Antibacterials - Mechanisms of action

Current Opinion in Microbiology

Volumn 1, Issue 5, 1998, Pages 502-508

  Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG DERIVATIVE; OXAZOLONE; PEPTIDE;

BACTERIUM; DRUG DESIGN; DRUG EFFECT; DRUG INDUSTRY; MYCOBACTERIUM; RESEARCH; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIA; DRUG DESIGN; DRUG INDUSTRY; MYCOBACTERIUM; OXAZOLONE; PEPTIDES; RESEARCH;

EID: 0032173625     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(98)80081-7     Document Type: Article

References (31)

1. White DG, Maneewannakul K, von Hofe E, Zillman M, Eisenberg W: Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs. Antimicrob Agents Chemother 1997, 41:2699-2704.
2. Chopra I, Brennan P: Molecular action of anti-mycobacterial agents. Tubercle Lung Disease 1998, 78:89-98. A review that covers this very wide area and gives a good background to antimycobacterial agents.
3. Mdluli K, Slayden RA, Zhu YQ, Ramaswamy S, Pan X, Mead D, Crane DD, Musser JM, Barry CE: Inhibition of a Mycobacterium tuberculosis beta-ketoacycl ACP synthase by isoniazid. Science 1998, 280:1601-1610.
4. Rozwarski DA, Grant GA, Barton DHR, Jacobs WR, Sacchettini JC: Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. Science 1998, 279:98-102.
5. Banerjee A, Dubnau E, Quermard A, Balasubramanian V, Um KS, Wilson T, Collins D, Delisle G, Jacobs WR: InhA, a gene encoding target for INH and ethionamide in Mycobacterium tuberculosis. Science 1994, 263:227-230.
6. Sifaoui F, Varon E, Kitzis MD, Gutmann L: In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother 1998, 42:173-175.
7. Liao XW, Hancock REW: Susceptibility to β-lactam antibiotics of Pseudomonas aeruginosa overproducing penicillin-binding protein 3, Antimicrob Agents Chemother 1997, 41:1158-1161.
8. Molnar J, Hever A, Fakla I, Fischer J, Ocsovski I, Aszatos A: Inhibition of the transport function of membrane proteins by some substituted phenothiazines in Escherichia coli and multi drug resistant tumor cells. Anticancer Res 1997, 17:481-486.
9. Maxwell A, Critchlow SE: Mode of action. In Quinolone Antibacterials. Edited by Kuhlmann J, Dalhoff A, Zeiler H-J. Springer-Verlag; 1997:119-158. This book chapter is included in a recent review of qumolone antibacterials. Although it is a little out of date in places, due to the long lead up lime to publication, it gives an excellent in depth review of the mode of action of this class of agents.
10. Cabral JHM, Jackson AP, Smith CV, Shikotra N, Maxwell A, Liddington RC; Crystal structure of the breakage-reunion domain of DNA gyrase. Nature 1997, 388:903-906.
11. Zhao X, Xu C, Domagala J, Drlica K: DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance. Proc Natl Acad Sci USA 1997, 94:13991-13996.
12. Everett MJ, Jin Y-F, RICCI V, Piddock LJV: Contribution of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli isolated from humans and animals. Antimicrob Agents Chemother 1996,40:2380-2386.
13. Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4 quinolones. Microbiol Mol Biol Rev 1997, 61:377-392. This review gives additional information that is not included in the Maxwell and Critchlow book chapter [9'].
14. Nicas TI, Zeckel ML, Braun DK: Beyond vancomycin: new therapies to meet the challenge of glycopeptide resistance. Trends Microbiol 1997, 5:240-249.
15. Beauregard DA, Williams DH, Gwynn MN, Knowles DJC: Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics. Antimicrob Agents Chemother 1995, 39:781-785.
16. Allen NE, LeTourneau DL, Hobbs JN: Molecular interactions of a semisynthetic glycopeptide antibiotic with D-alanyl-D-alanine and D-alanyl-D-lactate residues. Antimicrob Agents Chemother 1997, 41:66-71.
17. Testa RT, Petersen PJ, Jacobus NV, Sum P-E, Lee VJ, Tally FP: In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob Agents Chemother 1993, 37:2270-2277.
18. Edwards DI: Nitroimidazole drugs-action and resistance mechanisms. I. Mechanisms of action. J Antimicrob Chemother 1993, 31:9-20.
19. Smith MA, Edwards Dl: Redox potentials and oxygen concentration as factors in the susceptibility of Helicobacter pylori to nitroheterocyclic drugs. J Antimicrob Chemother 1995, 35:751-764.
20. Jorgensen MA, Manos J, Mendz GL, Hazell SL: The mode of action of metronidazole in Helicobacter pylori: futile cycling or reduction? J Antimicrob Chemother 1998, 41:67-75.
21. Kaihovaara P, Höök-Nikanne J, Uusi-Oukari M, Kosunen TU, Salaspuro M: Flavodoxin-dependent pyruvate oxidation, acetate production and metronidazole reduction by Helicobacter pylori. J Antimicrob Chemother 1998, 41:171-177.
22. Kurz M, Guba W. Vertesy L: Three dimensional structure of moenomycin A - a potent inhibitor of penicillin-binding protein 1b. Eur J Biochem 1998, 252:500-507
23. Shinabarger DL, Marotti KR, Murray RW, Lin AH, Melchior P, Swaney SM, Dunyak DS, Demyan WF, Buysse JM: Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents Chemother 1997, 41:2132-2136.
24. Lin AH, Murray RW, Vidmar TJ, Marotti KR: The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother 1997, 41:2127 2131.
25. Johansen C, Verheul A, Gram L, Gill T, Abee T: Protamine-induced permeabilization of cell envelopes of Gram-positive and Gramnegative bacteria. Appl Environ Microbiol 1997, 63:1155-1159.
26. Falla TJ, Hancock REW: Improved activity of a synthetic indolicidin analog. Antimicrob Agents Chemother 1997, 4-,771-775.
27. Subbalakshmi C, Sitaram N: Mechanism of antimicrobial action of indolicidin. FEMS Microbiol Letts 1998,160: 91-96.
28. Wyman TB, Nicol F, Zelphati O, Scaria PV, Plank C, Szoka FC Jr: Design, synthesis and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochem 1997, 36:3008-3017.
29. Shafer WM, Qu XD, Waring AJ, Lehrer RI: Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc Natl Acad Sci USA 1998, 95:1829-1833.
30. Brötz H, Bierbaum G, Leopold K, Reynolds PE, Sahl H-G: The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II. Anttmrcrob Agents Chemother 1998, 42:154-160.
31. Williams KJ, Piddock LJV: Accumulation of rifampicin by Escherichia colland Staphyfococcus aureus. J Antimicrob Chemother 1998. in press.