Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells

Molecular and Cellular Biology

Volumn 18, Issue 9, 1998, Pages 5082-5090

  Senechal, Kristen ^a   Heaney, Conor ^b   Druker, Brian ^b   Sawyers, Charles L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL TRANSFORMATION; FIBROBLAST; GENE OVEREXPRESSION; HEMATOPOIETIC CELL; MUTAGENESIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0031840440     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.9.5082     Document Type: Article

References (49)

1. Altun-Gultekin, Z. F., S. Chandriani, C. Bougeret, T. Ishizaki, S. Narumiya, P. de Graaf, P. Van Bergan en Henegouwen, H. Hanafusa, J. A. Wagner, and R. B. Birge. 1998. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adapter protein. Mol. Cell. Biol. 18:3044-3058.
2. Barber, D. L., J. M. Mason, T. Fukazawa, K. A. Reedquist, B. J. Druker, H. Band, and A. D. D'Andrea. 1997. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. Blood 89:3166-3174.
3. Bazzoni, G., N. Carlesso, J. D. Griffin, and M. E. Hemler. 1996. Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J. Clin. Invest. 98:521-528.
4. Bhat, A., K. Kolibaba, T. Oda, S. Ohno-Jones, C. Heaney, and B. J. Druker. 1997. Interactions of Cbl with Bcr-Abl and Crkl in Bcr-Abl-transformed myeloid cells. J. Biol. Chem. 272:16170-16175.
5. Bhatia, R., E. A. Wayner, P. B. McGIave, and C. M. Verfaillie. 1994. Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function. J. Clin. Invest. 94:384-391.
6. Boyle, W. J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:110-148.
7. Chardin, P., J. H. Camonis, N. W. Gale, L. van Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338-1343.
8. de Jong, R., J. ten Hoeve, N. Heisterkamp, and J. Groffen. 1995. Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. J. Biol. Chem. 270:21468-21471.
9. de Jong, R., J. ten Hoeve, N. Heisterkamp, and J. Groffen. 1997. Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene 14:507-513.
10. Downward, J. 1994. The GRB2/Sem-5 adaptor protein. FEBS Lett. 338:113-117.
11. Druker, B. J., and T. M. Roberts. 1991. Generation of a large library of point mutations in polyoma middle T antigen. Nucleic Acids Res. 19:6855-6861.
12. Feller, S. M., B. Knudsen, and H. Hanafusa. 1994. c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J. 13:2341-2351.
13. Feller, S. M., B. Knudsen, and H. Hanafusa. 1995. Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways. Oncogene 10:1465-1473.
14. Freed, E., and T. Hunter. 1992. A 41-kilodalton protein is a potential sub-strate for the p210bcr/abl protein-tyrosine kinase in chronic myelogenous leukemia cells. Mol. Cell. Biol. 12:1312-1323.
15. Goga, A., X. Liu, T. M. Hambuch, K. Senechal, E. Major, A. J. Berk, O. N. Witte, and C. L. Sawyers. 1995. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene 11:791-799.
16. Gordon, M., C. Dowding, G. Riley, J. Goldman, and M. Greaves. 1987. Altered adhesive interactions with marrow stroma of hematopoietic progenitor cells in chronic myeloid leukemia. Nature 328:342-344.
17. Klemke, R. L., J. Leng, R. Molander, P. C. Brooks, K. Vuori, and D. A. Cheresh. 1998. Cas/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell Biol. 140:961-972.
18. Kurzrock, R., J. U. Gutterman, and M. Talpaz. 1988. The molecular genetics of Philadelphia chromosome positive leukemias. N. Engl. J. Med. 319:990-998.
19. Laneuville, P., N. Heisterkamp, and J. Groffen. 1991. Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene 6:275-282.
20. Maru, Y., and O. N. Witte. 1991. The BCR gene encodes a novel serine/ threonine kinase activity within a single exon. Cell 67:459-468.
21. Matsuda, M., S. Tanaka, S. Nagata, A. Kojima, T. Kurata, and M. Shibuya. 1992. Two species of human CRK cDNA encode proteins with distinct biological activities. Mol. Cell. Biol. 12:3482-3489.
22. Muller, A. J., J. C. Young, A. M. Pendergast, M. Pondel, N. R. Landau, D. R. Littman, and O. N. Witte. 1991. Bcr first-exon sequences specifically activate the Bcr-Abl tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol. Cell. Biol. 11:1785-1792.
23. Nichols, G. L., M. A. Raines, J. C. Vera, L. Lacomis, P. Tempst, and D. W. Golde. 1994. Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells. Blood 84:2912-2918.
