Prohormones: Their clinical relevance

Trends in Endocrinology and Metabolism

Volumn 9, Issue 10, 1998, Pages 396-402

  Wilson, Helen E ^a   White, Anne ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE H; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; FURIN; GONADORELIN; HORMONE PRECURSOR; NEUROPEPTIDE; PRODYNORPHIN; PROENKEPHALIN; PROGASTRIN; PROGLUCAGON; PROINSULIN; PROLACTIN; PROOPIOMELANOCORTIN; RELAXIN; SERINE PROTEINASE; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOSTATIN;

COLORECTAL CARCINOMA; CUSHING SYNDROME; DIABETES MELLITUS; ENDOCRINE TUMOR; GENE MUTATION; HORMONE SYNTHESIS; HUMAN; HYPOGLYCEMIA; HYPOPHYSIS ADENOMA; INTESTINE CELL; NONHUMAN; OBESITY; PANCREAS CELL; PRIORITY JOURNAL; REVIEW;

EID: 0032402293     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00098-8     Document Type: Review

References (56)

1. Bailyes EM, Shennan KIJ, Seal AJet al. A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. Biochem. J 285:1992;391-394.
2. Baldwin GS Antiproliferative gastrin/cholecystokinin receptor antagonists target the 78-kDa gastrin-binding protein. Proc Natl Acad Sci U S. A 91:1994;7593-7597.
3. Baldwin GS, Shulkes A Gastrin, gastrin receptors and colorectal carcinoma. Gut. 42:1998;581-584.
4. Bennett DL, Bailyes EM, Nielsen Get al. Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. J Biol Chem. 267:1992;15229-15236.
5. Castro MG, Morrison E Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit Rev Neurobiol. 11:1997;35-57.
6. Cone RD, Ly D, Koppula Set al. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res. 51:1996;287-317.
7. Cool DR, Fenger M, Snell CR, Loh YP Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway. J Biol Chem. 270:1995;8723-8729.
8. Cool DR, Loh YP Carboxypeptidase E is a sorting receptor for prohormones: binding and kinetic studies. Mol Cell Endocrinol. 139:1998;7-13.
9. Crosby SR, Stewart MF, Ratcliffe JG, White A Direct measurement of the precursors of adrenocorticotrophin in human plasma by two-site immunoradiometric assay. J Clin Endocrinol Metab. 67:1988;1271-1277.
10. Daughaday WH, Rotwein P Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 10:1989;68-91.
11. Dhanvantari S, Seidah NG, Brubaker PL Role of prohormone convertases in the tissue-specific processing of proglucagon. Mol Endocrinol. 10:1996;342-355.
12. Drucker DJ Glucagon-like peptides. Diabetes. 47:1998;159-169.
13. Duguay SJ, Milewski WM, Young BD, Nakayama K, Steiner DF Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases. J Biol Chem. 272:1997;6663-6670.
14. Fernandez CJ, Haugwitz M, Eaton B, Moore H-PH Distinct molecular events during secretory granule biogenesis revealed by sensitivities to brefeldin A. Mol Biol Cell. 8:1997;2171-2185.
15. Fricker LD, Berman YL, Leiter EH, Devi LA Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing. J Biol Chem. 271:1996;30619-30624.
16. Furuta M, Yano H, Zhou Aet al. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S. A 94:1997;6646-6651.
17. Furuta M, Carroll R, Martin Set al. Incomplete processing of proinsulin to insulin accompanied by elevation of des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J Biol Chem. 273:1998;3431-3437.
18. Gibson S, Crosby SR, Stewart MF, Jennings AM, McCall E, White A Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays. J Clin Endocrinol Metab. 78:1994;835-841.
19. Gibson S, Ray DW, Crosby SRet al. Impaired processing of proopiomelanocortin in corticotroph macroadenomas. J Clin Endocrinol Metab. 81:1996;497-502.
20. Gorr SU, Darling DS An N-terminal hydrophobic peak is the sorting signal of regulated secretory proteins. FEBS Lett. 361:1995;8-12.
21. Hale AC, Besser GM, Rees LH Characterisation of proopiomelanocortin-derived peptides in pituitary and ectopic adrenocorticotrophin-secreting tumours. J Endocrinol. 108:1986;49-56.
22. Hoog A, Sandberg-Nordqvist AC, Hulting AL, Falkmer UG High-molecular weight IGF-2 expression in a haemangiopericytoma associated with hypoglycaemia. APMIS. 105:1997;469-482.
23. fat mice. J Biol Chem. 272:1997;27532-27534.
24. Jackson RS, Creemers JWM, Ohagi Set al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet. 16:1997;303-306.
