Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila

Genes and Development

Volumn 10, Issue 3, 1996, Pages 272-278

  Wassarman, David A ^a   Solomon, Noah M ^a   Chang, Henry C ^a   Karim, Felix D ^a   Therrien, Marc ^a   Rubin, Gerald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drosophila eye development; PP2A; R7 photoreceptor; Raf; Ras; signal transduction

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; DROSOPHILA; EYE DEVELOPMENT; GROWTH REGULATION; NONHUMAN; ONCOGENE RAS; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0030065261     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.3.272     Document Type: Article

References (51)

1. Alessi, D.R., N. Gomez, G. Moorhead, T. Lewis, S.M Keyse, and P. Cohen. 1995. Inactivation of p42 MAP kinase by protein phosphatase 2A and protein tyrosine phosphatase, but not CL100, in various cell lines. Curr. Biol. 5: 83-295.
2. Basler, K., B. Christen, and E. Hafen. 1991. Ligand-independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64: 1069-1081.
3. Biggs, W.H., K.H. Zavitz, B. Dickson, A. van der Straten, D. Brunner, E. Hafen, and S.L. Zipursky. 1994. The Drosophila rolled locus encodes a MAP kinase required in the Sevenless signal transduction pathway. EMBO J. 13: 1628-1635.
4. Brunner, D., N. Oellers, J. Szabad, W.H. Biggs, S.L. Zipursky, and E. Hafen. 1994. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signalling pathways. Cell 76: 875-888.
5. Bugering, B.M.T. and J.L. Bos. 1995. Regulation of Ras-mediated signalling: More than one way to skin a cat. Trends Biochem. Sci. 20: 18-22.
6. Chang, H.C., N.M. Solomon, D.A. Wassarman, F.D. Karim, M. Themen, G.M. Rubin, and T. Wolff. 1995. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80: 463-472.
7. Cohen, P. 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 485-497.
8. Coleman, T.R. and W.G. Dunphy. 1994. Cdc2 regulatory factors. Curr. Biol. 6: 877-882.
9. Daum, G., I. Eisenmann-Tappe, H.W. Fries, J. Troppmair, and U. R. Rapp. 1994. The ins and outs of Raf kinases. Trends Biochem. Sci. 19: 474-480.
10. Dent, P. and T.W. Sturgill. 1994. Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts. Proc. Natl. Acad. Sci. 91: 9544-9548.
11. Dent, P., T. Jelinek, D.K. Morrison, M.J. Weber, and T.W. Sturgill. 1995. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science 268: 1902-1906.
12. Dickson, B., F. Sprenger, D. Morrison, and E. Hafen. 1992. Raf functions downstream of Ras in the Sevenless signal transduction pathway. Nature 360: 600-603.
13. Dickson, B.J., M. Dominquez, A. van der Straten, and E. Hafen. 1995. Control of Drosophila photoreceptor cell fates by Phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80: 453-462.
14. Fortini, M.E. and G.M. Rubin. 1990. Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster. Genes & Dev. 4: 444-463.
15. Fortini, M.E., M.A. Simon, and G.M. Rubin. 1992 Signalling by the Sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355: 559-561.
16. Healy, A.M., S. Zolnierowicz, A.E. Stapleton, M. Goebl, A.A. DePaoli-Roach, and J.R. Pringle. 1991. CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: Identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase. Mol. Cell. Biol. 11: 5767-5780.
17. Heidecker, G., W. Kolch, D.K. Morrison, and U.R. Rapp. 1992. The role of Raf-1 phosphorylation in signal transduction. Adv. Can. Res. 58: 53-73.
18. Hou, X.S., T.B. Chou, M.B. Melnick, and N. Perrimon. 1995. The Torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell 81 63-71.
19. Hunter, T. 1995. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling. Cell 80: 225-236.
20. Karim, F.D., H.C. Chang, M. Therrien, D.A. Wassarman, T. Laverty, and G.M. Rubin. 1996. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics (in press).
21. Karpen, G.H. and A.C. Spradling. 1992. Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by P element insertional mutagenesis. Genetics 132: 737-753.
22. Kimmel, B.E., U. Heberlein, and G.M. Rubin. 1990. The homeodomain protein Rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes & Dev. 4: 712-727.
23. Kinoshita, N., H. Yamano, H. Niwa, Y. Yoshida, and M. Yanagida. 1993. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2. Genes & Dev. 7: 1059-1071.
24. Lai, Z.-C. and G.M. Rubin. 1992. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70: 609-620.
25. Lee, T.H., C. Turck, and M. Kirschner. 1994. Inhibition of cdc2 activation by INH/PP2A. Mol. Biol. Cell 5: 323-338.
