Effects of neonatal lesions of the basal forebrain cholinergic system by 192 immunoglobulin G-saporin: Biochemical, behavioural and morphological characterization

Neuroscience

Volumn 74, Issue 1, 1996, Pages 119-141

  Leanza, G ^a,b   Nilsson, O G ^a   Nikkhah, G ^a,c   Wiley, R G ^d   Bjorklund A ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF CATANIA   (Italy)

^c NORDSTADT HOSPITAL   (Germany)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

immunotoxin; low affinity NGF receptor; nucleus basalis; rat; septum

Indexed keywords

ATROPINE; CALBINDIN; CHOLINE ACETYLTRANSFERASE; DOPAMINE; IMMUNOGLOBULIN G; IMMUNOTOXIN; NORADRENALIN; PARVALBUMIN; SAPORIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN INJURY; CELL LOSS; CHOLINERGIC NERVE CELL; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; FEMALE; FOREBRAIN; LOCOMOTION; MALE; MAZE TEST; MORPHOLOGY; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; RAT;

EID: 0029762386     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00095-4     Document Type: Article

References (10)

1. Arendt T., Allen J., Marchbanks R. M., Schugens M. M., Sinden J., Lantos P. L. and Gray J. A. (1989) Cholinergic system and memory in the rat: effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of the cholinergic basal forebrain projection system. Neuroscience 33, 435-462.
2. Bartus R. T., Dean R. L., Beer B. and Lippa A. S. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408-417.
3. Batchelor P. E., Armstrong D. M., Blaker S. N. and Gage F. H. (1989) Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection. J. comp. Neurol. 284, 187-204.
4. Berger-Sweeney J., Heckers S., Mesulam M.-M., Wiley R. G., Lappi D. A. and Sharma M. (1994) Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. J. Neurosci. 14, 4507-4519.
5. Book A. A., Wiley R. G. and Schweitzer J. B. (1992) Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat. Brain Res. 590, 350-355.
6. Bruno J. P., Snyder A. M. and Stricker E. M. (1984) Effects of dopamine-depleting brain lesions on suckling and weaning in rats. Behav. Neurosci. 98, 156-161.
7. Castañeda E., Whishaw I., Lermer L. and Robinson T. E. (1990) Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood. Brain Res. 508, 30-39.
8. Collerton D. (1986) Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 19, 1-28.
9. Coyle J. T., Price D. L. and DeLong M. R. (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 1184-1190.
10. Coyle J. T. and Yamamura H. I. (1976) Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. Brain Res. 118, 429-440.