three F2 crosses. Genome Res 1997; 7:434-440.
54. Pravanec M, Gauguier D, Schott JJ, Buard J, Kren V, Bila V, et al.: A genetic linkage map of the rat derived from recombinant inbred strains. Mamm Genome 1996; 7:117-127.
55. Davidson AO, Schork N, Jaques BC, Kelman AW, Sutcliffe RG, Reid JL, Dominiczak AF: Blood pressure in genetically hypertensive rats: influence of the Y chromosome. Hypertension 1995; 26:452-459.
56. Johnson KJ, Hamilton G: Genomics. In: Rimoin DL, Connor JM. Pyeritz RE (editors). Principles and Practice of Medical Genetics. New York: Churchill Livingstone; 1996. pp. 127-135.
57. Bianchi G, Tripodi G, Casari G: Two point mutations within the adducin gene are involved in blood pressure variation. Proc Natl Acad Sci USA 1994; 91:3999-4003.
58. Kato N, Sugiyama T, Nabika T, Monta H, Kurihana H, Yazaki Y, Yamori Y: Lack of association between the α-adducin locus and essential hypertension in Japanese population. Hypertension 1998; 31:730-733.
59. Materson BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kocher MS, et al.: A comparison of six antihypertensive agents with placebo. N Engl J Med 1993; 328:914-921.
60. Vincent M, Samani N, Gauguier D, Thompson JR, Lathrop GM, Sassard J. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. J Clin Invest 1997; 100:2000-2006.