Convergence of CD19 and B cell antigen receptor signals at MEK1 in the ERK2 activation cascade

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 5901-5908

  Li, Xiaoli ^a   Carter, Robert H ^a,b,c,d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD19 ANTIGEN; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD19; B-LYMPHOCYTES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CELL LINE, TRANSFORMED; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN M; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 0032400926     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Fearon, D. T., and R. H. Carter. 1995. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13:127.
2. Tedder, T., M. Inaoki, and S. Sato. 1997. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 6:107.
3. Carter, R. H., D. A. Tuveson, D. J. Park, S. G. Rhee, and D. T. Fearon. 1991. The CD19 complex of B lymphocytes: activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J. Immunol. 147:3663.
4. Carter, R. H., and D. T. Fearon. 1992. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105.
5. Bradbury, L. E., G. S. Kansas, S. Levy, R. L. Evans, and T. F. Tedder. 1992. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J. Immunol. 149: 2841.
6. Li, X., D. Sandoval, L. Freeberg, and R. H. Carter. 1997. Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig. J. Immunol. 158:5649.
7. Callard, R. E., K. P. Rigley, S. H. Smith, S. Thurstan, and J. G. Shields. 1992. CD19 regulation of human B cell responses: B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used. J. Immunol. 148:2983.
8. Tooze, R., G. Doody, and D. Fearon. 1997. Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin. Immunity 7:59.
9. Engel, P., L.-J. Zhou, D. C. Ord, S. Sato, B. Koller, and T. F. Tedder. 1995. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39.
10. Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376: 352.
11. Sato, S., D. A. Steeber, and T. F. Tedder. 1995. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Prof. Natl. Acad. Sci. USA 92:11558.
12. Dempsey, P. W., M. E. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348.
13. Tuveson, D. A., R. H. Carter, S. P. Soltoff, and D. T. Fearon. 1993. CD19 of B cells as a surrogate kinase insert region Io bind phosphatidylinositol 3-kinase. Science 260:986.
14. Roifman, C. M., and S. Ke. 1993. CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells. Biochem. Biophys. Res. Commun. 194:222.
15. Chalupny, N. J., S. B. Kanner, G. L. Schieven, S. F. Wee, L. K. Gilliland, A. Aruffo, and J. A. Ledbetter. 1993. Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J. 12:2691.
16. Weng, W.-K., L. Jarvis, and T. W. LeBien. 1994. Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J. Biol. Chem. 269:32514.
17. O'Rourke, L., R. Tooze, M. Turner, D. Sandoval, R. Carter, V. Tybulewicz, and D. Fearon. 1998. CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity 8:635.
18. Sato, S., P. Jansen, and T. Tedder. 1997. CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc. Natl. Acad. Sci. USA 94:13158.
19. Crespo, P., K. E. Schuebel, A. A. Ostrom, J. S. Gutkind, and X. R. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385:169.
20. Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. Mosteller, U. Krishna, J. Flack, M. White, and D. Broek. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558.
21. Harwood, A., and J. Cambier. 1993. B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1. J. Immunol. 151:4513.
22. Tordai, A., R. A. Franklin, H. Patel, A. M. Gardner, G. L. Johnson, and E. W. Gelfand. 1994. Cross-linking of surface IgM stimulates the Ras/Raf-1/ MEK/MAPK cascade in human B lymphocytes. J. Biol. Chem. 269:7538.
23. Saxton, T. M., I. van Oostveen, R. Aebersold, and M. R. Gold. 1994. B cell antigen receptor cross-linking induces phosphorylation of the p21Ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein. J. Immunol. 153:623.
24. Lankester, A. C., G. M. van Schijndel, P. M. Rood, A. J. Verhoeven, and R. A. V. Lier. 1994. B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19-coligation. Eur. J. Immunol. 24:2818.
25. Gulbins, E., C. Langlet, G. Baier, N. Bonnefoy-Berard, E. Herbert, A. Altman, and K. Coggeshall. 1994. Tyrosine phosphorylation and activation of Vav GTP/ GDP exchange activity in antigen receptor-triggered B cells. J. Immunol. 152: 2123.
26. Crespo, P., X. Bustelo, D. Aaroson, O. Coso, M. Lopez-Barahona, M. Barbacid, and J. Gutkind. 1996. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13:455.
27. Coso, O., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SPK signaling pathway. Cell 81:1137.
28. Yan, M., and D. J. Templeton. 1994. Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase. J. Biol. Chem. 269:19067.
29. Lange-Carter, C. A., C. Pleiman, A. Gardner, K. Blumer, and G. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315.