25. Kelly RB Pathways of protein secretion in eukaryotes. Science. 230:1985;25-32.
26. Lindberg I The new eukaryotic precursor processing proteinases. Mol Endocrinol. 5:1991;1361-1365.
27. Mains RE, Eipper BA The tissue-specific processing of pro-ACTH/endorphin. Recent advances and unsolved problems. Trends Endocrinol Metab. 1:1990;388-394.
28. Naggert JK, Fricker LD, Varlamov Oet al. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet. 10:1995;135-142.
29. Normant E, Loh YP Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A. Endocrinology. 139:1998;2137-2145.
30. Nussey SS, Soo SC, Gibson Set al. Isolated congenital ACTH deficiency: a cleavage enzyme defect? Clin Endocrinol. 39:1993;381-385.
31. Odell WD Ectopic ACTH syndrome: a misnomer. Endocrinol Metab Clin North Am. 20:1991;371-379.
32. O'Rahilly S, Gray H, Humphreys PJet al. Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. New Engl J Med. 333:1995;1386-1390.
33. Perone MJ, Castro MG Prohormone and proneuropeptide synthesis and secretion. Histol Histopathol. 12:1997;1179-1188.
34. Raffin-Sanson M-L, Massias J-F, Dumont Cet al. High plasma proopiomelanocortin in aggressive adrenocorticotrophin-secreting tumours. J Clin Endocrinol Metab. 81:1996;4272-4277.
35. Ratter SJ, Gillies G, Hope Jet al. Pro-opiomelanocortin related peptides in human pituitary and ectopic ACTH secreting tumours. Clin Endocrinol. 18:1983;211-218.
36. Ravelli ACJ, van der Meulen JHP, Michels RPJet al. Glucose tolerance in adults after prenatal exposure to famine. Lancet. 351:1998;173-177.
37. Rhodes CJ, Alarcon C What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes. 43:1994;511-517.
38. Rothman JE, Wieland FT Protein sorting by transport vesicles. Science. 272:1996;227-234.
39. Rouille Y, Duguay SJ, Lund Ket al. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol. 16:1995;322-361.
40. Rouille Y, Bianchi M, Irminger J-C, Halban PA Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon. FEBS Lett. 413:1997;119-123.
41. Rouille Y, Kantengwa S, Irminger J-C, Halban PA Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem. 272:1997;32810-32816.
42. 65-His) not associated with impaired glucose tolerance: The contribution of mutant proinsulin to insulin bioactivity. J Clin Endocrinol Metab. 81:1996;1634-1640.
43. Sevarino KA, Stork P, Ventimiglia R, Mandel G, Goodman RH Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity. Cell. 57:1989;11-19.
44. Smith AI, Funder JW Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev. 9:1988;159-179.
45. Song L, Fricker LD Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D. J Biol Chem. 271:1996;28884-28889.
46. Steiner DF The proprotein convertases. Curr Opin Chem Biol. 2:1998;31-39.
47. Stewart PM, Gibson S, Crosby SRet al. ACTH precursors characterize the ectopic ACTH syndrome. Clin Endocrinol. 40:1994;199-204.
48. Tan F, Chan S, Steiner DF, Schilling JW, Skidgel RA Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M: comparison with carboxypeptidases A. B, H and N. J Biol Chem. 264:1989;13165-13170.
49. Thiele C, Gerdes H-H, Huttner WB Protein secretion: puzzling receptors. Curr Biol. 7:1997;R496-R500.
50. Tsigos C, Crosby SR, Gibson S, Young RJ, White A Proopiomelanocortin is the predominant adrenocorticotropin-related peptide in human cerebrospinal fluid. J Clin Endocrinol Metab. 76:1993;620-624.
51. Wang TC, Koh TJ, Varro Aet al. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest. 98:1996;1918-1929.
52. Watanabe T, Murakami K, Nakayama K Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway. FEBS Lett. 320:1993;215-218.
53. White A, Gibson S ACTH precursors: biological significance and clinical relevance. Clin Endocrinol. 48:1998;251-255.
54. Yalow RS, Berson SA Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymomas. Biochem Biophys Res Commun. 44:1971;439-445.
55. Yano H, Kitano N, Morimoto M, Polonsky KS, Imura H, Seino Y A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto). J Clin Invest. 89:1992;1902-1907.
56. Zhou A, Bloomquist BT, Mains RE The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J Biol Chem. 268:1993;1763-1769.