Impaired processing of proopiomelanocortin in corticotroph macroadenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 497-502

  Gibson, Sarah ^a   Ray, David W ^a   Crosby, Steven R ^a   Dornan, Timothy L ^b   Jennings, Adrian M ^c   Bevan, John S ^d   Davis, Julian R E ^a   White, Anne ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b HOPE HOSPITAL   (United Kingdom)

^c ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^d ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROOPIOMELANOCORTIN;

ADENOMA; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CROSS REACTION; CUSHING DISEASE; FEMALE; HORMONAL REGULATION; HUMAN; IMMUNORADIOMETRIC ASSAY; MALE; MICROADENOMA; PRIORITY JOURNAL; PROTEIN PROCESSING; STEM CELL; VISUAL IMPAIRMENT;

ADENOMA; ADRENOCORTICOTROPIC HORMONE; BETA-LIPOTROPIN; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE; HUMANS; HYDROCORTISONE; PITUITARY NEOPLASMS; PRO-OPIOMELANOCORTIN; PROTEIN PRECURSORS;

EID: 0030041371     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.497     Document Type: Article

References (26)

1. Yalow RS, Berson SA. 1971 Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH producing thymoma. Biochem Biophys Res Commun. 44:439-445.
2. Ratter SJ, Lowry PJ, Besser GM, Rees LH. 1980 Chromatographic characterization of adrenocorticotrophin in human plasma. J Endocrinol. 85:359-369.
3. Hale AC, Besser GM, Rees LH. 1985 Characterization of pro-opiomelanocortin-derived peptides in pituitary and ectopic adrenocorticotrophin-secreting tumors. J Endocrinol. 108:49-56.
4. Crosby SR, Stewart MF, Ratcliffe JG, White A. 1988 Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay. J Clin Endocrinol Metab. 67:1271-1277.
5. Stewart PM, Gibson S, Crosby SR, et al. 1994 ACTH precursors in the ectopic ACTH syndrome. Clin Endocrinol (Oxf). 40:199-204.
6. Howlett T, Besser M. 1989 Cushing's syndrome. Med Int. 63:2605-2611.
7. Aron DC, Findling JW, Fitzgerald PA, Forsham PH, Wilson CB, Tyrrell JB. 1982 Cushing's syndrome: problems in management. Endocr Rev. 3:229.
8. Reincke M, Allolio B, Saeger W, Kaulen D, Winkelmann W. 1987 A pituitary adenoma secreting high molecular weight adrenocorticotropin without evidence of Cushing's disease. J Clin Endocrinol Metab. 65:1296-1300.
9. Menendez EL, Lafita J, Forga L, et al. Episodic Cushing's syndrome in a patient with a pituitary macroadenoma secreting high molecular weight ACTH. Proc of the 3rd Int Pituitary Congr. 1993; MP36 (Abstract).
10. Fuller PJ, Lim ATW, Barlow JW, et al. 1984 A pituitary tumor producing high molecular weight adrenocorticotropin-related peptides: clinical and cell culture studies. J Clin Endocrinol Metab. 58:134-142.
11. Hale AC, Millar JBG, Ratter SJ, Pickard JD, Doniach I, Rees LH. 1985 A case of pituitary-dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. Clin Endocrinol (Oxf). 22:479-488.
12. Gibson S, Crosby SR, Stewart MF, Jennings AM, McCall E, White A. 1994 Differential release of pro-opiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays. J Clin Endocrinol Metab. 78:835-841.
13. Sorenson GD, Pettengill OS, Brinck-Johnsen T, Cate C, Maurer LH. 1981 Hormone production by cultures of small-cell carcinoma of the lung. Cancer. 47:1289-1296.
14. Crosby SR, Stewart MF, Farrell WE, Gibson S, White A. 1989 Comparison of ACTH and ACTH precursor peptides secreted by human pituitary and lung tumor cells in vitro. J Endocrinol. 125:147-152.
15. Trainer PJ, Grossman A. 1991 The diagnosis and differential diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf). 34:317-330.
16. White A, Smith H, Hoadley M, Dobson SH, Ratcliffe JG. 1987 Clinical evaluation of a two-site immunoradiometric assay for adrenocorticotrophin in unextracted plasma using monoclonal antibodies. Clin Endocrinol (Oxf). 26: 41-52.
17. Gibson S, Crosby SR, White A. 1993 Discrimination between β-endorphin and β-lipotrophin in human plasma using two-site immunoradiometric assays. Clin Endocrinol (Oxf). 39:445-453.
18. Wallace WHB, Crowne EC, Shalet SM, et al. 1991 Episodic ACTH and cortisol secretion in normal children. Clin Endocrinol (Oxf). 34:215-221.
19. Goverde HJM, Martens GJM, Pesman GJ, Smals AGH. 1993 Multiple forms of bioactive and immunoreactive adrenocorticotropin in human pituitary and blood of patients with Nelson's syndrome. J Clin Endocrinol Metab. 77:443-447.
20. Odell WD. 1991 Ectopic ACTH syndrome: a misnomer. Endocrinol Metab Clin North Am. 20:371-379.
21. Hale AC, Ratter SJ, Besser GM, Rees LH. Characterisation and bioactivity of N-proopiocortin fragments from tumors associated with Cushing's syndrome [Abstract]. Proc of the 7th Int Congr of Endocrinol, 1984; 361.
22. Ratter SJ, Gillies G, Hope J, et al. 1983 Pro-opiocortin related peptides in human pituitary and ectopic ACTH secreting tumors. Clin Endocrinol (Oxf). 18:211-218.
23. Vaughan NJ, Laroche CM, Goodman I, Davies MJ, Jenkins JS. 1985 Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. Clin Endocrinol (Oxf). 22:147-153.
24. Horvath E, Kovacs K, Killinger DW, Smyth HS, Platts ME, Singer W. 1979 Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic and ultrastructural study. Am J Pathol. 98:617-638.
25. Scheithauer BW, Kovacs KT, Laws ER, Randall RV. 1986 Pathology of invasive pituitary with special reference to functional classification. J Neurosurg. 65:733-805.
26. Ray DW, Gibson S, Crosby SR, Davis JRE, White A. 1943 Invasive pituitary corticotroph adenomas with aberrant pro-opiomelanocortin processing. J Endocrinol. 137(Suppl):135 (Abstract).