Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and Brown Norway rats

Journal of Autoimmunity

Volumn 10, Issue 1, 1997, Pages 35-41

  Jackerott, Malene ^a   Hornum, Lars ^a   Andreasen, Bodil E ^a   Markholst, Helle ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

BB rat; genetics; MHC; type 1 diabetes; X chromosome

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CHROMOSOME 18; CONGENITAL DISORDER; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETIOLOGY; FEMALE; GENE SEGREGATION; GENOTYPE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; X CHROMOSOME;

EID: 0031081321     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0105     Document Type: Article

References (31)

1. Crisá L., Mordes J., Rossini A. Autoimmune diabetes mellitus in the BB rat. Diabetes/Metabolism Reviews. 8:1992;9-37.
2. Colle E., Guttmann R., Seemayer T. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. J. Exp. Med. 154:1981;1237-1242.
3. Colle E., Guttmann R., Seemayer T., Michel F. Spontaneous diabetes mellitus syndrome in the rat. IV. Immunogenetic interactions of MHC and non-MHC components of the syndrome. Metabolism. 32 (Suppl. 1):1983;54-61.
4. Jackson R.A., Buse J.B., Rifai R., Pelletier D., Milford E.L., Carpenter C.B., Eisenbarth G.S., Williams R.M. Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J. Exp. Med. 159:1984;1629-1636.
5. Herberg L. On the genetics of the BB rat. Diabetes. Proc. of the 12th Congress of IDF Diabetes. Madrid, September 23-28, 1985. 1986;Elsevier Science Publishers B.V.
6. Brogren, C.-H. Buschard, K. Röpke, C. Rygaard, J. 1987, Genetics of the autoimmune BB-rat in the study of diabetes mellitus heredity, Immunodeficient animals in biochemical research. Rygaard, J.Brünner, F.Græm, N.Spang-Thomsen, O. S. Karger, Basel.
7. Klöting I., Stark O. Genetic studies of IDDM in BB rats: The incidence of diabetes in F2 and first backcross hybrids allows rejection of the recessive hypothesis. Exp. Clin. Endocrinol. 89:1987;312-318.
8. Günther E., Kiesel U., Kolb H., Krawczak M., Rothermel E., Wurst W. Genetic analysis of susceptibility to diabetes mellitus in F2-hybrids between diabetes-prone BB and various MHC-recombinant congenic rat strains. J. Autoimmunity. 4:1991;543-551.
9. Colle E., Fuks A., Poussier P., Edouard P., Guttmann R.D. Polygenic nature of spontaneous diabetes in the rat: Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes. 41:1992;1617-1623.
10. Jacob H., Petterson A., Wilson D., Mao Y., Lernmark Å., Lander E. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genet. 2:1992;56-60.
11. Jacob H., Petterson A., Wilson D., Mao Y., Lernmark Å., Lander E. Erratum: Genetic dissection of auto-immune type-1 diabetes in the BB rat (vol. 2, pp. 56-60, 1992). Nature Genet. 7:1994;215-215.
12. Guberski D.L., Butler L., Kastern W. Genetic studies in inbred BB/Wor rats: analysis of progeny produced by crossing lymphopenic diabetes-prone rats with nonlymphopenic diabetic rats. Diabetes. 38:1989;887-893.
13. Markholst H., Eastman S., Wilson D., Andreasen B., Lernmark Å. Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes. J. Exp. Med. 174:1991;297-300.
14. Hornum L., Jackerott M., Markholst H. The T-cell lymphopenia gene (Lyp) maps between D4Mit6 and Npy on RNO4. Mamm. Genome. 6:1995;371-372.
15. Colle E., Guttmann R., Fuks A. Insulin-dependent diabetes mellitus is associated with genes that map to the right of the class I RT1.A locus of the major histocompatibility complex of the rat. Diabetes. 35:1986;454-458.
16. Colle E., Fuks A., Guttmann R.D., Seemayer T.A. Genetic susceptibility to the development of spontaneous insulin-dependent Diabetes Mellitus in the rat. Transplant. Proc. 22:1990;2572-2573.
17. Platz P., Jackson B.K., Morling M., Ryder L.P., Svejgaard A., Thomsen M., Christy M., Kromann H., Benn J., Nerup J., Green A., Hauge M. HLA-D or -DR antigens in genetic analysis of insulin dependent diabetes mellitus. Diabetologia. 21:1981;108-115.
18. Hattori M., Buse J.B., Jackson R.A., Glimcher L., Dorf M.E., Minami M., Makino S., Moriwaki K., Kuxuya H., Imura H., Strauss W.M., Seidman J.G., Eisenbarth G.S. The NOD mouse: Recessive diabetogenic gene in the Major Histocompatibility Complex. Science. 231:1986;733-735.
19. Fuks A., Ono S., Colle E., Guttmann R. A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive of insulin-dependent diabetes mellitus in the BB rat. Exp. Clin. Immunogenet. 7:1990;162-169.
20. Colle E., Ono S.J., Fuks A., Guttmann R.D., Seemayer T.A. Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex. Diabetes. 37:1988;1438-1443.
21. Lang F., Kastern W. The gene for the T lymphocyte alloantigen, RT6, is not linked to either diabetes or lymphopenia and is not defective in the BB rat. Eur. J. Immunol. 19:1989;1785-1789.
22. Klöting I., Vogt L., Serikawa T. Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Diabete & Metabolisme. 21:1995;338-344.
23. Hedrich H.J. Genetic monitoring of inbred strains of rats. 1990;Gustav Fischer Verlag, Stuttgart.
24. Serikawa T., Kuramoto T., Hilbert P., Mori M., Yamada J., Dubay C., Lindpainter K., Ganten D., Guénet Y., Lathrop G., Beckmann J. Rat gene mapping using PCR-analyzed microsatellites. Genetics. 131:1992;701-721.
25. Siegel S., Castellan Jr. N.J. Anker J.D. Nonparametric statistics for the behavioral sciences. 1988;McGraw-Hill Book Company, New York.
26. Colle E., Guttmann R.D., Fuks A., Seemayer T.A., Prud'homme G.J. Genetics of spontaneous diabetic syndrome. Interactions of MHC and non-MHC-associated factors. Mol. Biol. Med. 3:1986;13-23.
27. Baxter A.G., Cooke A. The genetics of the NOD mouse. Diabetes/Metabolism Reviews. 11:1995;315-335.
28. Prins J.-B., Herberg L., Den Bieman M., Van Zutphen B.F.M. Genetic characterization and interrelationship of inbred lines of diabetes-prone and not diabetes-prone BB rats. Shafrir E. Frontiers in diabetes research. Lessons from animal diabetes III. 1990;Smith-Gordon, London.
29. Prins J.-B. DNA fingerprinting in 26 lines of diabetes-prone and non-diabetes-prone BB rats. Genetic characterization of inbred strains of the rat (diss.). 1990.
30. Ghosh S., Palmer S.M., Rodrigues N.R., Cordell H.J., Hearne C.M., Cornall R.J., Prins J.-B., McShane P., Lathrop G.M., Peterson L.B., Wicker L.S., Todd J.A. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genet. 4:1993;404-409.
31. Davies J.L., Kawagucki Y., Bennett S.T., Copeman J.B., Cordell H.J., Pritchard L.E., Reed P.W., Gough S.C.L., Jenkins S.C., Palmer S.M., Balfour K.M., Rowe B.R., Farrall M., Barnett A.H., Bain S.C., Todd J.A. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 371:1994;130-135.