Hyperproinsulinemia in a Three-Generation Caucasian Family due to Mutant Proinsulin (Arg65→His) Not Associated with Impaired Glucose Tolerance: The Contribution of Mutant Proinsulin to Insulin Bioactivity

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 4, 1996, Pages 1634-1640

  Røder, Michael E ^a   Vissing, Henrik ^b   Nauck, Michael A ^c  

^a STENO DIABETES CENTER   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; PROINSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL DISEASE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERINSULINEMIA; HYPERPROINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; MALE; ORAL GLUCOSE TOLERANCE TEST; POINT MUTATION; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ARGININE; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; FASTING; FEMALE; GLUCOSE INTOLERANCE; HETEROZYGOTE DETECTION; HISTIDINE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEDIGREE; POINT MUTATION; POLYMERASE CHAIN REACTION; PROINSULIN; REFERENCE VALUES;

EID: 0029877672     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.4.8636380     Document Type: Article

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