DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 25, 1997, Pages 13991-13996

  Zhao, Xilin ^a   Xu, Chen ^a   Domagala, John ^b   Drlica, Karl ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 7 (1 PIPERAZINYL) 3 QUINOLINECARBOXYLIC ACID; 1 CYCLOPROPYL 7 (3 ETHYL 1 PIPERAZINYL) 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; 1 CYCLOPROPYL 7 (3 ETHYL 1 PIPERAZINYL) 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINECARBOXYLIC ACID; ANTIBIOTIC AGENT; CIPROFLOXACIN; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; DNA DAMAGE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DNA, BACTERIAL; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GENES, BACTERIAL; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0031459911     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.25.13991     Document Type: Article

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