24. Oda, A., Y. Miyakawa, B. J. Druker, A. Ishida, K. Ozaki, H. Ohashi, M. Wakui, M. Handa, K. Watanabe, S. Okamoto, and Y. Ikeda. 1996. Crkl is constitutively phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin. Blood 88:4304-4313.
25. Oda, T., C. Heaney, J. R. Hagopian, K. Okuda, J. D. Griffin, and B. J. Druker. 1994. Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J. Biol. Chem. 269: 22925-22928.
26. Ogawa, S., H. Toyoshima, H. Kozutsumi, K. Hagiwara, R. Sakai, T. Tanaka, N. Hirano, H. Mano, Y. Yazaki, and H. Hirai. 1994. The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells. Oncogene 9:1669-1678.
27. Pawson, T., and J. Schlessinger. 1993. SH2 and SH3 domains. Curr. Biol. 3: 434-442.
28. Pendergast, A. M., M. L. Gishizky, M. H. Havlik, and O. N. Witte. 1993. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. Mol. Cell. Biol. 13:1728-1736.
29. Pendergast, A. M., L. A. Quilliam, L. D. Cripe, C. H. Bassing, Z. Dai, N. Li, A. Batzer, K. M. Rabun, C. J. Der, J. Schlessinger, and M. L. Gishizky. 1993. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75:175-185.
30. Reedquist, K. A., T. Fukazawa, G. Panchamoorthy, W. Y. Langdon, S. E. Shoelson, B. J. Druker, and H. Band. 1996. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J. Biol. Chem. 271:8435-8442.
31. Ribon, V., S. Hubbell, R. Herrera, and A. R. Saltiel. 1996. The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol. Cell. Biol. 16:45-52.
32. Rosen, M. K., T. Yamazaki, G. D. Gish, C. M. Kay, T. Pawson, and L. E. Kay. 1995. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. Nature 374:477-479.
33. Salgia, R., E. Pisick, M. Sattler, J. L. Li, N. Uemura, W. K. Wong, S. A. Burky, H. Hirai, L. B. Chen, and J. D. Griffin. 1996. p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J. Biol. Chem. 271:25198-25203.
34. Salgia, R., N. Uemura, K. Okuda, J. L. Li, E. Pisick, M. Sattler, R. de Jong, B. Druker, N. Heisterkamp, L. B. Chen, J. Groffen, and J. Griffin. 1995. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J. Biol. Chem. 270:29145-29150.
35. Sattler, M., R. Salgia, G. Shrikhande, S. Verma, E. Pisick, K. V. Prasad, and J. D. Griffin. 1997. Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL). J. Biol. Chem. 272:10248-10253.
36. Sattler, M., R. Salgia, G. Shrikhande, S. Verma, N. Uemura, S. F. Law, E. A. Golemis, and J. D. Griffin. 1997. Differential signaling after betal integrin ligation is mediated through binding of CRKL to p120(CBL) and p110 (HEF1). J. Biol. Chem. 272:14320-14326.
37. Sawyers, C. L., W. Callahan, and O. N. Witte. 1992. Dominant negative myc blocks transformation by ABL oncogenes. Cell 70:901-910.
38. Sawyers, C. L., J. McLaughlin, A. L. Goga, M. Havlik, and O. Witte. 1994. The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77: 121-131.
39. Sawyers, C. L., J. McLaughlin, and O. N. Witte. 1995. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J. Exp. Med. 181:307-313.
40. Senechal, K., J. Halpern, and C. L. Sawyers. 1996. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. J. Biol. Chem. 271:23255-23261.
41. Senechal, K., and C. L. Sawyers. Unpublished observations.
42. Smit, L., G. van der Horst, and J. Borst. 1996. Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. J. Biol. Chem. 271:8564-8569.
43. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, B. G. Neel, R. B. Birge, J. E. Fajardo, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. C. Cantley. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767-778.
44. Tanaka, M., R. Gupta, and B. J. Mayer. 1995. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol. Cell. Biol. 15:6829-6837.
45. + leukemia. Blood 84:1731-1736.
46. ten Hoeve, J., V. Kaartinen, T. Fioretos, L. Haataja, J.-W. Voncken, N. Heisterkamp, and J. Groffen. 1994. Cellular interactions of CRKL, an SH2-SH3 adaptor protein. Cancer Res. 54:2563-2567.
47. ten Hoeve, J., C. Morris, N. Heisterkamp, and J. Groffen. 1993. Isolation and chromosomal localization of CRK-L, a human crk-like gene. Oncogene 8: 2469-2474.
48. van der Geer, P., and T. Pawson. 1995. The PTB domain; a new protein module implicated in signal transduction. Trends Biochem. Sci. 20:277-280.
49. Verfaillie, C. M., J. B. McCarthy, and P. B. McGlave. 1992. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J. Clin. Invest. 90:1232-1241.