30. Fanger, G. R., N. L. Johnson, and G. L. Johnson. 1997. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16:4961.
31. Frost, J. A., H. Steen, P. S. Shapiro, T. Lewis, N. Ahn, P. E. Shaw, and M. H. Cobb. 1997. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16:6428.
32. Kolch, W., G. Heidecker, G. Kochs, R. Hummel, H. Vahidi, H. Mischak, G. Finkenzeller, D. Marme, and U. R. Rapp. 1993. Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature 364:249.
33. Marias, R., Y. Light, C. Mason, H. Paterson, M. Olson, and C. Marshall. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109.
34. Carter, R. H., M. O. Spycher, Y. C. Ng, R. Hoffman, and D. T. Fearon. 1988. Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes. J. Immunol. 141:457.
35. Taylor, S. J., and D. Shalloway. 1996. Cell cycle-dependent activation of Ras, Curr: Biol. 6:1621.
36. ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 16:6439.
37. de Rooij, J., and J. L. Bos. 1997. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14:623.
38. Niculescu, F., H. Rus, T. V. Biesen, and M. L. Shin. 1997. Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent. J. Immunol. 158:4405.
39. Kyriakis, J. M., A. Harald, X.-F. Zhang, P. Banerjee, D. L. Brautigan, U. R. Rapp, and J. Avruch. 1992. Raf-1 activates MAP kinase-kinase. Nature 358:417.
40. Crews, C. M., A. Alessandrini, and R. L. Erikson. 1992. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258: 478.
41. Seger, R., N. G. Ahn, J. Posada, E. S. Munar, A. M. Jenson, J. A. Cooper, C. M. H., and E. G. Krebs. 1992. Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J. Biol. Chem. 267:14373.
42. Li, T.-Y., M. Baccam, S. B. Waters, J. E. Pessin, G. A. Bishop, and G. A. Koretzky. 1996. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. J. Immunol. 157: 1440.
43. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, and T. Grand-Perret. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266:15771.
44. Sidorenko, S., C.-L. Law, S. Klaus, K. Chandran, M. Takata, T. Kurosaki, and E. Clark. 1996. Protein kinase C μ associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Immunity 5:353.
45. Doody, G. M., P. W. Dempsey, and D. T. Fearon. 1996. Activation of B lymphocytes: integrating signals from CD19, CD22 and FcγIIb1. Curr. Opin. Immunol. 8:378.
46. Cyster, J. G., and C. C. Goodnow. 1997. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity 6:509.
47. Tridandapani, S., G. W. Chacko, J. R. V. Brocklyn, and K. M. Coggeshall. 1997. Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions. J. Immunol. 158:1125.
48. Foy, T. M., A. Aruffo, J. Bajorath, J. E. Buhlmann, and R. J. Noelle. 1996. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14:591.
49. Kehry, M. R. 1996. CD40-mediated signaling in B cells, balancing cell survival, growth, and death. J. Immunol. 156:2345.
50. Purkerson, J., and D. Parker. 1998. Differential coupling of membrane Ig and CD40 to the extracellularly regulated kinase signaling pathway. J. Immunol. 160: 2121.
51. Weng, W.-K., N. Shah, D. O'Brien, B. van Ness, and T. LeBien. 1997. Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells. J. Immunol. 159:5502.
52. Kozono, Y., R. Abe, H. Kozono, R. Kelly, T. Azuma, and V. Holers. 1998. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J. Immunol. 160:1565.
53. 2+ mobilization. J. Exp. Med. 186:1897.
54. Alvarez, E., I. C. Northwood, F. A. Gonzaler, D. A. Latour, A. Seth, C. Abate, T. Curran, and R. J. Davis. 1991. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation: characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266:15277.
55. Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414.
56. Gille, H., M. Kortenjann, O. Thomae, C. Moomaw, C. Slaughter, M. H. Cobb, and P. E. Shaw. 1995. ERK phosphorylation potentiates Elk-!-mediated ternary complex formation and transactivation. EMBO J. 14:951.
57. McMahon, S. B., and J. G. Monroe. 1995. Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes. J. Exp. Med. 181:417.
58. Lange-Carter, C. A., and G. L. Johnson. 1994. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458.
59. Frost, J. A., S. Xu, M. R. Hutchison, S. Marcus, and M. H. Cobb. 1996. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol. Cell. Biol. 16:3707.
60. Nimnual, A., B. Yatsula, and D. Bar-Sagi. 1998. Coupling of Ras and Rac guanosine triphosphates through the Ras exchanger Sos. Science 279:560.