26. Lin, F.C. and K.T. Arndt. 1995. The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis. EMBO J 14: 2745-2759.
27. Mayer-Jaekel, R.E. and B.A. Hemmings. 1994. Protein phosphatase 2A - A "menage a trois". Trends Cell Biol 4: 287-291.
28. Mayer-Jaekel, R.E., S. Baumgartner, G. Bilbe, H. Ohkura, D.M. Glover, and B.A. Hemmings. 1992. Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila. Mol. Biol. Cell 3: 287-298.
29. Mayer-Jaekel, R.E., H. Ohkura, R. Gomes, C.E. Sunkel, S. Baumgartner, B.A. Hemmings, and D.M. Glover. 1993. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell 72: 621-633.
30. Melnick, M.B., L.A. Perkins, M. Lee, L. Ambrosio, and N. Perrimon. 1993. Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development 118: 127-138.
31. Mlodzik, M., N.E. Baker, and G.M. Rubin. 1990. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes & Dev. 4: 1848-1861.
32. Mumby, M and G. Walter. 1993. Protein serine/threonine phosphatases: Structure, regulation, and function in cell growth. Phys Rev. 73: 673-699.
33. Olivier, J.P., T. Rabbe, M. Henkemeyer, B Dickson, G. Mbamalu, B. Margolis, J. Schlessinger, E. Hafen, and T. Pawson. 1993. A Drosophila SH2-SH3 adaptor protein implicated in coupling the Sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 81: 857-866.
34. O'Neill, E.M., I. Rebay, R. Tjian, and G.M. Rubin. 1994 The activities of two ETS-related transcription factors required for Drosophila eye development are modulated by the Ras/ MAPK pathway. Cell 78: 137-147.
35. Orgad, S., N.D. Brewis, L. Alphey, J.M. Axton, Y. Dudai, and P.T W. Cohen. 1990. The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1. FEBS Lett 275: 44-48.
36. Ronne, H., M. Carlberg, G.-Z. Hu, and J.O. Nehlin. 1991. Protein phosphatase 2A in Saccharomyces cerevisiae: Effects on cell growth and bud morphogenesis. Mol. Cell. Biol. 11: 4876-4884.
37. Shiomi, K., M. Takeichi, Y. Nishida, Y. Nishi, and T. Uemura. 1994. Alternative cell fate choice induced by low-level expression of a regulator of protein phosphatase 2A in the Drosophila peripheral nervous system. Development 120: 1591-1599.
38. Simon, M.A., D.D.L. Bowtell, G.S. Dodson, T.R. Laverty, and G.M. Rubin. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signalling by the Sevenless protein tyrosine kinase. Cell 67: 701-716.
39. Simon, M.A., G S. Dodson, and G.M. Rubin. 1993. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to Sevenless and Sos proteins in vitro. Cell 73: 169-177.
40. Sontag, E., S. Fedorov, C. Kamibayashi, D. Roberts, M. Cobb, and M. Mumby. 1993. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation. Cell 75: 887-897.
41. Therrien, M., H.C. Chang, N.M. Solomon, F.D. Karim, D.A. Wassarman, and G.M. Rubin. 1995. Ksr, a novel protein kinase required for Ras signal transduction. Cell 83: 879-888.
42. Tomlinson, A. and D.F. Ready. 1987. Cell fate in the Drosophila ommatidium. Dev. Biol. 123: 264-275.
43. Torok, T., G. Tick, M. Alvoiado, and I. Kiss. 1993. P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: Isolation of lethals with different overgrowth phenotypes. Genetics 135: 71-80.
44. Tsuda, L., Y.H. Inoue, M.-A. Yoo, M. Mizuno, M. Hata, Y.-M. Lim, T. Adachi-Yamada, H. Ryo, Y. Masamune, and Y. Nishida. 1993. A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila. Cell 72: 407-414.
45. Uemura, T., K. Shiomi, S. Togashi, and M. Takeichi. 1993. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs. Genes & Dev. 7: 429-440.
46. van Zyl, W., W. Huang, A.A. Sneddon, M. Stark, S. Camier, M. Werner, C. Marck, A. Sentenac, and J.R. Broach. 1992. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cezevisiae. Mol. Cell. Biol. 12: 4946-4959.
47. Walter, G. and M. Mumby. 1993. Protein serine/threonine phosphatases and cell transformation. Biochem. Biophys. Acta 1155: 207-226.
48. Wassarman, D.A., M. Therrien, and G.M. Rubin. 1995. The Ras signalling pathway in Drosophila. Curr. Opin. Genet. Dev. 5: 44-50.
49. Wolff, T. and D.F. Ready. 1993. Pattern formation in the Drosophila retinae. In The development of Drosophila melanogaster (ed. M. Bate and A. Martinez-Arias), pp. 1277-1325. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
50. Xu, T. and G.M. Rubin. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117 1223-1237.
51. Zipursky, S.L. and G.M. Rubin. 1994. Determination of neuronal cell fate: Lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17: 373-397.