Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

Development

Volumn 124, Issue 23, 1997, Pages 4879-4886

  Greenwood, Simon ^a   Struhl, Gary ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

Body pattern; Drosophila; Gradients; Ras; Terminalia

Indexed keywords

ANIMAL TISSUE; ARTICLE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; MORPHOLOGY; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EMBRYONIC INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; RAS PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; TRANSGENES;

ANIMALIA; HEXAPODA; TERMINALIA;

EID: 0031455262     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Busler, K. and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
2. Brand, A. H. and Perrimon, N. (1994). Rat acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 8, 629-639.
3. Brönner, G. and Jäckle, H. (1991). Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embyro. Mech. Dev. 35, 205-211.
4. Brook, W. J. and Cohen, S. M. (1996). Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg. Science 273, 1373-1377.
5. Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E. (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888.
6. Campos-Ortega, J. and Hartenstein, V. (1985). The Embryonic Development of Drosophila melanogaster. Berlin: Springer-Verlag.
7. Campos-Ortega, J. A., Jürgens, G. and Hofbauer, A. (1979). Cell clones and pattern formation: Studies on sevenless a mutant of Drosophila melanogaster. Wilhelm Roux's Archives. Dev. Biol 186, 27-50.
8. Casanova, J. (1990). Pattern formation under the control of the terminal system in the Drosophila embryo. Development 110, 621-628.
9. Casanova, J., Furriols, M., McCormick, C. A. and Struhl, G. (1995). Similarities between trunk and spatzle. putative extracellular ligands specifying body pattern in Drosophila. Genes Dev. 9, 2539-2544.
10. Casnova, J., Llimargas, M., Greenwood, S. and Struhl, G. (1994) An oncogenic form of human raf can specify terminal body pattern in Drosophila. Mech. Dev. 48, 59-64.
11. Casanova, J. and Struhl, G. (1989). Localized surface activity of torso, a receptor tyrosine kinase. specifies terminal body pattern in Drosophila. Genes Dev. 3, 2025-2938.
12. Casanova, J. and Struhl, G. (1993). The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila. Nature 362, 152-155.
13. Clifford, R. J. and Schüpbach, T. (1989) Coordinated and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene, Genetics 123, 771-787.
14. Cowley, S., Paterson, H., Kemp, P. and Marshall, C. J. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC 12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
15. Diaz, R., Harbecke, R., Singer, J., Pignoni, F., Janning, W. and Lengyel, J. (1996). Graded effect of tailless on posterior gut development: molecular basis of an alleleic series of a nuclear receptor gene. Mech Dev 54, 119-139.
16. Duffy, J. B. and Perrimon, N. (1994). The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. Dev. Biol. 166, 380-395.
17. Kortini, M. E., Simon, M. A. and Rubin, G. M. (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation. Nature 355, 559-561.
18. Freeman, M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.
19. Furriols, M., Sprenger, F. and Casanova, J. (1996). Variation in the number of activated torso receptors correlates with differential gene expression. Development 122, 2313-2317.
20. Gaul, U. and Jäckle, H. (1989). Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Kruppel gene expression in the Drosophila blastoderm embryo. Development 107, 651-662.
21. Gray, S. and Levine, M. (1996). Transcriptional repression in development. Curr. Opin. Cell Biol. 8, 358-364.
22. Hulskamp, M., Schroder, C., Pfeifle, C., Jäckle, H. and Tautz., D. (1989) Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene. Nature 338, 629-632.
23. Irish, V., Lehmann, R. and Akam, M. (1989). The Drosophila posterior-group gene nanos functions by repressing hunchback activity. Nature 338, 646-648.
24. Jiang, J., Kosman, D., Ip, Y. T. and Levine, M. (1991). The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev. 5, 1881-1891.
25. Jiang, J. and Struhl, G. (1996). Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell 86, 401-409.
26. Jürgens, G. and Hartenstein, V. (1993). The terminal regions of the body pattern. In The Development of Drosophila melanogaster. (ed. M. Bate and A. Martinez Arias), pp. 687-746. Cold Spring Harbor Laboratory Press.
27. Katz, W. S., Hill, R. J., Clandinin, T. R. and Sternberg, P. W. (1995) Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82, 297-307.
28. Kayne, P. S. and Sternberg, P. W. (1995). Ras pathways in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 5, 38-43.
29. Kazlauskas, A. (1994). Receptor tyrosine kinases and their targets. Curr. Opin. Genet. Dev. 4, 5-14.
30. Kispert, A., Herrmann, B. G., Leptin, M. and Reuter, R. (1994) Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila. Tribolium. and Locusta. Genes Dev. 8, 2137-2150.
31. Klingler, M., Erdelyi, M., Szabad, J. and Nüsslein-Volhard, C. (1988) Function of torso in determining the terminal anlagen of the Drosophila embryo. Nature 335, 275-277.
32. Kongsuwan, K., Yu, Q., Vincent, A., Frisardi, M. C., Rosbash, M., Lengyel, J. A. and Merriam, J. (1985). A Drosophila Minute gene encodes a ribosomal protein. Nature 317, 555-558.
33. Liaw, G. J. and Lengyel, J. A. (1992). Control of tailless expression by bicoid. dorsal and synergistically interacting terminal system regulatory elements. Mech. Dev. 40, 47-61.
34. Liaw, G. J., Rudolph, K. M., Huang, J. D., Dubnicoff, T., Courey, A. J. and Lengyel, J. A. (1995). The torso response element binds GAGA and NTF-1/Elf-1. and regulates tailless by relief of repression. Genes Dev. 9, 3163-3176.
35. Lu, X., Chou, T. B., Williams, N. G., Roberts, T. and Perrimon, N. (1993a) Control of cell fate determination by p21 ras/Ras 1. an essential component of torso signaling in Drosophila. Genes Dev. 7, 621-32.
36. Lu, X., Perkins, L. A. and Perrimon, N. (1993b). The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction. Development Supplement 47-56.
37. Marshall, C. J. (1994). MAP kinase kinase kinase. MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4, 82-89
38. Marshall, C. J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
39. Martin, J. R., Raibaud, A. and Ollo, R. (1994). Terminal pattern elements in Drosophila embryo induced by the torso-like protein. Nature 367, 741-745.
40. McCormick, F. (1994). Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev. 4, 71-76.
41. Nüsslein-Volhard, C., Frohnhöfer, H. G. and Lehmann, R. (1987). Determination of anteroposterior polarity in Drosophila. Science 238, 1675-1681.
42. O'Connell, P. O. and Rosbash, M. (1984). Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene. Nucl. Acids Res. 12, 5495-5513.
43. Penton, A. and Hoffmann, K. M. (1996). Decapentaplegic restricts the domain of wingless during Drosophila limb patterning. Nature 382, 162-164.
44. Perrimon, N. (1993). The torso receptor protein-tyrosine kinase signaling pathway: an endless story. Cell 74, 219-222.
45. Perrimon, N.(1994). Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr. Opin. Cell Biol. 6, 260-266.
46. Pignoni, F., Baldarelli, R. M., Steingrimsson, E., Diaz, R. J., Patapoutian, A., Merriam, J. R. and Lengyel, J. A. (1990). The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62, 151-163.
47. Pignoni, F., Steingrimsson, K. and Lengyel, J. A. (1992) bicoid and the terminal system activate tailless expression in the early Drosophila embryo. Development 115, 239-251.
48. Pirrotta, V. (1988). Vectors for P-mediated transformations in Drosophila. In Vectors: A survey of Molecular Cloning Vectors and Their Uses. (ed. R. L. Rodriguez and D. T. Reinhardt), pp. 437-456. Boston: Butterworths.
49. Price, J. V., Clifford, R. J. and Schüpbach, T. (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal. and encodes the Drosophila HGF receptor homolog. Cell 56, 1085-1092.
50. Rubin, G. M. and Spradling, A. C. (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.
51. Savant-Bhonsale, S. and Montell, D. J. (1993). torso-like encodes the localized determinant of Drosophila terminal pattern formation. Genes Dev. 7, 2548-2555.
52. Schüpbach, T. and Wieschaus, E. (1986). Maternal effect mutations altering the anterior-posterior pattern of the Drosophila embryo. Roux's Arch Dev. Biol. 195, 302-317.
53. Schweitzer, R., Shaharabany, M., Seger, R. and Shilo, B. Z. (1995). Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518-1529.
54. Singer, J.B., Harbecke, R., Kusch, T. Reuter, R., and Lengyel, J.A. (1996). Drosophila brachyenteron regulates gene activity and morphogenesis in the gut. Development 122, 3707-3718.
55. Sprenger, F. and Nüsslein-Volhard, C. (1992). Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg. Cell 71, 987-1001.
56. Sprenger, F., Stevens, L. M. and Nüsslein-Volhard, C. (1989). The Drosophila gene torso encodes a putative receptor tyrosine kinase. Nature 338, 478-483.
57. St. Johnston, D. and Nüsslein-Volhard, C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.
58. Steingrimsson, E., Pignoni, F., Liaw, G. J. and Lengyel, J. A. (1991). Dual role of the Drosophila pattern gene tailless in embryonic termini. Science 254, 418-421.
59. Stevens, L. M., Krohnhöfer, H. G., Klingler, M. and Nüsslein-Volhard, C. (1990). Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo. Nature 346, 660-663.
60. Strahle, U., Blader, P., Adam, J. and Ingham, P. W. (1994) A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends Genet. 10, 75-76.
61. Strecker, T. R., Merriam, J. R. and Lengyel, J. A. (1988). Graded requirement for the zygotic terminal gene, tailless, in the brain and tail region of the Drosophila embryo. Development 102, 721 -734.
62. Struhl, G. (1984). Spiltting the bithorax complex in Drosophila. Nature 308, 454-457.
63. Struhl, G. (1989). Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos. Nature 338, 741-744.
64. Struhl, G. and Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.
65. Struhl, G., Johnston, P. and Lawrence, P. A. (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell 69, 237-249.
66. Struhl, G., Struhl, K. and Macdonald, P. M. (1989). The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57, 1259-1273.
67. Theurkauf, W. E., Baum, H., Bo, J. and Wensink, P. C. (1986). Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins. Proceedings of the National Academy of Sciences of the United States of America 83, 8477-8481.
68. Tomlinson, A. and Ready, D. F. (1987). Cell fate in the Drosophila ommatidium. Dev. Biol. 120, 366-376.
69. Trahey, M. and McCormick, F. (1987). A cytoplasmic protein stimulates normal N-ras p21 GTPase. but does not affect oncogenic mutants. Science 238, 542-545.
70. Tsuda, L., Inoue, Y. H., et al. (1993). A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila, Cell 72, 407-414.
71. Weigel, D., Jürgens, G., Klingler, M. and Jäckle, H. (1990). Two gap genes mediate maternal terminal pattern information in Drosophila. Science 248, 495-498.
72. Wharton, R. P. and Struhl, G. (1991) RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell. 67, 955-967.
73. Xu, T. and Rubin, G. M. (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.